{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:19:54Z","timestamp":1792696794631,"version":"4.5.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"crossref","award":["No. 2017B020209001"],"award-info":[{"award-number":["No. 2017B020209001"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-20187-3","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T14:42:55Z","timestamp":1760712175000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comprehensive analysis of LncRNA-miRNA-mRNA CeRNA network associated with umbilical cord blood PBMC in down syndrome"],"prefix":"10.1038","volume":"15","author":[{"given":"Zhipeng","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengying","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingping","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoshuang","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donge","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,17]]},"reference":[{"issue":"3","key":"20187_CR1","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.tig.2022.11.004","volume":"39","author":"M Krivega","year":"2023","unstructured":"Krivega, M. & Storchova, Z. Consequences of trisomy syndromes \u2013 21 and beyond. Trends Genet. 39 (3), 172\u2013174 (2023).","journal-title":"Trends Genet."},{"issue":"5","key":"20187_CR2","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1136\/jmg.33.5.387","volume":"33","author":"D Mutton","year":"1996","unstructured":"Mutton, D., Alberman, E. & Hook, E. B. Cytogenetic and epidemiological findings in down syndrome, England and Wales 1989 to 1993. National down syndrome cytogenetic register and the association of clinical cytogeneticists. J. Med. Genet. 33 (5), 387\u2013394 (1996).","journal-title":"J. Med. Genet."},{"issue":"11","key":"20187_CR3","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1016\/S1474-4422(21)00245-3","volume":"20","author":"J Fortea","year":"2021","unstructured":"Fortea, J. et al. Alzheimer\u2019s disease associated with down syndrome: a genetic form of dementia. Lancet Neurol. 20 (11), 930\u2013942 (2021).","journal-title":"Lancet Neurol."},{"issue":"3","key":"20187_CR4","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1007\/s40120-022-00361-9","volume":"11","author":"O Hamadelseed","year":"2022","unstructured":"Hamadelseed, O., Elkhidir, I. H. & Skutella, T. Psychosocial risk factors for alzheimer\u2019s disease in patients with down syndrome and their association with brain changes: A narrative review. Neurol. Therapy. 11 (3), 931\u2013953 (2022).","journal-title":"Neurol. Therapy"},{"issue":"10","key":"20187_CR5","doi-asserted-by":"publisher","first-page":"2570","DOI":"10.3324\/haematol.2023.283225","volume":"108","author":"A Baruchel","year":"2023","unstructured":"Baruchel, A. et al. Down syndrome and leukemia: from basic mechanisms to clinical advances. Haematologica 108 (10), 2570\u20132581 (2023).","journal-title":"Haematologica"},{"key":"20187_CR6","doi-asserted-by":"crossref","unstructured":"Arias-Lobo, R. et al. Abordaje terap\u00e9utico de cardiopat\u00edas cong\u00e9nitas en el s\u00edndrome de down. Archivos de Cardiolog\u00eda de M\u00e9xico. 93(3), 294\u2013299 (2023).","DOI":"10.24875\/ACM.22000053"},{"key":"20187_CR7","first-page":"98","volume":"7","author":"Z Rahmani","year":"1990","unstructured":"Rahmani, Z. et al. Down syndrome critical region around D21S55 on proximal 21q22.3. Am. J. Med. Genet. Supplement. 7, 98\u2013103 (1990).","journal-title":"Am. J. Med. Genet. Supplement"},{"issue":"11","key":"20187_CR8","doi-asserted-by":"publisher","first-page":"4997","DOI":"10.1073\/pnas.91.11.4997","volume":"91","author":"JR Korenberg","year":"1994","unstructured":"Korenberg, J. R. et al. Down syndrome phenotypes: the consequences of chromosomal imbalance. Proc. Natl. Acad. Sci. U.S.A. 91 (11), 4997\u20135001 (1994).","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"issue":"6","key":"20187_CR9","doi-asserted-by":"publisher","first-page":"1662","DOI":"10.1007\/s13577-021-00602-3","volume":"34","author":"M Salemi","year":"2021","unstructured":"Salemi, M. et al. Role of long non-coding RNAs in down syndrome patients: a transcriptome analysis study. Hum. Cell. 34 (6), 1662\u20131670 (2021).","journal-title":"Hum. Cell"},{"key":"20187_CR10","doi-asserted-by":"crossref","unstructured":"Venegas-Zamora, L. et al. New molecular and organelle alterations linked to down syndrome heart disease. Front. Genet. 12 (2022).","DOI":"10.3389\/fgene.2021.792231"},{"issue":"02","key":"20187_CR11","first-page":"293","volume":"42","author":"K Ding","year":"2022","unstructured":"Ding, K. et al. Differential expression profiling of MiRNAs in fetal amniotic fluid exosomes with down syndrome. J. S. Med. Univ.. 42 (02), 293\u2013299 (2022).","journal-title":"J. South. Med. Univ."},{"key":"20187_CR12","doi-asserted-by":"crossref","unstructured":"Sui, W. et al. Differential expression profile study and gene function analysis of maternal foetal-derived circRNA for screening for Down\u2019s syndrome. Exp. Therap. Med. (2019).","DOI":"10.3892\/etm.2019.8288"},{"issue":"5","key":"20187_CR13","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1007\/s00438-022-01922-1","volume":"297","author":"M Rashidmayvan","year":"2022","unstructured":"Rashidmayvan, M., Sahebi, R. & Ghayour-Mobarhan, M. Long non-coding rnas: a valuable biomarker for metabolic syndrome. Mol. Genet. Genomics. 297 (5), 1169\u20131183 (2022).","journal-title":"Mol. Genet. Genomics"},{"key":"20187_CR14","doi-asserted-by":"publisher","first-page":"649","DOI":"10.3389\/fonc.2019.00649","volume":"9","author":"J Long","year":"2019","unstructured":"Long, J. et al. Construction and investigation of a lncRNA-Associated CeRNA regulatory network in cholangiocarcinoma. Front. Oncol. 9, 649 (2019).","journal-title":"Front. Oncol."},{"key":"20187_CR15","doi-asserted-by":"publisher","first-page":"2058","DOI":"10.12659\/MSM.915555","volume":"25","author":"Y Chen","year":"2019","unstructured":"Chen, Y. et al. A long noncoding RNA (lncRNA)-Associated competing endogenous RNA (ceRNA) network identifies eight LncRNA biomarkers in patients with osteoarthritis of the knee. Med. Sci. Monit. 25, 2058\u20132065 (2019).","journal-title":"Med. Sci. Monit."},{"key":"20187_CR16","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1186\/s12935-020-01222-x","volume":"20","author":"X Tan","year":"2020","unstructured":"Tan, X. et al. Knockdown of LncRNA NEAT1 suppresses hypoxia-induced migration, invasion and Glycolysis in anaplastic thyroid carcinoma cells through regulation of miR-206 and miR-599. Cancer Cell. Int. 20, 132 (2020).","journal-title":"Cancer Cell. Int."},{"key":"20187_CR17","doi-asserted-by":"crossref","unstructured":"Zhang, L. et al. Clinical significance of MiRNAs in autoimmunity. J. Autoimmun. 109 (2020).","DOI":"10.1016\/j.jaut.2020.102438"},{"key":"20187_CR18","doi-asserted-by":"crossref","unstructured":"Zhou, Y. et al. Involvement of MicroRNAs and their potential diagnostic, therapeutic, and prognostic role in hepatocellular carcinoma. J. Clin. Lab. Anal. 36 (10) (2022).","DOI":"10.1002\/jcla.24673"},{"key":"20187_CR19","doi-asserted-by":"crossref","unstructured":"Rykova, E. et al. SNPs in 3\u2032UTR MiRNA target sequences associated with individual drug susceptibility. Int. J. Mol. Sci. 23 (22) (2022).","DOI":"10.3390\/ijms232213725"},{"issue":"9","key":"20187_CR20","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1038\/s41582-020-0369-8","volume":"16","author":"GP Brennan","year":"2020","unstructured":"Brennan, G. P. & Henshall, D. C. MicroRNAs as regulators of brain function and targets for treatment of epilepsy. Nat. Reviews Neurol. 16 (9), 506\u2013519 (2020).","journal-title":"Nat. Reviews Neurol."},{"key":"20187_CR21","doi-asserted-by":"crossref","unstructured":"Rybak-Wolf, A. & Plass, M. RNA dynamics in alzheimer\u2019s disease. Molecules 26 (17) (2021).","DOI":"10.3390\/molecules26175113"},{"issue":"1","key":"20187_CR22","first-page":"11","volume":"8","author":"A Br\u00e1s","year":"2018","unstructured":"Br\u00e1s, A. et al. Down syndrome and MicroRNAs. Biomed. Rep. 8 (1), 11\u201316 (2018).","journal-title":"Biomed. Rep."},{"issue":"3","key":"20187_CR23","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1007\/s10571-017-0514-0","volume":"38","author":"PN Alexandrov","year":"2018","unstructured":"Alexandrov, P. N., Percy, M. E. & Lukiw, W. J. Chromosome 21-Encoded MicroRNAs (mRNAs): impact on down\u2019s syndrome and Trisomy-21 linked disease. Cell. Mol. Neurobiol. 38 (3), 769\u2013774 (2018).","journal-title":"Cell. Mol. Neurobiol."},{"issue":"Suppl 24","key":"20187_CR24","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1186\/s12859-019-3247-x","volume":"20","author":"ZB Abrams","year":"2019","unstructured":"Abrams, Z. B. et al. A protocol to evaluate RNA sequencing normalization methods. BMC Bioinform. 20 (Suppl 24), 679 (2019).","journal-title":"BMC Bioinform."},{"issue":"5","key":"20187_CR25","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1038\/nbt.1621","volume":"28","author":"C Trapnell","year":"2010","unstructured":"Trapnell, C. et al. Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Nat. Biotechnol. 28 (5), 511\u2013515 (2010).","journal-title":"Nat. Biotechnol."},{"key":"20187_CR26","doi-asserted-by":"publisher","first-page":"D672","DOI":"10.1093\/nar\/gkae909","volume":"53","author":"M Kanehisa","year":"2025","unstructured":"Kanehisa, M. et al. KEGG: biological systems database as a model of the real world. Nucleic Acids Res. 53, D672\u2013D677 (2025).","journal-title":"Nucleic Acids Res."},{"issue":"19","key":"20187_CR27","doi-asserted-by":"publisher","first-page":"3787","DOI":"10.1093\/bioinformatics\/bti430","volume":"21","author":"X Mao","year":"2005","unstructured":"Mao, X. et al. Automated genome annotation and pathway identification using the KEGG orthology (KO) as a controlled vocabulary. Bioinf. (Oxford England). 21 (19), 3787\u20133793 (2005).","journal-title":"Bioinf. (Oxford England)"},{"issue":"2","key":"20187_CR28","doi-asserted-by":"publisher","first-page":"R14","DOI":"10.1186\/gb-2010-11-2-r14","volume":"11","author":"MD Young","year":"2010","unstructured":"Young, M. D. et al. Gene ontology analysis for RNA-seq: accounting for selection bias. Genome Biol. 11 (2), R14 (2010).","journal-title":"Genome Biol."},{"issue":"3","key":"20187_CR29","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.cell.2011.07.014","volume":"146","author":"L Salmena","year":"2011","unstructured":"Salmena, L. et al. A CeRNA hypothesis: the Rosetta stone of a hidden RNA language?. Cell 146 (3), 353\u2013358 (2011).","journal-title":"Cell"},{"key":"20187_CR30","doi-asserted-by":"publisher","first-page":"e8024","DOI":"10.7717\/peerj.8024","volume":"7","author":"X Wang","year":"2019","unstructured":"Wang, X. et al. Competing endogenous RNA (ceRNA) hypothetic model based on comprehensive analysis of long non-coding RNA expression in lung adenocarcinoma. PeerJ 7, e8024 (2019).","journal-title":"PeerJ"},{"key":"20187_CR31","unstructured":"Dube, U. et al. An atlas of cortical circular RNA expression in alzheimer disease brains demonstrates clinical and pathological associations. 22 (11), 1903\u20131912 (2019)."},{"key":"20187_CR32","doi-asserted-by":"crossref","unstructured":"Liu, X. et al. Single-c ell RNA-seq of the developing cardiac outflow tract reveals convergent development of the vascular smooth muscle cells. 28 (5), 1346\u20131361 (2019).","DOI":"10.1016\/j.celrep.2019.06.092"},{"key":"20187_CR33","doi-asserted-by":"crossref","unstructured":"Weichselbaum, L. et al. Epigenetic basis for monocyte dysfunction in patients with severe alcoholic hepatitis. J. Hepatol. (2020).","DOI":"10.1016\/j.jhep.2020.02.017"},{"key":"20187_CR34","unstructured":"Zhao, Y. et al. A microRNA cluster (let-7c, miRNA-99a, miRNA-125b, miRNA-155 and miRNA-802) encoded at chr21q21.1-chr21q21.3 and the phenotypic diversity of Down\u2019s syndrome (DS; trisomy 21). J. Nat. Sci. 3 (9) (2017)."},{"issue":"8","key":"20187_CR35","doi-asserted-by":"publisher","first-page":"647","DOI":"10.3390\/antiox9080647","volume":"9","author":"A Picca","year":"2020","unstructured":"Picca, A. et al. Mitochondrial dysfunction, oxidative stress, and neuroinflammation: intertwined roads to neurodegeneration. Antioxid. (Basel). 9 (8), 647 (2020).","journal-title":"Antioxid. (Basel)"},{"issue":"9","key":"20187_CR36","doi-asserted-by":"publisher","first-page":"e0239219","DOI":"10.1371\/journal.pone.0239219","volume":"15","author":"N Khayer","year":"2020","unstructured":"Khayer, N. et al. Rps27a might act as a controller of microglia activation in triggering neurodegenerative diseases. PloS One. 15 (9), e0239219 (2020).","journal-title":"PloS One"},{"issue":"4","key":"20187_CR37","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1016\/j.bbrc.2014.03.086","volume":"446","author":"H Wang","year":"2014","unstructured":"Wang, H. et al. RPS27a promotes proliferation, regulates cell cycle progression and inhibits apoptosis of leukemia cells. Biochem. Biophys. Res. Commun. 446 (4), 1204\u20131210 (2014).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"20187_CR38","doi-asserted-by":"publisher","first-page":"36780","DOI":"10.1038\/srep36780","volume":"6","author":"M Kobayashi","year":"2016","unstructured":"Kobayashi, M. et al. The ubiquitin hybrid gene UBA52 regulates ubiquitination of ribosome and sustains embryonic development. Sci. Rep. 6, 36780 (2016).","journal-title":"Sci. Rep."},{"issue":"4","key":"20187_CR39","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/j.cmet.2018.06.014","volume":"28","author":"T Yamada","year":"2018","unstructured":"Yamada, T. et al. Mitochondrial stasis reveals p62-Mediated ubiquitination in Parkin-Independent mitophagy and mitigates nonalcoholic fatty liver disease. Cell Metabol. 28 (4), 588\u2013604e5 (2018).","journal-title":"Cell Metabol."},{"issue":"4","key":"20187_CR40","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1038\/s41418-019-0424-4","volume":"27","author":"Y Xie","year":"2020","unstructured":"Xie, Y. et al. RBX1 prompts degradation of EXO1 to limit the homologous recombination pathway of DNA double-strand break repair in G1 phase. Cell. Death Differ. 27 (4), 1383\u20131397 (2020).","journal-title":"Cell. Death Differ."},{"key":"20187_CR41","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.canlet.2020.11.051","volume":"500","author":"M Bungsy","year":"2021","unstructured":"Bungsy, M. et al. Reduced RBX1 expression induces chromosome instability and promotes cellular transformation in high-grade serous ovarian cancer precursor cells. Cancer Lett. 500, 194\u2013207 (2021).","journal-title":"Cancer Lett."},{"issue":"3","key":"20187_CR42","doi-asserted-by":"publisher","first-page":"402","DOI":"10.3390\/molecules24030402","volume":"24","author":"Y Niikura","year":"2019","unstructured":"Niikura, Y., Kitagawa, R. & Kitagawa, K. CENP-A ubiquitylation contributes to maintaining the chromosomal location of the centromere. Molecules 24 (3), 402 (2019).","journal-title":"Molecules"},{"issue":"20","key":"20187_CR43","doi-asserted-by":"publisher","first-page":"2943","DOI":"10.1021\/acs.biochem.8b00158","volume":"57","author":"MC Mulero","year":"2018","unstructured":"Mulero, M. C. et al. Protein cofactors are essential for High-Affinity DNA binding by the nuclear factor \u03baB rela subunit. Biochemistry 57 (20), 2943\u20132957 (2018).","journal-title":"Biochemistry"},{"issue":"46","key":"20187_CR44","doi-asserted-by":"publisher","first-page":"18821","DOI":"10.1074\/jbc.M117.813980","volume":"292","author":"MC Mulero","year":"2017","unstructured":"Mulero, M. C. et al. DNA-binding affinity and transcriptional activity of the rela homodimer of nuclear factor \u03baB are not correlated. J. Biol. Chem. 292 (46), 18821\u201318830 (2017).","journal-title":"J. Biol. Chem."},{"issue":"3","key":"20187_CR45","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1083\/jcb.200905057","volume":"188","author":"SL Thompson","year":"2010","unstructured":"Thompson, S. L. & Compton, D. A. Proliferation of aneuploid human cells is limited by a p53-dependent mechanism. J. Cell Biol. 188 (3), 369\u2013381 (2010).","journal-title":"J. Cell Biol."},{"issue":"1","key":"20187_CR46","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1155\/2013\/302920","volume":"34","author":"JA Boquett","year":"2013","unstructured":"Boquett, J. A. et al. Maternal SNPs in the p53 pathway: risk factors for trisomy 21?. Dis. Markers. 34 (1), 41\u201349 (2013).","journal-title":"Dis. Markers"},{"issue":"24","key":"20187_CR47","doi-asserted-by":"publisher","first-page":"3145","DOI":"10.1038\/emboj.2013.245","volume":"32","author":"J Aprea","year":"2013","unstructured":"Aprea, J. et al. Transcriptome sequencing during mouse brain development identifies long non-coding RNAs functionally involved in neurogenic commitment. EMBO J. 32 (24), 3145\u20133160 (2013).","journal-title":"EMBO J."},{"issue":"31","key":"20187_CR48","doi-asserted-by":"publisher","first-page":"49688","DOI":"10.18632\/oncotarget.10434","volume":"7","author":"Q Jiang","year":"2016","unstructured":"Jiang, Q. et al. Long non-coding RNA-MIAT promotes neurovascular remodeling in the eye and brain. Oncotarget 7 (31), 49688\u201349698 (2016).","journal-title":"Oncotarget"},{"issue":"6","key":"20187_CR49","doi-asserted-by":"publisher","first-page":"107629","DOI":"10.1016\/j.celrep.2020.107629","volume":"31","author":"O Yildirim","year":"2020","unstructured":"Yildirim, O. et al. S-phase enriched Non-coding RNAs regulate gene expression and cell cycle progression. Cell. Rep. 31 (6), 107629 (2020).","journal-title":"Cell. Rep."},{"issue":"3","key":"20187_CR50","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.devcel.2019.12.015","volume":"52","author":"JT Czermi\u0144ski","year":"2020","unstructured":"Czermi\u0144ski, J. T. & Lawrence, J. B. Silencing trisomy 21 with XIST in neural stem cells promotes neuronal differentiation. Dev. Cell. 52 (3), 294\u2013308e3 (2020).","journal-title":"Dev. Cell"},{"issue":"1","key":"20187_CR51","doi-asserted-by":"publisher","first-page":"5180","DOI":"10.1038\/s41467-018-07630-y","volume":"9","author":"JC Chiang","year":"2018","unstructured":"Chiang, J. C. et al. Trisomy Silencing by XIST normalizes down syndrome cell pathogenesis demonstrated for hematopoietic defects in vitro. Nat. Commun. 9 (1), 5180 (2018).","journal-title":"Nat. Commun."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-20187-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-20187-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-20187-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T14:43:09Z","timestamp":1760712189000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-20187-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,17]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["20187"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-20187-3","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,17]]},"assertion":[{"value":"24 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study was performed according to the declaration of Helsinki and was approved by Ethics Committee of the Shenzhen People\u2019s Hospital, China (LL-KY2019362). All samples were collected in Shenzhen People\u2019s Hospital and all participants had signed the written informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"36352"}}