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This prospective study investigated ammonia concentrations at five portal and splanchnic venous sites in 50 fasting cirrhotic patients (20 female [40%]; mean age: 60.4 years) prior to TIPS implantation for ascites (33\/50, 66%) or variceal bleeding (17\/50, 34%). While ammonia levels were significantly higher in the superior mesenteric vein (mean: 143\u00a0\u00b5g\/dl) compared to the splenic vein (mean: 66\u00a0\u00b5g\/dl; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), mean ammonia concentrations in the right (104\u00a0\u00b5g\/dl) and left (107\u00a0\u00b5g\/dl) portal vein branches were found to be equivalent (<jats:italic>p<\/jats:italic>\u2009=\u20090.008 for equivalence). No systematic differences between right and left portal vein ammonia were observed. These findings suggest that in fasting cirrhotic patients, local ammonia levels in the main portal vein branches do not differ significantly. Therefore, other factors likely contribute to any observed differences in HE rates related to TIPS placement site, warranting further investigation into alternative mechanisms.<\/jats:p>","DOI":"10.1038\/s41598-025-21758-0","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T09:23:17Z","timestamp":1759310597000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Uniform intrahepatic portal ammonia distribution in cirrhosis"],"prefix":"10.1038","volume":"15","author":[{"given":"Carsten","family":"Meyer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Ramig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narine","family":"Mesropyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Kupczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Praktiknjo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Luetkens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Kuetting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Jansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2835-8560","authenticated-orcid":false,"given":"Tatjana","family":"Dell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,1]]},"reference":[{"key":"21758_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2025.01.029","author":"EASL Clinical Practice Guidelines on TIPS","year":"2025","unstructured":"EASL Clinical Practice Guidelines on TIPS. 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