{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T13:21:38Z","timestamp":1779888098769,"version":"3.53.1"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82171553"],"award-info":[{"award-number":["82171553"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-23458-1","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T12:04:42Z","timestamp":1762776282000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["inhibitory effect of hyperin on Staphylococcus aureus pathogenicity though interactions with sortase A and sortase B"],"prefix":"10.1038","volume":"15","author":[{"given":"Ting","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingzheng","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadi","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,10]]},"reference":[{"issue":"11","key":"23458_CR1","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1080\/14760584.2016.1179583","volume":"15","author":"GH Dayan","year":"2016","unstructured":"Dayan, G. H. et al. Staphylococcus aureus: the current state of disease, pathophysiology and strategies for prevention. Expert Rev Vaccines 15(11), 1373\u20131392 (2016).","journal-title":"Expert Rev Vaccines"},{"key":"23458_CR2","doi-asserted-by":"crossref","unstructured":"Foster T J. Surface Proteins of Staphylococcus aureus. Microbiol Spectr,\u00a07(4) (2019)","DOI":"10.1128\/microbiolspec.GPP3-0046-2018"},{"issue":"2","key":"23458_CR3","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1055\/s-0041-1740583","volume":"43","author":"CI Pickens","year":"2022","unstructured":"Pickens, C. I. & Wunderink, R. G. Methicillin-Resistant Staphylococcus aureus Hospital-Acquired Pneumonia\/Ventilator-Associated Pneumonia. Semin Respir Crit Care Med 43(2), 304\u2013309 (2022).","journal-title":"Semin Respir Crit Care Med"},{"issue":"6","key":"23458_CR4","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1111\/jth.15703","volume":"20","author":"K Jahn","year":"2022","unstructured":"Jahn, K. et al. \u03b1-hemolysin of Staphylococcus aureus impairs thrombus formation. J Thromb Haemost 20(6), 1464\u20131475 (2022).","journal-title":"J Thromb Haemost"},{"issue":"1","key":"23458_CR5","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1186\/s12866-021-02257-4","volume":"21","author":"S Dehbashi","year":"2021","unstructured":"Dehbashi, S. et al. Regulation of virulence and \u03b2-lactamase gene expression in Staphylococcus aureus isolates: cooperation of two-component systems in bloodstream superbugs. BMC Microbiol 21(1), 192 (2021).","journal-title":"BMC Microbiol"},{"key":"23458_CR6","doi-asserted-by":"crossref","unstructured":"Nomura R, et al. A class A \u03b2-lactamase produced by borderline oxacillin-resistant Staphylococcus aureus hydrolyses oxacillin. J Glob Antimicrob Resist, 22, 244\u20137\u00a0(2020).","DOI":"10.1016\/j.jgar.2020.03.002"},{"key":"23458_CR7","doi-asserted-by":"crossref","unstructured":"Jacobitz A W, et al. Sortase Transpeptidases: Structural Biology and Catalytic Mechanism. Adv Protein Chem Struct Biol, 109, 223\u201364 (2017).","DOI":"10.1016\/bs.apcsb.2017.04.008"},{"issue":"7","key":"23458_CR8","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.tibs.2024.04.003","volume":"49","author":"JF Amacher","year":"2024","unstructured":"Amacher, J. F. & Antos, J. M. Sortases: structure, mechanism, and implications for protein engineering. Trends Biochem Sci 49(7), 596\u2013610 (2024).","journal-title":"Trends Biochem Sci"},{"issue":"5","key":"23458_CR9","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1046\/j.1365-2958.2001.02411.x","volume":"40","author":"SK Mazmanian","year":"2001","unstructured":"Mazmanian, S. K., Ton-That, H. & Schneewind, O. Sortase-catalysed anchoring of surface proteins to the cell wall of Staphylococcus aureus. Mol Microbiol 40(5), 1049\u20131057 (2001).","journal-title":"Mol Microbiol"},{"issue":"12","key":"23458_CR10","doi-asserted-by":"publisher","first-page":"1923","DOI":"10.1007\/s10096-016-2763-0","volume":"35","author":"TJ Foster","year":"2016","unstructured":"Foster, T. J. The remarkably multifunctional fibronectin binding proteins of Staphylococcus aureus. Eur J Clin Microbiol Infect Dis 35(12), 1923\u20131931 (2016).","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"23458_CR11","doi-asserted-by":"crossref","unstructured":"Speziale P\u00a0& Pietrocola G. The Multivalent Role of Fibronectin-Binding Proteins A and B (FnBPA and FnBPB) of Staphylococcus aureus in Host Infections. Front Microbiol, 11, 2054 (2020).","DOI":"10.3389\/fmicb.2020.02054"},{"issue":"3","key":"23458_CR12","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1097\/00001432-200306000-00007","volume":"16","author":"BE Menzies","year":"2003","unstructured":"Menzies, B. E. The role of fibronectin binding proteins in the pathogenesis of Staphylococcus aureus infections. Curr Opin Infect Dis 16(3), 225\u2013229 (2003).","journal-title":"Curr Opin Infect Dis"},{"issue":"1","key":"23458_CR13","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/nrmicro3161","volume":"12","author":"TJ Foster","year":"2014","unstructured":"Foster, T. J. et al. Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus. Nat Rev Microbiol 12(1), 49\u201362 (2014).","journal-title":"Nat Rev Microbiol"},{"key":"23458_CR14","doi-asserted-by":"crossref","unstructured":"Anderson A S et al. Staphylococcus aureus Clumping Factor A Remains a Viable Vaccine Target for Prevention of S. aureus Infection. mBio, 7(2): e00225 (2016)","DOI":"10.1128\/mBio.00225-16"},{"issue":"41","key":"23458_CR15","doi-asserted-by":"publisher","first-page":"5452","DOI":"10.1016\/j.vaccine.2015.08.029","volume":"33","author":"IL Scully","year":"2015","unstructured":"Scully, I. L. et al. Demonstration of the preclinical correlate of protection for Staphylococcus aureus clumping factor A in a murine model of infection. Vaccine 33(41), 5452\u20135457 (2015).","journal-title":"Vaccine"},{"issue":"4","key":"23458_CR16","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1016\/j.micinf.2003.12.008","volume":"6","author":"EP Skaar","year":"2004","unstructured":"Skaar, E. P. & Schneewind, O. Iron-regulated surface determinants (Isd) of Staphylococcus aureus: stealing iron from heme. Microbes Infect 6(4), 390\u2013397 (2004).","journal-title":"Microbes Infect"},{"issue":"5608","key":"23458_CR17","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1126\/science.1081147","volume":"299","author":"SK Mazmanian","year":"2003","unstructured":"Mazmanian, S. K. et al. Passage of heme-iron across the envelope of Staphylococcus aureus. Science 299(5608), 906\u2013909 (2003).","journal-title":"Science"},{"issue":"3","key":"23458_CR18","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.jinorgbio.2009.09.012","volume":"104","author":"JC Grigg","year":"2010","unstructured":"Grigg, J. C. et al. Structural biology of heme binding in the Staphylococcus aureus Isd system. J Inorg Biochem 104(3), 341\u2013348 (2010).","journal-title":"J Inorg Biochem"},{"key":"23458_CR19","doi-asserted-by":"crossref","unstructured":"Speziale P, et al. Protein-based biofilm matrices in Staphylococci. Front Cell Infect Microbiol, 4, 171\u00a0(2014).","DOI":"10.3389\/fcimb.2014.00171"},{"key":"23458_CR20","doi-asserted-by":"crossref","unstructured":"Xu Z, et al. Cell-wall-anchored proteins affect invasive host colonization and biofilm formation inStaphylococcus aureus. Microbiol Res, 285, 127782\u00a0(2024).","DOI":"10.1016\/j.micres.2024.127782"},{"issue":"10","key":"23458_CR21","doi-asserted-by":"publisher","first-page":"5510","DOI":"10.1073\/pnas.080520697","volume":"97","author":"SK Mazmanian","year":"2000","unstructured":"Mazmanian, S. K. et al. Staphylococcus aureus sortase mutants defective in the display of surface proteins and in the pathogenesis of animal infections. Proc Natl Acad Sci U S A 97(10), 5510\u20135515 (2000).","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"23458_CR22","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.1073\/pnas.032523999","volume":"99","author":"SK Mazmanian","year":"2002","unstructured":"Mazmanian, S. K. et al. An iron-regulated sortase anchors a class of surface protein during Staphylococcus aureus pathogenesis. Proc Natl Acad Sci U S A 99(4), 2293\u20132298 (2002).","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"9","key":"23458_CR23","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/S1286-4579(03)00143-6","volume":"5","author":"IM Jonsson","year":"2003","unstructured":"Jonsson, I. M. et al. The role of Staphylococcus aureus sortase A and sortase B in murine arthritis. Microbes Infect 5(9), 775\u2013780 (2003).","journal-title":"Microbes Infect"},{"issue":"3","key":"23458_CR24","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1093\/jac\/dkh078","volume":"53","author":"WJ Weiss","year":"2004","unstructured":"Weiss, W. J. et al. Effect of srtA and srtB gene expression on the virulence of Staphylococcus aureus in animal models of infection. J Antimicrob Chemother 53(3), 480\u2013486 (2004).","journal-title":"J Antimicrob Chemother"},{"issue":"3","key":"23458_CR25","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1111\/j.1365-2958.2004.04436.x","volume":"55","author":"SM Newton","year":"2005","unstructured":"Newton, S. M. et al. The svpA-srtB locus of Listeria monocytogenes: fur-mediated iron regulation and effect on virulence. Mol Microbiol 55(3), 927\u2013940 (2005).","journal-title":"Mol Microbiol"},{"issue":"10","key":"23458_CR26","first-page":"1219","volume":"38","author":"D Qian","year":"2023","unstructured":"Qian, D. et al. Hyperin up-regulates miR-7031-5P to promote osteogenic differentiation of MC3T3-E1 cells. Histol Histopathol 38(10), 1219\u20131229 (2023).","journal-title":"Histol Histopathol"},{"key":"23458_CR27","doi-asserted-by":"crossref","unstructured":"Ping M H. Hyperin Controls the Development and Therapy of Gastric Cancer via Regulating Wnt\/\u03b2-Catenin Signaling. Cancer Manag Res, 12, 11773\u201382\u00a0(2020).","DOI":"10.2147\/CMAR.S270544"},{"issue":"8","key":"23458_CR28","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1590\/s0102-865020170080000005","volume":"32","author":"C Niu","year":"2017","unstructured":"Niu, C. et al. Hyperin protects against cisplatin-induced liver injury in mice. Acta Cir Bras 32(8), 633\u2013640 (2017).","journal-title":"Acta Cir Bras"},{"key":"23458_CR29","doi-asserted-by":"crossref","unstructured":"Wang S, et al. Hyperoside attenuates non-alcoholic fatty liver disease in rats via cholesterol metabolism and bile acid metabolism. J Adv Res, 34, 109\u201322 (2021).","DOI":"10.1016\/j.jare.2021.06.001"},{"key":"23458_CR30","doi-asserted-by":"crossref","unstructured":"Xu S, et al. Hyperoside: A Review of Its Structure, Synthesis, Pharmacology, Pharmacokinetics and Toxicity. Molecules, 27(9),\u00a0(2022).","DOI":"10.3390\/molecules27093009"},{"issue":"10","key":"23458_CR31","doi-asserted-by":"publisher","first-page":"2586","DOI":"10.1111\/jcmm.13179","volume":"21","author":"M Song","year":"2017","unstructured":"Song, M. et al. Epigallocatechin gallate inhibits Streptococcus pneumoniae virulence by simultaneously targeting pneumolysin and sortase A. J Cell Mol Med 21(10), 2586\u20132598 (2017).","journal-title":"J Cell Mol Med"},{"key":"23458_CR32","doi-asserted-by":"crossref","unstructured":"Zhang C, et al. Alnustone inhibits Streptococcus pneumoniae virulence by targeting pneumolysin and sortase A. Fitoterapia, 162,\u00a0105261 (2022).","DOI":"10.1016\/j.fitote.2022.105261"},{"issue":"2","key":"23458_CR33","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1002\/jcc.21334","volume":"31","author":"O Trott","year":"2010","unstructured":"Trott, O. & Olson, A. J. AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J Comput Chem 31(2), 455\u2013461 (2010).","journal-title":"J Comput Chem"},{"issue":"16","key":"23458_CR34","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1002\/jcc.20291","volume":"26","author":"D van der Spoel","year":"2005","unstructured":"van der Spoel, D. et al. GROMACS: fast, flexible, and free. J Comput Chem 26(16), 1701\u20131718 (2005).","journal-title":"J Comput Chem"},{"issue":"15","key":"23458_CR35","doi-asserted-by":"publisher","first-page":"2583","DOI":"10.1111\/bph.16377","volume":"181","author":"B Han","year":"2024","unstructured":"Han, B., Wang, H. & Niu, X. A natural inhibitor of diapophytoene desaturase attenuates methicillin-resistant Staphylococcus aureus (MRSA) pathogenicity and overcomes drug-resistance. Br J Pharmacol 181(15), 2583\u20132599 (2024).","journal-title":"Br J Pharmacol"},{"key":"23458_CR36","doi-asserted-by":"crossref","unstructured":"Yang Y, et al. Insight into the Dual inhibitory Mechanism of verbascoside targeting serine\/threonine phosphatase Stp1 against Staphylococcus aureus. Eur J Pharm Sci, 157, 105628 (2021).","DOI":"10.1016\/j.ejps.2020.105628"},{"key":"23458_CR37","doi-asserted-by":"crossref","unstructured":"Xu L, et al. Anti-inflammatory, antioxidant and anti-virulence roles of atractylodin in attenuating Listeria monocytogenes infection. Front Immunol, 13, 977051 (2022).","DOI":"10.3389\/fimmu.2022.977051"},{"key":"23458_CR38","doi-asserted-by":"crossref","unstructured":"Dib K. Histamine Promotes Pseudomonas aeruginosa Biofilm Formation and Renders P. aeruginosa Biofilms More Resistant to Gentamicin and Azithromycin. Med Princ Pract, 1\u201312 (2025).","DOI":"10.1159\/000544111"},{"key":"23458_CR39","doi-asserted-by":"crossref","unstructured":"R\u00edos-Moreno A, et al. Quantification of fungal growth and destruxin A during infection of Galleria mellonella larvae by Metarhizium brunneum. J Invertebr Pathol,\u00a0149, 29\u201335 (2017).","DOI":"10.1016\/j.jip.2017.06.007"},{"key":"23458_CR40","doi-asserted-by":"crossref","unstructured":"Xu M N, et al. Zinc Oxide Nanoparticles Prime a Protective Immune Response in Galleria mellonella to Defend Against Candida albicans. Front Microbiol, 12,\u00a0766138 (2021).","DOI":"10.3389\/fmicb.2021.766138"},{"issue":"11","key":"23458_CR41","doi-asserted-by":"publisher","first-page":"6056","DOI":"10.1073\/pnas.101064198","volume":"98","author":"U Ilangovan","year":"2001","unstructured":"Ilangovan, U. et al. Structure of sortase, the transpeptidase that anchors proteins to the cell wall of Staphylococcus aureus. Proc Natl Acad Sci U S A 98(11), 6056\u20136061 (2001).","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"23458_CR42","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1002\/pro.4266","volume":"31","author":"M Gao","year":"2022","unstructured":"Gao, M. et al. Structural and biochemical analyses of selectivity determinants in chimeric Streptococcus Class A sortase enzymes. Protein Sci 31(3), 701\u2013715 (2022).","journal-title":"Protein Sci"},{"issue":"30","key":"23458_CR43","doi-asserted-by":"publisher","first-page":"31383","DOI":"10.1074\/jbc.M401374200","volume":"279","author":"Y Zong","year":"2004","unstructured":"Zong, Y. et al. Crystal structures of Staphylococcus aureus sortase A and its substrate complex. J Biol Chem 279(30), 31383\u201331389 (2004).","journal-title":"J Biol Chem"},{"issue":"1","key":"23458_CR44","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.str.2003.11.021","volume":"12","author":"Y Zong","year":"2004","unstructured":"Zong, Y. et al. The structure of sortase B, a cysteine transpeptidase that tethers surface protein to the Staphylococcus aureus cell wall. Structure 12(1), 105\u2013112 (2004).","journal-title":"Structure"},{"issue":"3","key":"23458_CR45","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1016\/j.bbamem.2017.12.003","volume":"1860","author":"SJ Kim","year":"2018","unstructured":"Kim, S. J. et al. Surface proteins and the formation of biofilms by Staphylococcus aureus. Biochim Biophys Acta Biomembr 1860(3), 749\u2013756 (2018).","journal-title":"Biochim Biophys Acta Biomembr"},{"issue":"10","key":"23458_CR46","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1515\/hsz-2018-0472","volume":"400","author":"G von Hoven","year":"2019","unstructured":"von Hoven, G. et al. Staphylococcus aureus \u03b1-toxin: small pore, large consequences. Biol Chem 400(10), 1261\u20131276 (2019).","journal-title":"Biol Chem"},{"key":"23458_CR47","doi-asserted-by":"crossref","unstructured":"Bush K\u00a0& Bradford P A. Epidemiology of \u03b2-Lactamase-Producing Pathogens. Clin Microbiol Rev, 33(2) (2020).","DOI":"10.1128\/CMR.00047-19"},{"key":"23458_CR48","doi-asserted-by":"crossref","unstructured":"Zhang B, et al. Chalcone Attenuates Staphylococcus aureus Virulence by Targeting Sortase A and Alpha-Hemolysin. Front Microbiol, 8,\u00a01715 (2017).","DOI":"10.3389\/fmicb.2017.01715"},{"key":"23458_CR49","doi-asserted-by":"crossref","unstructured":"Zhu S, et al. Daphnetin weakened the pathogenicity of methicillin-resistant Staphylococcus aureus by inhibiting Sortase A and \u03b1-hemolysin. Biochimie, 229,\u00a084\u201394 (2025).","DOI":"10.1016\/j.biochi.2024.10.010"},{"key":"23458_CR50","doi-asserted-by":"crossref","unstructured":"Younis S, Taj S\u00a0& Rashid S. Structural studies of Staphylococcus aureus Sortase inhibiton via Conus venom peptides. Arch Biochem Biophys, 671, 87\u2013102 (2019).","DOI":"10.1016\/j.abb.2019.06.003"},{"key":"23458_CR51","doi-asserted-by":"crossref","unstructured":"Touzout S N, et al. Antibacterial Properties of Methanolic Leaf Extracts of Melia azedarach L. against Gram-Positive and Gram-Negative Pathogenic Bacteria. Microorganisms, 11(8) (2023).","DOI":"10.3390\/microorganisms11082062"},{"key":"23458_CR52","doi-asserted-by":"crossref","unstructured":"Mogana R, et al. Antibacterial activities of the extracts, fractions and isolated compounds from Canarium patentinervium Miq. against bacterial clinical isolates. BMC Complement Med Ther, 20(1), 55 (2020).","DOI":"10.1186\/s12906-020-2837-5"},{"key":"23458_CR53","doi-asserted-by":"crossref","unstructured":"Bush, K. et al. Epidemiology of \u03b2-lactamase-producing pathogens [J]. Clin. Microbiol. Rev. 33(2) (2020).","DOI":"10.1128\/CMR.00047-19"},{"key":"23458_CR54","doi-asserted-by":"crossref","unstructured":"Zhang, B. et al. Chalcone attenuates staphylococcus aureus Vvrulence by targeting sortase A and alpha-hemolysin [J]. Front Microbiol. 8, 1715 (2017).","DOI":"10.3389\/fmicb.2017.01715"},{"key":"23458_CR55","doi-asserted-by":"crossref","unstructured":"Zhu, S. et al. Daphnetin weakened the pathogenicity of methicillin-resistant Staphylococcus aureus by inhibiting Sortase A and \u03b1-hemolysin [J]. Biochimie 229, 84\u201394 (2025).","DOI":"10.1016\/j.biochi.2024.10.010"},{"key":"23458_CR56","doi-asserted-by":"crossref","unstructured":"Younis, S. et al. Structural studies of Staphylococcus aureus Sortase inhibiton via Conus venom peptides [J]. Arch. Biochem. Biophys. 671, 87\u2013102 (2019).","DOI":"10.1016\/j.abb.2019.06.003"},{"key":"23458_CR57","doi-asserted-by":"crossref","unstructured":"Touzout, S. N. et al. Antibacterial properties of methanolic leaf extracts of melia azedarach L. against gram-positive and gram-negative pathogenic bacteria [J]. Microorganisms 11(8) (2023).","DOI":"10.3390\/microorganisms11082062"},{"key":"23458_CR58","doi-asserted-by":"crossref","unstructured":"Mogana, R. et al. Antibacterial activities of the extracts, fractions and isolated compounds from Canarium patentinervium Miq. against bacterial clinical isolates [J]. BMC Complement Med. Ther. 20(1), 55 (2020).","DOI":"10.1186\/s12906-020-2837-5"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-23458-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-23458-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-23458-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T00:02:52Z","timestamp":1763164972000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-23458-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,10]]},"references-count":58,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["23458"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-23458-1","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,10]]},"assertion":[{"value":"27 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All the animal test performed in this study follow the regulations of the Laboratory Animal Ethics Committee of Jilin University and all the methods were performed in accordance with relevant guidelines and regulations of ARRIVE guidelines.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics declaration"}}],"article-number":"39190"}}