{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T10:00:34Z","timestamp":1781085634799,"version":"3.54.1"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:00:00Z","timestamp":1758758400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:00:00Z","timestamp":1758758400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-18282-6","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T13:57:37Z","timestamp":1758808657000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A systematic review and meta-analysis of randomized controlled trials evaluating the effect of whole body vibration training on fibromyalgia"],"prefix":"10.1038","volume":"15","author":[{"given":"Po-Chuan","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-An","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-An","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Tien","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-Shin","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung-Chou","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,25]]},"reference":[{"issue":"8","key":"18282_CR1","doi-asserted-by":"publisher","first-page":"3891","DOI":"10.3390\/ijms22083891","volume":"22","author":"R Siracusa","year":"2021","unstructured":"Siracusa, R. et al. Fibromyalgia: Pathogenesis, mechanisms, diagnosis and treatment options update. Int. J. Mol. Sci. 22 (8), 3891 (2021).","journal-title":"Int. J. Mol. Sci."},{"key":"18282_CR2","first-page":"426130","volume":"2012","author":"E Bellato","year":"2012","unstructured":"Bellato, E. et al. Fibromyalgia syndrome: Etiology, pathogenesis, diagnosis, and treatment. Pain Res. Treat. 2012, 426130 (2012).","journal-title":"Pain Res. Treat."},{"key":"18282_CR3","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/B978-0-7020-4086-3.00033-3","volume":"119","author":"JE Sumpton","year":"2014","unstructured":"Sumpton, J. E. & Moulin, D. E. Fibromyalgia. Handb. Clin. Neurol. 119, 513\u2013527 (2014).","journal-title":"Handb. Clin. Neurol."},{"issue":"5","key":"18282_CR4","doi-asserted-by":"publisher","first-page":"ITC33","DOI":"10.7326\/AITC202003030","volume":"172","author":"MJ Bair","year":"2020","unstructured":"Bair, M. J. & Krebs, E. E. Fibromyalgia (Japanese version). Ann. Intern. Med. 172(5), ITC33\u2013ITC48 (2020).","journal-title":"Ann. Intern. Med."},{"issue":"15","key":"18282_CR5","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1001\/jama.2014.3266","volume":"311","author":"DJ Clauw","year":"2014","unstructured":"Clauw, D. J. Fibromyalgia: A clinical review. JAMA 311 (15), 1547\u20131555 (2014).","journal-title":"JAMA"},{"issue":"3","key":"18282_CR6","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.berh.2007.03.003","volume":"21","author":"J McBeth","year":"2007","unstructured":"McBeth, J. & Jones, K. Epidemiology of chronic musculoskeletal pain. Best Pract. Res. Clin. Rheumatol. 21 (3), 403\u2013425 (2007).","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"issue":"2","key":"18282_CR7","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1002\/art.38905","volume":"67","author":"GT Jones","year":"2015","unstructured":"Jones, G. T. et al. The prevalence of fibromyalgia in the general population: A comparison of the American college of rheumatology 1990, 2010, and modified 2010 classification criteria. Arthritis Rheumatol. 67 (2), 568\u2013575 (2015).","journal-title":"Arthritis Rheumatol."},{"issue":"5","key":"18282_CR8","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1007\/s11916-003-0035-z","volume":"7","author":"L Neumann","year":"2003","unstructured":"Neumann, L. & Buskila, D. Epidemiology of fibromyalgia. Curr. Pain Headache Rep. 7 (5), 362\u2013368 (2003).","journal-title":"Curr. Pain Headache Rep."},{"issue":"9","key":"18282_CR9","doi-asserted-by":"publisher","first-page":"1560","DOI":"10.1002\/art.1780400904","volume":"40","author":"F Wolfe","year":"1997","unstructured":"Wolfe, F. et al. A prospective, longitudinal, multicenter study of service utilization and costs in fibromyalgia. Arthritis Rheum. 40 (9), 1560\u20131570 (1997).","journal-title":"Arthritis Rheum."},{"issue":"7","key":"18282_CR10","first-page":"1391","volume":"31","author":"JR Penrod","year":"2004","unstructured":"Penrod, J. R. et al. Health services costs and their determinants in women with fibromyalgia. J. Rheumatol. 31 (7), 1391\u20131398 (2004).","journal-title":"J. Rheumatol."},{"issue":"8","key":"18282_CR11","first-page":"1621","volume":"31","author":"RL Robinson","year":"2004","unstructured":"Robinson, R. L. et al. Depression and fibromyalgia: Treatment and cost when diagnosed separately or concurrently. J. Rheumatol. 31 (8), 1621\u20131629 (2004).","journal-title":"J. Rheumatol."},{"issue":"1","key":"18282_CR12","doi-asserted-by":"publisher","first-page":"101933","DOI":"10.1016\/j.berh.2024.101933","volume":"38","author":"JE Martinez","year":"2024","unstructured":"Martinez, J. E. & Guimar\u00e3es, I. Fibromyalgia: Are there any new approaches? Best Pract. Res. Clin. Rheumatol. 38 (1), 101933 (2024).","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"issue":"6","key":"18282_CR13","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.3390\/biomedicines12061266","volume":"12","author":"EA Jones","year":"2024","unstructured":"Jones, E. A. et al. Management of fibromyalgia: An update. Biomedicines 12 (6), 1266 (2024).","journal-title":"Biomedicines"},{"issue":"9","key":"18282_CR14","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1136\/bjsm.2005.016857","volume":"39","author":"M Cardinale","year":"2005","unstructured":"Cardinale, M. & Wakeling, J. Whole body vibration exercise: Are vibrations good for you? Br. J. Sports Med. 39 (9), 585\u2013589 (2005).","journal-title":"Br. J. Sports Med."},{"issue":"2","key":"18282_CR15","doi-asserted-by":"publisher","first-page":"105276","DOI":"10.1016\/j.jbspin.2021.105276","volume":"89","author":"Z Wang","year":"2022","unstructured":"Wang, Z., Zhang, X. & Sun, M. The application of whole-body vibration training in knee osteoarthritis. Joint Bone Spine. 89 (2), 105276 (2022).","journal-title":"Joint Bone Spine"},{"issue":"2","key":"18282_CR16","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.apmr.2004.05.019","volume":"86","author":"O Bruyere","year":"2005","unstructured":"Bruyere, O. et al. Controlled whole body vibration to decrease fall risk and improve health-related quality of life of nursing home residents. Arch. Phys. Med. Rehabil. 86 (2), 303\u2013307 (2005).","journal-title":"Arch. Phys. Med. Rehabil"},{"issue":"7","key":"18282_CR17","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1016\/j.apmr.2007.03.028","volume":"88","author":"WH Cheung","year":"2007","unstructured":"Cheung, W. H. et al. High-frequency whole-body vibration improves balancing ability in elderly women. Arch. Phys. Med. Rehabil. 88 (7), 852\u2013857 (2007).","journal-title":"Arch. Phys. Med. Rehabil"},{"issue":"1","key":"18282_CR18","doi-asserted-by":"publisher","first-page":"28","DOI":"10.2302\/kjm.56.28","volume":"56","author":"K Kawanabe","year":"2007","unstructured":"Kawanabe, K. et al. Effect of whole-body vibration exercise and muscle strengthening, balance, and walking exercises on walking ability in the elderly. Keio J. Med. 56 (1), 28\u201333 (2007).","journal-title":"Keio J. Med."},{"issue":"12","key":"18282_CR19","doi-asserted-by":"publisher","first-page":"116","DOI":"10.5312\/wjo.v2.i12.116","volume":"2","author":"A Elfering","year":"2011","unstructured":"Elfering, A. et al. Stochastic resonance whole body vibration reduces musculoskeletal pain: A randomized controlled trial. World J. Orthop. 2 (12), 116\u2013120 (2011).","journal-title":"World J. Orthop."},{"key":"18282_CR20","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.gerinurse.2024.07.040","volume":"59","author":"SA Moawd","year":"2024","unstructured":"Moawd, S. A., Abdelhalim, E. H. N. & Ibrahim, A. M. A comparison between the effects of vibration exercise and needle therapy on fibromyalgia symptoms and well-being in community-dwelling older adults: A randomized control study. Geriatr. Nurs. 59, 485\u2013490 (2024).","journal-title":"Geriatr. Nurs."},{"key":"18282_CR21","doi-asserted-by":"publisher","first-page":"7593802","DOI":"10.1155\/2021\/7593802","volume":"2021","author":"VGC Ribeiro","year":"2021","unstructured":"Ribeiro, V. G. C. et al. Efficacy of whole-body vibration training on brain-derived neurotrophic factor, clinical and functional outcomes, and quality of life in women with fibromyalgia syndrome: A randomized controlled trial. J. Healthc. Eng. 2021, 7593802 (2021).","journal-title":"J. Healthc. Eng."},{"issue":"6","key":"18282_CR22","doi-asserted-by":"publisher","first-page":"3007","DOI":"10.3390\/ijerph18063007","volume":"18","author":"JA Mingorance","year":"2021","unstructured":"Mingorance, J. A. et al. A comparison of the effect of two types of whole-body vibration platforms on fibromyalgia: A randomized controlled trial. Int. J. Environ. Res. Public. Health. 18 (6), 3007 (2021).","journal-title":"Int. J. Environ. Res. Public. Health"},{"key":"18282_CR23","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.ctcp.2017.06.008","volume":"28","author":"A Alev","year":"2017","unstructured":"Alev, A. et al. Effects of whole body vibration therapy in pain, function, and depression of the patients with fibromyalgia. Complement. Ther. Clin. Pract. 28, 200\u2013203 (2017).","journal-title":"Complement. Ther. Clin. Pract."},{"issue":"8","key":"18282_CR24","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1089\/acm.2010.0296","volume":"17","author":"PR Olivares","year":"2011","unstructured":"Olivares, P. R. et al. Tilting whole body vibration improves quality of life in women with fibromyalgia: A randomized controlled trial. J. Altern. Complement. Med. 17 (8), 723\u2013728 (2011).","journal-title":"J. Altern. Complement. Med."},{"issue":"6 Suppl 63","key":"18282_CR25","first-page":"S40","volume":"28","author":"B Sa\u00f1udo","year":"2010","unstructured":"Sa\u00f1udo, B. et al. The effect of 6-week exercise programme and whole body vibration on strength and quality of life in women with fibromyalgia: A randomised study. Clin. Exp. Rheumatol. 28 (6 Suppl 63), S40\u2013S45 (2010).","journal-title":"Clin. Exp. Rheumatol."},{"issue":"7","key":"18282_CR26","doi-asserted-by":"publisher","first-page":"678","DOI":"10.2340\/16501977-1174","volume":"45","author":"B Sa\u00f1udo","year":"2013","unstructured":"Sa\u00f1udo, B. et al. Changes in body balance and functional performance following whole-body vibration training in patients with fibromyalgia syndrome: A randomized controlled trial. J. Rehabil Med. 45 (7), 678\u2013684 (2013).","journal-title":"J. Rehabil Med."},{"issue":"1","key":"18282_CR27","first-page":"85","volume":"52","author":"JC Adsuar","year":"2012","unstructured":"Adsuar, J. C. et al. Whole body vibration improves the single-leg stance static balance in women with fibromyalgia: A randomized controlled trial. J. Sports Med. Phys. Fit. 52 (1), 85\u201391 (2012).","journal-title":"J. Sports Med. Phys. Fit."},{"issue":"11","key":"18282_CR28","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.1016\/j.apmr.2019.03.011","volume":"100","author":"Y Dong","year":"2019","unstructured":"Dong, Y. et al. Whole body vibration exercise for chronic musculoskeletal pain: A systematic review and meta-analysis of randomized controlled trials. Arch. Phys. Med. Rehabil. 100 (11), 2167\u20132178 (2019).","journal-title":"Arch. Phys. Med. Rehabil"},{"issue":"9","key":"18282_CR29","first-page":"CD011755","volume":"9","author":"J Bidonde","year":"2017","unstructured":"Bidonde, J. et al. Whole body vibration exercise training for fibromyalgia. Cochrane Database Syst. Rev. 9 (9), CD011755 (2017).","journal-title":"Cochrane Database Syst. Rev."},{"issue":"9","key":"18282_CR30","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1080\/09638288.2017.1282989","volume":"40","author":"E Moretti","year":"2018","unstructured":"Moretti, E. et al. Efficacy of whole-body vibration for pain, fatigue, and quality of life in women with fibromyalgia: A systematic review. Disabil. Rehabil. 40 (9), 988\u2013996 (2018).","journal-title":"Disabil. Rehabil"},{"key":"18282_CR31","doi-asserted-by":"publisher","first-page":"719082","DOI":"10.1155\/2015\/719082","volume":"2015","author":"D Collado-Mateo","year":"2015","unstructured":"Collado-Mateo, D. et al. Effects of whole-body vibration therapy in patients with fibromyalgia: A systematic literature review. Evid. Based Complement. Alternat Med. 2015, 719082 (2015).","journal-title":"Evid. Based Complement. Alternat Med."},{"key":"18282_CR32","doi-asserted-by":"publisher","first-page":"3639","DOI":"10.2147\/JPR.S384215","volume":"15","author":"KD Zhang","year":"2022","unstructured":"Zhang, K. D. et al. Effect of exercise interventions on health-related quality of life in patients with fibromyalgia syndrome: A systematic review and network meta-analysis. J. Pain Res. 15, 3639\u20133656 (2022).","journal-title":"J. Pain Res."},{"key":"18282_CR33","unstructured":"Higgins, J. P. T. et al. August. Cochrane Handbook for Systematic Reviews of Interventions version 6.5 (updated (2024)."},{"issue":"1","key":"18282_CR34","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1186\/s13643-021-01626-4","volume":"10","author":"MJ Page","year":"2021","unstructured":"Page, M. J. et al. The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. Syst. Reviews. 10 (1), 89 (2021).","journal-title":"Syst. Reviews"},{"issue":"5","key":"18282_CR35","first-page":"728","volume":"18","author":"CS Burckhardt","year":"1991","unstructured":"Burckhardt, C. S., Clark, S. R. & Bennett, R. M. The fibromyalgia impact questionnaire: Development and validation. J. Rheumatol. 18 (5), 728\u2013733 (1991).","journal-title":"J. Rheumatol."},{"issue":"11","key":"18282_CR36","first-page":"1600","volume":"61","author":"RM Bennett","year":"2009","unstructured":"Bennett, R. M. et al. The revised fibromyalgia impact questionnaire (FIQR): Validation and psychometric properties. Arthritis Care Res. (Hoboken). 61 (11), 1600\u20131606 (2009).","journal-title":"Arthritis Care Res. (Hoboken)"},{"issue":"1","key":"18282_CR37","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/S0004-9514(14)60281-6","volume":"48","author":"AM Moseley","year":"2002","unstructured":"Moseley, A. M. et al. Evidence for physiotherapy practice: A survey of the physiotherapy evidence database (PEDro). Aust J. Physiother. 48 (1), 43\u201349 (2002).","journal-title":"Aust J. Physiother"},{"issue":"6","key":"18282_CR38","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1177\/0962280216669183","volume":"27","author":"D Luo","year":"2018","unstructured":"Luo, D. et al. Optimally estimating the sample mean from the sample size, median, mid-range, and\/or mid-quartile range. Stat. Methods Med. Res. 27 (6), 1785\u20131805 (2018).","journal-title":"Stat. Methods Med. Res."},{"key":"18282_CR39","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/1471-2288-14-135","volume":"14","author":"X Wan","year":"2014","unstructured":"Wan, X. et al. Estimating the sample mean and standard deviation from the sample size, median, range and\/or interquartile range. BMC Med. Res. Methodol. 14, 135 (2014).","journal-title":"BMC Med. Res. Methodol."},{"issue":"2","key":"18282_CR40","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1111\/1469-0691.12494","volume":"20","author":"WG Melsen","year":"2014","unstructured":"Melsen, W. G. et al. The effects of clinical and statistical heterogeneity on the predictive values of results from meta-analyses. Clin. Microbiol. Infect. 20 (2), 123\u2013129 (2014).","journal-title":"Clin. Microbiol. Infect."},{"key":"18282_CR41","doi-asserted-by":"crossref","unstructured":"Cohen, J. Statistical Power Analysis for the Behavioral Sciences 2nd edn (Routledge, 2013).","DOI":"10.4324\/9780203771587"},{"key":"18282_CR42","doi-asserted-by":"publisher","first-page":"h870","DOI":"10.1136\/bmj.h870","volume":"350","author":"A Iorio","year":"2015","unstructured":"Iorio, A. et al. Use of GRADE for assessment of evidence about prognosis: Rating confidence in estimates of event rates in broad categories of patients. BMJ 350, h870 (2015).","journal-title":"BMJ"},{"key":"18282_CR43","unstructured":"EndNote Version EndNote 20. Clarivate; (2013)."},{"key":"18282_CR44","unstructured":"Biodex Medical Systems. Biodex Balance System SD: Operation Manual (Biodex Medical Systems, Inc., 2010)."},{"issue":"3","key":"18282_CR45","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1002\/pmrj.12216","volume":"12","author":"JL de Oliveira Lira","year":"2020","unstructured":"de Oliveira Lira, J. L. et al. Minimal detectable change for balance using the biodex balance system in patients with Parkinson disease. PMR. 12 (3), 281\u2013287 (2020).","journal-title":"PMR"},{"issue":"5","key":"18282_CR46","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.jbspin.2006.10.010","volume":"74","author":"A Gay","year":"2007","unstructured":"Gay, A. et al. Proprioceptive feedback enhancement induced by vibratory stimulation in complex regional pain syndrome type I: An open comparative pilot study in 11 patients. Joint Bone Spine. 74 (5), 461\u2013466 (2007).","journal-title":"Joint Bone Spine"},{"issue":"3699","key":"18282_CR47","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1126\/science.150.3699.971","volume":"150","author":"R Melzack","year":"1965","unstructured":"Melzack, R. & Wall, P. D. Pain mechanisms: A new theory. Science 150 (3699), 971\u2013979 (1965).","journal-title":"Science"},{"issue":"3","key":"18282_CR48","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1113\/jphysiol.1976.sp011581","volume":"261","author":"D Burke","year":"1976","unstructured":"Burke, D. et al. The responses of human muscle spindle endings to vibration during isometric contraction. J. Physiol. 261 (3), 695\u2013711 (1976).","journal-title":"J. Physiol."},{"issue":"3","key":"18282_CR49","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1113\/jphysiol.1976.sp011580","volume":"261","author":"D Burke","year":"1976","unstructured":"Burke, D. et al. The responses of human muscle spindle endings to vibration of non-contracting muscles. J. Physiol. 261 (3), 673\u2013693 (1976).","journal-title":"J. Physiol."},{"key":"18282_CR50","unstructured":"World Health Organization. Medical Devices: Managing the Mismatch: An Outcome of the Priority Medical Devices Project (World Health Organization, 2010)."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-18282-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-18282-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-18282-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T15:19:10Z","timestamp":1758813550000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-18282-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,25]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["18282"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-18282-6","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,25]]},"assertion":[{"value":"12 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"32918"}}