{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T02:46:56Z","timestamp":1785034016027,"version":"3.55.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"the Natural Science Key project of Bengbu Medical University","award":["No.2023byzd063"],"award-info":[{"award-number":["No.2023byzd063"]}]},{"name":"the Anhui Province science and technology leader reserve candidate scientific research project","award":["No. 2020H213"],"award-info":[{"award-number":["No. 2020H213"]}]},{"name":"the Anhui province university outstanding young talents to support key project","award":["No. gxydZD2021117"],"award-info":[{"award-number":["No. gxydZD2021117"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-22698-5","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T13:20:09Z","timestamp":1762435209000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinicopathological significance of Kruppel-like factor 15 and epithelial-to-mesenchymal transition related factors in bladder cancer"],"prefix":"10.1038","volume":"15","author":[{"given":"Wenyong","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudi","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Husong","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wuyue","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongfei","family":"Ci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,6]]},"reference":[{"issue":"23","key":"22698_CR1","doi-asserted-by":"publisher","first-page":"23924","DOI":"10.1021\/acsnano.3c08391","volume":"17","author":"H Chen","year":"2023","unstructured":"Chen, H. et al. Heterogeneous Mxene hybrid-oriented exosome isolation and metabolic profiling for early screening, subtyping and follow-up evaluation of bladder cancer. ACS Nano. 17 (23), 23924\u201323935 (2023).","journal-title":"ACS Nano"},{"key":"22698_CR2","doi-asserted-by":"crossref","unstructured":"HensleyPJ et al. Competing mortality risk from second primary malignancy in bladder cancer patients following radical cystectomy: implications for survivorship. Urol. Oncol. 41 (2), 108e11\u2013108e17 (2023).","DOI":"10.1016\/j.urolonc.2022.10.015"},{"issue":"1","key":"22698_CR3","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.eururo.2018.09.003","volume":"75","author":"JI Warrick","year":"2019","unstructured":"Warrick, J. I. et al. Intratumoral heterogeneity of bladder cancer by molecular subtypes and histologic variants. Eur. Urol. 75 (1), 18\u201322 (2019).","journal-title":"Eur. Urol."},{"key":"22698_CR4","doi-asserted-by":"publisher","first-page":"148027","DOI":"10.1016\/j.gene.2023.148027","volume":"895","author":"K Yuce","year":"2024","unstructured":"Yuce, K. & Ismail Ozkan, A. T. Kruppel-like factor (KLF) family, diseases, and physiological events. Gene 895, 148027 (2024).","journal-title":"Gene"},{"key":"22698_CR5","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.yjmcc.2023.11.006","volume":"186","author":"ZK Song","year":"2023","unstructured":"Song, Z. K. et al. Macrophage KLF15 prevents foam cell formation and atherosclerosis via transcriptional suppression of OLR-1. J. Mol. Cell. Cardiol. 186, 57\u201370 (2023).","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"33","key":"22698_CR6","doi-asserted-by":"publisher","first-page":"e2204338119","DOI":"10.1073\/pnas.2204338119","volume":"119","author":"N Suzuki","year":"2022","unstructured":"Suzuki, N. et al. Adrenergic receptor signaling induced by Klf15, a regulator of regeneration enhancer, promotes kidney reconstruction. Proc. Natl. Acad. Sci. U S A. 119 (33), e2204338119 (2022).","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"issue":"1","key":"22698_CR7","doi-asserted-by":"publisher","first-page":"8807","DOI":"10.1038\/s41598-022-12763-8","volume":"12","author":"R Takala","year":"2022","unstructured":"Takala, R. et al. Pinolenic acid exhibits anti-inflammatory and anti-atherogenic effects in peripheral blood-derived monocytes from patients with rheumatoid arthritis. Sci. Rep. 12 (1), 8807 (2022).","journal-title":"Sci. Rep."},{"issue":"3","key":"22698_CR8","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.tcb.2018.12.001","volume":"29","author":"I Pastushenko","year":"2019","unstructured":"Pastushenko, I. & Blanpain, C. EMT transition States during tumor progression and metastasis. Trends Cell. Biol. 29 (3), 212\u2013226 (2019).","journal-title":"Trends Cell. Biol."},{"key":"22698_CR9","doi-asserted-by":"crossref","unstructured":"Basu, S., Cheriyamundath, S. & Ben-Ze\u2019ev, A. Cell-cell adhesion: linking Wnt\/\u03b2-catenin signaling with partial EMT and stemness traits in tumorigenesis. F1000Res.\u00a0Faculty. Rev.\u00a07. 1488 (2018).","DOI":"10.12688\/f1000research.15782.1"},{"issue":"1","key":"22698_CR10","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1111\/jcmm.14767","volume":"24","author":"R Cao","year":"2020","unstructured":"Cao, R. et al. An EMT-related gene signature for the prognosis of human bladder cancer. J. Cell. Mol. Med. 24 (1), 605\u2013617 (2020).","journal-title":"J. Cell. Mol. Med."},{"issue":"1","key":"22698_CR11","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1186\/s13046-022-02377-3","volume":"41","author":"M Chi","year":"2022","unstructured":"Chi, M. et al. TEAD4 functions as a prognostic biomarker and triggers EMT via PI3K\/AKT pathway in bladder cancer. J. Exp. Clin. Cancer Res. 41 (1), 175 (2022).","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"24","key":"22698_CR12","doi-asserted-by":"publisher","first-page":"8649","DOI":"10.3390\/molecules27248649","volume":"27","author":"SY Hsiao","year":"2022","unstructured":"Hsiao, S. Y. et al. Melatonin inhibits EMT in bladder cancer by targeting autophagy. Molecules 27 (24), 8649 (2022).","journal-title":"Molecules"},{"issue":"2","key":"22698_CR13","doi-asserted-by":"publisher","first-page":"e230319","DOI":"10.1530\/JOE-23-0319","volume":"261","author":"Y Huang","year":"2024","unstructured":"Huang, Y. et al. Loss of KLF15 impairs endometrial receptivity by inhibiting EMT in endometriosis. J. Endocrinol. 261 (2), e230319 (2024).","journal-title":"J. Endocrinol."},{"issue":"1","key":"22698_CR14","doi-asserted-by":"publisher","first-page":"114117","DOI":"10.1016\/j.yexcr.2024.114117","volume":"440","author":"D Ni","year":"2024","unstructured":"Ni, D. et al. KLF15-activated MARCH2 boosts cell proliferation and epithelial-mesenchymal transition and presents diagnostic significance for hepatocellular carcinoma. Exp. Cell. Res. 440 (1), 114117 (2024).","journal-title":"Exp. Cell. Res."},{"issue":"4","key":"22698_CR15","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1111\/his.14764","volume":"81","author":"E Comp\u00e9rat","year":"2022","unstructured":"Comp\u00e9rat, E. et al. What\u2019s new in WHO fifth edition - urinary tract. Histopathology 81 (4), 439\u2013446 (2022).","journal-title":"Histopathology"},{"issue":"6B","key":"22698_CR16","first-page":"2489","volume":"13","author":"DG Kieback","year":"1993","unstructured":"Kieback, D. G. et al. Prognostic significance of Estrogen receptor expression in ovarian cancer. Immunoreactive score (IRS) vs. Composition adjusted receptorlevel (CARL). Anticancer Res. 13 (6B), 2489\u20132496 (1993).","journal-title":"Anticancer Res."},{"issue":"1","key":"22698_CR17","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.eururo.2016.06.010","volume":"71","author":"S Antoni","year":"2017","unstructured":"Antoni, S. et al. Bladder cancer incidence and mortality: a global overview and recent trends. Eur. Urol. 71 (1), 96\u2013108 (2017).","journal-title":"Eur. Urol."},{"issue":"1","key":"22698_CR18","doi-asserted-by":"publisher","first-page":"17022","DOI":"10.1038\/nrdp.2017.22","volume":"3","author":"O Sanli","year":"2017","unstructured":"Sanli, O. et al. Bladder cancer[J]. Nat. Reviews Disease Primers. 3 (1), 17022 (2017).","journal-title":"Nat. Reviews Disease Primers"},{"issue":"11","key":"22698_CR19","doi-asserted-by":"publisher","first-page":"4044","DOI":"10.1158\/1078-0432.CCR-04-2409","volume":"11","author":"E Blaveri","year":"2005","unstructured":"Blaveri, E. et al. Bladder cancer outcome and subtype classification by gene expression. Clin. Cancer Res. 11 (11), 4044\u20134055 (2005).","journal-title":"Clin. Cancer Res."},{"issue":"1","key":"22698_CR20","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1002\/path.4886","volume":"242","author":"G Sj\u00f6dahl","year":"2017","unstructured":"Sj\u00f6dahl, G. et al. Molecular classification of urothelial carcinoma: global mRNA classification versus tumour-cell phenotype classification. J. Pathol. 242 (1), 113\u2013125 (2017).","journal-title":"J. Pathol."},{"issue":"6","key":"22698_CR21","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1007\/s10620-017-4558-2","volume":"62","author":"C Sun","year":"2017","unstructured":"Sun, C. et al. klf15 inhibits cell proliferation in gastric cancer cells via up-regulating CDKN1A\/p21 and CDKN1C\/p57 expression. Dig. Dis. Sci. 62 (6), 1518\u20131526 (2017).","journal-title":"Dig. Dis. Sci."},{"issue":"6","key":"22698_CR22","doi-asserted-by":"publisher","first-page":"966","DOI":"10.3748\/wjg.v8.i6.966","volume":"8","author":"N Wang","year":"2002","unstructured":"Wang, N. et al. Down-regulation of gut-enriched Kruppel-like factor expression in esophageal cancer. World J. Gastroenterol. 8 (6), 966\u2013970 (2002).","journal-title":"World J. Gastroenterol."},{"issue":"6","key":"22698_CR23","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1007\/s11010-022-04579-x","volume":"478","author":"K Tripathi","year":"2023","unstructured":"Tripathi, K. et al. Immunohistochemical expressions of EMT markers in pan-RAS-pERK1\/2-positive tumors improve diagnosis and prognosis assessment of non-muscle invasive bladder cancer and muscle invasive bladder cancer patients. Mol. Cell. Biochem. 478 (6), 1169\u20131190 (2023).","journal-title":"Mol. Cell. Biochem."},{"issue":"7","key":"22698_CR24","doi-asserted-by":"publisher","first-page":"722","DOI":"10.3109\/00016489.2016.1144143","volume":"136","author":"X Qian","year":"2016","unstructured":"Qian, X. et al. Expression and prognostic value of E-cadherin in laryngeal cancer. Acta Otolaryngol. 136 (7), 722\u2013728 (2016).","journal-title":"Acta Otolaryngol."},{"issue":"3","key":"22698_CR25","first-page":"3472","volume":"15","author":"GJ Zhu","year":"2018","unstructured":"Zhu, G. J. et al. Role of epithelial-mesenchymal transition markers E-cadherin, N-cadherin, \u03b2-catenin and ZEB2 in laryngeal squamous cell carcinoma. Oncol. Lett. 15 (3), 3472\u20133481 (2018).","journal-title":"Oncol. Lett."},{"issue":"10","key":"22698_CR26","doi-asserted-by":"publisher","first-page":"645","DOI":"10.4111\/kju.2013.54.10.645","volume":"54","author":"SJ Yun","year":"2013","unstructured":"Yun, S. J. & Kim, W. J. Role of the epithelial-mesenchymal transition in bladder cancer: from prognosis to therapeutic target. Korean J. Urol. 54 (10), 645\u2013650 (2013).","journal-title":"Korean J. Urol."},{"issue":"1","key":"22698_CR27","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1007\/s12094-021-02670-1","volume":"24","author":"CX Sun","year":"2022","unstructured":"Sun, C. X. et al. MiR-181a promotes cell proliferation and migration through targeting KLF15 in papillary thyroid cancer. Clin. Transl Oncol. 24 (1), 66\u201375 (2022).","journal-title":"Clin. Transl Oncol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-22698-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-22698-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-22698-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T13:20:13Z","timestamp":1762435213000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-22698-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,6]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["22698"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-22698-5","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,6]]},"assertion":[{"value":"4 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"38862"}}