{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T17:53:01Z","timestamp":1773683581243,"version":"3.50.1"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2024-00347292"],"award-info":[{"award-number":["RS-2024-00347292"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2024-00347292"],"award-info":[{"award-number":["RS-2024-00347292"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2024-00347292"],"award-info":[{"award-number":["RS-2024-00347292"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-23282-7","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T18:33:30Z","timestamp":1762886010000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Therapeutic potential of no-ozone cold plasma-activated saline in osteosarcoma through mitochondrial and MAPK pathway modulation"],"prefix":"10.1038","volume":"15","author":[{"given":"M Shriya","family":"Jaiswal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoon-Seo","family":"Jang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae-Seok","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,11]]},"reference":[{"key":"23282_CR1","doi-asserted-by":"publisher","first-page":"17521","DOI":"10.1038\/s41598-021-96857-9","volume":"11","author":"I Hamouda","year":"2021","unstructured":"Hamouda, I. et al. Selectivity of direct plasma treatment and plasma-conditioned media in bone cancer cell lines. Sci. Rep. 11, 17521. https:\/\/doi.org\/10.1038\/s41598-021-96857-9 (2021).","journal-title":"Sci. Rep."},{"key":"23282_CR2","doi-asserted-by":"publisher","first-page":"229","DOI":"10.21851\/obr.41.04.201712.229","volume":"41","author":"BBR Choi","year":"2017","unstructured":"Choi, B. B. R. & Kim, G. C. Induction apoptosis and G2\/M phase cell cycle arrest by non-thermal plasma in human osteosarcoma MG-63 cell line. Oral Biol. Res. 41, 229\u2013235. https:\/\/doi.org\/10.21851\/obr.41.04.201712.229 (2017).","journal-title":"Oral Biol. Res."},{"key":"23282_CR3","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.jbo.2012.12.005","volume":"2","author":"R Garimella","year":"2013","unstructured":"Garimella, R. et al. Biological characterization of preclinical bioluminescent osteosarcoma orthotopic mouse (BOOM) model: A multi-modality approach. J. Bone Oncol. 2, 11\u201321. https:\/\/doi.org\/10.1016\/j.jbo.2012.12.005 (2013).","journal-title":"J. Bone Oncol."},{"key":"23282_CR4","doi-asserted-by":"publisher","first-page":"893","DOI":"10.3390\/jcm10040893","volume":"10","author":"M Mateu-Sanz","year":"2021","unstructured":"Mateu-Sanz, M. et al. Cold atmospheric plasma: A new strategy based primarily on oxidative stress for osteosarcoma therapy. J. Clin. Med. 10, 893. https:\/\/doi.org\/10.3390\/jcm10040893 (2021).","journal-title":"J. Clin. Med."},{"issue":"e27444","key":"23282_CR5","doi-asserted-by":"publisher","first-page":"20180925","DOI":"10.1002\/pbc.27444","volume":"66","author":"HL Spraker-Perlman","year":"2019","unstructured":"Spraker-Perlman, H. L. et al. Factors influencing survival after recurrence in osteosarcoma: A report from the children\u2019s oncology group. Pediatr. Blood Cancer 66(e27444), 20180925. https:\/\/doi.org\/10.1002\/pbc.27444 (2019).","journal-title":"Pediatr. Blood Cancer"},{"issue":"72\u201380","key":"23282_CR6","doi-asserted-by":"publisher","first-page":"20170529","DOI":"10.1016\/j.freeradbiomed.2017.05.023","volume":"110","author":"C Canal","year":"2017","unstructured":"Canal, C. et al. Plasma-induced selectivity in bone cancer cells death. Free Radic. Biol. Med. 110(72\u201380), 20170529. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2017.05.023 (2017).","journal-title":"Free Radic. Biol. Med."},{"key":"23282_CR7","doi-asserted-by":"publisher","first-page":"5915","DOI":"10.21873\/anticanres.11178","volume":"36","author":"D G\u00fcmbel","year":"2016","unstructured":"G\u00fcmbel, D. et al. New treatment options for osteosarcoma\u2014Inactivation of Osteosarcoma cells by cold atmospheric plasma. Anticancer Res. 36, 5915\u20135922. https:\/\/doi.org\/10.21873\/anticanres.11178 (2016).","journal-title":"Anticancer Res."},{"issue":"46","key":"23282_CR8","doi-asserted-by":"publisher","first-page":"20240120","DOI":"10.1186\/s12906-023-04313-0","volume":"24","author":"JH Lee","year":"2024","unstructured":"Lee, J. H. et al. No-ozone cold plasma induces apoptosis in human neuroblastoma cell line via increased intracellular reactive oxygen species (ROS). BMC Complement Med. Ther. 24(46), 20240120. https:\/\/doi.org\/10.1186\/s12906-023-04313-0 (2024).","journal-title":"BMC Complement Med. Ther."},{"key":"23282_CR9","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1634\/theoncologist.8-3-278","volume":"8","author":"JL Weinstein","year":"2003","unstructured":"Weinstein, J. L., Katzenstein, H. M. & Cohn, S. L. Advances in the diagnosis and treatment of neuroblastoma. Oncologist 8, 278\u2013292. https:\/\/doi.org\/10.1634\/theoncologist.8-3-278 (2003).","journal-title":"Oncologist"},{"key":"23282_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1468-3083.2010.03702.x","volume":"25","author":"J Heinlin","year":"2011","unstructured":"Heinlin, J. et al. Plasma applications in medicine with a special focus on dermatology. J. Eur. Acad. Dermatol. Venereol. 25, 1\u201311. https:\/\/doi.org\/10.1111\/j.1468-3083.2010.03702.x (2011).","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"23282_CR11","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1002\/ppap.201500170","volume":"12","author":"A Kramer","year":"2015","unstructured":"Kramer, A. et al. Cold physical plasmas in the field of hygiene\u2014Relevance, significance, and future applications. Plasma Processes Polym. 12, 1410\u20131422. https:\/\/doi.org\/10.1002\/ppap.201500170 (2015).","journal-title":"Plasma Processes Polym."},{"key":"23282_CR12","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10092259","author":"JH Choi","year":"2022","unstructured":"Choi, J. H. et al. Anti-cancer activity of the combinational treatment of Noozone cold plasma with p-FAK Antibody-conjugated gold nanoparticles in OSCC xenograft mice. Biomedicines https:\/\/doi.org\/10.3390\/biomedicines10092259 (2022).","journal-title":"Biomedicines"},{"key":"23282_CR13","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1002\/ppap.200700154","volume":"5","author":"G Fridman","year":"2008","unstructured":"Fridman, G. et al. Applied plasma medicine. Plasma Processes Polym. 5, 503\u2013533. https:\/\/doi.org\/10.1002\/ppap.200700154 (2008).","journal-title":"Plasma Processes Polym."},{"key":"23282_CR14","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.3390\/cancers13071737","volume":"13","author":"H Tanaka","year":"2021","unstructured":"Tanaka, H. et al. Plasma-treated solutions (PTS) in cancer therapy. Cancers 13, 1737 (2021).","journal-title":"Cancers"},{"key":"23282_CR15","doi-asserted-by":"publisher","first-page":"1732 1742","DOI":"10.7150\/ijms.77484","volume":"19","author":"SY Park","year":"2022","unstructured":"Park, S. Y. et al. Effect of no-ozone cold plasma on regeneration after crushed mental nerve injury in rats. Int. J. Med. Sci. 19, 1732 1742. https:\/\/doi.org\/10.7150\/ijms.77484 (2022).","journal-title":"Int. J. Med. Sci."},{"key":"23282_CR16","doi-asserted-by":"publisher","first-page":"117863611986459","DOI":"10.1177\/1178636119864594","volume":"12","author":"J Gr\u00e4b","year":"2019","unstructured":"Gr\u00e4b, J. & Rybniker, J. The expanding role of p38 mitogen-activated protein kinase in programmed host cell death. Microbiol. Insights 12, 1178636119864594. https:\/\/doi.org\/10.1177\/1178636119864594 (2019).","journal-title":"Microbiol. Insights"},{"key":"23282_CR17","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1080\/01926230701320337","volume":"35","author":"S Elmore","year":"2007","unstructured":"Elmore, S. Apoptosis: A review of programmed cell death. Toxicol. Pathol. 35, 495\u2013516. https:\/\/doi.org\/10.1080\/01926230701320337 (2007).","journal-title":"Toxicol. Pathol."},{"key":"23282_CR18","doi-asserted-by":"publisher","first-page":"13760","DOI":"10.1039\/C6RA26713K.DOI:10.1039\/C6RA26713K","volume":"7","author":"W Gong","year":"2017","unstructured":"Gong, W. et al. A novel nano-sized bioactive glass stimulates osteogenesis via the MAPK pathway. RSC Adv. 7, 13760\u201313767. https:\/\/doi.org\/10.1039\/C6RA26713K.DOI:10.1039\/C6RA26713K (2017).","journal-title":"RSC Adv."},{"key":"23282_CR19","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.3892\/etm.2020.8454","volume":"19","author":"YJ Guo","year":"2020","unstructured":"Guo, Y. J. et al. ERK\/MAPK signalling pathway and tumorigenesis. Exp. Ther. Med. 19, 1997\u20132007. https:\/\/doi.org\/10.3892\/etm.2020.8454 (2020).","journal-title":"Exp. Ther. Med."},{"key":"23282_CR20","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1002\/mco2.308","volume":"4","author":"Z Ji","year":"2023","unstructured":"Ji, Z. et al. Targeting signaling pathways in osteosarcoma: Mechanisms and clinical studies. Med. Comm 4, 308. https:\/\/doi.org\/10.1002\/mco2.308 (2023).","journal-title":"Med. Comm"},{"key":"23282_CR21","doi-asserted-by":"publisher","first-page":"6785","DOI":"10.1007\/s00432-023-04614-4","volume":"149","author":"S Li","year":"2023","unstructured":"Li, S. et al. Targeted therapy for osteosarcoma: a review. J. Cancer Res. Clin. Oncol. 149, 6785\u20136797. https:\/\/doi.org\/10.1007\/s00432-023-04614-4 (2023).","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"23282_CR22","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/j.cvsm.2023.12.007","volume":"54","author":"JN Bryan","year":"2024","unstructured":"Bryan, J. N. Updates in osteosarcoma. Vet. Clin. North Am. Small Anim. Pract. 54, 523\u2013539. https:\/\/doi.org\/10.1016\/j.cvsm.2023.12.007 (2024).","journal-title":"Vet. Clin. North Am. Small Anim. Pract."},{"key":"23282_CR23","doi-asserted-by":"publisher","first-page":"7597","DOI":"10.1038\/s41598-022-11665-z","volume":"12","author":"NS Park","year":"2022","unstructured":"Park, N. S. et al. No-ozone cold plasma can kill oral pathogenic microbes in HO-dependent and independent manner. Sci. Rep. UK. 12, 7597. https:\/\/doi.org\/10.1038\/s41598-022-11665-z (2022).","journal-title":"Sci. Rep. UK."},{"key":"23282_CR24","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.3390\/biomedicines9111542","volume":"9","author":"BB Choi","year":"2021","unstructured":"Choi, B. B. et al. Enhancement of osteoblast differentiation using no-ozone cold plasma on human periodontal ligament cells. Biomedicines 9, 1542. https:\/\/doi.org\/10.3390\/biomedicines9111542 (2021).","journal-title":"Biomedicines"},{"key":"23282_CR25","doi-asserted-by":"publisher","DOI":"10.1088\/0963-0252\/21\/4\/043001","author":"GY Park","year":"2012","unstructured":"Park, G. Y. et al. Atmospheric-pressure plasma sources for biomedical applications. Plasma Sour. Sci. Technol. https:\/\/doi.org\/10.1088\/0963-0252\/21\/4\/043001 (2012).","journal-title":"Plasma Sour. Sci. Technol."},{"key":"23282_CR26","doi-asserted-by":"publisher","first-page":"115026","DOI":"10.1088\/1367-2630\/11\/11\/115026","volume":"11","author":"HJ Lee","year":"2009","unstructured":"Lee, H. J. et al. Degradation of adhesion molecules of G361 melanoma cells by a non-thermal atmospheric pressure microplasma. New J. Phys. 11, 115026. https:\/\/doi.org\/10.1088\/1367-2630\/11\/11\/115026 (2009).","journal-title":"New J. Phys."},{"key":"23282_CR27","first-page":"312","volume":"45","author":"XQ Wu","year":"2005","unstructured":"Wu, X. Q. et al. Sterilizing effect of atmospheric pressure plasma jet on microbes. Wei Sheng Wu Xue Bao. 45, 312\u2013314 (2005).","journal-title":"Wei Sheng Wu Xue Bao."},{"key":"23282_CR28","doi-asserted-by":"publisher","first-page":"15868","DOI":"10.1038\/s41598-022-20063-4","volume":"12","author":"CB Do","year":"2022","unstructured":"Do, C. B. et al. Non-thermal plasma directly accelerates neuronal proliferation by stimulating axon formation. Sci. Rep. 12, 15868. https:\/\/doi.org\/10.1038\/s41598-022-20063-4 (2022).","journal-title":"Sci. Rep."},{"key":"23282_CR29","doi-asserted-by":"publisher","first-page":"5407","DOI":"10.21873\/anticanres.11968","volume":"37","author":"D G\u00fcmbel","year":"2017","unstructured":"G\u00fcmbel, D. et al. Comparison of cold atmospheric plasma devices\u2019 efficacy on osteosarcoma and fibroblastic in vitro cell models. Anticancer Res. 37, 5407\u20135414. https:\/\/doi.org\/10.21873\/anticanres.11968 (2017).","journal-title":"Anticancer Res."},{"key":"23282_CR30","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.jpedsurg.2012.10.020","volume":"48","author":"RM Walk","year":"2013","unstructured":"Walk, R. M. et al. Cold atmospheric plasma for the ablative treatment of neuroblastoma. J. Pediatr. Surg. 48, 67\u201373. https:\/\/doi.org\/10.1016\/j.jpedsurg.2012.10.020 (2013).","journal-title":"J. Pediatr. Surg."},{"key":"23282_CR31","first-page":"729","volume":"15","author":"X Xu","year":"2023","unstructured":"Xu, X., Liu, M. & Wu, H. Berberine inhibits the growth of osteosarcoma through modulating MMP\/NM-23 and MAPK\/JNK signal pathways. Am. J. Transl. Res. 15, 729\u2013744 (2023).","journal-title":"Am. J. Transl. Res."},{"key":"23282_CR32","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/bjc.2016.12","volume":"114","author":"GE Conway","year":"2016","unstructured":"Conway, G. E. et al. Non-thermal atmospheric plasma induces ROS-independent cell death in U373MG glioma cells and augments the cytotoxicity of temozolomide. Br. J. Cancer 114, 435\u2013443. https:\/\/doi.org\/10.1038\/bjc.2016.12 (2016).","journal-title":"Br. J. Cancer"},{"key":"23282_CR33","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1038\/s41392-020-0134-x","volume":"5","author":"J Fares","year":"2020","unstructured":"Fares, J. et al. Molecular principles of metastasis: A hallmark of cancer revisited. Signal Transduct. Target. Ther. 5, 28. https:\/\/doi.org\/10.1038\/s41392-020-0134-x (2020).","journal-title":"Signal Transduct. Target. Ther."},{"key":"23282_CR34","doi-asserted-by":"publisher","first-page":"4666","DOI":"10.1158\/1078-0432.Ccr-05-0165","volume":"11","author":"OS Bruland","year":"2005","unstructured":"Bruland, O. S. et al. Hematogenous micrometastases in osteosarcoma patients. Clin. Cancer Res. 11, 4666\u20134673. https:\/\/doi.org\/10.1158\/1078-0432.Ccr-05-0165 (2005).","journal-title":"Clin. Cancer Res."},{"key":"23282_CR35","doi-asserted-by":"publisher","first-page":"118709","DOI":"10.1016\/j.jep.2024.118709","volume":"335","author":"W Xu","year":"2024","unstructured":"Xu, W. et al. Eurycomanone inhibits osteosarcoma growth and metastasis by suppressing GRP78 expression. J. Ethnopharmacol. 335, 118709. https:\/\/doi.org\/10.1016\/j.jep.2024.118709 (2024).","journal-title":"J. Ethnopharmacol."},{"key":"23282_CR36","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.3390\/cells8111441","volume":"8","author":"RC Lin","year":"2019","unstructured":"Lin, R. C. et al. Licochalcone a-induced apoptosis through the activation of p38MAPK pathway mediated mitochondrial pathways of apoptosis in human osteosarcoma cells in vitro and in vivo. Cells 8, 1441. https:\/\/doi.org\/10.3390\/cells8111441 (2019).","journal-title":"Cells"},{"key":"23282_CR37","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.3390\/ijms23031124","volume":"23","author":"M Suzuki-Karasaki","year":"2022","unstructured":"Suzuki-Karasaki, M. et al. Air plasma-activated medium evokes a death-associated perinuclear mitochondrial clustering. Int. J. Mol. Sci. 23, 1124 (2022).","journal-title":"Int. J. Mol. Sci."},{"key":"23282_CR38","doi-asserted-by":"publisher","first-page":"111202","DOI":"10.1016\/j.biopha.2020.111202","volume":"136","author":"H Lin","year":"2021","unstructured":"Lin, H. et al. EF24 induces ferroptosis in osteosarcoma cells through HMOX1. Biomed. Pharmacother 136, 111202. https:\/\/doi.org\/10.1016\/j.biopha.2020.111202 (2021).","journal-title":"Biomed. Pharmacother"},{"key":"23282_CR39","doi-asserted-by":"publisher","first-page":"18339","DOI":"10.1038\/srep18339","volume":"5","author":"D Yan","year":"2015","unstructured":"Yan, D. et al. Principles of using cold atmospheric plasma stimulated media for cancer treatment. Sci. Rep. 5, 18339. https:\/\/doi.org\/10.1038\/srep18339 (2015).","journal-title":"Sci. Rep."},{"key":"23282_CR40","doi-asserted-by":"publisher","first-page":"29098","DOI":"10.1038\/srep29098","volume":"6","author":"P-M Girard","year":"2016","unstructured":"Girard, P.-M. et al. Synergistic effect of H2O2 and NO2 in cell death induced by cold atmospheric he plasma. Sci. Rep. 6, 29098. https:\/\/doi.org\/10.1038\/srep29098 (2016).","journal-title":"Sci. Rep."},{"key":"23282_CR41","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13071737","author":"H Tanaka","year":"2021","unstructured":"Tanaka, H. et al. Plasma-treated solutions (PTS) in cancer therapy. Cancers https:\/\/doi.org\/10.3390\/cancers13071737 (2021).","journal-title":"Cancers"},{"key":"23282_CR42","doi-asserted-by":"publisher","first-page":"19910","DOI":"10.18632\/oncotarget.7889","volume":"7","author":"K Saito","year":"2016","unstructured":"Saito, K. et al. Tumor-selective mitochondrial network collapse induced by atmospheric gas plasma-activated medium. Oncotarget 7, 19910\u201319927. https:\/\/doi.org\/10.18632\/oncotarget.7889 (2016).","journal-title":"Oncotarget"},{"key":"23282_CR43","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1038\/cddis.2013.250","volume":"4","author":"K Boland","year":"2013","unstructured":"Boland, K., Flanagan, L. & Prehn, J. H. Paracrine control of tissue regeneration and cell proliferation by caspase-3. Cell Death Dis. 4, 725. https:\/\/doi.org\/10.1038\/cddis.2013.250 (2013).","journal-title":"Cell Death Dis."},{"key":"23282_CR44","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/bf00048059","volume":"11","author":"JA Hickman","year":"1992","unstructured":"Hickman, J. A. Apoptosis induced by anticancer drugs. Cancer Metastasis Rev. 11, 121\u2013139. https:\/\/doi.org\/10.1007\/bf00048059 (1992).","journal-title":"Cancer Metastasis Rev."},{"key":"23282_CR45","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.abb.2017.09.005","volume":"633","author":"W Li","year":"2017","unstructured":"Li, W. et al. Non-thermal plasma induces mitochondria-mediated apoptotic signaling pathway via ROS generation in HeLa cells. Arch. Biochem. Biophys. 633, 68\u201377. https:\/\/doi.org\/10.1016\/j.abb.2017.09.005 (2017).","journal-title":"Arch. Biochem. Biophys."},{"key":"23282_CR46","doi-asserted-by":"publisher","first-page":"3580","DOI":"10.1093\/emboj\/cdg343","volume":"22","author":"B Gillissen","year":"2003","unstructured":"Gillissen, B. et al. Induction of cell death by the BH3-only Bcl-2 homolog Nbk\/Bik is mediated by an entirely Bax-dependent mitochondrial pathway. Embo J. 22, 3580\u20133590. https:\/\/doi.org\/10.1093\/emboj\/cdg343 (2003).","journal-title":"Embo J."},{"key":"23282_CR47","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1002\/mc.20583","volume":"49","author":"YT Deng","year":"2010","unstructured":"Deng, Y. T., Huang, H. C. & Lin, J. K. Rotenone induces apoptosis in MCF-7 human breast cancer cell-mediated ROS through JNK and p38 signaling. Mol. Carcinog. 49, 141\u2013151. https:\/\/doi.org\/10.1002\/mc.20583 (2010).","journal-title":"Mol. Carcinog."},{"key":"23282_CR48","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1126\/science.1072682","volume":"298","author":"GL Johnson","year":"2002","unstructured":"Johnson, G. L. & Lapadat, R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298, 1911\u20131912. https:\/\/doi.org\/10.1126\/science.1072682 (2002).","journal-title":"Science"},{"key":"23282_CR49","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.1126\/science.270.5240.1326","volume":"270","author":"Z Xia","year":"1995","unstructured":"Xia, Z. et al. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270, 1326\u20131331. https:\/\/doi.org\/10.1126\/science.270.5240.1326 (1995).","journal-title":"Science"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-23282-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-23282-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-23282-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T18:33:31Z","timestamp":1762886011000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-23282-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,11]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["23282"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-23282-7","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,11]]},"assertion":[{"value":"26 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"39544"}}