{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T13:05:09Z","timestamp":1763557509552,"version":"3.45.0"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82404143","82073443"],"award-info":[{"award-number":["82404143","82073443"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014175","name":"Shanghai Municipal Health and Family Planning Commission","doi-asserted-by":"publisher","award":["2023ZZ02018"],"award-info":[{"award-number":["2023ZZ02018"]}],"id":[{"id":"10.13039\/501100014175","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Municipal Key Clinical Specialty","award":["shslczdzk01002"],"award-info":[{"award-number":["shslczdzk01002"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-24401-0","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T12:06:41Z","timestamp":1763554001000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification and experimental validation of glycosylation related differentially expressed genes as diagnostic biomarkers in systemic lupus erythematosus"],"prefix":"10.1038","volume":"15","author":[{"given":"Chenghui","family":"Zheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yilun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengmeng","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanyan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyu","family":"Chu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhua","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"key":"24401_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jaut.2018.11.001","volume":"96","author":"A Fava","year":"2019","unstructured":"Fava, A. & Petri, M. Systemic lupus erythematosus: diagnosis and clinical management. J. Autoimmun. 96, 1\u201313 (2019).","journal-title":"J. Autoimmun."},{"key":"24401_CR2","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1146\/annurev-med-043021-032611","volume":"74","author":"S Lazar","year":"2023","unstructured":"Lazar, S. & Kahlenberg, J. M. Systemic lupus erythematosus: new diagnostic and therapeutic approaches. Annu. Rev. Med. 74, 339\u2013352 (2023).","journal-title":"Annu. Rev. Med."},{"key":"24401_CR3","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1038\/s41584-021-00668-1","volume":"17","author":"MRW Barber","year":"2021","unstructured":"Barber, M. R. W. et al. Global epidemiology of systemic lupus erythematosus. Nat. Rev. Rheumatol. 17, 515\u2013532 (2021).","journal-title":"Nat. Rev. Rheumatol."},{"key":"24401_CR4","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1136\/ard-2023-224762","volume":"83","author":"A Fanouriakis","year":"2024","unstructured":"Fanouriakis, A. et al. EULAR recommendations for the management of systemic lupus erythematosus: 2023 update. Ann. Rheum. Dis. 83, 15\u201329 (2024).","journal-title":"Ann. Rheum. Dis."},{"key":"24401_CR5","doi-asserted-by":"publisher","first-page":"R229","DOI":"10.1016\/j.cub.2019.01.003","volume":"29","author":"J Eichler","year":"2019","unstructured":"Eichler, J. Protein glycosylation. Curr. Biol. 29, R229\u2013R231 (2019).","journal-title":"Curr. Biol."},{"key":"24401_CR6","doi-asserted-by":"publisher","first-page":"102804","DOI":"10.1016\/j.autrev.2021.102804","volume":"20","author":"X Zhou","year":"2021","unstructured":"Zhou, X. et al. Antibody glycosylation in autoimmune diseases. Autoimmun. rev. 20, 102804 (2021).","journal-title":"Autoimmun. rev."},{"key":"24401_CR7","doi-asserted-by":"publisher","first-page":"1257906","DOI":"10.3389\/fimmu.2023.1257906","volume":"14","author":"X Lu","year":"2023","unstructured":"Lu, X. et al. Association between Immunoglobulin G N-glycosylation and lupus nephritis in female patients with systemic lupus erythematosus: a case-control study. Front. Immunol. 14, 1257906 (2023).","journal-title":"Front. Immunol."},{"key":"24401_CR8","unstructured":"Vu\u02c7ckovic, F. et al. Association of Systemic Lupus Erythematosus With Decreased Immunosuppressive Potential of the IgG Glycome."},{"key":"24401_CR9","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1177\/0961203314558861","volume":"24","author":"C Sj\u00f6wall","year":"2015","unstructured":"Sj\u00f6wall, C. et al. Altered glycosylation of complexed native IgG molecules is associated with disease activity of systemic lupus erythematosus. Lupus 24, 569\u2013581 (2015).","journal-title":"Lupus"},{"key":"24401_CR10","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/s41573-020-00093-1","volume":"20","author":"BAH Smith","year":"2021","unstructured":"Smith, B. A. H. & Bertozzi, C. R. The clinical impact of glycobiology: targeting selectins, Siglecs and mammalian glycans. Nat. Rev. Drug Discov. 20, 217\u2013243 (2021).","journal-title":"Nat. Rev. Drug Discov"},{"key":"24401_CR11","doi-asserted-by":"publisher","first-page":"1846","DOI":"10.1093\/bioinformatics\/btm254","volume":"23","author":"S Davis","year":"2007","unstructured":"Davis, S. & Meltzer, P. S. GEOquery: a Bridge between the gene expression omnibus (GEO) and bioconductor. Bioinformatics 23, 1846\u20131847 (2007).","journal-title":"Bioinformatics"},{"key":"24401_CR12","doi-asserted-by":"publisher","first-page":"e000080","DOI":"10.1136\/lupus-2014-000080","volume":"2","author":"WP Kennedy","year":"2015","unstructured":"Kennedy, W. P. et al. Association of the interferon signature metric with serological disease manifestations but not global activity scores in multiple cohorts of patients with SLE. Lupus Sci. Med. 2, e000080 (2015).","journal-title":"Lupus Sci. Med."},{"key":"24401_CR13","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1186\/s13075-016-1050-x","volume":"18","author":"H Zhu","year":"2016","unstructured":"Zhu, H. et al. Whole-genome transcription and DNA methylation analysis of peripheral blood mononuclear cells identified aberrant gene regulation pathways in systemic lupus erythematosus. Arthritis Res. Ther. 18, 162 (2016).","journal-title":"Arthritis Res. Ther."},{"key":"24401_CR14","doi-asserted-by":"publisher","first-page":"R63","DOI":"10.1186\/ar3317","volume":"13","author":"HM Lee","year":"2011","unstructured":"Lee, H. M., Sugino, H., Aoki, C. & Nishimoto, N. Underexpression of mitochondrial-DNA encoded ATP synthesis-related genes and DNA repair genes in systemic lupus erythematosus. Arthritis Res. Ther. 13, R63 (2011).","journal-title":"Arthritis Res. Ther."},{"key":"24401_CR15","doi-asserted-by":"publisher","first-page":"D991","DOI":"10.1093\/nar\/gks1193","volume":"41","author":"T Barrett","year":"2012","unstructured":"Barrett, T. et al. NCBI GEO: archive for functional genomics data sets\u2014update. Nucleic Acids Res. 41, D991\u2013D995 (2012).","journal-title":"Nucleic Acids Res."},{"key":"24401_CR16","doi-asserted-by":"crossref","unstructured":"Stelzer, G. et al. The genecards suite: from gene data mining to disease genome sequence analyses. CP Bioinformatics 54, (2016).","DOI":"10.1002\/cpbi.5"},{"key":"24401_CR17","first-page":"1","volume":"2022","author":"L Chen","year":"2022","unstructured":"Chen, L., Ling, Y. & Yang, H. Comprehensive analysis of the potential prognostic value of 11 Glycosylation-Related genes in head and neck squamous cell carcinoma and their correlation with PD-L1 expression and immune infiltration. J. Oncol. 2022, 1\u201316 (2022).","journal-title":"J. Oncol."},{"key":"24401_CR18","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1093\/bioinformatics\/bts034","volume":"28","author":"JT Leek","year":"2012","unstructured":"Leek, J. T., Johnson, W. E., Parker, H. S., Jaffe, A. E. & Storey, J. D. The Sva package for removing batch effects and other unwanted variation in high-throughput experiments. Bioinformatics 28, 882\u2013883 (2012).","journal-title":"Bioinformatics"},{"key":"24401_CR19","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","volume":"43","author":"ME Ritchie","year":"2015","unstructured":"Ritchie, M. E. et al. Limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43, e47\u2013e47 (2015).","journal-title":"Nucleic Acids Res."},{"key":"24401_CR20","unstructured":"Salem, K. B. & Abdelaziz, A. B. S\u00e9rie de Fiches M\u00e9thodologiques En recherche et En R\u00e9daction scientifique Fiche M\u00e9thodologique n: 3\/2021 analyse En composantes principales (ACP) principal component analysis (PCA). LA TUNISIE MEDICALE 99 (2021)."},{"key":"24401_CR21","doi-asserted-by":"publisher","first-page":"D419","DOI":"10.1093\/nar\/gky1038","volume":"47","author":"H Mi","year":"2019","unstructured":"Mi, H., Muruganujan, A., Ebert, D., Huang, X. & Thomas, P. D. PANTHER version 14: more genomes, a new PANTHER GO-slim and improvements in enrichment analysis tools. Nucleic Acids Res. 47, D419\u2013D426 (2019).","journal-title":"Nucleic Acids Res."},{"key":"24401_CR22","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa, M. & Goto, S. K. E. G. G. Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28, 27\u201330 (2000).","journal-title":"Nucleic Acids Res."},{"key":"24401_CR23","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1002\/pro.3715","volume":"28","author":"M Kanehisa","year":"2019","unstructured":"Kanehisa, M. Toward Understanding the origin and evolution of cellular organisms. Protein Sci. 28, 1947\u20131951 (2019).","journal-title":"Protein Sci."},{"key":"24401_CR24","doi-asserted-by":"publisher","first-page":"D672","DOI":"10.1093\/nar\/gkae909","volume":"53","author":"M Kanehisa","year":"2025","unstructured":"Kanehisa, M., Furumichi, M., Sato, Y., Matsuura, Y. & Ishiguro-Watanabe, M. KEGG: biological systems database as a model of the real world. Nucleic Acids Res. 53, D672\u2013D677 (2025).","journal-title":"Nucleic Acids Res."},{"key":"24401_CR25","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","volume":"16","author":"G Yu","year":"2012","unstructured":"Yu, G., Wang, L. G., Han, Y. & He, Q. Y. ClusterProfiler: an R package for comparing biological themes among gene clusters. OMICS: J. Integr. Biology. 16, 284\u2013287 (2012).","journal-title":"OMICS: J. Integr. Biology"},{"key":"24401_CR26","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1186\/s13148-019-0730-1","volume":"11","author":"S Engebretsen","year":"2019","unstructured":"Engebretsen, S. & Bohlin, J. Statistical predictions with Glmnet. Clin. Epigenet. 11, 123 (2019).","journal-title":"Clin. Epigenet"},{"key":"24401_CR27","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/1471-2105-12-77","volume":"12","author":"X Robin","year":"2011","unstructured":"Robin, X. et al. pROC: an open-source package for R and S\u2009+\u2009to analyze and compare ROC curves. BMC Bioinform. 12, 77 (2011).","journal-title":"BMC Bioinform."},{"key":"24401_CR28","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1002\/cac2.12067","volume":"40","author":"J Wu","year":"2020","unstructured":"Wu, J. et al. A nomogram for predicting overall survival in patients with low-grade endometrial stromal sarcoma: A population\u2010based analysis. Cancer Commun. 40, 301\u2013312 (2020).","journal-title":"Cancer Commun."},{"key":"24401_CR29","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1016\/j.eururo.2018.08.038","volume":"74","author":"B Van Calster","year":"2018","unstructured":"Van Calster, B. et al. Reporting and interpreting decision curve analysis: A guide for investigators. Eur. Urol. 74, 796\u2013804 (2018).","journal-title":"Eur. Urol."},{"key":"24401_CR30","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1093\/bioinformatics\/btq064","volume":"26","author":"G Yu","year":"2010","unstructured":"Yu, G. et al. GOSemSim: an R package for measuring semantic similarity among GO terms and gene products. Bioinformatics 26, 976\u2013978 (2010).","journal-title":"Bioinformatics"},{"key":"24401_CR31","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian, A. et al. Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl. Acad. Sci. U S A. 102, 15545\u201315550 (2005).","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"24401_CR32","doi-asserted-by":"publisher","first-page":"D43","DOI":"10.1093\/nar\/gkw965","volume":"45","author":"KR Zhou","year":"2017","unstructured":"Zhou, K. R. et al. ChIPBase v2.0: decoding transcriptional regulatory networks of non-coding RNAs and protein-coding genes from ChIP-seq data. Nucleic Acids Res. 45, D43\u2013D50 (2017).","journal-title":"Nucleic Acids Res."},{"key":"24401_CR33","doi-asserted-by":"publisher","first-page":"D92","DOI":"10.1093\/nar\/gkt1248","volume":"42","author":"JH Li","year":"2014","unstructured":"Li, J. H., Liu, S., Zhou, H., Qu, L. H. & Yang, J. H. StarBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein\u2013RNA interaction networks from large-scale CLIP-Seq data. Nucl. Acids Res. 42, D92\u2013D97 (2014).","journal-title":"Nucl. Acids Res."},{"key":"24401_CR34","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon, P. et al. Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13, 2498\u20132504 (2003).","journal-title":"Genome Res."},{"key":"24401_CR35","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1038\/nmeth.3337","volume":"12","author":"AM Newman","year":"2015","unstructured":"Newman, A. M. et al. Robust enumeration of cell subsets from tissue expression profiles. Nat. Methods. 12, 453\u2013457 (2015).","journal-title":"Nat. Methods"},{"key":"24401_CR36","doi-asserted-by":"publisher","first-page":"155640","DOI":"10.1016\/j.cyto.2021.155640","volume":"146","author":"S Ghafouri-Fard","year":"2021","unstructured":"Ghafouri-Fard, S., Shahir, M., Taheri, M. & Salimi, A. A review on the role of chemokines in the pathogenesis of systemic lupus erythematosus. Cytokine 146, 155640 (2021).","journal-title":"Cytokine"},{"key":"24401_CR37","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1089\/jir.2011.0047","volume":"31","author":"LS Davis","year":"2011","unstructured":"Davis, L. S., Hutcheson, J. & Mohan, C. The role of cytokines in the pathogenesis and treatment of systemic lupus erythematosus. J. Interferon Cytokine Res. 31, 781\u2013789 (2011).","journal-title":"J. Interferon Cytokine Res."},{"key":"24401_CR38","doi-asserted-by":"publisher","unstructured":"Arriens, C., Wren, J. D., Munroe, M. E. & Mohan, C. Systemic lupus erythematosus biomarkers: the challenging quest. Rheumatology kew407 https:\/\/doi.org\/10.1093\/rheumatology\/kew407 (2016).","DOI":"10.1093\/rheumatology\/kew407"},{"key":"24401_CR39","doi-asserted-by":"publisher","first-page":"1658","DOI":"10.3899\/jrheum.091123","volume":"37","author":"LJ Zhu","year":"2010","unstructured":"Zhu, L. J. et al. Altered expression of TNF-\u03b1 signaling pathway proteins in systemic lupus erythematosus. J. Rheumatol. 37, 1658\u20131666 (2010).","journal-title":"J. Rheumatol."},{"key":"24401_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.clim.2014.05.004","volume":"152","author":"JC Martin","year":"2014","unstructured":"Martin, J. C. Emerging role of IL-17 and Th17 cells in systemic lupus erythematosus. Clin. Immunol. 152, 1\u201312 (2014).","journal-title":"Clin. Immunol."},{"key":"24401_CR41","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1080\/1744666X.2019.1593141","volume":"15","author":"T Koga","year":"2019","unstructured":"Koga, T. The role of IL-17 in systemic lupus erythematosus and its potential as a therapeutic target. Expert Rev. Clin. Immunol. 15, 459\u2013469 (2019).","journal-title":"Expert Rev. Clin. Immunol."},{"key":"24401_CR42","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.clim.2016.08.010","volume":"185","author":"P Mistry","year":"2018","unstructured":"Mistry, P. & Kaplan, M. J. Cell death in the pathogenesis of systemic lupus erythematosus and lupus nephritis. Clin. Immunol. 185, 59\u201373 (2018).","journal-title":"Clin. Immunol."},{"key":"24401_CR43","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1038\/s41418-021-00880-2","volume":"29","author":"S Hu","year":"2022","unstructured":"Hu, S. et al. Glycoprotein PTGDS promotes tumorigenesis of diffuse large B-cell lymphoma by MYH9-mediated regulation of Wnt\u2013\u03b2-catenin\u2013STAT3 signaling. Cell. Death Differ. 29, 642\u2013656 (2022).","journal-title":"Cell. Death Differ."},{"key":"24401_CR44","doi-asserted-by":"crossref","unstructured":"Frank, M., Beccati, D., Leeflang, B. R. & Vliegenthart, J. F. G. C-Mannosylation enhances the structural stability of human RNase 2. iScience 23, 101371 (2020).","DOI":"10.1016\/j.isci.2020.101371"},{"key":"24401_CR45","doi-asserted-by":"publisher","first-page":"e2347","DOI":"10.1038\/cddis.2016.243","volume":"7","author":"KP Tan","year":"2016","unstructured":"Tan, K. P. et al. Fucosylation of LAMP-1 and LAMP-2 by FUT1 correlates with lysosomal positioning and autophagic flux of breast cancer cells. Cell. Death Dis. 7, e2347\u2013e2347 (2016).","journal-title":"Cell. Death Dis."},{"key":"24401_CR46","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1177\/1753425912446955","volume":"19","author":"SK Gupta","year":"2013","unstructured":"Gupta, S. K., Haigh, B. J., Griffin, F. J. & Wheeler, T. T. The mammalian secreted rnases: mechanisms of action in host defence. Innate Immun. 19, 86\u201397 (2013).","journal-title":"Innate Immun."},{"key":"24401_CR47","doi-asserted-by":"publisher","first-page":"752189","DOI":"10.3389\/fimmu.2022.752189","volume":"13","author":"Y Zhu","year":"2022","unstructured":"Zhu, Y. et al. RNASE2 mediates Age-Associated B cell expansion through monocyte derived IL-10 in patients with systemic lupus erythematosus. Front. Immunol. 13, 752189 (2022).","journal-title":"Front. Immunol."},{"key":"24401_CR48","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1177\/0961203318778774","volume":"27","author":"DJ Go","year":"2018","unstructured":"Go, D. J. et al. Urinary vitamin D-binding protein, a novel biomarker for lupus nephritis, predicts the development of proteinuric flare. Lupus 27, 1600\u20131615 (2018).","journal-title":"Lupus"},{"key":"24401_CR49","doi-asserted-by":"crossref","unstructured":"Pan, G. et al. Identi\u00a2cation and functional characterization of DR6, a novel death domain-containing TNF receptor. FEBS Lett. (1998).","DOI":"10.1016\/S0014-5793(98)00791-1"},{"key":"24401_CR50","doi-asserted-by":"publisher","first-page":"13957","DOI":"10.1038\/ncomms13957","volume":"8","author":"D Fujikura","year":"2017","unstructured":"Fujikura, D. et al. Death receptor 6 contributes to autoimmunity in lupus-prone mice. Nat. Commun. 8, 13957 (2017).","journal-title":"Nat. Commun."},{"key":"24401_CR51","doi-asserted-by":"publisher","first-page":"756825","DOI":"10.3389\/fimmu.2021.756825","volume":"12","author":"B Yang","year":"2021","unstructured":"Yang, B. et al. Decreased miR-4512 levels in monocytes and macrophages of individuals with systemic lupus erythematosus contribute to innate immune activation and neutrsophil NETosis by targeting TLR4 and CXCL2. Front. Immunol. 12, 756825 (2021).","journal-title":"Front. Immunol."},{"key":"24401_CR52","doi-asserted-by":"publisher","first-page":"15169","DOI":"10.1038\/s41598-020-71669-5","volume":"10","author":"T Tanaka","year":"2020","unstructured":"Tanaka, T. et al. LAMP3 induces apoptosis and autoantigen release in Sj\u00f6gren\u2019s syndrome patients. Sci. Rep. 10, 15169 (2020).","journal-title":"Sci. Rep."},{"key":"24401_CR53","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.smim.2017.12.002","volume":"35","author":"C Qian","year":"2018","unstructured":"Qian, C. & Cao, X. Dendritic cells in the regulation of immunity and inflammation. Semin. Immunol. 35, 3\u201311 (2018).","journal-title":"Semin. Immunol."},{"key":"24401_CR54","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1097\/00002281-200309000-00005","volume":"15","author":"V Pascual","year":"2003","unstructured":"Pascual, V., Banchereau, J. & Palucka, A. K. The central role of dendritic cells and interferon-\u03b1 in systemic lupus erythematosus. Curr. Opin. Rheumatol. 15, 548\u2013556 (2003).","journal-title":"Curr. Opin. Rheumatol."},{"key":"24401_CR55","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1038\/nri1733","volume":"5","author":"S Gordon","year":"2005","unstructured":"Gordon, S. & Taylor, P. R. Monocyte and macrophage heterogeneity. Nat. Rev. Immunol. 5, 953\u2013964 (2005).","journal-title":"Nat. Rev. Immunol."},{"key":"24401_CR56","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.cell.2008.05.009","volume":"133","author":"S Sakaguchi","year":"2008","unstructured":"Sakaguchi, S., Yamaguchi, T., Nomura, T. & Ono, M. Regulatory T cells and immune tolerance. Cell 133, 775\u2013787 (2008).","journal-title":"Cell"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-24401-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-24401-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-24401-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T13:03:55Z","timestamp":1763557435000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-24401-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,19]]},"references-count":56,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["24401"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-24401-0","relation":{},"ISSN":["2045-2322"],"issn-type":[{"type":"electronic","value":"2045-2322"}],"subject":[],"published":{"date-parts":[[2025,11,19]]},"assertion":[{"value":"6 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"40694"}}