{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T07:09:17Z","timestamp":1763363357641,"version":"3.45.0"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Henan Health Innovation Program for Young Scholars","award":["YQRC2024002"],"award-info":[{"award-number":["YQRC2024002"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82103226","82470184"],"award-info":[{"award-number":["82103226","82470184"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Henan Provincial Key R&D Program","award":["242102311116"],"award-info":[{"award-number":["242102311116"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-23386-0","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T18:25:00Z","timestamp":1762971900000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["HPCAL1 as a novel prognostic biomarker in acute myeloid leukemia and its correlation with immune infiltrates"],"prefix":"10.1038","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4193-4585","authenticated-orcid":false,"given":"Linna","family":"Cheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiyang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyue","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6635-7454","authenticated-orcid":false,"given":"Zunmin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,12]]},"reference":[{"key":"23386_CR1","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3322\/caac.21820","volume":"74","author":"RL Siegel","year":"2024","unstructured":"Siegel, R. L., Giaquinto, A. N. & Jemal, A. Cancer statistics, 2024. CA Cancer J. Clin. 74, 12\u201349. https:\/\/doi.org\/10.3322\/caac.21820 (2024).","journal-title":"CA Cancer J. Clin."},{"key":"23386_CR2","doi-asserted-by":"publisher","first-page":"503","DOI":"10.6004\/jnccn.2023.0025","volume":"21","author":"DA Pollyea","year":"2023","unstructured":"Pollyea, D. A. et al. Acute myeloid Leukemia, version 3.2023, NCCN clinical practice guidelines in oncology. J. Natl. Compr. Canc Netw. 21, 503\u2013513. https:\/\/doi.org\/10.6004\/jnccn.2023.0025 (2023).","journal-title":"J. Natl. Compr. Canc Netw."},{"key":"23386_CR3","doi-asserted-by":"publisher","first-page":"2073","DOI":"10.1016\/s0140-6736(23)00108-3","volume":"401","author":"CD DiNardo","year":"2023","unstructured":"DiNardo, C. D., Erba, H. P., Freeman, S. D. & Wei, A. H. Acute myeloid leukaemia. Lancet 401, 2073\u20132086. https:\/\/doi.org\/10.1016\/s0140-6736(23)00108-3 (2023).","journal-title":"Lancet"},{"key":"23386_CR4","doi-asserted-by":"publisher","first-page":"101286","DOI":"10.1016\/j.drup.2025.101286","volume":"83","author":"F Song","year":"2025","unstructured":"Song, F. et al. Targeted therapy in acute myeloid leukemia: resistance and overcoming strategy. Drug Resist. Updat. 83, 101286. https:\/\/doi.org\/10.1016\/j.drup.2025.101286 (2025).","journal-title":"Drug Resist. Updat"},{"key":"23386_CR5","doi-asserted-by":"publisher","first-page":"133","DOI":"10.3389\/fgene.2019.00133","volume":"10","author":"SL Goldman","year":"2019","unstructured":"Goldman, S. L. et al. Epigenetic modifications in acute myeloid leukemia: Prognosis, Treatment, and heterogeneity. Front. Genet. 10, 133. https:\/\/doi.org\/10.3389\/fgene.2019.00133 (2019).","journal-title":"Front. Genet."},{"key":"23386_CR6","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1001\/jamaoncol.2015.0617","volume":"1","author":"TM Kadia","year":"2015","unstructured":"Kadia, T. M., Ravandi, F., Cortes, J. & Kantarjian, H. Toward individualized therapy in acute myeloid leukemia: A contemporary review. JAMA Oncol. 1, 820\u2013828. https:\/\/doi.org\/10.1001\/jamaoncol.2015.0617 (2015).","journal-title":"JAMA Oncol."},{"key":"23386_CR7","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1186\/s13045-020-00992-1","volume":"13","author":"MT Gebru","year":"2020","unstructured":"Gebru, M. T. & Wang, H. G. Therapeutic targeting of FLT3 and associated drug resistance in acute myeloid leukemia. J. Hematol. Oncol. 13, 155. https:\/\/doi.org\/10.1186\/s13045-020-00992-1 (2020).","journal-title":"J. Hematol. Oncol."},{"key":"23386_CR8","doi-asserted-by":"publisher","first-page":"3316","DOI":"10.1038\/onc.2013.290","volume":"33","author":"W Wang","year":"2014","unstructured":"Wang, W. et al. Mutations that disrupt PHOXB interaction with the neuronal calcium sensor HPCAL1 impede cellular differentiation in neuroblastoma. Oncogene 33, 3316\u20133324. https:\/\/doi.org\/10.1038\/onc.2013.290 (2014).","journal-title":"Oncogene"},{"key":"23386_CR9","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/s13402-022-00661-0","volume":"45","author":"X Wang","year":"2022","unstructured":"Wang, X. et al. Hippocalcin-like 1 is a key regulator of LDHA activation that promotes the growth of non-small cell lung carcinoma. Cell. Oncol. (Dordr). 45, 179\u2013191. https:\/\/doi.org\/10.1007\/s13402-022-00661-0 (2022).","journal-title":"Cell. Oncol. (Dordr)"},{"key":"23386_CR10","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1002\/cam4.4897","volume":"12","author":"M Ma","year":"2023","unstructured":"Ma, M. et al. Expressional and prognostic value of HPCAL1 in cholangiocarcinoma via integrated bioinformatics analyses and experiments. Cancer Med. 12, 824\u2013836. https:\/\/doi.org\/10.1002\/cam4.4897 (2023).","journal-title":"Cancer Med."},{"key":"23386_CR11","doi-asserted-by":"publisher","first-page":"3108","DOI":"10.1111\/jcmm.14083","volume":"23","author":"D Zhang","year":"2019","unstructured":"Zhang, D. et al. HPCAL1 promotes glioblastoma proliferation via activation of Wnt\/\u03b2-catenin signalling pathway. J. Cell. Mol. Med. 23, 3108\u20133117. https:\/\/doi.org\/10.1111\/jcmm.14083 (2019).","journal-title":"J. Cell. Mol. Med."},{"key":"23386_CR12","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1002\/hep.28395","volume":"63","author":"Y Zhang","year":"2016","unstructured":"Zhang, Y. et al. Hippocalcin-like 1 suppresses hepatocellular carcinoma progression by promoting p21(Waf\/Cip1) stabilization by activating the ERK1\/2-MAPK pathway. Hepatology 63, 880\u2013897. https:\/\/doi.org\/10.1002\/hep.28395 (2016).","journal-title":"Hepatology"},{"key":"23386_CR13","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1080\/15548627.2022.2059170","volume":"19","author":"X Chen","year":"2023","unstructured":"Chen, X. et al. Identification of HPCAL1 as a specific autophagy receptor involved in ferroptosis. Autophagy 19, 54\u201374. https:\/\/doi.org\/10.1080\/15548627.2022.2059170 (2023).","journal-title":"Autophagy"},{"key":"23386_CR14","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1631\/jzus.B2300241","volume":"24","author":"L Wang","year":"2023","unstructured":"Wang, L., Li, Q., Liu, H. & Li, L. HPCAL1 is a novel driver of autophagy-dependent ferroptosis. J. Zhejiang Univ. Sci. B. 24, 1053\u20131056. https:\/\/doi.org\/10.1631\/jzus.B2300241 (2023).","journal-title":"J. Zhejiang Univ. Sci. B"},{"key":"23386_CR15","doi-asserted-by":"publisher","first-page":"100191","DOI":"10.1016\/j.xinn.2021.100191","volume":"3","author":"L Cheng","year":"2022","unstructured":"Cheng, L. et al. DCLK1 autoinhibition and activation in tumorigenesis. Innov. (Camb). 3, 100191. https:\/\/doi.org\/10.1016\/j.xinn.2021.100191 (2022).","journal-title":"Innov. (Camb)"},{"key":"23386_CR16","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1038\/s41590-024-02063-w","volume":"26","author":"BM Barton","year":"2025","unstructured":"Barton, B. M. et al. IRE1\u03b1-XBP1 safeguards hematopoietic stem and progenitor cells by restricting pro-leukemogenic gene programs. Nat. Immunol. 26, 200\u2013214. https:\/\/doi.org\/10.1038\/s41590-024-02063-w (2025).","journal-title":"Nat. Immunol."},{"key":"23386_CR17","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/s41375-024-02500-7","volume":"39","author":"Z Shi","year":"2025","unstructured":"Shi, Z. et al. ADAR1 is required for acute myeloid leukemia cell survival by modulating post-transcriptional Wnt signaling through impairing MiRNA biogenesis. Leukemia 39, 599\u2013613. https:\/\/doi.org\/10.1038\/s41375-024-02500-7 (2025).","journal-title":"Leukemia"},{"key":"23386_CR18","doi-asserted-by":"publisher","first-page":"2621","DOI":"10.1038\/s41375-022-01719-6","volume":"36","author":"S Qiu","year":"2022","unstructured":"Qiu, S. et al. Autophagy Inhibition impairs leukemia stem cell function in FLT3-ITD AML but has antagonistic interactions with tyrosine kinase Inhibition. Leukemia 36, 2621\u20132633. https:\/\/doi.org\/10.1038\/s41375-022-01719-6 (2022).","journal-title":"Leukemia"},{"key":"23386_CR19","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.freeradbiomed.2025.03.031","volume":"233","author":"J Shi","year":"2025","unstructured":"Shi, J. et al. SR-B1 deficiency suppresses progression in acute myeloid leukemia via ferroptosis and reverses resistance to venetoclax. Free Radic Biol. Med. 233, 24\u201338. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2025.03.031 (2025).","journal-title":"Free Radic Biol. Med."},{"key":"23386_CR20","doi-asserted-by":"publisher","first-page":"2529","DOI":"10.1200\/jco.2009.23.4732","volume":"28","author":"T Haferlach","year":"2010","unstructured":"Haferlach, T. et al. Clinical utility of microarray-based gene expression profiling in the diagnosis and subclassification of leukemia: report from the international microarray innovations in leukemia study group. J. Clin. Oncol. 28, 2529\u20132537. https:\/\/doi.org\/10.1200\/jco.2009.23.4732 (2010).","journal-title":"J. Clin. Oncol."},{"key":"23386_CR21","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/j.ccr.2012.08.028","volume":"22","author":"X Jiang","year":"2012","unstructured":"Jiang, X. et al. Blockade of miR-150 maturation by MLL-fusion\/MYC\/LIN-28 is required for MLL-associated leukemia. Cancer Cell. 22, 524\u2013535. https:\/\/doi.org\/10.1016\/j.ccr.2012.08.028 (2012).","journal-title":"Cancer Cell."},{"key":"23386_CR22","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1016\/j.stem.2010.11.014","volume":"7","author":"Y Kikushige","year":"2010","unstructured":"Kikushige, Y. et al. TIM-3 is a promising target to selectively kill acute myeloid leukemia stem cells. Cell. Stem Cell. 7, 708\u2013717. https:\/\/doi.org\/10.1016\/j.stem.2010.11.014 (2010).","journal-title":"Cell. Stem Cell."},{"key":"23386_CR23","unstructured":"Therneau, T. M. A Package for survival analysis in R (R package version 3.5-0)[Computer software]. https:\/\/cran.r-project.org\/package=survival (2023)."},{"key":"23386_CR24","unstructured":"Kassambara, A., & Biecek, P.  survminer: Drawing Survival Curves using \u2018ggplot2\u2019 (R package version 0.4.9) [Computer software]. https:\/\/cran.r-project.org\/package=survminer (2021)."},{"key":"23386_CR25","unstructured":"Yoshihara, K. K. H. & Verhaak, R. G. Estimate: estimate of stromal and immune cells in malignant tumor tissues from expression data (R package version 1.0.13\/r21) [Computer software].  https:\/\/R-Forge.R-project.org\/projects\/estimate\/ (2016)."},{"key":"23386_CR26","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","volume":"43","author":"ME Ritchie","year":"2015","unstructured":"Ritchie, M. E. et al. Limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43, e47. https:\/\/doi.org\/10.1093\/nar\/gkv007 (2015).","journal-title":"Nucleic Acids Res."},{"key":"23386_CR27","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa, M. & Goto, S. KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28, 27\u201330. https:\/\/doi.org\/10.1093\/nar\/28.1.27 (2000).","journal-title":"Nucleic Acids Res."},{"key":"23386_CR28","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1002\/pro.3715","volume":"28","author":"M Kanehisa","year":"2019","unstructured":"Kanehisa, M. Toward Understanding the origin and evolution of cellular organisms. Protein Sci. 28, 1947\u20131951. https:\/\/doi.org\/10.1002\/pro.3715 (2019).","journal-title":"Protein Sci."},{"key":"23386_CR29","doi-asserted-by":"publisher","first-page":"D587","DOI":"10.1093\/nar\/gkac963","volume":"51","author":"M Kanehisa","year":"2023","unstructured":"Kanehisa, M., Furumichi, M., Sato, Y., Kawashima, M. & Ishiguro-Watanabe, M. KEGG for taxonomy-based analysis of pathways and genomes. Nucleic Acids Res. 51, D587\u2013d592. https:\/\/doi.org\/10.1093\/nar\/gkac963 (2023).","journal-title":"Nucleic Acids Res."},{"key":"23386_CR30","doi-asserted-by":"publisher","first-page":"100141","DOI":"10.1016\/j.xinn.2021.100141","volume":"2","author":"T Wu","year":"2021","unstructured":"Wu, T. et al. ClusterProfiler 4.0: A universal enrichment tool for interpreting omics data. Innov. (Camb). 2, 100141. https:\/\/doi.org\/10.1016\/j.xinn.2021.100141 (2021).","journal-title":"Innov. (Camb)"},{"key":"23386_CR31","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-14-7","author":"S H\u00e4nzelmann","year":"2013","unstructured":"H\u00e4nzelmann, S., Castelo, R. & Guinney, J. GSVA: gene set variation analysis for microarray and RNA-seq data. BMC Bioinform. ; 14: 7. https:\/\/doi.org\/10.1186\/1471-2105-14-7 (2013)."},{"key":"23386_CR32","doi-asserted-by":"publisher","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","volume":"184","author":"Y Hao","year":"2021","unstructured":"Hao, Y. et al. Integrated analysis of multimodal single-cell data. Cell 184, 3573\u20133587e3529. https:\/\/doi.org\/10.1016\/j.cell.2021.04.048 (2021).","journal-title":"Cell"},{"key":"23386_CR33","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.cels.2019.03.003","volume":"8","author":"CS McGinnis","year":"2019","unstructured":"McGinnis, C. S., Murrow, L. M., Gartner, Z. J. & DoubletFinder Doublet detection in Single-Cell RNA sequencing data using artificial nearest neighbors. Cell. Syst. 8, 329\u2013337e324. https:\/\/doi.org\/10.1016\/j.cels.2019.03.003 (2019).","journal-title":"Cell. Syst."},{"key":"23386_CR34","doi-asserted-by":"crossref","unstructured":"Korsunsky, I. M. N., Fan, J., Slowikowski, K. & Raychaudhuri, S. harmony: Fast, sensitive, and accurate integration of single cell datam (R package version 1.0) [Computer software]. https:\/\/CRAN.R-project.org\/package=harmony (2022).","DOI":"10.32614\/CRAN.package.harmony"},{"key":"23386_CR35","doi-asserted-by":"publisher","first-page":"D721","DOI":"10.1093\/nar\/gky900","volume":"47","author":"X Zhang","year":"2019","unstructured":"Zhang, X. et al. CellMarker: a manually curated resource of cell markers in human and mouse. Nucleic Acids Res. 47, D721\u2013d728. https:\/\/doi.org\/10.1093\/nar\/gky900 (2019).","journal-title":"Nucleic Acids Res."},{"key":"23386_CR36","doi-asserted-by":"crossref","unstructured":"Jin, S. CellChat: Inference and analysis of cell-cell communication from single-cell and spatial transcriptomics data  (R package version 1.6.1) [Computer software]. https:\/\/CRAN.R-project.org\/package=CellChat (2023).","DOI":"10.1101\/2023.11.05.565674"},{"key":"23386_CR37","unstructured":"Chu, T., D\u2019Costa, D., & Zhang, L. BayesPrism Bayesian cell type and gene expression deconvolution (R package version 2.0.2) [Computer software]. https:\/\/github.com\/Danko-Lab\/BayesPrism (2022)."},{"key":"23386_CR38","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1038\/s43018-022-00356-3","volume":"3","author":"T Chu","year":"2022","unstructured":"Chu, T., Wang, Z., Pe\u2019er, D. & Danko, C. G. Cell type and gene expression Deconvolution with bayesprism enables bayesian integrative analysis across bulk and single-cell RNA sequencing in oncology. Nat. Cancer. 3, 505\u2013517. https:\/\/doi.org\/10.1038\/s43018-022-00356-3 (2022).","journal-title":"Nat. Cancer"},{"key":"23386_CR39","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1172\/jci129204","volume":"130","author":"L Vago","year":"2020","unstructured":"Vago, L. & Gojo, I. Immune escape and immunotherapy of acute myeloid leukemia. J. Clin. Invest. 130, 1552\u20131564. https:\/\/doi.org\/10.1172\/jci129204 (2020).","journal-title":"J. Clin. Invest."},{"key":"23386_CR40","doi-asserted-by":"publisher","unstructured":"Vadakekolathu, J. et al. Immune landscapes predict chemotherapy resistance and immunotherapy response in acute myeloid leukemia. Sci. Transl Med. 12 https:\/\/doi.org\/10.1126\/scitranslmed.aaz0463 (2020).","DOI":"10.1126\/scitranslmed.aaz0463"},{"key":"23386_CR41","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1056\/NEJMra1406184","volume":"373","author":"H D\u00f6hner","year":"2015","unstructured":"D\u00f6hner, H., Weisdorf, D. J. & Bloomfield, C. D. Acute myeloid leukemia. N Engl. J. Med. 373, 1136\u20131152. https:\/\/doi.org\/10.1056\/NEJMra1406184 (2015).","journal-title":"N Engl. J. Med."},{"key":"23386_CR42","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1038\/s41408-023-00911-w","volume":"13","author":"NJ Short","year":"2023","unstructured":"Short, N. J., Nguyen, D. & Ravandi, F. Treatment of older adults with FLT3-mutated AML: emerging paradigms and the role of frontline FLT3 inhibitors. Blood Cancer J. 13, 142. https:\/\/doi.org\/10.1038\/s41408-023-00911-w (2023).","journal-title":"Blood Cancer J."},{"key":"23386_CR43","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1158\/2643-3230.Bcd-23-0144","volume":"5","author":"B Falini","year":"2024","unstructured":"Falini, B. & Dillon, R. Criteria for diagnosis and molecular monitoring of NPM1-Mutated AML. Blood Cancer Discov. 5, 8\u201320. https:\/\/doi.org\/10.1158\/2643-3230.Bcd-23-0144 (2024).","journal-title":"Blood Cancer Discov"},{"key":"23386_CR44","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1182\/blood.2021013557","volume":"139","author":"L Bullinger","year":"2022","unstructured":"Bullinger, L. CEBPA mutations in AML: site matters. Blood 139, 6\u20137. https:\/\/doi.org\/10.1182\/blood.2021013557 (2022).","journal-title":"Blood"},{"key":"23386_CR45","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1038\/s41591-019-0472-9","volume":"25","author":"AG Chapuis","year":"2019","unstructured":"Chapuis, A. G. et al. T cell receptor gene therapy targeting WT1 prevents acute myeloid leukemia relapse post-transplant. Nat. Med. 25, 1064\u20131072. https:\/\/doi.org\/10.1038\/s41591-019-0472-9 (2019).","journal-title":"Nat. Med."},{"key":"23386_CR46","doi-asserted-by":"publisher","unstructured":"Torres, V. J. Interleukin 10 drives Staphylococcus aureus imprinting and vaccine failure in murine models via antibody glycosylation. J. Clin. Invest. 134. https:\/\/doi.org\/10.1172\/jci187055 (2024).","DOI":"10.1172\/jci187055"},{"key":"23386_CR47","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiae626","author":"JY Tang","year":"2024","unstructured":"Tang, J. Y., Chen, T. B., Kouznetsova, V. L. & Tsigelny, I. F. Anelloviruses and cancer. J. Infect. Dis. https:\/\/doi.org\/10.1093\/infdis\/jiae626 (2024).","journal-title":"J. Infect. Dis."},{"key":"23386_CR48","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1146\/annurev.pathol.4.110807.092239","volume":"4","author":"G Chen","year":"2009","unstructured":"Chen, G., Shaw, M. H., Kim, Y. G. & Nu\u00f1ez, G. NOD-like receptors: role in innate immunity and inflammatory disease. Annu. Rev. Pathol. 4, 365\u2013398. https:\/\/doi.org\/10.1146\/annurev.pathol.4.110807.092239 (2009).","journal-title":"Annu. Rev. Pathol."},{"key":"23386_CR49","doi-asserted-by":"publisher","first-page":"1122586","DOI":"10.3389\/fimmu.2023.1122586","volume":"14","author":"CLC Almeida-da-Silva","year":"2023","unstructured":"Almeida-da-Silva, C. L. C., Savio, L. E. B., Coutinho-Silva, R. & Ojcius, D. M. The role of NOD-like receptors in innate immunity. Front. Immunol. 14, 1122586. https:\/\/doi.org\/10.3389\/fimmu.2023.1122586 (2023).","journal-title":"Front. Immunol."},{"key":"23386_CR50","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1146\/annurev-pathmechdis-012418-013058","volume":"16","author":"S Ugel","year":"2021","unstructured":"Ugel, S., Can\u00e8, S., De Sanctis, F. & Bronte, V. Monocytes in the tumor microenvironment. Annu. Rev. Pathol. 16, 93\u2013122. https:\/\/doi.org\/10.1146\/annurev-pathmechdis-012418-013058 (2021).","journal-title":"Annu. Rev. Pathol."},{"key":"23386_CR51","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.1038\/s41375-018-0360-1","volume":"33","author":"H Hohtari","year":"2019","unstructured":"Hohtari, H. et al. Immune cell constitution in bone marrow microenvironment predicts outcome in adult ALL. Leukemia 33, 1570\u20131582. https:\/\/doi.org\/10.1038\/s41375-018-0360-1 (2019).","journal-title":"Leukemia"},{"key":"23386_CR52","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.stem.2018.04.003","volume":"22","author":"S Haas","year":"2018","unstructured":"Haas, S., Trumpp, A. & Milsom, M. D. Causes and consequences of hematopoietic stem cell heterogeneity. Cell. Stem Cell. 22, 627\u2013638. https:\/\/doi.org\/10.1016\/j.stem.2018.04.003 (2018).","journal-title":"Cell. Stem Cell."},{"key":"23386_CR53","doi-asserted-by":"publisher","first-page":"110854","DOI":"10.1016\/j.biopha.2020.110854","volume":"132","author":"V Niazi","year":"2020","unstructured":"Niazi, V. et al. Communication between stromal and hematopoietic stem cell by exosomes in normal and malignant bone marrow niche. Biomed. Pharmacother. 132, 110854. https:\/\/doi.org\/10.1016\/j.biopha.2020.110854 (2020).","journal-title":"Biomed. Pharmacother"},{"key":"23386_CR54","doi-asserted-by":"publisher","unstructured":"Rommelfanger, M. K. & MacLean, A. L. A single-cell resolved cell-cell communication model explains lineage commitment in hematopoiesis. Development 148. https:\/\/doi.org\/10.1242\/dev.199779 (2021).","DOI":"10.1242\/dev.199779"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-23386-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-23386-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-23386-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T07:05:03Z","timestamp":1763363103000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-23386-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,12]]},"references-count":54,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["23386"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-23386-0","relation":{"references":[{"id-type":"doi","id":"10.1186\/1471-2105-14-7","asserted-by":"subject"}]},"ISSN":["2045-2322"],"issn-type":[{"type":"electronic","value":"2045-2322"}],"subject":[],"published":{"date-parts":[[2025,11,12]]},"assertion":[{"value":"21 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"39625"}}