{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T02:58:52Z","timestamp":1787626732962,"version":"build-2736575974"},"reference-count":113,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Hangzhou Health Science and Technology Plan Projects for 2025","award":["A20251673"],"award-info":[{"award-number":["A20251673"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-20595-5","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T09:31:57Z","timestamp":1761125517000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Integrated transcriptomic analysis identifies lysosomal autophagy-related genes in sarcopenia"],"prefix":"10.1038","volume":"15","author":[{"given":"Ye","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,22]]},"reference":[{"key":"20595_CR1","doi-asserted-by":"publisher","first-page":"e1281164146","DOI":"10.2174\/1874467216666230308142137","volume":"17","author":"P Prajapati","year":"2024","unstructured":"Prajapati, P. et al. A comprehensive review of essential aspects of molecular pathophysiological mechanisms with emerging interventions for sarcopenia in older people. Curr. Mol. Pharmacol. 17, e1281164146. https:\/\/doi.org\/10.2174\/1874467216666230308142137 (2024).","journal-title":"Curr. Mol. Pharmacol."},{"key":"20595_CR2","doi-asserted-by":"publisher","first-page":"111449","DOI":"10.1016\/j.exger.2021.111449","volume":"152","author":"D Lopes","year":"2021","unstructured":"Lopes, D. et al. Regular physical activity reduces the Proinflammatory response in older women with diabetes and hypertension in the postmenopausal phase. Exp. Gerontol. 152, 111449. https:\/\/doi.org\/10.1016\/j.exger.2021.111449 (2021).","journal-title":"Exp. Gerontol."},{"key":"20595_CR3","doi-asserted-by":"publisher","unstructured":"Tretter, B. L. et al. Neurogenic aging after spinal cord injury: highlighting the unique characteristics of aging after spinal cord injury. J. Clin. Med. 13 https:\/\/doi.org\/10.3390\/jcm13237197 (2024).","DOI":"10.3390\/jcm13237197"},{"key":"20595_CR4","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1038\/nrrheum.2017.60","volume":"13","author":"EM Dennison","year":"2017","unstructured":"Dennison, E. M., Sayer, A. A. & Cooper, C. Epidemiology of sarcopenia and insight into possible therapeutic targets. Nat. Rev. Rheumatol. 13, 340\u2013347. https:\/\/doi.org\/10.1038\/nrrheum.2017.60 (2017).","journal-title":"Nat. Rev. Rheumatol."},{"key":"20595_CR5","doi-asserted-by":"publisher","unstructured":"Mellen, R. H. et al. Insights into pathogenesis, nutritional and drug approach in sarcopenia: a systematic review. Biomedicines 11 https:\/\/doi.org\/10.3390\/biomedicines11010136 (2023).","DOI":"10.3390\/biomedicines11010136"},{"key":"20595_CR6","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1186\/s12877-021-02146-5","volume":"21","author":"YY Chen","year":"2021","unstructured":"Chen, Y. Y. et al. Cross-sectional associations among p3np, htra, hsp70, Apelin and sarcopenia in Taiwanese population. Bmc Geriatr. 21, 192. https:\/\/doi.org\/10.1186\/s12877-021-02146-5 (2021).","journal-title":"Bmc Geriatr."},{"key":"20595_CR7","doi-asserted-by":"publisher","first-page":"105115","DOI":"10.1016\/j.archger.2023.105115","volume":"115","author":"HE Shin","year":"2023","unstructured":"Shin, H. E., Won, C. W. & Kim, M. Development of multiple biomarker panels for prediction of sarcopenia in community-dwelling older adults. Arch. Gerontol. Geriatr. 115, 105115. https:\/\/doi.org\/10.1016\/j.archger.2023.105115 (2023).","journal-title":"Arch. Gerontol. Geriatr."},{"key":"20595_CR8","doi-asserted-by":"publisher","first-page":"1119782","DOI":"10.3389\/fendo.2023.1119782","volume":"14","author":"Y Tan","year":"2023","unstructured":"Tan, Y. et al. Metabolomics analysis reveals serum biomarkers in patients with diabetic sarcopenia. Front. Endocrinol. (Lausanne). 14, 1119782. https:\/\/doi.org\/10.3389\/fendo.2023.1119782 (2023).","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"20595_CR9","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1091\/mbc.e03-09-0704","volume":"15","author":"N Mizushima","year":"2004","unstructured":"Mizushima, N. et al. In vivo analysis of autophagy in response to nutrient starvation using Transgenic mice expressing a fluorescent autophagosome marker. Mol. Biol. Cell. 15, 1101\u20131111. https:\/\/doi.org\/10.1091\/mbc.e03-09-0704 (2004).","journal-title":"Mol. Biol. Cell."},{"key":"20595_CR10","doi-asserted-by":"publisher","first-page":"3048","DOI":"10.1002\/jcsm.13062","volume":"13","author":"M Eggelbusch","year":"2022","unstructured":"Eggelbusch, M. et al. The nlrp3 inflammasome contributes to inflammation-induced morphological and metabolic alterations in skeletal muscle. J. Cachexia Sarcopenia Muscle. 13, 3048\u20133061. https:\/\/doi.org\/10.1002\/jcsm.13062 (2022).","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"20595_CR11","doi-asserted-by":"publisher","first-page":"3363","DOI":"10.1038\/s41440-024-01898-y","volume":"47","author":"A Toba","year":"2024","unstructured":"Toba, A. & Ishikawa, J. Sarcopenia as a risk factor for hypertension. Hypertens. Res. 47, 3363\u20133366. https:\/\/doi.org\/10.1038\/s41440-024-01898-y (2024).","journal-title":"Hypertens. Res."},{"key":"20595_CR12","unstructured":"Elagina, L. V. et al. [Circulating immune complexes and indicators of nonspecific defense in surgical patients]. Khirurgiia (Mosk):33\u201336. (1986)."},{"key":"20595_CR13","doi-asserted-by":"publisher","unstructured":"Tezze, C. et al. A combination of Metformin and galantamine exhibits synergistic benefits in the treatment of sarcopenia. Jci Insight. 8 https:\/\/doi.org\/10.1172\/jci.insight.168787 (2023).","DOI":"10.1172\/jci.insight.168787"},{"key":"20595_CR14","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/s12979-024-00458-9","volume":"21","author":"N Zhang","year":"2024","unstructured":"Zhang, N. et al. Harnessing Immunomodulation to combat sarcopenia: current insights and possible approaches. Immun. Ageing. 21, 55. https:\/\/doi.org\/10.1186\/s12979-024-00458-9 (2024).","journal-title":"Immun. Ageing"},{"key":"20595_CR15","doi-asserted-by":"publisher","unstructured":"Welch, N. et al. Compound sarcopenia in hospitalized patients with cirrhosis worsens outcomes with increasing age. Nutrients 13 https:\/\/doi.org\/10.3390\/nu13020659 (2021).","DOI":"10.3390\/nu13020659"},{"key":"20595_CR16","doi-asserted-by":"publisher","unstructured":"Bellanti, F., Lo, B. A. & Vendemiale, G. Mitochondrial impairment in sarcopenia. Biology (Basel). 10. https:\/\/doi.org\/10.3390\/biology10010031 (2021).","DOI":"10.3390\/biology10010031"},{"key":"20595_CR17","doi-asserted-by":"publisher","first-page":"112","DOI":"10.3389\/fcimb.2017.00112","volume":"7","author":"PM Mansilla","year":"2017","unstructured":"Mansilla, P. M. et al. Alterations of the Coxiella burnetii replicative vacuole membrane integrity and interplay with the autophagy pathway. Front. Cell. Infect. Microbiol. 7, 112. https:\/\/doi.org\/10.3389\/fcimb.2017.00112 (2017).","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"20595_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2025.110484","author":"H Wang","year":"2025","unstructured":"Wang, H. et al. The ubiquitin ligase triad1 influences myeloid leukemogenesis by regulating the integrated stress response. J. Biol. Chem:110484. https:\/\/doi.org\/10.1016\/j.jbc.2025.110484 (2025).","journal-title":"J. Biol. Chem:110484"},{"key":"20595_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/boc.201700046","volume":"110","author":"J Joachim","year":"2018","unstructured":"Joachim, J. & Tooze, S. A. Control of gabarap-mediated autophagy by the golgi complex, centrosome and centriolar satellites. Biol. Cell. 110, 1\u20135. https:\/\/doi.org\/10.1111\/boc.201700046 (2018).","journal-title":"Biol. Cell."},{"key":"20595_CR20","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.stemcr.2024.01.002","volume":"19","author":"JA Klickstein","year":"2024","unstructured":"Klickstein, J. A. et al. Als-related p97 r155h mutation disrupts lysophagy in ipsc-derived motor neurons. Stem Cell. Rep. 19, 366\u2013382. https:\/\/doi.org\/10.1016\/j.stemcr.2024.01.002 (2024).","journal-title":"Stem Cell. Rep."},{"key":"20595_CR21","doi-asserted-by":"publisher","first-page":"9663","DOI":"10.1074\/jbc.RA120.013206","volume":"295","author":"H Wang","year":"2020","unstructured":"Wang, H. et al. An aberrantly sustained emergency granulopoiesis response accelerates postchemotherapy relapse in mll1-rearranged acute myeloid leukemia in mice. J. Biol. Chem. 295, 9663\u20139675. https:\/\/doi.org\/10.1074\/jbc.RA120.013206 (2020).","journal-title":"J. Biol. Chem."},{"key":"20595_CR22","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/978-1-4939-8873-0_21","volume":"1880","author":"S Aits","year":"2019","unstructured":"Aits, S. Methods to detect loss of lysosomal membrane integrity. Methods Mol. Biol. 1880, 315\u2013329. https:\/\/doi.org\/10.1007\/978-1-4939-8873-0_21 (2019).","journal-title":"Methods Mol. Biol."},{"key":"20595_CR23","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.jmb.2019.08.010","volume":"432","author":"C Papadopoulos","year":"2020","unstructured":"Papadopoulos, C., Kravic, B. & Meyer, H. Repair or lysophagy: dealing with damaged lysosomes. J. Mol. Biol. 432, 231\u2013239. https:\/\/doi.org\/10.1016\/j.jmb.2019.08.010 (2020).","journal-title":"J. Mol. Biol."},{"key":"20595_CR24","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1038\/s41580-024-00757-5","volume":"25","author":"RA Nixon","year":"2024","unstructured":"Nixon, R. A. & Rubinsztein, D. C. Mechanisms of autophagy-lysosome dysfunction in neurodegenerative diseases. Nat. Rev. Mol. Cell. Biol. 25, 926\u2013946. https:\/\/doi.org\/10.1038\/s41580-024-00757-5 (2024).","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"20595_CR25","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1007\/s10157-025-02653-4","volume":"29","author":"T Yamamoto","year":"2025","unstructured":"Yamamoto, T. Autophagic stagnation: a key mechanism in kidney disease progression linked to aging and obesity. Clin. Exp. Nephrol. 29, 711\u2013719. https:\/\/doi.org\/10.1007\/s10157-025-02653-4 (2025).","journal-title":"Clin. Exp. Nephrol."},{"key":"20595_CR26","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1016\/j.tem.2024.06.010","volume":"35","author":"C Arden","year":"2024","unstructured":"Arden, C. et al. Autophagy and lysosomal dysfunction in diabetes and its complications. Trends Endocrinol. Metab. 35, 1078\u20131090. https:\/\/doi.org\/10.1016\/j.tem.2024.06.010 (2024).","journal-title":"Trends Endocrinol. Metab."},{"key":"20595_CR27","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1002\/2211-5463.13347","volume":"12","author":"JM Carosi","year":"2022","unstructured":"Carosi, J. M. et al. The mtor-lysosome axis at the centre of ageing. Febs Open. Bio. 12, 739\u2013757. https:\/\/doi.org\/10.1002\/2211-5463.13347 (2022).","journal-title":"Febs Open. Bio"},{"key":"20595_CR28","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.3233\/JAD-230658","volume":"97","author":"EA Asiamah","year":"2024","unstructured":"Asiamah, E. A. et al. The contributions of the endolysosomal compartment and autophagy to apoevarepsilon4 allele-mediated increase in alzheimer\u2019s disease risk. J. Alzheimers Dis. 97, 1007\u20131031. https:\/\/doi.org\/10.3233\/JAD-230658 (2024).","journal-title":"J. Alzheimers Dis."},{"key":"20595_CR29","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1007\/s00401-024-02799-7","volume":"148","author":"RA Nixon","year":"2024","unstructured":"Nixon, R. A. Autophagy-lysosomal-associated neuronal death in neurodegenerative disease. Acta Neuropathol. 148, 42. https:\/\/doi.org\/10.1007\/s00401-024-02799-7 (2024).","journal-title":"Acta Neuropathol."},{"key":"20595_CR30","doi-asserted-by":"publisher","first-page":"8276","DOI":"10.1111\/jcmm.15301","volume":"24","author":"HJ Zheng","year":"2020","unstructured":"Zheng, H. J. et al. Lysosomal dysfunction-induced autophagic stress in diabetic kidney disease. J. Cell. Mol. Med. 24, 8276\u20138290. https:\/\/doi.org\/10.1111\/jcmm.15301 (2020).","journal-title":"J. Cell. Mol. Med."},{"key":"20595_CR31","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1038\/s41419-019-2002-6","volume":"10","author":"WJ Liu","year":"2019","unstructured":"Liu, W. J. et al. Lysosome restoration to activate podocyte autophagy: a new therapeutic strategy for diabetic kidney disease. Cell. Death Dis. 10, 806. https:\/\/doi.org\/10.1038\/s41419-019-2002-6 (2019).","journal-title":"Cell. Death Dis."},{"key":"20595_CR32","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/s00441-020-03375-7","volume":"385","author":"C Meyer-Schwesinger","year":"2021","unstructured":"Meyer-Schwesinger, C. Lysosome function in glomerular health and disease. Cell. Tissue Res. 385, 371\u2013392. https:\/\/doi.org\/10.1007\/s00441-020-03375-7 (2021).","journal-title":"Cell. Tissue Res."},{"key":"20595_CR33","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/s11658-024-00633-2","volume":"29","author":"V Ferrari","year":"2024","unstructured":"Ferrari, V. et al. Lysosome quality control in health and neurodegenerative diseases. Cell. Mol. Biol. Lett. 29, 116. https:\/\/doi.org\/10.1186\/s11658-024-00633-2 (2024).","journal-title":"Cell. Mol. Biol. Lett."},{"key":"20595_CR34","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1007\/s11011-024-01409-5","volume":"39","author":"X Zhu","year":"2024","unstructured":"Zhu, X., Gao, J. & Qiu, C. Integrative analysis reveals key lysosomal genes as potential therapeutic targets in alzheimer\u2019s disease. Metab. Brain Dis. 39, 1433\u20131445. https:\/\/doi.org\/10.1007\/s11011-024-01409-5 (2024).","journal-title":"Metab. Brain Dis."},{"key":"20595_CR35","doi-asserted-by":"publisher","first-page":"e13583","DOI":"10.1111\/acel.13583","volume":"21","author":"A Irazoki","year":"2022","unstructured":"Irazoki, A. et al. Coordination of mitochondrial and lysosomal homeostasis mitigates inflammation and muscle atrophy during aging. Aging Cell. 21, e13583. https:\/\/doi.org\/10.1111\/acel.13583 (2022).","journal-title":"Aging Cell."},{"key":"20595_CR36","doi-asserted-by":"publisher","unstructured":"Triolo, M. & Hood, D. A. Manifestations of age on autophagy, mitophagy and lysosomes in skeletal muscle. Cells 10 https:\/\/doi.org\/10.3390\/cells10051054 (2021).","DOI":"10.3390\/cells10051054"},{"key":"20595_CR37","doi-asserted-by":"publisher","unstructured":"Lee, J. H., Jeon, J. H. & Lee, M. J. Docosahexaenoic acid, a potential treatment for sarcopenia, modulates the ubiquitin-proteasome and the autophagy-lysosome systems. Nutrients 12 https:\/\/doi.org\/10.3390\/nu12092597 (2020).","DOI":"10.3390\/nu12092597"},{"key":"20595_CR38","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1007\/s00592-023-02131-x","volume":"60","author":"K Wu","year":"2023","unstructured":"Wu, K. et al. The cebpa-fgf21 regulatory network May participate in the t2dm-induced skeletal muscle atrophy by regulating the autophagy-lysosomal pathway. Acta Diabetol. 60, 1491\u20131503. https:\/\/doi.org\/10.1007\/s00592-023-02131-x (2023).","journal-title":"Acta Diabetol."},{"key":"20595_CR39","doi-asserted-by":"publisher","first-page":"1846","DOI":"10.1093\/bioinformatics\/btm254","volume":"23","author":"S Davis","year":"2007","unstructured":"Davis, S. & Meltzer, P. S. Geoquery: a Bridge between the gene expression omnibus (geo) and bioconductor. Bioinformatics 23, 1846\u20131847. https:\/\/doi.org\/10.1093\/bioinformatics\/btm254 (2007).","journal-title":"Bioinformatics"},{"key":"20595_CR40","doi-asserted-by":"publisher","first-page":"D991","DOI":"10.1093\/nar\/gks1193","volume":"41","author":"T Barrett","year":"2013","unstructured":"Barrett, T. et al. Ncbi geo: archive for functional genomics data sets\u2013update. Nucleic Acids Res. 41, D991\u2013D995. https:\/\/doi.org\/10.1093\/nar\/gks1193 (2013).","journal-title":"Nucleic Acids Res."},{"key":"20595_CR41","doi-asserted-by":"publisher","first-page":"e465","DOI":"10.1371\/journal.pone.0000465","volume":"2","author":"S Melov","year":"2007","unstructured":"Melov, S. et al. Resistance exercise reverses aging in human skeletal muscle. Plos One. 2, e465. https:\/\/doi.org\/10.1371\/journal.pone.0000465 (2007).","journal-title":"Plos One"},{"key":"20595_CR42","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1152\/physiolgenomics.00249.2004","volume":"21","author":"PG Giresi","year":"2005","unstructured":"Giresi, P. G. et al. Identification of a molecular signature of sarcopenia. Physiol. Genomics. 21, 253\u2013263. https:\/\/doi.org\/10.1152\/physiolgenomics.00249.2004 (2005).","journal-title":"Physiol. Genomics"},{"key":"20595_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/cpbi.5","volume":"54","author":"G Stelzer","year":"2016","unstructured":"Stelzer, G. et al. The genecards suite: from gene data mining to disease genome sequence analyses. Curr. Protoc. Bioinf. 54, 1\u201330. https:\/\/doi.org\/10.1002\/cpbi.5 (2016).","journal-title":"Curr. Protoc. Bioinf."},{"key":"20595_CR44","doi-asserted-by":"publisher","unstructured":"Eapen, V. V. et al. Quantitative proteomics reveals the selectivity of ubiquitin-binding autophagy receptors in the turnover of damaged lysosomes by lysophagy. Elife 10. https:\/\/doi.org\/10.7554\/eLife.72328 (2021).","DOI":"10.7554\/eLife.72328"},{"key":"20595_CR45","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1080\/15548627.2019.1687217","volume":"16","author":"B Kravic","year":"2020","unstructured":"Kravic, B., Behrends, C. & Meyer, H. Regulation of lysosome integrity and lysophagy by the ubiquitin-conjugating enzyme ube2ql1. Autophagy 16, 179\u2013180. https:\/\/doi.org\/10.1080\/15548627.2019.1687217 (2020).","journal-title":"Autophagy"},{"key":"20595_CR46","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1093\/bioinformatics\/bts034","volume":"28","author":"JT Leek","year":"2012","unstructured":"Leek, J. T. et al. The Sva package for removing batch effects and other unwanted variation in high-throughput experiments. Bioinformatics 28, 882\u2013883. https:\/\/doi.org\/10.1093\/bioinformatics\/bts034 (2012).","journal-title":"Bioinformatics"},{"key":"20595_CR47","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","volume":"43","author":"ME Ritchie","year":"2015","unstructured":"Ritchie, M. E. et al. Limma powers differential expression analyses for rna-sequencing and microarray studies. Nucleic Acids Res. 43, e47. https:\/\/doi.org\/10.1093\/nar\/gkv007 (2015).","journal-title":"Nucleic Acids Res."},{"key":"20595_CR48","first-page":"383","volume":"99","author":"SK Ben","year":"2021","unstructured":"Ben, S. K. & Ben, A. A. Principal component analysis (pca). Tunis Med. 99, 383\u2013389 (2021).","journal-title":"Tunis Med."},{"key":"20595_CR49","doi-asserted-by":"publisher","first-page":"D419","DOI":"10.1093\/nar\/gky1038","volume":"47","author":"H Mi","year":"2019","unstructured":"Mi, H. et al. Panther version 14: more genomes, a new Panther go-slim and improvements in enrichment analysis tools. Nucleic Acids Res. 47, D419\u2013D426. https:\/\/doi.org\/10.1093\/nar\/gky1038 (2019).","journal-title":"Nucleic Acids Res."},{"key":"20595_CR50","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa, M. & Goto, S. Kegg: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28, 27\u201330. https:\/\/doi.org\/10.1093\/nar\/28.1.27 (2000).","journal-title":"Nucleic Acids Res."},{"key":"20595_CR51","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","volume":"16","author":"G Yu","year":"2012","unstructured":"Yu, G. et al. Clusterprofiler: an r package for comparing biological themes among gene clusters. Omics 16, 284\u2013287 (2012).","journal-title":"Omics"},{"key":"20595_CR52","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian, A. et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl. Acad. Sci. U S A. 102, 15545\u201315550. https:\/\/doi.org\/10.1073\/pnas.0506580102 (2005).","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"20595_CR53","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1093\/bioinformatics\/btr260","volume":"27","author":"A Liberzon","year":"2011","unstructured":"Liberzon, A. et al. Molecular signatures database (msigdb) 3.0. Bioinformatics 27, 1739\u20131740. https:\/\/doi.org\/10.1093\/bioinformatics\/btr260 (2011).","journal-title":"Bioinformatics"},{"key":"20595_CR54","doi-asserted-by":"publisher","first-page":"D607","DOI":"10.1093\/nar\/gky1131","volume":"47","author":"D Szklarczyk","year":"2019","unstructured":"Szklarczyk, D. et al. String v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res. 47, D607\u2013D613. https:\/\/doi.org\/10.1093\/nar\/gky1131 (2019).","journal-title":"Nucleic Acids Res."},{"key":"20595_CR55","doi-asserted-by":"publisher","unstructured":"Chin, C. H. et al. Cytohubba: identifying hub objects and sub-networks from complex interactome. Bmc Syst. Biol. 8 Suppl. (4), S11. https:\/\/doi.org\/10.1186\/1752-0509-8-S4-S11 (2014).","DOI":"10.1186\/1752-0509-8-S4-S11"},{"key":"20595_CR56","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon, P. et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 13, 2498\u20132504. https:\/\/doi.org\/10.1101\/gr.1239303 (2003).","journal-title":"Genome Res."},{"key":"20595_CR57","doi-asserted-by":"publisher","first-page":"W60","DOI":"10.1093\/nar\/gky311","volume":"46","author":"M Franz","year":"2018","unstructured":"Franz, M. et al. Genemania update 2018. Nucleic Acids Res. 46, W60\u2013W64. https:\/\/doi.org\/10.1093\/nar\/gky311 (2018).","journal-title":"Nucleic Acids Res."},{"key":"20595_CR58","doi-asserted-by":"publisher","first-page":"D43","DOI":"10.1093\/nar\/gkw965","volume":"45","author":"KR Zhou","year":"2017","unstructured":"Zhou, K. R. et al. Chipbase v2.0: decoding transcriptional regulatory networks of non-coding Rnas and protein-coding genes from chip-seq data. Nucleic Acids Res. 45, D43\u2013D50. https:\/\/doi.org\/10.1093\/nar\/gkw965 (2017).","journal-title":"Nucleic Acids Res."},{"key":"20595_CR59","doi-asserted-by":"publisher","first-page":"D153","DOI":"10.1093\/nar\/gku1215","volume":"43","author":"IS Vlachos","year":"2015","unstructured":"Vlachos, I. S. et al. Diana-tarbase v7.0: indexing more than half a million experimentally supported mirna:mrna interactions. Nucleic Acids Res. 43, D153\u2013D159. https:\/\/doi.org\/10.1093\/nar\/gku1215 (2015).","journal-title":"Nucleic Acids Res."},{"key":"20595_CR60","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/1471-2105-12-77","volume":"12","author":"X Robin","year":"2011","unstructured":"Robin, X. et al. Proc: an open-source package for r and s\u2009+\u2009to analyze and compare Roc curves. BMC Bioinform. 12, 77 (2011).","journal-title":"BMC Bioinform."},{"key":"20595_CR61","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1038\/nmeth.3337","volume":"12","author":"AM Newman","year":"2015","unstructured":"Newman, A. M. et al. Robust enumeration of cell subsets from tissue expression profiles. Nat. Methods. 12, 453\u2013457. https:\/\/doi.org\/10.1038\/nmeth.3337 (2015).","journal-title":"Nat. Methods"},{"key":"20595_CR62","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1186\/s12967-023-04796-y","volume":"21","author":"Q Fang","year":"2023","unstructured":"Fang, Q. et al. Erbin accelerates tfeb-mediated lysosome biogenesis and autophagy and alleviates sepsis-induced inflammatory responses and organ injuries. J. Transl Med. 21, 916. https:\/\/doi.org\/10.1186\/s12967-023-04796-y (2023).","journal-title":"J. Transl Med."},{"key":"20595_CR63","doi-asserted-by":"publisher","unstructured":"Kuczynska, M., Moskot, M. & Gabig-Ciminska, M. Insights into autophagic machinery and lysosomal function in cells involved in the psoriatic immune-mediated inflammatory cascade. Arch. Immunol. Ther. Exp. (Warsz). 72. https:\/\/doi.org\/10.2478\/aite-2024-0005 (2024).","DOI":"10.2478\/aite-2024-0005"},{"key":"20595_CR64","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s12979-023-00381-5","volume":"20","author":"JS Baek","year":"2023","unstructured":"Baek, J. S. et al. Bifidobacterium bifidum and Lactobacillus paracasei alleviate sarcopenia and cognitive impairment in aged mice by regulating gut microbiota-mediated akt, nf-kappab, and foxo3a signaling pathways. Immun. Ageing. 20, 56. https:\/\/doi.org\/10.1186\/s12979-023-00381-5 (2023).","journal-title":"Immun. Ageing"},{"key":"20595_CR65","doi-asserted-by":"publisher","first-page":"112316","DOI":"10.1016\/j.exger.2023.112316","volume":"183","author":"Y Zhang","year":"2023","unstructured":"Zhang, Y. et al. A bibliometric analysis of inflammation in sarcopenia from 2007 to 2022. Exp. Gerontol. 183, 112316. https:\/\/doi.org\/10.1016\/j.exger.2023.112316 (2023).","journal-title":"Exp. Gerontol."},{"key":"20595_CR66","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/s11934-023-01157-6","volume":"24","author":"BN Schmeusser","year":"2023","unstructured":"Schmeusser, B. N. et al. Imaging techniques to determine degree of sarcopenia and systemic inflammation in advanced renal cell carcinoma. Curr. Urol. Rep. 24, 317\u2013334. https:\/\/doi.org\/10.1007\/s11934-023-01157-6 (2023).","journal-title":"Curr. Urol. Rep."},{"key":"20595_CR67","doi-asserted-by":"publisher","unstructured":"Bakinowska, E. et al. Pathogenesis of sarcopenia in chronic kidney disease-the role of inflammation, metabolic dysregulation, gut dysbiosis, and Microrna. Int. J. Mol. Sci. 25. https:\/\/doi.org\/10.3390\/ijms25158474 (2024).","DOI":"10.3390\/ijms25158474"},{"key":"20595_CR68","doi-asserted-by":"publisher","first-page":"1162385","DOI":"10.3389\/fpubh.2023.1162385","volume":"11","author":"B Morawin","year":"2023","unstructured":"Morawin, B. et al. Diagnostics of inflammaging in relation to sarcopenia. Front. Public. Health. 11, 1162385. https:\/\/doi.org\/10.3389\/fpubh.2023.1162385 (2023).","journal-title":"Front. Public. Health"},{"key":"20595_CR69","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.freeradbiomed.2024.11.046","volume":"227","author":"H Xu","year":"2025","unstructured":"Xu, H. et al. Reactive oxygen species in the pathogenesis of sarcopenia. Free Radic Biol. Med. 227, 446\u2013458. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2024.11.046 (2025).","journal-title":"Free Radic Biol. Med."},{"key":"20595_CR70","doi-asserted-by":"publisher","first-page":"251","DOI":"10.11005\/jbm.24.739","volume":"31","author":"RI Alnaser","year":"2024","unstructured":"Alnaser, R. I., Alassaf, F. A. & Abed, M. N. Incretin-based therapies: a promising approach for modulating oxidative stress and insulin resistance in sarcopenia. J. Bone Metab. 31, 251\u2013263. https:\/\/doi.org\/10.11005\/jbm.24.739 (2024).","journal-title":"J. Bone Metab."},{"key":"20595_CR71","doi-asserted-by":"publisher","first-page":"4432584","DOI":"10.1155\/2022\/4432584","volume":"2022","author":"C Ma","year":"2022","unstructured":"Ma, C. et al. Therapeutic effect of gypenosides on antioxidant stress injury in orbital fibroblasts of graves\u2019 orbitopathy. J. Immunol. Res. 2022, 4432584. https:\/\/doi.org\/10.1155\/2022\/4432584 (2022).","journal-title":"J. Immunol. Res."},{"key":"20595_CR72","doi-asserted-by":"publisher","first-page":"93","DOI":"10.3760\/cma.j.cn121430-20230711-00510","volume":"36","author":"Z Zhang","year":"2024","unstructured":"Zhang, Z. et al. [New research direction of organ dysfunction caused by hemorrhagic shock: mechanisms of mitochondrial quality control]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 36, 93\u201397. https:\/\/doi.org\/10.3760\/cma.j.cn121430-20230711-00510 (2024).","journal-title":"Zhonghua Wei Zhong Bing Ji Jiu Yi Xue"},{"key":"20595_CR73","doi-asserted-by":"publisher","first-page":"2839","DOI":"10.1080\/15548627.2024.2413295","volume":"20","author":"Y Sasazawa","year":"2024","unstructured":"Sasazawa, Y. et al. Clustering lysosomes around the mtoc: a promising strategy for snca\/alpha-synuclein breakdown leading to Parkinson disease treatment. Autophagy 20, 2839\u20132840. https:\/\/doi.org\/10.1080\/15548627.2024.2413295 (2024).","journal-title":"Autophagy"},{"key":"20595_CR74","doi-asserted-by":"publisher","first-page":"580687","DOI":"10.3389\/fphys.2020.580687","volume":"11","author":"H Bretscher","year":"2020","unstructured":"Bretscher, H. & O\u2019Connor, M. B. The role of muscle in insect energy homeostasis. Front. Physiol. 11, 580687. https:\/\/doi.org\/10.3389\/fphys.2020.580687 (2020).","journal-title":"Front. Physiol."},{"key":"20595_CR75","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1002\/jcsm.13112","volume":"14","author":"Y Huang","year":"2023","unstructured":"Huang, Y. et al. The impact of senescence on muscle wasting in chronic kidney disease. J. Cachexia Sarcopenia Muscle. 14, 126\u2013141. https:\/\/doi.org\/10.1002\/jcsm.13112 (2023).","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"20595_CR76","doi-asserted-by":"publisher","first-page":"100030","DOI":"10.1074\/mcp.RA120.002166","volume":"20","author":"R Blazev","year":"2021","unstructured":"Blazev, R. et al. Integrated glycoproteomics identifies a role of n-glycosylation and galectin-1 on myogenesis and muscle development. Mol. Cell. Proteom. 20, 100030. https:\/\/doi.org\/10.1074\/mcp.RA120.002166 (2021).","journal-title":"Mol. Cell. Proteom."},{"key":"20595_CR77","doi-asserted-by":"publisher","first-page":"115165","DOI":"10.1016\/j.taap.2020.115165","volume":"403","author":"H Sakai","year":"2020","unstructured":"Sakai, H. et al. Upregulation of ubiquitinated proteins and their degradation pathway in muscle atrophy induced by cisplatin in mice. Toxicol. Appl. Pharmacol. 403, 115165. https:\/\/doi.org\/10.1016\/j.taap.2020.115165 (2020).","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"20595_CR78","doi-asserted-by":"publisher","DOI":"10.1101\/2023.02.13.528372","author":"A Podlesny-Drabiniok","year":"2023","unstructured":"Podlesny-Drabiniok, A. et al. Bhlhe40\/41 regulate macrophage\/microglia responses associated with alzheimer\u2019s disease and other disorders of lipid-rich tissues. Biorxiv https:\/\/doi.org\/10.1101\/2023.02.13.528372 (2023).","journal-title":"Biorxiv"},{"key":"20595_CR79","doi-asserted-by":"publisher","first-page":"615787","DOI":"10.3389\/fonc.2021.615787","volume":"11","author":"N Apanovich","year":"2021","unstructured":"Apanovich, N. et al. The choice of candidates in survival markers based on coordinated gene expression in renal cancer. Front. Oncol. 11, 615787. https:\/\/doi.org\/10.3389\/fonc.2021.615787 (2021).","journal-title":"Front. Oncol."},{"key":"20595_CR80","first-page":"550","volume":"21","author":"L Wei","year":"2021","unstructured":"Wei, L. et al. Identification of key pathways and Rnas associated with skeletal muscle atrophy after spinal cord injury. J. Musculoskelet. Neuronal Interact. 21, 550\u2013559 (2021).","journal-title":"J. Musculoskelet. Neuronal Interact."},{"key":"20595_CR81","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1186\/s12935-019-1051-3","volume":"19","author":"H Guo","year":"2019","unstructured":"Guo, H. et al. Cancer-associated fibroblast-derived Exosomal microrna-98-5p promotes cisplatin resistance in ovarian cancer by targeting cdkn1a. Cancer Cell. Int. 19, 347. https:\/\/doi.org\/10.1186\/s12935-019-1051-3 (2019).","journal-title":"Cancer Cell. Int."},{"key":"20595_CR82","doi-asserted-by":"publisher","unstructured":"Zhu, B. et al. Y box-binding protein 1 regulates zebrafish folliculogenesis partly through p21-mediated control of follicle cell proliferation. Development 151 https:\/\/doi.org\/10.1242\/dev.202898 (2024).","DOI":"10.1242\/dev.202898"},{"key":"20595_CR83","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1667\/RADE-24-00261.1","volume":"204","author":"L Ma","year":"2025","unstructured":"Ma, L. et al. Characterization of two stable biodosimeters for absorbed ionizing radiation dose Estimation in multiple combined injury models. Radiat. Res. 204, 27\u201345. https:\/\/doi.org\/10.1667\/RADE-24-00261.1 (2025).","journal-title":"Radiat. Res."},{"key":"20595_CR84","doi-asserted-by":"publisher","first-page":"e2081081176","DOI":"10.1073\/pnas.2213886120","volume":"120","author":"J Altuzar","year":"2023","unstructured":"Altuzar, J. et al. Lysosome-targeted multifunctional lipid probes reveal the sterol transporter npc1 as a sphingosine interactor. Proc. Natl. Acad. Sci. U S A. 120, e2081081176. https:\/\/doi.org\/10.1073\/pnas.2213886120 (2023).","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"20595_CR85","doi-asserted-by":"publisher","first-page":"e319163","DOI":"10.1371\/journal.pone.0319163","volume":"20","author":"T Kitamoto","year":"2025","unstructured":"Kitamoto, T. & Kitamoto, A. Integrative proteomic and lipidomic analysis of gnb1 and scarb2 knockdown in human subcutaneous adipocytes. Plos One. 20, e319163. https:\/\/doi.org\/10.1371\/journal.pone.0319163 (2025).","journal-title":"Plos One"},{"key":"20595_CR86","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1093\/procel\/pwae016","volume":"15","author":"Y Li","year":"2024","unstructured":"Li, Y. et al. Gut dysbiosis impairs intestinal renewal and lipid absorption in scarb2 deficiency-associated neurodegeneration. Protein Cell. 15, 818\u2013839. https:\/\/doi.org\/10.1093\/procel\/pwae016 (2024).","journal-title":"Protein Cell."},{"key":"20595_CR87","doi-asserted-by":"publisher","unstructured":"Montellese, C. et al. Usp16 counteracts mono-ubiquitination of rps27a and promotes maturation of the 40s ribosomal subunit. Elife 9 https:\/\/doi.org\/10.7554\/eLife.54435 (2020).","DOI":"10.7554\/eLife.54435"},{"key":"20595_CR88","doi-asserted-by":"publisher","first-page":"134213","DOI":"10.1016\/j.ijbiomac.2024.134213","volume":"277","author":"YT Hagoss","year":"2024","unstructured":"Hagoss, Y. T. et al. African swine fever virus pcp312r interacts with host rps27a to shut off host protein translation and promotes viral replication. Int. J. Biol. Macromol. 277, 134213. https:\/\/doi.org\/10.1016\/j.ijbiomac.2024.134213 (2024).","journal-title":"Int. J. Biol. Macromol."},{"key":"20595_CR89","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1002\/jcsm.12060","volume":"7","author":"C Polge","year":"2016","unstructured":"Polge, C. et al. Ube2b is implicated in myofibrillar protein loss in catabolic c2c12 myotubes. J. Cachexia Sarcopenia Muscle. 7, 377\u2013387. https:\/\/doi.org\/10.1002\/jcsm.12060 (2016).","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"20595_CR90","doi-asserted-by":"publisher","unstructured":"Furukawa, T. et al. Approach to functions of bhlhe41\/dec2 in non-small lung cancer development. Int. J. Mol. Sci. 24 https:\/\/doi.org\/10.3390\/ijms241411731 (2023).","DOI":"10.3390\/ijms241411731"},{"key":"20595_CR91","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1186\/s40478-020-01037-x","volume":"8","author":"M Huang","year":"2020","unstructured":"Huang, M. et al. Network analysis of the progranulin-deficient mouse brain proteome reveals pathogenic mechanisms shared in human frontotemporal dementia caused by Grn mutations. Acta Neuropathol. Commun. 8, 163. https:\/\/doi.org\/10.1186\/s40478-020-01037-x (2020).","journal-title":"Acta Neuropathol. Commun."},{"key":"20595_CR92","doi-asserted-by":"publisher","first-page":"3671","DOI":"10.1080\/15548627.2021.1886839","volume":"17","author":"S Robichaud","year":"2021","unstructured":"Robichaud, S. et al. Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells. Autophagy 17, 3671\u20133689. https:\/\/doi.org\/10.1080\/15548627.2021.1886839 (2021).","journal-title":"Autophagy"},{"key":"20595_CR93","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1038\/s41467-019-13668-3","volume":"11","author":"I Martinez-Reyes","year":"2020","unstructured":"Martinez-Reyes, I. & Chandel, N. S. Mitochondrial Tca cycle metabolites control physiology and disease. Nat. Commun. 11, 102. https:\/\/doi.org\/10.1038\/s41467-019-13668-3 (2020).","journal-title":"Nat. Commun."},{"key":"20595_CR94","doi-asserted-by":"publisher","first-page":"121619","DOI":"10.1016\/j.lfs.2023.121619","volume":"323","author":"P He","year":"2023","unstructured":"He, P. et al. Reduced energy metabolism contributing to aging of skeletal muscle by serum metabolomics and gut microbiota analysis. Life Sci. 323, 121619. https:\/\/doi.org\/10.1016\/j.lfs.2023.121619 (2023).","journal-title":"Life Sci."},{"key":"20595_CR95","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1002\/jcsm.13433","volume":"15","author":"Y He","year":"2024","unstructured":"He, Y. et al. Metabolomic analysis of dietary-restriction-induced Attenuation of sarcopenia in prematurely aging Dna repair-deficient mice. J. Cachexia Sarcopenia Muscle. 15, 868\u2013882. https:\/\/doi.org\/10.1002\/jcsm.13433 (2024).","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"20595_CR96","doi-asserted-by":"publisher","first-page":"1113200","DOI":"10.3389\/fragi.2023.1113200","volume":"4","author":"S Kobayashi","year":"2023","unstructured":"Kobayashi, S. et al. Lysosomal dysfunction in diabetic cardiomyopathy. Front. Aging. 4, 1113200. https:\/\/doi.org\/10.3389\/fragi.2023.1113200 (2023).","journal-title":"Front. Aging"},{"key":"20595_CR97","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/s12933-025-02639-2","volume":"24","author":"K Shi","year":"2025","unstructured":"Shi, K. et al. Association of body composition with left ventricular remodeling and outcomes in diabetic heart failure with reduced ejection fraction: assessment of sarcopenic obesity using cardiac mri. Cardiovasc. Diabetol. 24, 79. https:\/\/doi.org\/10.1186\/s12933-025-02639-2 (2025).","journal-title":"Cardiovasc. Diabetol."},{"key":"20595_CR98","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1007\/s00592-022-01883-2","volume":"59","author":"HA Giha","year":"2022","unstructured":"Giha, H. A., Alamin, O. & Sater, M. S. Diabetic sarcopenia: metabolic and molecular appraisal. Acta Diabetol. 59, 989\u20131000. https:\/\/doi.org\/10.1007\/s00592-022-01883-2 (2022).","journal-title":"Acta Diabetol."},{"key":"20595_CR99","doi-asserted-by":"publisher","unstructured":"Lisco, G. et al. Sarcopenia and diabetes: a detrimental liaison of advancing age. Nutrients 16 https:\/\/doi.org\/10.3390\/nu16010063 (2023).","DOI":"10.3390\/nu16010063"},{"key":"20595_CR100","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1007\/s00223-020-00742-y","volume":"107","author":"P Anagnostis","year":"2020","unstructured":"Anagnostis, P. et al. Type 2 diabetes mellitus is associated with increased risk of sarcopenia: a systematic review and meta-analysis. Calcif Tissue Int. 107, 453\u2013463. https:\/\/doi.org\/10.1007\/s00223-020-00742-y (2020).","journal-title":"Calcif Tissue Int."},{"key":"20595_CR101","doi-asserted-by":"publisher","first-page":"37","DOI":"10.53941\/ijddp.0201004","volume":"2","author":"J Van","year":"2023","unstructured":"Van, J. et al. Metformin inhibits autophagy, mitophagy and antagonizes doxorubicin-induced cardiomyocyte death. Int. J. Drug Discov Pharm. 2, 37\u201351. https:\/\/doi.org\/10.53941\/ijddp.0201004 (2023).","journal-title":"Int. J. Drug Discov Pharm."},{"key":"20595_CR102","doi-asserted-by":"publisher","first-page":"765778","DOI":"10.3389\/fcell.2021.765778","volume":"9","author":"SF Rodrigues","year":"2021","unstructured":"Rodrigues, S. F. et al. Editorial: interplay between autophagy and metabolic syndrome: causes, consequences and therapeutic challenges. Front. Cell. Dev. Biol. 9, 765778. https:\/\/doi.org\/10.3389\/fcell.2021.765778 (2021).","journal-title":"Front. Cell. Dev. Biol."},{"key":"20595_CR103","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1093\/cvr\/cvad100","volume":"119","author":"DL Da","year":"2023","unstructured":"Da, D. L. et al. Cardiac lipid metabolism, mitochondrial function, and heart failure. Cardiovasc. Res. 119, 1905\u20131914. https:\/\/doi.org\/10.1093\/cvr\/cvad100 (2023).","journal-title":"Cardiovasc. Res."},{"key":"20595_CR104","doi-asserted-by":"publisher","first-page":"C1248","DOI":"10.1152\/ajpcell.00035.2022","volume":"322","author":"A Georgiev","year":"2022","unstructured":"Georgiev, A., Granata, C. & Roden, M. The role of mitochondria in the pathophysiology and treatment of common metabolic diseases in humans. Am. J. Physiol. Cell. Physiol. 322, C1248\u2013C1259. https:\/\/doi.org\/10.1152\/ajpcell.00035.2022 (2022).","journal-title":"Am. J. Physiol. Cell. Physiol."},{"key":"20595_CR105","doi-asserted-by":"publisher","first-page":"414","DOI":"10.14218\/JCTH.2020.00065","volume":"8","author":"S Altajar","year":"2020","unstructured":"Altajar, S. & Baffy, G. Skeletal muscle dysfunction in the development and progression of nonalcoholic fatty liver disease. J. Clin. Transl Hepatol. 8, 414\u2013423. https:\/\/doi.org\/10.14218\/JCTH.2020.00065 (2020).","journal-title":"J. Clin. Transl Hepatol."},{"key":"20595_CR106","doi-asserted-by":"publisher","unstructured":"Antuna, E. et al. Inflammaging: implications in sarcopenia. Int. J. Mol. Sci. 23 https:\/\/doi.org\/10.3390\/ijms232315039 (2022).","DOI":"10.3390\/ijms232315039"},{"key":"20595_CR107","doi-asserted-by":"publisher","first-page":"4035","DOI":"10.18632\/aging.204750","volume":"15","author":"N Liu","year":"2023","unstructured":"Liu, N. et al. Changes in macrophage immunometabolism as a marker of skeletal muscle dysfunction across the lifespan. Aging (Albany Ny). 15, 4035\u20134050. https:\/\/doi.org\/10.18632\/aging.204750 (2023).","journal-title":"Aging (Albany Ny)"},{"key":"20595_CR108","doi-asserted-by":"publisher","unstructured":"Millozzi, F. et al. Nano-immunomodulation: a new strategy for skeletal muscle diseases and aging? Int. J. Mol. Sci. 24 https:\/\/doi.org\/10.3390\/ijms24021175 (2023).","DOI":"10.3390\/ijms24021175"},{"key":"20595_CR109","doi-asserted-by":"publisher","first-page":"111823","DOI":"10.1016\/j.exger.2022.111823","volume":"164","author":"X Zhang","year":"2022","unstructured":"Zhang, X. et al. Immune system and sarcopenia: presented relationship and future perspective. Exp. Gerontol. 164, 111823. https:\/\/doi.org\/10.1016\/j.exger.2022.111823 (2022).","journal-title":"Exp. Gerontol."},{"key":"20595_CR110","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.3389\/fphys.2020.01037","volume":"11","author":"BN VanderVeen","year":"2020","unstructured":"VanderVeen, B. N., Murphy, E. A. & Carson, J. A. The impact of immune cells on the skeletal muscle microenvironment during cancer cachexia. Front. Physiol. 11, 1037. https:\/\/doi.org\/10.3389\/fphys.2020.01037 (2020).","journal-title":"Front. Physiol."},{"key":"20595_CR111","doi-asserted-by":"publisher","first-page":"13380","DOI":"10.18632\/aging.203110","volume":"13","author":"JA Lopez-Dominguez","year":"2021","unstructured":"Lopez-Dominguez, J. A. et al. Cdkn1a transcript variant 2 is a marker of aging and cellular senescence. Aging (Albany Ny). 13, 13380\u201313392. https:\/\/doi.org\/10.18632\/aging.203110 (2021).","journal-title":"Aging (Albany Ny)"},{"key":"20595_CR112","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1007\/s12192-020-01090-4","volume":"25","author":"SA Ock","year":"2020","unstructured":"Ock, S. A., Knott, J. G. & Choi, I. Involvement of cdkn1a (p21) in cellular senescence in response to heat and irradiation stress during preimplantation development. Cell. Stress Chaperones. 25, 503\u2013508. https:\/\/doi.org\/10.1007\/s12192-020-01090-4 (2020).","journal-title":"Cell. Stress Chaperones"},{"key":"20595_CR113","doi-asserted-by":"publisher","first-page":"9393","DOI":"10.18632\/aging.204435","volume":"14","author":"K Perez","year":"2022","unstructured":"Perez, K. et al. Single nuclei profiling identifies cell specific markers of skeletal muscle aging, frailty, and senescence. Aging (Albany Ny). 14, 9393\u20139422. https:\/\/doi.org\/10.18632\/aging.204435 (2022).","journal-title":"Aging (Albany Ny)"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-20595-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-20595-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-20595-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T09:32:00Z","timestamp":1761125520000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-20595-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,22]]},"references-count":113,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["20595"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-20595-5","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,22]]},"assertion":[{"value":"30 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. This research did not involve a human subject trial. Instead, the data came exclusively from the GEO and GeneCards database. The study was conducted in accordance with the Declaration of Helsinki (as revised in 2013).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All the authors have read the manuscript and consented for publication.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"36844"}}