{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T10:11:18Z","timestamp":1762164678467,"version":"build-2065373602"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-22249-y","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:09:04Z","timestamp":1762160944000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Conscientiousness personality is associated with increased thyroid nodule risk and sleep quality plays a masking role in this association"],"prefix":"10.1038","volume":"15","author":[{"given":"Huali","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunmei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guizhi","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongliang","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,3]]},"reference":[{"issue":"7","key":"22249_CR1","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/S2213-8587(22)00101-2","volume":"10","author":"EK Alexander","year":"2022","unstructured":"Alexander, E. K. & Cibas, E. S. Diagnosis of thyroid nodules. Lancet Diabetes Endocrinol. 10 (7), 533\u2013539 (2022).","journal-title":"Lancet Diabetes Endocrinol."},{"issue":"7","key":"22249_CR2","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/S2213-8587(22)00139-5","volume":"10","author":"EK Alexander","year":"2022","unstructured":"Alexander, E. K., Doherty, G. M. & Barletta, J. A. Management of thyroid nodules. Lancet Diabetes Endocrinol. 10 (7), 540\u2013548 (2022).","journal-title":"Lancet Diabetes Endocrinol."},{"issue":"1","key":"22249_CR3","doi-asserted-by":"publisher","first-page":"20251079","DOI":"10.1515\/biol-2025-1079","volume":"20","author":"D Han","year":"2025","unstructured":"Han, D. et al. Analysis of the detection rate and related factors of thyroid nodules in the healthy population. Open. Life Sci. 20 (1), 20251079 (2025).","journal-title":"Open. Life Sci."},{"key":"22249_CR4","doi-asserted-by":"publisher","first-page":"1202122","DOI":"10.3389\/fpsyg.2023.1202122","volume":"14","author":"Z Lei","year":"2023","unstructured":"Lei, Z. et al. Associations of psychological status and ultrasonic characteristics of thyroid nodules in adults during the COVID-19 pandemic. Front. Psychol. 14, 1202122 (2023).","journal-title":"Front. Psychol."},{"key":"22249_CR5","doi-asserted-by":"publisher","first-page":"1113977","DOI":"10.3389\/fendo.2023.1113977","volume":"14","author":"N Uppal","year":"2023","unstructured":"Uppal, N., Collins, R. & James, B. Thyroid nodules: Global, economic, and personal burdens. Front. Endocrinol. (Lausanne). 14, 1113977 (2023).","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"22249_CR6","doi-asserted-by":"publisher","first-page":"1405167","DOI":"10.3389\/fpsyt.2024.1405167","volume":"15","author":"A Sz\u00fccs","year":"2024","unstructured":"Sz\u00fccs, A. et al. Personality and help-seeking for psychological distress: a systematic review and meta-analysis. Front. Psychiatry. 15, 1405167 (2024).","journal-title":"Front. Psychiatry"},{"key":"22249_CR7","doi-asserted-by":"publisher","first-page":"111423","DOI":"10.1016\/j.jpsychores.2023.111423","volume":"172","author":"W Kang","year":"2023","unstructured":"Kang, W. & Malvaso, A. Can the big five personality traits predict ever chance and 7-year risk of clinically diagnosed chronic bronchitis in middle-aged and older adults? J. Psychosom. Res. 172, 111423 (2023).","journal-title":"J. Psychosom. Res."},{"issue":"1","key":"22249_CR8","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1186\/s40359-025-03220-y","volume":"13","author":"Q Yang","year":"2025","unstructured":"Yang, Q. et al. The influence of personality traits on college students\u2019 exercise behavior: a chain mediation model of exercise self-efficacy and exercise motivation. BMC Psychol. 13 (1), 864 (2025).","journal-title":"BMC Psychol."},{"key":"22249_CR9","unstructured":"Song, B. Epidemic status of thyroid nodules in middle-aged and elderly people in Fengxian District and discussion on the influencing factors [D], (2019)."},{"issue":"3","key":"22249_CR10","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1080\/00325481.2022.2139485","volume":"135","author":"Y Yan","year":"2023","unstructured":"Yan, Y. et al. Short night-time sleep duration is associated with thyroid nodules: A community-based survey from Guangzhou, China. Postgrad. Med. 135 (3), 290\u2013295 (2023).","journal-title":"Postgrad. Med."},{"key":"22249_CR11","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.coemr.2020.10.002","volume":"17","author":"S Shekhar","year":"2021","unstructured":"Shekhar, S., Hall, J. E. & Klubo-Gwiezdzinska, J. The hypothalamic pituitary thyroid axis and sleep. Curr. Opin. Endocr. Metab. Res. 17, 8\u201314 (2021).","journal-title":"Curr. Opin. Endocr. Metab. Res."},{"issue":"3","key":"22249_CR12","doi-asserted-by":"publisher","first-page":"426","DOI":"10.25122\/jml-2020-0130","volume":"13","author":"NP Tkachuk","year":"2020","unstructured":"Tkachuk, N. P. Thyroid and pseudothyroid dysfunction as a cause that is promoting the relapse of benign focal thyroid pathology. J. Med. Life. 13 (3), 426\u2013430 (2020).","journal-title":"J. Med. Life"},{"issue":"3","key":"22249_CR13","doi-asserted-by":"publisher","first-page":"368","DOI":"10.21037\/gs-24-435","volume":"14","author":"Y Fan","year":"2025","unstructured":"Fan, Y. et al. Sleep factors and risk of thyroid cancer, nodules and dysfunction: Mendelian randomization study. Gland Surg. 14 (3), 368\u2013379 (2025).","journal-title":"Gland Surg."},{"issue":"1","key":"22249_CR14","doi-asserted-by":"publisher","first-page":"1854","DOI":"10.1186\/s12889-024-19375-z","volume":"24","author":"X Li","year":"2024","unstructured":"Li, X. et al. Prevalence of thyroid nodule and relationship with physiological and psychosocial factors among adults in Zhejiang Province, china: a baseline survey of a cohort study. BMC Public. Health. 24 (1), 1854 (2024).","journal-title":"BMC Public. Health"},{"issue":"3","key":"22249_CR15","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1037\/hea0000577","volume":"37","author":"Y Stephan","year":"2018","unstructured":"Stephan, Y. et al. Personality and sleep quality: evidence from four prospective studies. Health Psychol. 37 (3), 271\u2013281 (2018).","journal-title":"Health Psychol."},{"key":"22249_CR16","doi-asserted-by":"crossref","unstructured":"Cao, L. et al. Relationship between personality and sleep: a dual validation study combining empirical and big data-driven approaches. Front. Psychiatry,  (2025).","DOI":"10.3389\/fpsyt.2025.1596269"},{"issue":"6","key":"22249_CR17","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1037\/0033-2909.130.6.887","volume":"130","author":"T Bogg","year":"2004","unstructured":"Bogg, T. & Roberts, B. W. Conscientiousness and health-related behaviors: a meta-analysis of the leading behavioral contributors to mortality. Psychol. Bull. 130 (6), 887\u2013919 (2004).","journal-title":"Psychol. Bull."},{"issue":"6","key":"22249_CR18","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1037\/pspp0000083","volume":"111","author":"KA Leger","year":"2016","unstructured":"Leger, K. A. et al. Personality and stressor-related affect. J. Pers. Soc. Psychol. 111 (6), 917\u2013928 (2016).","journal-title":"J. Pers. Soc. Psychol."},{"key":"22249_CR19","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1016\/j.jad.2021.09.017","volume":"295","author":"S Kummer","year":"2021","unstructured":"Kummer, S. et al. The conscientiousness-health link in depression: results from a path analysis. J. Affect. Disord.. 295, 1220\u20131228 (2021).","journal-title":"J. Affect. Disord"},{"issue":"1","key":"22249_CR20","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1089\/thy.2014.0116","volume":"25","author":"RK Orosco","year":"2015","unstructured":"Orosco, R. K. et al. Analysis of age and disease status as predictors of thyroid cancer-specific mortality using the Surveillance, Epidemiology, and end results database. Thyroid 25 (1), 125\u2013132 (2015).","journal-title":"Thyroid"},{"issue":"2","key":"22249_CR21","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.surg.2012.02.015","volume":"152","author":"HS Tran Cao","year":"2012","unstructured":"Tran Cao, H. S. et al. A critical analysis of the American joint committee on cancer (AJCC) staging system for differentiated thyroid carcinoma in young patients on the basis of the Surveillance, Epidemiology, and end results (SEER) registry. Surgery 152 (2), 145\u2013151 (2012).","journal-title":"Surgery"},{"key":"22249_CR22","unstructured":"Weir, C. B. & Jan, A. BMI Classification Percentile and Cut Off Points [M]. StatPearls. Treasure Island (FL) Ineligible companies. Disclosure: Arif Jan Declares No Relevant Financial Relationships with Ineligible companies.; StatPearls Publishing Copyright \u00a9 2025 (StatPearls Publishing LLC, 2025)."},{"issue":"1","key":"22249_CR23","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.eprac.2024.05.016","volume":"31","author":"AA Parsa","year":"2025","unstructured":"Parsa, A. A. & Gharib, H. Thyroid nodules: Past, Present, and future. Endocr. Pract. 31 (1), 114\u2013123 (2025).","journal-title":"Endocr. Pract."},{"issue":"6","key":"22249_CR24","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/j.rcl.2020.06.006","volume":"58","author":"DM Richman","year":"2020","unstructured":"Richman, D. M. & Frates, M. C. Ultrasound of the normal thyroid with technical pearls and pitfalls. Radiol. Clin. North. Am. 58 (6), 1033\u20131039 (2020).","journal-title":"Radiol. Clin. North. Am."},{"issue":"1","key":"22249_CR25","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1148\/radiol.2017171240","volume":"287","author":"FN Tessler","year":"2018","unstructured":"Tessler, F. N., Middleton, W. D. & Grant, E. G. Thyroid imaging reporting and data system (TI-RADS): A user\u2019s guide. Radiology 287 (1), 29\u201336 (2018).","journal-title":"Radiology"},{"key":"22249_CR26","unstructured":"Costa, P. T., Mccrae, R. R. & Revised, N. E. O. Personality Inventory (NEO PI-R) and NEO Five-Factor Inventory (NEO-FFI) (Springer, 1992)."},{"key":"22249_CR27","doi-asserted-by":"crossref","unstructured":"Rammstedt, B. & John, O. P. Big Five Inventory [M]\/\/ZEIGLER-HILL V, Shackelford T K. Encyclopedia of Personality and Individual Differences. Cham; Springer International Publishing. : 469\u2009\u2013\u200971. (2020).","DOI":"10.1007\/978-3-319-24612-3_445"},{"issue":"8","key":"22249_CR28","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1176\/ajp.151.8.1172","volume":"151","author":"CM Morin","year":"1994","unstructured":"Morin, C. M., Culbert, J. P. & Schwartz, S. M. Nonpharmacological interventions for insomnia: a meta-analysis of treatment efficacy. Am. J. Psychiatry. 151 (8), 1172\u20131180 (1994).","journal-title":"Am. J. Psychiatry"},{"key":"22249_CR29","doi-asserted-by":"publisher","first-page":"106219","DOI":"10.1016\/j.msard.2024.106219","volume":"93","author":"A Moradi","year":"2025","unstructured":"Moradi, A. et al. Sleep quality in multiple sclerosis: A systematic review and meta-analysis based on Pittsburgh sleep quality index. Mult Scler. Relat. Disord.. 93, 106219 (2025).","journal-title":"Mult Scler. Relat. Disord"},{"issue":"8","key":"22249_CR30","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1007\/s11121-021-01268-x","volume":"22","author":"DP MacKinnon","year":"2021","unstructured":"MacKinnon, D. P. & Lamp, S. J. A unification of Mediator, Confounder, and collider effects. Prev. Sci. 22 (8), 1185\u20131193 (2021).","journal-title":"Prev. Sci."},{"key":"22249_CR31","doi-asserted-by":"crossref","unstructured":"Sarstedt, M., Ringle, C. M. & Hair, J. F. Partial Least Squares Structural Equation Modeling [M]\/\/HOMBURG C, Klarmann M, Vomberg A. Handbook of Market Research. Cham; Springer International Publishing. : 587\u2013632. (2022).","DOI":"10.1007\/978-3-319-57413-4_15"},{"issue":"6","key":"22249_CR32","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1037\/0022-3514.51.6.1173","volume":"51","author":"RM Baron","year":"1986","unstructured":"Baron, R. M. & Kenny, D. A. The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. J. Pers. Soc. Psychol. 51 (6), 1173\u20131182 (1986).","journal-title":"J. Pers. Soc. Psychol."},{"key":"22249_CR33","doi-asserted-by":"publisher","first-page":"1331159","DOI":"10.3389\/fpubh.2023.1331159","volume":"11","author":"Y Chen","year":"2023","unstructured":"Chen, Y. et al. Association between systemic immune-inflammatory index and diabetes mellitus: mediation analysis involving obesity indicators in the NHANES. Front. Public. Health. 11, 1331159 (2023).","journal-title":"Front. Public. Health"},{"key":"22249_CR34","doi-asserted-by":"crossref","unstructured":"Rockwood, N. J., Hayes, A. F. & Mediation Moderation, and Conditional Process Analysis: Regression-Based Approaches for Clinical Research [M]\/\/WRIGHT A G C, HALLQUIST M N. The Cambridge Handbook of Research Methods in Clinical Psychology. Cambridge; Cambridge University Press. : 396\u2013414. (2020).","DOI":"10.1017\/9781316995808.037"},{"key":"22249_CR35","doi-asserted-by":"crossref","unstructured":"Dauksiene, D. et al. Factors Associated with the Prevalence of Thyroid Nodules and Goiter in Middle-Aged Euthyroid Subjects. Int J Endocrinol, 2017: 8401518. (2017).","DOI":"10.1155\/2017\/8401518"},{"issue":"1","key":"22249_CR36","doi-asserted-by":"publisher","first-page":"13682","DOI":"10.1038\/s41598-021-93106-x","volume":"11","author":"X Lou","year":"2021","unstructured":"Lou, X. et al. Alterations of sleep quality and circadian rhythm genes expression in elderly thyroid nodule patients and risks associated with thyroid malignancy. Sci. Rep. 11 (1), 13682 (2021).","journal-title":"Sci. Rep."},{"issue":"1","key":"22249_CR37","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/s11596-022-2666-5","volume":"43","author":"MY Qu","year":"2023","unstructured":"Qu, M. Y. et al. Increased prevalence of thyroid nodules across nearly 10 years in Shanghai, China. Curr. Med. Sci. 43 (1), 191\u2013197 (2023).","journal-title":"Curr. Med. Sci."},{"issue":"9","key":"22249_CR38","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1080\/08870446.2021.1934468","volume":"37","author":"J Kim","year":"2022","unstructured":"Kim, J. Personality, health behaviours and physical health in young adulthood. Psychol. Health. 37 (9), 1164\u20131183 (2022).","journal-title":"Psychol. Health"},{"issue":"3","key":"22249_CR39","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1037\/pspp0000399","volume":"122","author":"J Luo","year":"2022","unstructured":"Luo, J. et al. Personality and health: disentangling their between-person and within-person relationship in three longitudinal studies. J. Pers. Soc. Psychol. 122 (3), 493\u2013522 (2022).","journal-title":"J. Pers. Soc. Psychol."},{"issue":"5","key":"22249_CR40","first-page":"773","volume":"36","author":"P Lili","year":"2022","unstructured":"Lili, P. et al. Mediating effect of perfectionism on Anxiety, depression and social support in patients with benign thyroid nodules. Chin. Nurs. Res. 36 (5), 773\u2013779 (2022).","journal-title":"Chin. Nurs. Res."},{"issue":"3","key":"22249_CR41","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1177\/0146167220929824","volume":"47","author":"S Kitayama","year":"2021","unstructured":"Kitayama, S. & Park, J. Is conscientiousness always associated with better health? A U.S.-Japan Cross-Cultural examination of biological health risk. Pers. Soc. Psychol. Bull. 47 (3), 486\u2013498 (2021).","journal-title":"Pers. Soc. Psychol. Bull."},{"issue":"4","key":"22249_CR42","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1037\/a0024298","volume":"101","author":"RE Lucas","year":"2011","unstructured":"Lucas, R. E. & Donnellan, M. B. Personality development across the life span: longitudinal analyses with a National sample from Germany. J. Pers. Soc. Psychol. 101 (4), 847\u2013861 (2011).","journal-title":"J. Pers. Soc. Psychol."},{"issue":"3","key":"22249_CR43","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1037\/pspp0000210","volume":"117","author":"RI Damian","year":"2019","unstructured":"Damian, R. I. et al. Sixteen going on sixty-six: A longitudinal study of personality stability and change across 50 years. J. Pers. Soc. Psychol. 117 (3), 674\u2013695 (2019).","journal-title":"J. Pers. Soc. Psychol."},{"issue":"7\u20138","key":"22249_CR44","first-page":"588","volume":"148","author":"W Bleidorn","year":"2022","unstructured":"Bleidorn, W. et al. Personality stability and change: A meta-analysis of longitudinal studies. Psychol. Bull. 148 (7\u20138), 588\u2013619 (2022).","journal-title":"Psychol. Bull."},{"issue":"2","key":"22249_CR45","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1037\/pspp0000477","volume":"126","author":"L Buchinger","year":"2024","unstructured":"Buchinger, L. et al. Codevelopment of life goals and the big five personality traits across adulthood and old age. J. Pers. Soc. Psychol. 126 (2), 346\u2013368 (2024).","journal-title":"J. Pers. Soc. Psychol."},{"issue":"5","key":"22249_CR46","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1111\/jopy.12791","volume":"91","author":"ND Brandt","year":"2023","unstructured":"Brandt, N. D. et al. Beyond big five trait domains: stability and change in personality facets across midlife and old age. J. Pers. 91 (5), 1171\u20131188 (2023).","journal-title":"J. Pers."},{"issue":"2","key":"22249_CR47","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1080\/15427600802034827","volume":"5","author":"AM Freund","year":"2008","unstructured":"Freund, A. M. Successful aging as management of resources: the role of Selection, Optimization, and compensation. Res. Hum. Dev. 5 (2), 94\u2013106 (2008).","journal-title":"Res. Hum. Dev."},{"key":"22249_CR48","doi-asserted-by":"crossref","unstructured":"Baltes, P. B. & Baltes, M. M. Successful aging: Psychological perspectives on successful aging: The model of selective optimization with compensation [M]. (1990).","DOI":"10.1017\/CBO9780511665684"},{"issue":"4","key":"22249_CR49","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1111\/j.1467-6494.2011.00752.x","volume":"80","author":"CJ Soto","year":"2012","unstructured":"Soto, C. J. & John, O. P. Development of big five domains and facets in adulthood: mean-level age trends and broadly versus narrowly acting mechanisms. J. Pers. 80 (4), 881\u2013914 (2012).","journal-title":"J. Pers."},{"key":"22249_CR50","doi-asserted-by":"publisher","first-page":"101731","DOI":"10.1016\/j.copsyc.2023.101731","volume":"55","author":"W Bleidorn","year":"2024","unstructured":"Bleidorn, W. & Hopwood, C. J. A motivational framework of personality development in late adulthood. Curr. Opin. Psychol. 55, 101731 (2024).","journal-title":"Curr. Opin. Psychol."},{"issue":"10","key":"22249_CR51","doi-asserted-by":"publisher","first-page":"e4221","DOI":"10.1210\/clinem\/dgab224","volume":"106","author":"R Li","year":"2021","unstructured":"Li, R. et al. Psychological distress and sleep disturbance throughout thyroid nodule Screening, Diagnosis, and treatment. J. Clin. Endocrinol. Metab. 106 (10), e4221\u2013e30 (2021).","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"22249_CR52","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.2147\/NSS.S467842","volume":"16","author":"J Guerreiro","year":"2024","unstructured":"Guerreiro, J. et al. The relationship between big five personality traits and sleep patterns: A systematic review. Nat. Sci. Sleep. 16, 1327\u20131337 (2024).","journal-title":"Nat. Sci. Sleep."},{"issue":"9","key":"22249_CR53","doi-asserted-by":"publisher","first-page":"e30075","DOI":"10.1016\/j.heliyon.2024.e30075","volume":"10","author":"M Cui","year":"2024","unstructured":"Cui, M. et al. The effect of emotion regulation strategies on nomophobia in college students: the masking role of resilience. Heliyon 10 (9), e30075 (2024).","journal-title":"Heliyon"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-22249-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-22249-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-22249-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T10:04:28Z","timestamp":1762164268000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-22249-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,3]]},"references-count":53,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["22249"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-22249-y","relation":{},"ISSN":["2045-2322"],"issn-type":[{"type":"electronic","value":"2045-2322"}],"subject":[],"published":{"date-parts":[[2025,11,3]]},"assertion":[{"value":"12 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study was approved by the Ethics Committee of Jinzhou Medical University (JZMULL2025108). This study was in compliance with the Helsinki Declaration. Written informed consent was obtained from all the participants.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval consent to participate"}}],"article-number":"38373"}}