{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:06:43Z","timestamp":1760573203266,"version":"build-2065373602"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"crossref","award":["2021J01740"],"award-info":[{"award-number":["2021J01740"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Joint Funds for the Innovation of Science and Technology, Fujian Province","award":["2023Y9136"],"award-info":[{"award-number":["2023Y9136"]}]},{"name":"Subsidy Funds for the health, Fujian Provincial Department of Finance","award":["2023CZ007"],"award-info":[{"award-number":["2023CZ007"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-19218-w","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T13:36:11Z","timestamp":1760448971000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dosimetric and radiobiological benefits of patient-specific respiratory motion management for liver tumor stereotactic body radiotherapy"],"prefix":"10.1038","volume":"15","author":[{"given":"Zhenhang","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaxiang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Te","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haihua","family":"Lei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianhong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangshan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miaoyun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuangui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,14]]},"reference":[{"key":"19218_CR1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray, F. et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 74, 229\u2013263. https:\/\/doi.org\/10.3322\/caac.21834 (2024).","journal-title":"CA Cancer J. Clin."},{"key":"19218_CR2","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/s41572-021-00261-6","volume":"7","author":"DI Tsilimigras","year":"2021","unstructured":"Tsilimigras, D. I. et al. Liver metastases. Nat. Rev. Dis. Primers. 7, 27. https:\/\/doi.org\/10.1038\/s41572-021-00261-6 (2021).","journal-title":"Nat. Rev. Dis. Primers"},{"key":"19218_CR3","doi-asserted-by":"publisher","first-page":"3301","DOI":"10.1245\/s10434-007-9549-7","volume":"14","author":"WY Lau","year":"2007","unstructured":"Lau, W. Y. & Lai, E. C. Salvage surgery following downstaging of unresectable hepatocellular carcinoma\u2013a strategy to increase resectability. Ann. Surg. Oncol. 14, 3301\u20133309. https:\/\/doi.org\/10.1245\/s10434-007-9549-7 (2007).","journal-title":"Ann. Surg. Oncol."},{"key":"19218_CR4","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1002\/cncr.20892","volume":"103","author":"R Tateishi","year":"2005","unstructured":"Tateishi, R. et al. Percutaneous radiofrequency ablation for hepatocellular carcinoma. An analysis of 1000 cases. Cancer 103, 1201\u20131209. https:\/\/doi.org\/10.1002\/cncr.20892 (2005).","journal-title":"Cancer"},{"key":"19218_CR5","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.ijrobp.2011.12.026","volume":"84","author":"A Nakamura","year":"2012","unstructured":"Nakamura, A. et al. Analysis of dosimetric parameters associated with acute Gastrointestinal toxicity and upper Gastrointestinal bleeding in locally advanced pancreatic cancer patients treated with gemcitabine-based concurrent chemoradiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 84, 369\u2013375. https:\/\/doi.org\/10.1016\/j.ijrobp.2011.12.026 (2012).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"19218_CR6","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.ijrobp.2009.06.092","volume":"76","author":"CC Pan","year":"2010","unstructured":"Pan, C. C. et al. Radiation-associated liver injury. Int. J. Radiat. Oncol. Biol. Phys. 76, 94\u2013100. https:\/\/doi.org\/10.1016\/j.ijrobp.2009.06.092 (2010).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"19218_CR7","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.radonc.2019.12.004","volume":"145","author":"J Lee","year":"2020","unstructured":"Lee, J., Shin, I. S., Yoon, W. S., Koom, W. S. & Rim, C. H. Comparisons between radiofrequency ablation and stereotactic body radiotherapy for liver malignancies: Meta-analyses and a systematic review. Radiother Oncol. 145, 63\u201370. https:\/\/doi.org\/10.1016\/j.radonc.2019.12.004 (2020).","journal-title":"Radiother Oncol."},{"key":"19218_CR8","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.radonc.2019.08.018","volume":"142","author":"R Thompson","year":"2020","unstructured":"Thompson, R. et al. Outcomes of extra-cranial stereotactic body radiotherapy for metastatic colorectal cancer: dose and site of metastases matter. Radiother Oncol. 142, 236\u2013245. https:\/\/doi.org\/10.1016\/j.radonc.2019.08.018 (2020).","journal-title":"Radiother Oncol."},{"key":"19218_CR9","doi-asserted-by":"publisher","unstructured":"Schaub, S. K. et al. Stereotactic body radiation therapy for hepatocellular carcinoma: current trends and controversies. Technol. Cancer Res. Treat. 17 https:\/\/doi.org\/10.1177\/1533033818790217 (2018).","DOI":"10.1177\/1533033818790217"},{"key":"19218_CR10","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/s0360-3016(01)01453-5","volume":"50","author":"KM Langen","year":"2001","unstructured":"Langen, K. M. & Jones, D. T. Organ motion and its management. Int. J. Radiat. Oncol. Biol. Phys. 50, 265\u2013278. https:\/\/doi.org\/10.1016\/s0360-3016(01)01453-5 (2001).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"19218_CR11","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/s0360-3016(97)00009-6","volume":"38","author":"RK Ten Haken","year":"1997","unstructured":"Ten Haken, R. K., Balter, J. M., Marsh, L. H., Robertson, J. M. & Lawrence, T. S. Potential benefits of eliminating planning target volume expansions for patient breathing in the treatment of liver tumors. Int. J. Radiat. Oncol. Biol. Phys. 38, 613\u2013617. https:\/\/doi.org\/10.1016\/s0360-3016(97)00009-6 (1997).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"19218_CR12","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1186\/s13014-019-1300-6","volume":"14","author":"M Gargett","year":"2019","unstructured":"Gargett, M., Haddad, C., Kneebone, A., Booth, J. T. & Hardcastle, N. Clinical impact of removing respiratory motion during liver SABR. Radiat. Oncol. 14, 93. https:\/\/doi.org\/10.1186\/s13014-019-1300-6 (2019).","journal-title":"Radiat. Oncol."},{"key":"19218_CR13","doi-asserted-by":"publisher","first-page":"100407","DOI":"10.1016\/j.phro.2022.12.004","volume":"25","author":"N Hardcastle","year":"2023","unstructured":"Hardcastle, N. et al. Selection of motion management in liver stereotactic body radiotherapy and its impact on treatment time. Phys. Imaging Radiat. Oncol. 25, 100407. https:\/\/doi.org\/10.1016\/j.phro.2022.12.004 (2023).","journal-title":"Phys. Imaging Radiat. Oncol."},{"key":"19218_CR14","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1177\/153303461000900502","volume":"9","author":"W Kilby","year":"2010","unstructured":"Kilby, W., Dooley, J. R., Kuduvalli, G., Sayeh, S. & Maurer, C. R. Jr. The cyberknife robotic radiosurgery system in 2010. Technol. Cancer Res. Treat. 9, 433\u2013452. https:\/\/doi.org\/10.1177\/153303461000900502 (2010).","journal-title":"Technol. Cancer Res. Treat."},{"key":"19218_CR15","doi-asserted-by":"publisher","first-page":"259","DOI":"10.7785\/tcrt.2012.500379","volume":"13","author":"DM Lovelock","year":"2014","unstructured":"Lovelock, D. M., Zatcky, J., Goodman, K. & Yamada, Y. The effectiveness of a pneumatic compression belt in reducing respiratory motion of abdominal tumors in patients undergoing stereotactic body radiotherapy. Technol. Cancer Res. Treat. 13, 259\u2013267. https:\/\/doi.org\/10.7785\/tcrt.2012.500379 (2014).","journal-title":"Technol. Cancer Res. Treat."},{"key":"19218_CR16","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1111\/1754-9485.12681","volume":"62","author":"K West","year":"2018","unstructured":"West, K. et al. Evaluation of kidney motion with and without a pneumatic abdominal compression belt: considerations for stereotactic radiotherapy. J. Med. Imaging Radiat. Oncol. 62, 128\u2013132. https:\/\/doi.org\/10.1111\/1754-9485.12681 (2018).","journal-title":"J. Med. Imaging Radiat. Oncol."},{"key":"19218_CR17","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1016\/j.ijrobp.2010.08.003","volume":"80","author":"CL Eccles","year":"2011","unstructured":"Eccles, C. L., Dawson, L. A., Moseley, J. L. & Brock, K. K. Interfraction liver shape variability and impact on GTV position during liver stereotactic radiotherapy using abdominal compression. Int. J. Radiat. Oncol. Biol. Phys. 80, 938\u2013946. https:\/\/doi.org\/10.1016\/j.ijrobp.2010.08.003 (2011).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"19218_CR18","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1016\/j.ijrobp.2012.05.006","volume":"85","author":"J Ge","year":"2013","unstructured":"Ge, J., Santanam, L., Yang, D. & Parikh, P. J. Accuracy and consistency of respiratory gating in abdominal cancer patients. Int. J. Radiat. Oncol. Biol. Phys. 85, 854\u2013861. https:\/\/doi.org\/10.1016\/j.ijrobp.2012.05.006 (2013).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"19218_CR19","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.meddos.2010.03.006","volume":"36","author":"M Xi","year":"2011","unstructured":"Xi, M. et al. Dosimetric analysis of respiratory-gated radiotherapy for hepatocellular carcinoma. Med. Dosim. 36, 213\u2013218. https:\/\/doi.org\/10.1016\/j.meddos.2010.03.006 (2011).","journal-title":"Med. Dosim"},{"key":"19218_CR20","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.ejmp.2018.10.021","volume":"56","author":"S Dieterich","year":"2018","unstructured":"Dieterich, S., Green, O. & Booth, J. SBRT targets that move with respiration. Phys. Med. 56, 19\u201324. https:\/\/doi.org\/10.1016\/j.ejmp.2018.10.021 (2018).","journal-title":"Phys. Med."},{"key":"19218_CR21","doi-asserted-by":"publisher","first-page":"2595","DOI":"10.1002\/mp.12227","volume":"44","author":"ED Brandner","year":"2017","unstructured":"Brandner, E. D., Chetty, I. J., Giaddui, T. G., Xiao, Y. & Huq, M. S. Motion management strategies and technical issues associated with stereotactic body radiotherapy of thoracic and upper abdominal tumors: A review from NRG oncology. Med. Phys. 44, 2595\u20132612. https:\/\/doi.org\/10.1002\/mp.12227 (2017).","journal-title":"Med. Phys."},{"key":"19218_CR22","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.radonc.2021.11.022","volume":"166","author":"M Sharma","year":"2022","unstructured":"Sharma, M. et al. A systematic review and meta-analysis of liver tumor position variability during SBRT using various motion management and IGRT strategies. Radiother Oncol. 166, 195\u2013202. https:\/\/doi.org\/10.1016\/j.radonc.2021.11.022 (2022).","journal-title":"Radiother Oncol."},{"key":"19218_CR23","doi-asserted-by":"publisher","first-page":"4335","DOI":"10.1118\/1.4953190","volume":"43","author":"Y Hu","year":"2016","unstructured":"Hu, Y., Zhou, Y. K., Chen, Y. X., Shi, S. M. & Zeng, Z. C. 4D-CT scans reveal reduced magnitude of respiratory liver motion achieved by different abdominal compression plate positions in patients with intrahepatic tumors undergoing helical tomotherapy. Med. Phys. 43, 4335. https:\/\/doi.org\/10.1118\/1.4953190 (2016).","journal-title":"Med. Phys."},{"key":"19218_CR24","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s00066-011-0015-x","volume":"188","author":"N Hodapp","year":"2012","unstructured":"Hodapp, N. & [The, I. C. R. U. Report 83: prescribing, recording and reporting photon-beam intensity-modulated radiation therapy (IMRT)]. Strahlenther Onkol. 188, 97\u201399. https:\/\/doi.org\/10.1007\/s00066-011-0015-x (2012).","journal-title":"Strahlenther Onkol"},{"key":"19218_CR25","doi-asserted-by":"publisher","first-page":"573279","DOI":"10.3389\/fonc.2020.573279","volume":"10","author":"P Naumann","year":"2020","unstructured":"Naumann, P. et al. Feasibility of optical Surface-Guidance for position verification and monitoring of stereotactic body radiotherapy in Deep-Inspiration Breath-Hold. Front. Oncol. 10, 573279. https:\/\/doi.org\/10.3389\/fonc.2020.573279 (2020).","journal-title":"Front. Oncol."},{"key":"19218_CR26","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.radonc.2007.11.022","volume":"86","author":"MA Admiraal","year":"2008","unstructured":"Admiraal, M. A., Schuring, D. & Hurkmans, C. W. Dose calculations accounting for breathing motion in stereotactic lung radiotherapy based on 4D-CT and the internal target volume. Radiother Oncol. 86, 55\u201360. https:\/\/doi.org\/10.1016\/j.radonc.2007.11.022 (2008).","journal-title":"Radiother Oncol."},{"key":"19218_CR27","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.radonc.2008.07.004","volume":"88","author":"ED Ehler","year":"2008","unstructured":"Ehler, E. D. & Tom\u00e9, W. A. Lung 4D-IMRT treatment planning: an evaluation of three methods applied to four-dimensional data sets. Radiother Oncol. 88, 319\u2013325. https:\/\/doi.org\/10.1016\/j.radonc.2008.07.004 (2008).","journal-title":"Radiother Oncol."},{"key":"19218_CR28","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.rpor.2015.03.005","volume":"20","author":"PM Wang","year":"2015","unstructured":"Wang, P. M. et al. Stereotactic body radiation therapy in hepatocellular carcinoma: optimal treatment strategies based on liver segmentation and functional hepatic reserve. Rep. Pract. Oncol. Radiother. 20, 417\u2013424. https:\/\/doi.org\/10.1016\/j.rpor.2015.03.005 (2015).","journal-title":"Rep. Pract. Oncol. Radiother"},{"key":"19218_CR29","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1080\/02841860600897934","volume":"45","author":"A M\u00e9ndez Romero","year":"2006","unstructured":"M\u00e9ndez Romero, A. et al. Stereotactic body radiation therapy for primary and metastatic liver tumors: A single institution phase i-ii study. Acta Oncol. 45, 831\u2013837. https:\/\/doi.org\/10.1080\/02841860600897934 (2006).","journal-title":"Acta Oncol."},{"key":"19218_CR30","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/1748-717x-9-18","volume":"9","author":"PM Wang","year":"2014","unstructured":"Wang, P. M. et al. Feasibility of stereotactic body radiation therapy with volumetric modulated Arc therapy and high intensity photon beams for hepatocellular carcinoma patients. Radiat. Oncol. 9, 18. https:\/\/doi.org\/10.1186\/1748-717x-9-18 (2014).","journal-title":"Radiat. Oncol."},{"key":"19218_CR31","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.ijrobp.2021.09.027","volume":"112","author":"RA Timmerman","year":"2022","unstructured":"Timmerman, R. A. Story of hypofractionation and the table on the wall. Int. J. Radiat. Oncol. Biol. Phys. 112, 4\u201321. https:\/\/doi.org\/10.1016\/j.ijrobp.2021.09.027 (2022).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"19218_CR32","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1118\/1.598063","volume":"24","author":"A Niemierko","year":"1997","unstructured":"Niemierko, A. Reporting and analyzing dose distributions: a concept of equivalent uniform dose. Med. Phys. 24, 103\u2013110. https:\/\/doi.org\/10.1118\/1.598063 (1997).","journal-title":"Med. Phys."},{"key":"19218_CR33","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.ejmp.2007.07.001","volume":"23","author":"HA Gay","year":"2007","unstructured":"Gay, H. A. & Niemierko, A. A free program for calculating EUD-based NTCP and TCP in external beam radiotherapy. Phys. Med. 23, 115\u2013125. https:\/\/doi.org\/10.1016\/j.ejmp.2007.07.001 (2007).","journal-title":"Phys. Med."},{"key":"19218_CR34","doi-asserted-by":"publisher","unstructured":"Gao, J. et al. Stereotactic body radiotherapy boost with the cyberknife for locally advanced cervical cancer: dosimetric analysis and potential clinical benefits. Cancers 14 https:\/\/doi.org\/10.3390\/cancers14205166 (2022).","DOI":"10.3390\/cancers14205166"},{"key":"19218_CR35","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/1748-717x-7-11","volume":"7","author":"J Liu","year":"2012","unstructured":"Liu, J., Wang, J. Z., Zhao, J. D., Xu, Z. Y. & Jiang, G. L. Use of combined maximum and minimum intensity projections to determine internal target volume in 4-dimensional CT scans for hepatic malignancies. Radiat. Oncol. 7, 11. https:\/\/doi.org\/10.1186\/1748-717x-7-11 (2012).","journal-title":"Radiat. Oncol."},{"key":"19218_CR36","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.semradonc.2018.06.007","volume":"28","author":"EJ Koay","year":"2018","unstructured":"Koay, E. J., Owen, D. & Das, P. Radiation-Induced liver disease and modern radiotherapy. Semin Radiat. Oncol. 28, 321\u2013331. https:\/\/doi.org\/10.1016\/j.semradonc.2018.06.007 (2018).","journal-title":"Semin Radiat. Oncol."},{"key":"19218_CR37","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.ijrobp.2019.02.032","volume":"105","author":"CE Hsieh","year":"2019","unstructured":"Hsieh, C. E. et al. Predictors of Radiation-Induced liver disease in Eastern and Western patients with hepatocellular carcinoma undergoing proton beam therapy. Int. J. Radiat. Oncol. Biol. Phys. 105, 73\u201386. https:\/\/doi.org\/10.1016\/j.ijrobp.2019.02.032 (2019).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"19218_CR38","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/j.ijrobp.2010.04.028","volume":"79","author":"CL Eccles","year":"2011","unstructured":"Eccles, C. L. et al. Comparison of liver tumor motion with and without abdominal compression using cine-magnetic resonance imaging. Int. J. Radiat. Oncol. Biol. Phys. 79, 602\u2013608. https:\/\/doi.org\/10.1016\/j.ijrobp.2010.04.028 (2011).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"19218_CR39","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1016\/j.ijrobp.2007.12.023","volume":"70","author":"JH Heinzerling","year":"2008","unstructured":"Heinzerling, J. H. et al. Four-dimensional computed tomography scan analysis of tumor and organ motion at varying levels of abdominal compression during stereotactic treatment of lung and liver. Int. J. Radiat. Oncol. Biol. Phys. 70, 1571\u20131578. https:\/\/doi.org\/10.1016\/j.ijrobp.2007.12.023 (2008).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"19218_CR40","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.radonc.2011.09.006","volume":"100","author":"D Gabry\u015b","year":"2011","unstructured":"Gabry\u015b, D., Kulik, R., Trela, K. & \u015alosarek, K. Dosimetric comparison of liver tumour radiotherapy in all respiratory phases and in one phase using 4DCT. Radiother Oncol. 100, 360\u2013364. https:\/\/doi.org\/10.1016\/j.radonc.2011.09.006 (2011).","journal-title":"Radiother Oncol."},{"key":"19218_CR41","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/0360-3016(91)90171-y","volume":"21","author":"B Emami","year":"1991","unstructured":"Emami, B. et al. Tolerance of normal tissue to therapeutic irradiation. Int. J. Radiat. Oncol. Biol. Phys. 21, 109\u2013122. https:\/\/doi.org\/10.1016\/0360-3016(91)90171-y (1991).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"19218_CR42","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.ejmp.2015.10.091","volume":"RADBIOMOD","author":"JH Chang","year":"2016","unstructured":"Chang, J. H. et al. A simple program for utilising biological modelling in radiotherapy plan evaluation. Phys. Med. 32. RADBIOMOD, 248\u2013254. https:\/\/doi.org\/10.1016\/j.ejmp.2015.10.091 (2016).","journal-title":"Phys. Med. 32"},{"key":"19218_CR43","doi-asserted-by":"publisher","first-page":"4233","DOI":"10.31557\/apjcp.2022.23.12.4233","volume":"23","author":"S Balasubramanian","year":"2022","unstructured":"Balasubramanian, S. & Shobana, M. K. A dosimetric and Radiobiological comparison of intensity modulated radiotherapy, volumetric modulated Arc therapy and helical tomotherapy planning techniques in synchronous bilateral breast cancer. Asian Pac. J. Cancer Prev. 23, 4233\u20134241. https:\/\/doi.org\/10.31557\/apjcp.2022.23.12.4233 (2022).","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"19218_CR44","doi-asserted-by":"publisher","first-page":"244","DOI":"10.4103\/jmp.jmp_75_21","volume":"46","author":"S Balasubramanian","year":"2021","unstructured":"Balasubramanian, S. & Shobana, M. K. Pediatric craniospinal Irradiation - The implementation and use of normal tissue complication probability in comparing photon versus proton planning. J. Med. Phys. 46, 244\u2013252. https:\/\/doi.org\/10.4103\/jmp.jmp_75_21 (2021).","journal-title":"J. Med. Phys."},{"key":"19218_CR45","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1002\/acm2.13373","volume":"22","author":"H Vaithianathan","year":"2021","unstructured":"Vaithianathan, H. & Harris, B. Transmission study of the abdominal compression plate (BodyFIX diaphragm Control) for abdominal and stereotactic body radiotherapy. J. Appl. Clin. Med. Phys. 22, 232\u2013241. https:\/\/doi.org\/10.1002\/acm2.13373 (2021).","journal-title":"J. Appl. Clin. Med. Phys."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-19218-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-19218-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-19218-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T02:09:51Z","timestamp":1760494191000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-19218-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,14]]},"references-count":45,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["19218"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-19218-w","relation":{},"ISSN":["2045-2322"],"issn-type":[{"type":"electronic","value":"2045-2322"}],"subject":[],"published":{"date-parts":[[2025,10,14]]},"assertion":[{"value":"1 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Research Ethics Committee of Fujian Medical University Union Hospital (Fuzhou, China; approval no. 2024ky017).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"35769"}}