{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T02:43:36Z","timestamp":1793241816415,"version":"4.5.0"},"reference-count":103,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["PJT 162279"],"award-info":[{"award-number":["PJT 162279"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Sciences and Engineering Research Council of Canada Discovery Grants","award":["RGPIN-2020-04646"],"award-info":[{"award-number":["RGPIN-2020-04646"]}]},{"name":"National Sciences and Engineering Research Council of Canada Discovery Grants","award":["RGPIN-2020-07232"],"award-info":[{"award-number":["RGPIN-2020-07232"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-20107-5","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T10:29:08Z","timestamp":1760610548000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Modelling of immune infiltration in prostate cancer treated with HDR-brachytherapy using Raman spectroscopy and machine learning"],"prefix":"10.1038","volume":"15","author":[{"given":"Sandra N.","family":"Popescu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsty","family":"Milligan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell","family":"Wiebe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Fuentes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan M.","family":"Brewer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina K.","family":"Haston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian J.","family":"Lum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Punch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Raudales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre G.","family":"Brolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanita M.","family":"Crook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L.","family":"Andrews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Jirasek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,16]]},"reference":[{"key":"20107_CR1","unstructured":"Brenner, D. et al. Canadian cancer statistics 2023. Tech. Rep., Canadian Cancer Statistics Advisory Committee in collaboration with the Canadian Cancer Society, Statistics Canada and the Public Health Agency of Canada (2023)."},{"key":"20107_CR2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27175730","author":"M Sekhoacha","year":"2022","unstructured":"Sekhoacha, M. et al. Prostate cancer review: Genetics, diagnosis, treatment options, and alternative approaches. Molecules https:\/\/doi.org\/10.3390\/molecules27175730 (2022).","journal-title":"Molecules"},{"key":"20107_CR3","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/0046-8177(92)90108-F","volume":"23","author":"DF Gleason","year":"1992","unstructured":"Gleason, D. F. Histologic grading of prostate cancer: A perspective. Hum. Pathol. 23, 273\u2013279 (1992).","journal-title":"Hum. Pathol."},{"key":"20107_CR4","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1046\/j.1464-410X.2002.02669.x","volume":"89","author":"L Egevad","year":"2002","unstructured":"Egevad, L., Granfors, T., Karlberg, L., Bergh, A. & Stattin, P. Prognostic value of the Gleason score in prostate cancer. BJU Int. 89, 538\u2013542. https:\/\/doi.org\/10.1046\/j.1464-410X.2002.02669.x (2002).","journal-title":"BJU Int."},{"key":"20107_CR5","doi-asserted-by":"publisher","first-page":"e1450","DOI":"10.1002\/cnr2.1450","volume":"5","author":"I Strouthos","year":"2022","unstructured":"Strouthos, I., Karagiannis, E., Zamboglou, N. & Ferentinos, K. High-dose-rate brachytherapy for prostate cancer: Rationale, current applications, and clinical outcome. Cancer Rep. 5, e1450. https:\/\/doi.org\/10.1002\/cnr2.1450 (2022).","journal-title":"Cancer Rep."},{"key":"20107_CR6","doi-asserted-by":"publisher","first-page":"357","DOI":"10.21037\/tau.2017.12.08","volume":"7","author":"LC Mendez","year":"2018","unstructured":"Mendez, L. C. & Morton, G. C. High dose-rate brachytherapy in the treatment of prostate cancer. Transl. Androl. Urol. 7, 357\u2013370. https:\/\/doi.org\/10.21037\/tau.2017.12.08 (2018).","journal-title":"Transl. Androl. Urol."},{"key":"20107_CR7","doi-asserted-by":"publisher","first-page":"533","DOI":"10.5114\/JCB.2020.101685","volume":"12","author":"CP Soatti","year":"2021","unstructured":"Soatti, C. P. et al. High-dose-rate brachytherapy as monotherapy for localized prostate cancer using three different doses - 14 years of single-centre experience. J. Contemp. Brachyther. 12, 533\u2013539. https:\/\/doi.org\/10.5114\/JCB.2020.101685 (2021).","journal-title":"J. Contemp. Brachyther."},{"key":"20107_CR8","doi-asserted-by":"publisher","DOI":"10.1101\/gad.314617","author":"H Gonzalez","year":"2018","unstructured":"Gonzalez, H., Hagerling, C. & Werb, Z. Roles of the immune system in cancer: from tumor initiation to metastatic progression. Genes Dev. https:\/\/doi.org\/10.1101\/gad.314617 (2018).","journal-title":"Genes Dev."},{"key":"20107_CR9","doi-asserted-by":"publisher","first-page":"128","DOI":"10.3389\/fonc.2015.00128","volume":"5","author":"A Strasner","year":"2015","unstructured":"Strasner, A. & Karin, M. Immune infiltration and prostate cancer. Front. Oncol. 5, 128. https:\/\/doi.org\/10.3389\/fonc.2015.00128 (2015).","journal-title":"Front. Oncol."},{"key":"20107_CR10","doi-asserted-by":"publisher","first-page":"1664","DOI":"10.1016\/j.ejca.2009.02.015","volume":"45","author":"K Ebelt","year":"2009","unstructured":"Ebelt, K. et al. Prostate cancer lesions are surrounded by foxp3+, pd-1+ and b7\u2013h1+ lymphocyte clusters. Eur. J. Cancer 45, 1664\u20131672. https:\/\/doi.org\/10.1016\/j.ejca.2009.02.015 (2009).","journal-title":"Eur. J. Cancer"},{"key":"20107_CR11","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1159\/000342396","volume":"80","author":"T Fujii","year":"2013","unstructured":"Fujii, T. et al. Immunohistochemical analysis of inflammatory cells in benign and precancerous lesions and carcinoma of the prostate. Pathobiology 80, 119\u2013126. https:\/\/doi.org\/10.1159\/000342396 (2013).","journal-title":"Pathobiology"},{"key":"20107_CR12","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.yexmp.2008.11.010","volume":"86","author":"MRA Hussein","year":"2009","unstructured":"Hussein, M. R. A., AL-Assiri, M. & Musalam, A. O. Phenotypic characterization of the infiltrating immune cells in normal prostate, benign nodular prostatic hyperplasia and prostatic adenocarcinoma. Exp. Mol. Pathol. 86, 108\u2013113. https:\/\/doi.org\/10.1016\/j.yexmp.2008.11.010 (2009).","journal-title":"Exp. Mol. Pathol."},{"key":"20107_CR13","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1002\/path.5757","volume":"255","author":"LB Andersen","year":"2021","unstructured":"Andersen, L. B. et al. Immune cell analyses of the tumor microenvironment in prostate cancer highlight infiltrating regulatory t cells and macrophages as adverse prognostic factors. J. Pathol. 255, 155\u2013165. https:\/\/doi.org\/10.1002\/path.5757 (2021).","journal-title":"J. Pathol."},{"key":"20107_CR14","doi-asserted-by":"publisher","first-page":"111588","DOI":"10.1016\/j.yexcr.2019.111588","volume":"384","author":"Q Zhang","year":"2019","unstructured":"Zhang, Q. et al. Tumor infiltrating m2 macrophages could predict biochemical recurrence of localized prostate cancer after radical prostatectomy. Exp. Cell Res. 384, 111588. https:\/\/doi.org\/10.1016\/j.yexcr.2019.111588 (2019).","journal-title":"Exp. Cell Res."},{"key":"20107_CR15","doi-asserted-by":"publisher","first-page":"60257","DOI":"10.18632\/oncotarget.19528","volume":"8","author":"E R\u00e5destad","year":"2017","unstructured":"R\u00e5destad, E. et al. Characterization of infiltrating lymphocytes in human benign and malignant prostate tissue. Oncotarget 8, 60257\u201360269 (2017).","journal-title":"Oncotarget"},{"key":"20107_CR16","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1038\/s41416-021-01435-5","volume":"125","author":"F Ahmad","year":"2021","unstructured":"Ahmad, F., Cherukuri, M. K. & Choyke, P. L. Metabolic reprogramming in prostate cancer. Br. J. Cancer 125, 1185\u20131196. https:\/\/doi.org\/10.1038\/s41416-021-01435-5 (2021).","journal-title":"Br. J. Cancer"},{"key":"20107_CR17","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1038\/s41423-024-01148-8","volume":"21","author":"S Ma","year":"2024","unstructured":"Ma, S., Ming, Y., Wu, J. & Cui, G. Cellular metabolism regulates the differentiation and function of t-cell subsets. Cell. Mol. Immunol. 21, 419\u2013435. https:\/\/doi.org\/10.1038\/s41423-024-01148-8 (2024).","journal-title":"Cell. Mol. Immunol."},{"key":"20107_CR18","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1002\/med.21766","volume":"41","author":"HJ Cardoso","year":"2021","unstructured":"Cardoso, H. J. et al. Revisiting prostate cancer metabolism: From metabolites to disease and therapy. Med. Res. Rev. 41, 1499\u20131538. https:\/\/doi.org\/10.1002\/med.21766 (2021).","journal-title":"Med. Res. Rev."},{"key":"20107_CR19","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.tem.2024.01.009","volume":"35","author":"M Ji","year":"2024","unstructured":"Ji, M., Xu, Q. & Li, X. Dietary methionine restriction in cancer development and antitumor immunity. Trends Endocrinol. Metabol. 35, 400\u2013412. https:\/\/doi.org\/10.1016\/j.tem.2024.01.009 (2024).","journal-title":"Trends Endocrinol. Metabol."},{"key":"20107_CR20","doi-asserted-by":"publisher","first-page":"3602","DOI":"10.3390\/ijms20143602","volume":"20","author":"M Rudzi\u0144ska","year":"2019","unstructured":"Rudzi\u0144ska, M. et al. The role of cysteine cathepsins in cancer progression and drug resistance. Int. J. Mol. Sci. 20, 3602. https:\/\/doi.org\/10.3390\/ijms20143602 (2019).","journal-title":"Int. J. Mol. Sci."},{"key":"20107_CR21","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1158\/0008-5472.CAN-09-2587","volume":"70","author":"MK Srivastava","year":"2010","unstructured":"Srivastava, M. K., Sinha, P., Clements, V. K., Rodriguez, P. & Ostrand-Rosenberg, S. Myeloid-derived suppressor cells inhibit t-cell activation by depleting cystine and cysteine. Cancer Res. 70, 68\u201377. https:\/\/doi.org\/10.1158\/0008-5472.CAN-09-2587 (2010).","journal-title":"Cancer Res."},{"key":"20107_CR22","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01239","volume":"8","author":"M Diotallevi","year":"2017","unstructured":"Diotallevi, M. et al. Glutathione fine-tunes the innate immune response toward antiviral pathways in a macrophage cell line independently of its antioxidant properties. Front. Immunol. 8, 289507. https:\/\/doi.org\/10.3389\/fimmu.2017.01239 (2017).","journal-title":"Front. Immunol."},{"key":"20107_CR23","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1002\/mc.21939","volume":"53","author":"R Kanwal","year":"2014","unstructured":"Kanwal, R. et al. Protection against oxidative dna damage and stress in human prostate by glutathione s-transferase p1. Mol. Carcinogenes 53, 8\u201318. https:\/\/doi.org\/10.1002\/mc.21939 (2014).","journal-title":"Mol. Carcinogenes"},{"key":"20107_CR24","doi-asserted-by":"publisher","first-page":"82","DOI":"10.3390\/antiox8040082","volume":"8","author":"DH Kwon","year":"2019","unstructured":"Kwon, D. H. et al. Protective effect of glutathione against oxidative stress-induced cytotoxicity in raw 264.7 macrophages through activating the nuclear factor erythroid 2-related factor-2\/heme oxygenase-1 pathway. Antioxidants 8, 82 (2019).","journal-title":"Antioxidants"},{"key":"20107_CR25","doi-asserted-by":"publisher","first-page":"4503","DOI":"10.3390\/nu13124503","volume":"13","author":"A Matos","year":"2021","unstructured":"Matos, A., Carvalho, M., Bicho, M. & Ribeiro, R. Arginine and arginases modulate metabolism, tumor microenvironment and prostate cancer progression. Nutrients 13, 4503. https:\/\/doi.org\/10.3390\/nu13124503 (2021).","journal-title":"Nutrients"},{"key":"20107_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107292","volume":"206","author":"X Wang","year":"2024","unstructured":"Wang, X., Gong, W., Xiong, X., Jia, X. & Xu, J. Asparagine: A key metabolic junction in targeted tumor therapy. Pharmacol. Res. 206, 107292. https:\/\/doi.org\/10.1016\/j.phrs.2024.107292 (2024).","journal-title":"Pharmacol. Res."},{"key":"20107_CR27","doi-asserted-by":"publisher","first-page":"2593","DOI":"10.1038\/s41467-023-38316-9","volume":"14","author":"M Pandit","year":"2023","unstructured":"Pandit, M. et al. Methionine consumption by cancer cells drives a progressive upregulation of pd-1 expression in cd4 t cells. Nat. Commun. 14, 2593. https:\/\/doi.org\/10.1038\/s41467-023-38316-9 (2023).","journal-title":"Nat. Commun."},{"key":"20107_CR28","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1136\/gutjnl-2022-326928","volume":"72","author":"T Li","year":"2023","unstructured":"Li, T. et al. Methionine deficiency facilitates antitumour immunity by altering m 6 a methylation of immune checkpoint transcripts. Gut 72, 501\u2013511. https:\/\/doi.org\/10.1136\/gutjnl-2022-326928 (2023).","journal-title":"Gut"},{"key":"20107_CR29","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.immuni.2017.03.019","volume":"46","author":"TW Mak","year":"2017","unstructured":"Mak, T. W. et al. Glutathione primes t cell metabolism for inflammation. Immunity 46, 675\u2013689. https:\/\/doi.org\/10.1016\/j.immuni.2017.03.019 (2017).","journal-title":"Immunity"},{"key":"20107_CR30","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1038\/s41423-024-01148-8","volume":"21","author":"S Ma","year":"2024","unstructured":"Ma, S., Ming, Y., Wu, J. & Cui, G. Cellular metabolism regulates the differentiation and function of t-cell subsets. Cell. Mol. Immunol. 21, 419\u2013435. https:\/\/doi.org\/10.1038\/s41423-024-01148-8 (2024).","journal-title":"Cell. Mol. Immunol."},{"key":"20107_CR31","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/j.molcel.2020.09.006","volume":"80","author":"W Wang","year":"2020","unstructured":"Wang, W. & Zou, W. Amino acids and their transporters in t cell immunity and cancer therapy. Mol. Cell 80, 384\u2013395. https:\/\/doi.org\/10.1016\/j.molcel.2020.09.006 (2020).","journal-title":"Mol. Cell"},{"key":"20107_CR32","doi-asserted-by":"publisher","first-page":"9584932","DOI":"10.1155\/2017\/9584932","volume":"2017","author":"P Bin","year":"2017","unstructured":"Bin, P., Huang, R. & Zhou, X. Oxidation resistance of the sulfur amino acids: Methionine and cysteine. BioMed Res. Int. 2017, 9584932. https:\/\/doi.org\/10.1155\/2017\/9584932 (2017).","journal-title":"BioMed Res. Int."},{"key":"20107_CR33","doi-asserted-by":"publisher","first-page":"5826932","DOI":"10.1155\/2021\/5826932","volume":"2021","author":"P Yang","year":"2021","unstructured":"Yang, P. et al. Ionizing radiation upregulates glutamine metabolism and induces cell death via accumulation of reactive oxygen species. Oxidative Med. Cell. Longev. 2021, 5826932. https:\/\/doi.org\/10.1155\/2021\/5826932 (2021).","journal-title":"Oxidative Med. Cell. Longev."},{"key":"20107_CR34","doi-asserted-by":"publisher","first-page":"2396558","DOI":"10.1080\/07853890.2024.2396558","volume":"56","author":"MM Islam","year":"2024","unstructured":"Islam, M. M. et al. Impact of dietary ingredients on radioprotection and radiosensitization: a comprehensive review. Ann. Med. 56, 2396558. https:\/\/doi.org\/10.1080\/07853890.2024.2396558 (2024).","journal-title":"Ann. Med."},{"key":"20107_CR35","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1152\/ajpgi.00351.2019.-Methionine","volume":"318","author":"IR Miousse","year":"2020","unstructured":"Miousse, I. R. et al. Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome. Am. J. Physiol. Gastrointest. Liver Physiol. 318, 439\u2013450. https:\/\/doi.org\/10.1152\/ajpgi.00351.2019.-Methionine (2020).","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"20107_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/cancers12102835","volume":"12","author":"S Cheng","year":"2020","unstructured":"Cheng, S., Cheadle, E. J. & Illidge, T. M. Understanding the effects of radiotherapy on the tumour immune microenvironment to identify potential prognostic and predictive biomarkers of radiotherapy response. Cancers 12, 1\u201320. https:\/\/doi.org\/10.3390\/cancers12102835 (2020).","journal-title":"Cancers"},{"key":"20107_CR37","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1080\/15384047.2016.1235666","volume":"17","author":"V Nardone","year":"2016","unstructured":"Nardone, V. et al. Tumor infiltrating t lymphocytes expressing foxp3, ccr7 or pd-1 predict the outcome of prostate cancer patients subjected to salvage radiotherapy after biochemical relapse. Cancer Biol. Ther. 17, 1213\u20131220. https:\/\/doi.org\/10.1080\/15384047.2016.1235666 (2016).","journal-title":"Cancer Biol. Ther."},{"key":"20107_CR38","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1038\/bjc.2016.171","volume":"115","author":"Y Yamamoto","year":"2016","unstructured":"Yamamoto, Y. et al. Tumour and immune cell dynamics explain the psa bounce after prostate cancer brachytherapy. Br. J. Cancer 115, 195\u2013202. https:\/\/doi.org\/10.1038\/bjc.2016.171 (2016).","journal-title":"Br. J. Cancer"},{"key":"20107_CR39","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.34007","author":"M Vila\u00e7a","year":"2023","unstructured":"Vila\u00e7a, M., Pinto, J. C., Magalh\u00e3es, H., Reis, F. & Mesquita, A. Tumor-infiltrating lymphocytes in localized prostate cancer: Do they play an important role?. Cureus https:\/\/doi.org\/10.7759\/cureus.34007 (2023).","journal-title":"Cureus"},{"key":"20107_CR40","doi-asserted-by":"publisher","first-page":"22495","DOI":"10.1038\/s41598-021-01900-4","volume":"11","author":"Y Yanai","year":"2021","unstructured":"Yanai, Y. et al. Cd8-positive t cells and cd204-positive m2-like macrophages predict postoperative prognosis of very high-risk prostate cancer. Sci. Rep. 11, 22495. https:\/\/doi.org\/10.1038\/s41598-021-01900-4 (2021).","journal-title":"Sci. Rep."},{"key":"20107_CR41","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1002\/pros.24068","volume":"81","author":"Y Yang","year":"2021","unstructured":"Yang, Y. et al. High intratumoral cd8+ t-cell infiltration is associated with improved survival in prostate cancer patients undergoing radical prostatectomy. Prostate 81, 20\u201328. https:\/\/doi.org\/10.1002\/pros.24068 (2021).","journal-title":"Prostate"},{"key":"20107_CR42","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.prnil.2019.12.001","volume":"8","author":"P Yuri","year":"2020","unstructured":"Yuri, P. et al. Increased tumor-associated macrophages in the prostate cancer microenvironment predicted patients\u2019 survival and responses to androgen deprivation therapies in indonesian patients cohort. Prostate Int. 8, 62\u201369. https:\/\/doi.org\/10.1016\/j.prnil.2019.12.001 (2020).","journal-title":"Prostate Int."},{"key":"20107_CR43","doi-asserted-by":"publisher","first-page":"e0159109","DOI":"10.1371\/journal.pone.0159109","volume":"11","author":"C Zeigler-Johnson","year":"2016","unstructured":"Zeigler-Johnson, C., Morales, K. H., Lal, P. & Feldman, M. The relationship between obesity, prostate tumor infiltrating lymphocytes and macrophages, and biochemical failure. PLoS ONE 11, e0159109. https:\/\/doi.org\/10.1371\/journal.pone.0159109 (2016).","journal-title":"PLoS ONE"},{"key":"20107_CR44","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-024-00797-0","author":"NA Zorko","year":"2024","unstructured":"Zorko, N. A. et al. Natural killer cell infiltration in prostate cancers predict improved patient outcomes. Prostate Cancer Prostatic Dis. https:\/\/doi.org\/10.1038\/s41391-024-00797-0 (2024).","journal-title":"Prostate Cancer Prostatic Dis."},{"key":"20107_CR45","doi-asserted-by":"publisher","first-page":"e002455","DOI":"10.1136\/jitc-2021-002455","volume":"9","author":"Q Zhou","year":"2021","unstructured":"Zhou, Q. et al. B7 score and t cell infiltration stratify immune status in prostate cancer. J. Immunother. Cancer 9, e002455. https:\/\/doi.org\/10.1136\/jitc-2021-002455 (2021).","journal-title":"J. Immunother. Cancer"},{"key":"20107_CR46","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1186\/s42269-023-01106-w","volume":"47","author":"K Apusiga","year":"2023","unstructured":"Apusiga, K. Immune cell infiltration-based prognosis in prostate cancer: a review of current knowledge. Bull. Natl. Res. Centre 47, 131. https:\/\/doi.org\/10.1186\/s42269-023-01106-w (2023).","journal-title":"Bull. Natl. Res. Centre"},{"key":"20107_CR47","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1038\/s41536-017-0014-3","volume":"2","author":"KJI Ember","year":"2017","unstructured":"Ember, K. J. I. et al. Raman spectroscopy and regenerative medicine: a review. npj Regen. Med. 2, 12. https:\/\/doi.org\/10.1038\/s41536-017-0014-3 (2017).","journal-title":"npj Regen. Med."},{"key":"20107_CR48","doi-asserted-by":"publisher","first-page":"386","DOI":"10.3390\/cells11030386","volume":"11","author":"ES Allakhverdiev","year":"2022","unstructured":"Allakhverdiev, E. S. et al. Raman spectroscopy and its modifications applied to biological and medical research. Cells 11, 386. https:\/\/doi.org\/10.3390\/cells11030386 (2022).","journal-title":"Cells"},{"key":"20107_CR49","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.addr.2015.06.011","volume":"89","author":"T Huser","year":"2015","unstructured":"Huser, T. & Chan, J. Raman spectroscopy for physiological investigations of tissues and cells. Adv. Drug Deliv. Rev. 89, 57\u201370. https:\/\/doi.org\/10.1016\/j.addr.2015.06.011 (2015).","journal-title":"Adv. Drug Deliv. Rev."},{"key":"20107_CR50","doi-asserted-by":"publisher","first-page":"R370","DOI":"10.1088\/0031-9155\/61\/23\/R370","volume":"61","author":"M Jermyn","year":"2016","unstructured":"Jermyn, M. et al. A review of Raman spectroscopy advances with an emphasis on clinical translation challenges in oncology. Phys. Med. Biol. 61, R370\u2013R400. https:\/\/doi.org\/10.1088\/0031-9155\/61\/23\/R370 (2016).","journal-title":"Phys. Med. Biol."},{"key":"20107_CR51","doi-asserted-by":"publisher","first-page":"2594","DOI":"10.1039\/d3an00121k","volume":"148","author":"IE Hill","year":"2023","unstructured":"Hill, I. E. et al. Understanding radiation response and cell cycle variation in brain tumour cells using Raman spectroscopy. Analyst 148, 2594\u20132608. https:\/\/doi.org\/10.1039\/d3an00121k (2023).","journal-title":"Analyst"},{"key":"20107_CR52","doi-asserted-by":"publisher","first-page":"e202000252","DOI":"10.1002\/jbio.202000252","volume":"13","author":"M Roman","year":"2020","unstructured":"Roman, M., Wrobel, T. P., Panek, A., Paluszkiewicz, C. & Kwiatek, W. M. Physicochemical damage and early-stage biological response to x-ray radiation studied in prostate cancer cells by raman spectroscopy. J. Biophotonics 13, e202000252. https:\/\/doi.org\/10.1002\/jbio.202000252 (2020).","journal-title":"J. Biophotonics"},{"key":"20107_CR53","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1177\/0003702820906221","volume":"74","author":"X Deng","year":"2020","unstructured":"Deng, X. et al. Monitor ionizing radiation-induced cellular responses with Raman spectroscopy, non-negative matrix factorization, and non-negative least squares. Appl. Spectrosc. 74, 701\u2013711. https:\/\/doi.org\/10.1177\/0003702820906221 (2020).","journal-title":"Appl. Spectrosc."},{"key":"20107_CR54","doi-asserted-by":"publisher","first-page":"3709","DOI":"10.1039\/d1an00387a","volume":"146","author":"KS Tipatet","year":"2021","unstructured":"Tipatet, K. S. et al. Detection of acquired radioresistance in breast cancer cell lines using Raman spectroscopy and machine learning. Analyst 146, 3709\u20133716. https:\/\/doi.org\/10.1039\/d1an00387a (2021).","journal-title":"Analyst"},{"key":"20107_CR55","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1007\/s12561-023-09398-2","volume":"15","author":"P Shreeves","year":"2023","unstructured":"Shreeves, P., Andrews, J. L., Deng, X., Ali-Adeeb, R. & Jirasek, A. Nonnegative matrix factorization with group and basis restrictions. Stat. Biosci. 15, 608\u2013632. https:\/\/doi.org\/10.1007\/s12561-023-09398-2 (2023).","journal-title":"Stat. Biosci."},{"key":"20107_CR56","doi-asserted-by":"publisher","first-page":"15104","DOI":"10.1038\/s41598-022-19446-4","volume":"12","author":"K Milligan","year":"2022","unstructured":"Milligan, K. et al. Prediction of disease progression indicators in prostate cancer patients receiving hdr-brachytherapy using Raman spectroscopy and semi-supervised learning: a pilot study. Sci. Rep. 12, 15104. https:\/\/doi.org\/10.1038\/s41598-022-19446-4 (2022).","journal-title":"Sci. Rep."},{"key":"20107_CR57","doi-asserted-by":"publisher","first-page":"3853","DOI":"10.1038\/s41598-021-83343-5","volume":"11","author":"K Milligan","year":"2021","unstructured":"Milligan, K. et al. Raman spectroscopy and group and basis-restricted non negative matrix factorisation identifies radiation induced metabolic changes in human cancer cells. Sci. Rep. 11, 3853. https:\/\/doi.org\/10.1038\/s41598-021-83343-5 (2021).","journal-title":"Sci. Rep."},{"key":"20107_CR58","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.canlet.2021.10.027","volume":"525","author":"C Wang","year":"2022","unstructured":"Wang, C., Zhang, Y. & Gao, W. Q. The evolving role of immune cells in prostate cancer. Cancer Lett. 525, 9\u201321. https:\/\/doi.org\/10.1016\/j.canlet.2021.10.027 (2022).","journal-title":"Cancer Lett."},{"key":"20107_CR59","doi-asserted-by":"publisher","first-page":"039463202311580","DOI":"10.1177\/03946320231158025","volume":"37","author":"A Erlandsson","year":"2023","unstructured":"Erlandsson, A. et al. Infiltrating immune cells in prostate cancer tissue after androgen deprivation and radiotherapy. Int. J. Immunopathol. Pharmacol. 37, 03946320231158025. https:\/\/doi.org\/10.1177\/03946320231158025 (2023).","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"20107_CR60","doi-asserted-by":"publisher","first-page":"e000792","DOI":"10.1136\/jitc-2020-000792","volume":"8","author":"SP Keam","year":"2020","unstructured":"Keam, S. P. et al. High dose-rate brachytherapy of localized prostate cancer converts tumors from cold to hot. J.r Immunother. Cancer 8, e000792. https:\/\/doi.org\/10.1136\/jitc-2020-000792 (2020).","journal-title":"J.r Immunother. Cancer"},{"key":"20107_CR61","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/s41391-022-00498-6","volume":"26","author":"N Kane","year":"2023","unstructured":"Kane, N. et al. Significant changes in macrophage and cd8 t cell densities in primary prostate tumors 2 weeks after sbrt. Prostate Cancer Prostatic Dis. 26, 207\u2013209. https:\/\/doi.org\/10.1038\/s41391-022-00498-6 (2023).","journal-title":"Prostate Cancer Prostatic Dis."},{"key":"20107_CR62","doi-asserted-by":"publisher","first-page":"7844","DOI":"10.7150\/THNO.58655","volume":"11","author":"A Mukha","year":"2021","unstructured":"Mukha, A. et al. Gls-driven glutamine catabolism contributes to prostate cancer radiosensitivity by regulating the redox state, stemness and atg5-mediated autophagy. Theranostics 11, 7844\u20137868. https:\/\/doi.org\/10.7150\/THNO.58655 (2021).","journal-title":"Theranostics"},{"key":"20107_CR63","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.3390\/antiox10121925","volume":"10","author":"S Kumar","year":"2021","unstructured":"Kumar, S. & Clair, D. S. Radioresistance in prostate cancer: Focus on the interplay between nf-$$\\kappa$$b and sod. Antioxidants 10, 1925. https:\/\/doi.org\/10.3390\/antiox10121925 (2021).","journal-title":"Antioxidants"},{"key":"20107_CR64","doi-asserted-by":"publisher","first-page":"e2848","DOI":"10.1038\/CDDIS.2017.225","volume":"8","author":"EH Cheteh","year":"2017","unstructured":"Cheteh, E. H. et al. Human cancer-associated fibroblasts enhance glutathione levels and antagonize drug-induced prostate cancer cell death. Cell Death Dis. 8, e2848. https:\/\/doi.org\/10.1038\/CDDIS.2017.225 (2017).","journal-title":"Cell Death Dis."},{"key":"20107_CR65","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1155\/2013\/972913","volume":"7","author":"N Traverso","year":"2013","unstructured":"Traverso, N. et al. Role of glutathione in cancer progression and chemoresistance. Oxidative Med. Cell. Longev. 7, 8. https:\/\/doi.org\/10.1155\/2013\/972913 (2013).","journal-title":"Oxidative Med. Cell. Longev."},{"key":"20107_CR66","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1016\/j.ijrobp.2021.07.1713","volume":"111","author":"MR Ferreira","year":"2021","unstructured":"Ferreira, M. R. et al. Impact of pelvic radiation therapy for prostate cancer on global metabolic profiles and microbiota-driven gastrointestinal late side effects: A longitudinal observational study. Int. J. Radiat. Oncol. Biol. Phys. 111, 1204\u20131213. https:\/\/doi.org\/10.1016\/j.ijrobp.2021.07.1713 (2021).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"20107_CR67","doi-asserted-by":"publisher","first-page":"969563","DOI":"10.3389\/fonc.2022.969563","volume":"12","author":"T Zhao","year":"2022","unstructured":"Zhao, T. & Lum, J. J. Methionine cycle-dependent regulation of t cells in cancer immunity. Front. Oncol. 12, 969563. https:\/\/doi.org\/10.3389\/fonc.2022.969563 (2022).","journal-title":"Front. Oncol."},{"key":"20107_CR68","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1038\/s42255-022-00551-7","volume":"4","author":"PB Ampomah","year":"2022","unstructured":"Ampomah, P. B. et al. Macrophages use apoptotic cell-derived methionine and dnmt3a during efferocytosis to promote tissue resolution. Nat. Metab. 4, 444\u2013457. https:\/\/doi.org\/10.1038\/s42255-022-00551-7 (2022).","journal-title":"Nat. Metab."},{"key":"20107_CR69","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.immuni.2017.03.019","volume":"46","author":"TW Mak","year":"2017","unstructured":"Mak, T. W. et al. Glutathione primes t cell metabolism for inflammation. Immunity 46, 675\u2013689. https:\/\/doi.org\/10.1016\/j.immuni.2017.03.019 (2017).","journal-title":"Immunity"},{"key":"20107_CR70","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.cmet.2019.04.002","volume":"30","author":"X Ma","year":"2019","unstructured":"Ma, X. et al. Cholesterol induces cd8+ t cell exhaustion in the tumor microenvironment. Cell Metab. 30, 143-156.e5. https:\/\/doi.org\/10.1016\/j.cmet.2019.04.002 (2019).","journal-title":"Cell Metab."},{"key":"20107_CR71","doi-asserted-by":"publisher","first-page":"574","DOI":"10.21037\/TAU-20-924","volume":"10","author":"JJ Park","year":"2021","unstructured":"Park, J. J. et al. Diagnostic accuracy of Raman spectroscopy for prostate cancer: A systematic review and meta-analysis. Transl. Androl. Urol. 10, 574\u2013583. https:\/\/doi.org\/10.21037\/TAU-20-924 (2021).","journal-title":"Transl. Androl. Urol."},{"key":"20107_CR72","doi-asserted-by":"publisher","first-page":"111801","DOI":"10.1016\/j.jphotobiol.2020.111801","volume":"204","author":"NA Correia","year":"2020","unstructured":"Correia, N. A. et al. Detection of prostate cancer by Raman spectroscopy: A multivariate study on patients with normal and altered psa values. J. Photochem. Photobiol. B: Biol. 204, 111801. https:\/\/doi.org\/10.1016\/j.jphotobiol.2020.111801 (2020).","journal-title":"J. Photochem. Photobiol. B: Biol."},{"key":"20107_CR73","doi-asserted-by":"publisher","first-page":"e0197910","DOI":"10.1371\/journal.pone.0197910","volume":"13","author":"A Kirpich","year":"2018","unstructured":"Kirpich, A. et al. Variable selection in omics data: A practical evaluation of small sample sizes. PLoS ONE 13, e0197910. https:\/\/doi.org\/10.1371\/journal.pone.0197910 (2018).","journal-title":"PLoS ONE"},{"key":"20107_CR74","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1111\/j.1467-9868.2005.00503.x","volume":"67","author":"H Zou","year":"2005","unstructured":"Zou, H. & Hastie, T. Regularization and variable selection via the elastic net. J. R. Stat. Soc. Ser. B 67, 301\u2013320 (2005).","journal-title":"J. R. Stat. Soc. Ser. B"},{"key":"20107_CR75","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s10994-006-6226-1","volume":"63","author":"P Geurts","year":"2006","unstructured":"Geurts, P., Ernst, D. & Wehenkel, L. Extremely randomized trees. Mach. Learn. 63, 3\u201342. https:\/\/doi.org\/10.1007\/s10994-006-6226-1 (2006).","journal-title":"Mach. Learn."},{"key":"20107_CR76","doi-asserted-by":"publisher","first-page":"10046","DOI":"10.1038\/s41598-023-37232-8","volume":"13","author":"M Ghazwani","year":"2023","unstructured":"Ghazwani, M. & Begum, M. Y. Computational intelligence modeling of hyoscine drug solubility and solvent density in supercritical processing: gradient boosting, extra trees, and random forest models. Sci. Rep. 13, 10046. https:\/\/doi.org\/10.1038\/s41598-023-37232-8 (2023).","journal-title":"Sci. Rep."},{"key":"20107_CR77","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.36158.001","volume":"7","author":"G Lian","year":"2018","unstructured":"Lian, G. et al. Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine t cell differentiation. eLife 7, e36158. https:\/\/doi.org\/10.7554\/eLife.36158.001 (2018).","journal-title":"eLife"},{"key":"20107_CR78","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1016\/j.cmet.2020.03.004","volume":"31","author":"H Kurniawan","year":"2020","unstructured":"Kurniawan, H. et al. Glutathione restricts serine metabolism to preserve regulatory t cell function. Cell Metab. 31, 920-936.e7. https:\/\/doi.org\/10.1016\/j.cmet.2020.03.004 (2020).","journal-title":"Cell Metab."},{"key":"20107_CR79","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/s13045-023-01478-6","volume":"16","author":"M Li","year":"2023","unstructured":"Li, M. et al. Metabolism, metabolites, and macrophages in cancer. J. Hematol. Oncol. 16, 80. https:\/\/doi.org\/10.1186\/s13045-023-01478-6 (2023).","journal-title":"J. Hematol. Oncol."},{"key":"20107_CR80","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1002\/pros.10249","volume":"56","author":"M Li","year":"2003","unstructured":"Li, M. et al. Glutathione s-transferase pi is upregulated in the stromal compartment of hormone independent prostate cancer. Prostate 56, 98\u2013105. https:\/\/doi.org\/10.1002\/pros.10249 (2003).","journal-title":"Prostate"},{"key":"20107_CR81","doi-asserted-by":"publisher","first-page":"14269","DOI":"10.1038\/s41598-018-32549-1","volume":"8","author":"MK Andersen","year":"2018","unstructured":"Andersen, M. K. et al. Integrative metabolic and transcriptomic profiling of prostate cancer tissue containing reactive stroma. Sci. Rep. 8, 14269. https:\/\/doi.org\/10.1038\/s41598-018-32549-1 (2018).","journal-title":"Sci. Rep."},{"key":"20107_CR82","doi-asserted-by":"publisher","first-page":"2634","DOI":"10.1158\/1078-0432.CCR-06-2163","volume":"13","author":"J Banyard","year":"2007","unstructured":"Banyard, J. et al. Collagen xxiii expression is associated with prostate cancer recurrence and distant metastases. Clin. Cancer Res. 13, 2634\u20132642. https:\/\/doi.org\/10.1158\/1078-0432.CCR-06-2163 (2007).","journal-title":"Clin. Cancer Res."},{"key":"20107_CR83","doi-asserted-by":"publisher","first-page":"2315","DOI":"10.1084\/jem.20151193","volume":"213","author":"R Afik","year":"2016","unstructured":"Afik, R. et al. Tumor macrophages are pivotal constructors of tumor collagenous matrix. J. Exp. Med. 213, 2315\u20132331. https:\/\/doi.org\/10.1084\/jem.20151193 (2016).","journal-title":"J. Exp. Med."},{"key":"20107_CR84","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1016\/j.jaci.2011.06.051","volume":"128","author":"L O\u2019Mahony","year":"2011","unstructured":"O\u2019Mahony, L., Akdis, M. & Akdis, C. A. Regulation of the immune response and inflammation by histamine and histamine receptors. J. Allergy Clin. Immunol. 128, 1153\u20131162. https:\/\/doi.org\/10.1016\/j.jaci.2011.06.051 (2011).","journal-title":"J. Allergy Clin. Immunol."},{"key":"20107_CR85","doi-asserted-by":"publisher","first-page":"7191","DOI":"10.1016\/j.bmcl.2010.10.041","volume":"20","author":"P Igel","year":"2010","unstructured":"Igel, P., Dove, S. & Buschauer, A. Histamine h4 receptor agonists. Bioorgan. Med. Chem. Lett. 20, 7191\u20137199. https:\/\/doi.org\/10.1016\/j.bmcl.2010.10.041 (2010).","journal-title":"Bioorgan. Med. Chem. Lett."},{"key":"20107_CR86","doi-asserted-by":"publisher","first-page":"9524075","DOI":"10.1155\/2018\/9524075","volume":"2018","author":"ACCC Branco","year":"2018","unstructured":"Branco, A. C. C. C., Yoshikawa, F. S. Y., Pietrobon, A. J. & Sato, M. N. Role of histamine in modulating the immune response and inflammation. Mediat. Inflamm. 2018, 9524075. https:\/\/doi.org\/10.1155\/2018\/9524075 (2018).","journal-title":"Mediat. Inflamm."},{"key":"20107_CR87","doi-asserted-by":"publisher","first-page":"100149","DOI":"10.1016\/j.phanu.2019.100149","volume":"8","author":"AA Tantawy","year":"2019","unstructured":"Tantawy, A. A. & Naguib, D. M. Arginine, histidine and tryptophan: A new hope for cancer immunotherapy. PharmaNutrition 8, 100149. https:\/\/doi.org\/10.1016\/j.phanu.2019.100149 (2019).","journal-title":"PharmaNutrition"},{"key":"20107_CR88","doi-asserted-by":"publisher","first-page":"1740","DOI":"10.1158\/1535-7163.MCT-09-1064","volume":"9","author":"V Fritz","year":"2010","unstructured":"Fritz, V. et al. Abrogation of de novo lipogenesis by stearoyl-coa desaturase 1 inhibition interferes with oncogenic signaling and blocks prostate cancer progression in mice. Mol. Cancer Ther. 9, 1740\u20131754. https:\/\/doi.org\/10.1158\/1535-7163.MCT-09-1064 (2010).","journal-title":"Mol. Cancer Ther."},{"key":"20107_CR89","doi-asserted-by":"publisher","first-page":"8789","DOI":"10.1038\/s41598-025-93089-z","volume":"15","author":"JP Dulude","year":"2025","unstructured":"Dulude, J. P. et al. Intraoperative use of high-speed Raman spectroscopy during soft tissue sarcoma resection. Sci. Rep. 15, 8789. https:\/\/doi.org\/10.1038\/s41598-025-93089-z (2025).","journal-title":"Sci. Rep."},{"key":"20107_CR90","doi-asserted-by":"publisher","first-page":"24230","DOI":"10.1038\/s41598-025-08222-9","volume":"15","author":"A Bali","year":"2025","unstructured":"Bali, A. et al. Establishment of a clinical workflow for in vivo Raman spectroscopy during head and neck cancer surgery. Sci. Rep. 15, 24230. https:\/\/doi.org\/10.1038\/s41598-025-08222-9 (2025).","journal-title":"Sci. Rep."},{"key":"20107_CR91","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1097\/JU.0000000000004393","volume":"213","author":"MP Mannas","year":"2025","unstructured":"Mannas, M. P. et al. Stimulated Raman histology and artificial intelligence provide near real-time interpretation of radical prostatectomy surgical margins. J. Urol. 213, 609\u2013616. https:\/\/doi.org\/10.1097\/JU.0000000000004393 (2025).","journal-title":"J. Urol."},{"key":"20107_CR92","doi-asserted-by":"publisher","first-page":"117210","DOI":"10.1016\/j.saa.2019.117210","volume":"222","author":"HF Nargis","year":"2019","unstructured":"Nargis, H. F. et al. Raman spectroscopy of blood plasma samples from breast cancer patients at different stages. Spectrochim. Acta Part A Mol. Biomol. Spectrosc. 222, 117210. https:\/\/doi.org\/10.1016\/j.saa.2019.117210 (2019).","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"20107_CR93","doi-asserted-by":"publisher","first-page":"18464","DOI":"10.1038\/s41598-022-22197-x","volume":"12","author":"HJ Koster","year":"2022","unstructured":"Koster, H. J. et al. Fused Raman spectroscopic analysis of blood and saliva delivers high accuracy for head and neck cancer diagnostics. Sci. Rep. 12, 18464. https:\/\/doi.org\/10.1038\/s41598-022-22197-x (2022).","journal-title":"Sci. Rep."},{"key":"20107_CR94","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-025-03050-0","author":"R Schiemer","year":"2025","unstructured":"Schiemer, R. et al. Infrared and Raman spectroscopy of blood plasma for rapid endometrial cancer detection: Clinical studies. Br. J. Cancer https:\/\/doi.org\/10.1038\/s41416-025-03050-0 (2025).","journal-title":"Br. J. Cancer"},{"key":"20107_CR95","doi-asserted-by":"publisher","first-page":"175883592091849","DOI":"10.1177\/1758835920918499","volume":"12","author":"DK Medipally","year":"2020","unstructured":"Medipally, D. K. et al. Vibrational spectroscopy of liquid biopsies for prostate cancer diagnosis. Ther. Adv. Med. Oncol. 12, 1758835920918499. https:\/\/doi.org\/10.1177\/1758835920918499 (2020).","journal-title":"Ther. Adv. Med. Oncol."},{"key":"20107_CR96","doi-asserted-by":"publisher","first-page":"925","DOI":"10.3390\/cancers11070925","volume":"11","author":"DK Medipally","year":"2019","unstructured":"Medipally, D. K. et al. Monitoring radiotherapeutic response in prostate cancer patients using high throughput ftir spectroscopy of liquid biopsies. Cancers 11, 925. https:\/\/doi.org\/10.3390\/cancers11070925 (2019).","journal-title":"Cancers"},{"key":"20107_CR97","doi-asserted-by":"publisher","first-page":"e201900035","DOI":"10.1002\/tbio.201900035","volume":"2","author":"D Cullen","year":"2020","unstructured":"Cullen, D. et al. Raman spectroscopy of lymphocytes for the identification of prostate cancer patients with late radiation toxicity following radiotherapy. Transl. Biophotonics 2, e201900035. https:\/\/doi.org\/10.1002\/tbio.201900035 (2020).","journal-title":"Transl. Biophotonics"},{"key":"20107_CR98","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2025.102840","volume":"68","author":"D Andras","year":"2025","unstructured":"Andras, D. et al. Sers liquid biopsy in colorectal cancer detection and treatment response: Revealing metabolic memory post-radiochemotherapy. Nanomed.: Nanotechnol. Biol. Med. 68, 102840. https:\/\/doi.org\/10.1016\/j.nano.2025.102840 (2025).","journal-title":"Nanomed.: Nanotechnol. Biol. Med."},{"key":"20107_CR99","doi-asserted-by":"publisher","first-page":"119356","DOI":"10.1016\/j.saa.2020.119356","volume":"250","author":"A Shrivastava","year":"2021","unstructured":"Shrivastava, A. et al. Diagnostic and prognostic application of Raman spectroscopy in carcinoma cervix: A biomolecular approach. Spectrochim. Acta Part A: Mol. Biomol. Spectrosc. 250, 119356. https:\/\/doi.org\/10.1016\/j.saa.2020.119356 (2021).","journal-title":"Spectrochim. Acta Part A: Mol. Biomol. Spectrosc."},{"key":"20107_CR100","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1667\/RR13891.1","volume":"183","author":"A Maguire","year":"2015","unstructured":"Maguire, A. et al. Analyses of ionizing radiation effects in vitro in peripheral blood lymphocytes with Raman spectroscopy. Radiat. Res. 183, 407\u2013416. https:\/\/doi.org\/10.1667\/RR13891.1 (2015).","journal-title":"Radiat. Res."},{"key":"20107_CR101","doi-asserted-by":"publisher","first-page":"100808","DOI":"10.1016\/j.neo.2022.100808","volume":"31","author":"MJ Gough","year":"2022","unstructured":"Gough, M. J. & Crittenden, M. R. The paradox of radiation and t cells in tumors. Neoplasia (United States) 31, 100808. https:\/\/doi.org\/10.1016\/j.neo.2022.100808 (2022).","journal-title":"Neoplasia (United States)"},{"key":"20107_CR102","doi-asserted-by":"publisher","first-page":"12564","DOI":"10.3390\/app132312564","volume":"13","author":"A Gkikoudi","year":"2023","unstructured":"Gkikoudi, A. et al. Molecular biomarkers for predicting cancer patient radiosensitivity and radiotoxicity in clinical practice. Appl. Sci. (Switzerland) 13, 12564. https:\/\/doi.org\/10.3390\/app132312564 (2023).","journal-title":"Appl. Sci. (Switzerland)"},{"key":"20107_CR103","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1038\/s41416-023-02398-5","volume":"129","author":"DB McLaren","year":"2023","unstructured":"McLaren, D. B. & Aitman, T. J. Redefining precision radiotherapy through liquid biopsy. Br. J. Cancer 129, 900\u2013903. https:\/\/doi.org\/10.1038\/s41416-023-02398-5 (2023).","journal-title":"Br. J. Cancer"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-20107-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-20107-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-20107-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T10:29:11Z","timestamp":1760610551000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-20107-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,16]]},"references-count":103,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["20107"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-20107-5","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,16]]},"assertion":[{"value":"11 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"36248"}}