{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T22:52:00Z","timestamp":1794091920976,"version":"4.8.0"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Z\u00fcrcher Stiftung f\u00fcr das H\u00f6ren"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-24549-9","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T12:20:24Z","timestamp":1763554824000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Hyperplastic growth, not hydrostatic distension, in endolymphatic hydrops in humans challenges the classic view of Meniere\u2019s disease"],"prefix":"10.1038","volume":"15","author":[{"given":"Corey","family":"Bryton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana M.","family":"Correa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"B\u00e4chinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentin","family":"Fankhauser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole C.","family":"Kamber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng Yu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer T.","family":"O\u2019Malley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler T.","family":"Hickman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Robles-Bolivar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven D.","family":"Rauch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas H.","family":"Eckhard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"key":"24549_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3233\/VES-150549","volume":"25","author":"JA Lopez-Escamez","year":"2015","unstructured":"Lopez-Escamez, J. A. et al. Diagnostic criteria for meniere\u2019s disease. J. Vestib. Res. 25, 1\u20137 (2015).","journal-title":"J. Vestib. Res."},{"key":"24549_CR2","doi-asserted-by":"publisher","first-page":"1496384","DOI":"10.3389\/fneur.2024.1496384","volume":"15","author":"I Pyykko","year":"2024","unstructured":"Pyykko, I., Zou, J. & Vetkas, N. Changes in symptom pattern in meniere\u2019s disease by duration: the need for comprehensive management. Front. Neurol. 15, 1496384 (2024).","journal-title":"Front. Neurol."},{"key":"24549_CR3","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1177\/000348946207100417","volume":"71","author":"HF Schuknecht","year":"1962","unstructured":"Schuknecht, H. F., Benitez, J. T. & Beekhuis, J. Further observations on the pathology of meniere\u2019s disease. Ann. Otol Rhinol Laryngol. 71, 1039\u20131053 (1962).","journal-title":"Ann. Otol Rhinol Laryngol"},{"key":"24549_CR4","first-page":"1317","volume":"31","author":"CS Hallpike","year":"1938","unstructured":"HallpikeCS & Cairns, H. Observations on the pathology of M\u00e9ni\u00e8re\u2019s syndrome. Proc. R Soc. Med. 31, 1317\u20131336 (1938).","journal-title":"Proc. R Soc. Med."},{"key":"24549_CR5","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1002\/aja.1000390103","volume":"39","author":"SR Guild","year":"1927","unstructured":"Guild, S. R. The circulation of the endolymph. Am. J. Anat. 39, 57\u201381 (1927).","journal-title":"Am. J. Anat."},{"key":"24549_CR6","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1001\/archotol.1927.00610010329001","volume":"64","author":"G Portmann","year":"1927","unstructured":"Portmann, G. Vertigo: surgical treatment by opening the saccus endolymphaticus. Arch. Otolaryngol. Head Neck Surg. 64, 309\u2013319 (1927).","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"24549_CR7","volume-title":"A clinical analysis of the inflammatory affections of the inner ear","author":"HJ Knapp","year":"1871","unstructured":"Knapp, H. J. A clinical analysis of the inflammatory affections of the inner ear (W. Wood & Company, 1871)."},{"key":"24549_CR8","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/S0196-0709(83)80071-4","volume":"4","author":"BIR Carlborg","year":"1983","unstructured":"Carlborg, B. I. R. & Farmer, J. C. Transmission of cerebrospinal fluid pressure via the cochlear aqueduct and endolymphatic sac. Am. J. Otolaryngol. 4, 273\u2013282 (1983).","journal-title":"Am. J. Otolaryngol."},{"key":"24549_CR9","first-page":"2310","volume":"4","author":"K Yamakawa","year":"1938","unstructured":"Yamakawa, K. \u00dcber die pathologische Ver\u00e4nderung Bei einem M\u00e9ni\u00e8re-Kranken. J. Otorhinolaryngol. Soc. Jpn. 4, 2310\u20132312 (1938).","journal-title":"J. Otorhinolaryngol. Soc. Jpn"},{"key":"24549_CR10","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1097\/MLG.0b013e31802c300c","volume":"117","author":"T Nakashima","year":"2007","unstructured":"Nakashima, T. et al. Visualization of endolymphatic hydrops in patients with meniere\u2019s disease. Laryngoscope 117, 415\u2013420 (2007).","journal-title":"Laryngoscope"},{"key":"24549_CR11","doi-asserted-by":"publisher","first-page":"357","DOI":"10.2463\/mrms.tn.2016-0126","volume":"16","author":"S Naganawa","year":"2017","unstructured":"Naganawa, S., Kawai, H., Taoka, T. & Sone, M. Improved HYDROPS: imaging of endolymphatic hydrops after intravenous administration of gadolinium. Magn. Reson. Med. Sci. 16, 357\u2013361 (2017).","journal-title":"Magn. Reson. Med. Sci."},{"key":"24549_CR12","doi-asserted-by":"publisher","first-page":"1927","DOI":"10.1001\/jama.1959.03010320017005","volume":"171","author":"M Lawrence","year":"1959","unstructured":"Lawrence, M. & McCabe, B. F. Inner-ear mechanics and deafness. Special consideration of meniere\u2019s syndrome. JAMA 171, 1927\u20131932 (1959).","journal-title":"JAMA"},{"key":"24549_CR13","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1177\/000348945706600315","volume":"66","author":"J Tonndorf","year":"1957","unstructured":"Tonndorf, J. Mechanism of hearing loss in early cases of endolymphatic hydrops. Ann. Otol Rhinol Laryngol. 66, 1011\u20131020 (1957).","journal-title":"Ann. Otol Rhinol Laryngol"},{"key":"24549_CR14","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/s00405-002-0518-2","volume":"260","author":"TJ Warmerdam","year":"2003","unstructured":"Warmerdam, T. J., Schr\u00f6der, F. H., Wit, H. P. & Albers, F. W. Perilymphatic and endolymphatic pressures during endolymphatic hydrops. Eur. Arch. Otorhinolaryngol. 260, 9\u201311 (2003).","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"24549_CR15","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/BF00168023","volume":"252","author":"SN Merchant","year":"1995","unstructured":"Merchant, S. N., Rauch, S. D. & Nadol, J. B. Jr Meniere\u2019s disease. Eur. Arch. Otorhinolaryngol. 252, 63\u201375 (1995).","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"24549_CR16","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1097\/00129492-200501000-00013","volume":"26","author":"SN Merchant","year":"2005","unstructured":"Merchant, S. N., Adams, J. C. & Nadol, J. B. Jr Pathophysiology of meniere\u2019s syndrome: are symptoms caused by endolymphatic hydrops? Otol Neurotol. 26, 74\u201381 (2005).","journal-title":"Otol Neurotol"},{"key":"24549_CR17","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1001\/jamaoto.2021.4282","volume":"148","author":"HG Rizk","year":"2022","unstructured":"Rizk, H. G. et al. Pathogenesis and etiology of M\u00e9ni\u00e8re disease: a scoping review of a century of evidence. JAMA Otolaryngol. Head Neck Surg. 148, 360\u2013368 (2022).","journal-title":"JAMA Otolaryngol. Head Neck Surg."},{"key":"24549_CR18","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1097\/MAO.0000000000001377","volume":"38","author":"APO Ferster","year":"2017","unstructured":"Ferster, A. P. O., Cureoglu, S., Keskin, N., Paparella, M. M. & Isildak, H. Secondary endolymphatic hydrops. Otol Neurotol. 38, 774\u2013779 (2017).","journal-title":"Otol Neurotol"},{"key":"24549_CR19","doi-asserted-by":"publisher","first-page":"879","DOI":"10.3109\/00016489.2016.1169556","volume":"136","author":"T Ito","year":"2016","unstructured":"Ito, T. et al. Endolymphatic space size in patients with meniere\u2019s disease and healthy controls. Acta Otolaryngol. 136, 879\u2013882 (2016).","journal-title":"Acta Otolaryngol."},{"key":"24549_CR20","doi-asserted-by":"publisher","first-page":"e001555","DOI":"10.1136\/bmjopen-2012-001555","volume":"3","author":"I Pyykko","year":"2013","unstructured":"Pyykko, I., Nakashima, T., Yoshida, T., Zou, J. & Naganawa, S. Meniere\u2019s disease: a reappraisal supported by a variable latency of symptoms and the MRI visualisation of endolymphatic hydrops. BMJ Open. 3, e001555 (2013).","journal-title":"BMJ Open."},{"key":"24549_CR21","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD015249.pub2","author":"A Lee","year":"2023","unstructured":"Lee, A. et al. Surgical interventions for M\u00e9ni\u00e8re\u2019s disease. Cochrane Database Syst. Rev. https:\/\/doi.org\/10.1002\/14651858.CD015249.pub2 (2023).","journal-title":"Cochrane Database Syst. Rev."},{"key":"24549_CR22","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD015171.pub2","author":"KE Webster","year":"2023","unstructured":"Webster, K. E. et al. Systemic Pharmacological interventions for M\u00e9ni\u00e8re\u2019s disease. Cochrane Database Syst. Rev. https:\/\/doi.org\/10.1002\/14651858.CD015171.pub2 (2023).","journal-title":"Cochrane Database Syst. Rev."},{"key":"24549_CR23","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1007\/s00401-018-1927-7","volume":"137","author":"AH Eckhard","year":"2019","unstructured":"Eckhard, A. H. et al. Inner ear pathologies impair sodium-regulated ion transport in meniere\u2019s disease. Acta Neuropathol. 137, 343\u2013357 (2019).","journal-title":"Acta Neuropathol."},{"key":"24549_CR24","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.otohns.2003.09.008","volume":"130","author":"S Cureoglu","year":"2004","unstructured":"Cureoglu, S., Schachern, P. A., Paul, S., Paparella, M. M. & Singh, R. K. Cellular changes of reissner\u2019s membrane in meniere\u2019s disease: human Temporal bone study. Otolaryngol. Head Neck Surg. 130, 113\u2013119 (2004).","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"24549_CR25","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1177\/000348949110000405","volume":"100","author":"TH Yoon","year":"1991","unstructured":"Yoon, T. H., Schachern, P. A., Paparella, M. M. & Le, C. T. Cellular changes in reissner\u2019s membrane in endolymphatic hydrops. Ann. Otol Rhinol Laryngol. 100, 288\u2013293 (1991).","journal-title":"Ann. Otol Rhinol Laryngol"},{"key":"24549_CR26","doi-asserted-by":"publisher","first-page":"e2119903119","DOI":"10.1073\/pnas.2119903119","volume":"119","author":"C Okimura","year":"2022","unstructured":"Okimura, C. et al. Leading-edge elongation by follower cell interruption in advancing epithelial cell sheets. Proc. Natl. Acad. Sci. USA. 119, e2119903119 (2022).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"24549_CR27","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1097\/MAO.0000000000001094","volume":"37","author":"JB Nadol Jr","year":"2016","unstructured":"Nadol, J. B. Jr Focal endolymphatic hydrops as seen in the Pars inferior of the human inner ear. Otol Neurotol. 37, 859\u2013864 (2016).","journal-title":"Otol Neurotol"},{"key":"24549_CR28","doi-asserted-by":"publisher","first-page":"674170","DOI":"10.3389\/fneur.2021.674170","volume":"12","author":"D Bachinger","year":"2021","unstructured":"Bachinger, D., Schuknecht, B., Dlugaiczyk, J. & Eckhard, A. H. Radiological configuration of the vestibular aqueduct predicts bilateral progression in meniere\u2019s disease. Front. Neurol. 12, 674170 (2021).","journal-title":"Front. Neurol."},{"key":"24549_CR29","first-page":"547","volume-title":"Osmotic and Ionic Regulation: Cells and Animals","author":"ZML K RKH","year":"2008","unstructured":"K RKH, Z. M. L. Specific organ adaptations to osmoregulatory demands. In Osmotic and Ionic Regulation: Cells and Animals 547\u2013553 (CRC, 2008)."},{"key":"24549_CR30","doi-asserted-by":"publisher","first-page":"C544","DOI":"10.1152\/ajpcell.00338.2008","volume":"296","author":"SH Kim","year":"2009","unstructured":"Kim, S. H., Marcus, D. C. & Adams, J. C. Regulation of ENaC-mediated sodium transport by glucocorticoids in reissner\u2019s membrane epithelium. Am. J. Physiol. Cell. Physiol. 296, C544\u2013C557 (2009).","journal-title":"Am. J. Physiol. Cell. Physiol."},{"key":"24549_CR31","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1046\/j.1460-9568.2001.01426.x","volume":"13","author":"S Gr\u00fcnder","year":"2001","unstructured":"Gr\u00fcnder, S., M\u00fcller, A. & Ruppersberg, J. P. Developmental and cellular expression pattern of epithelial sodium channel alpha, beta and gamma subunits in the inner ear of the rat. Eur. J. Neurosci. 13, 641\u2013648 (2001).","journal-title":"Eur. J. Neurosci."},{"key":"24549_CR32","doi-asserted-by":"publisher","first-page":"e95730","DOI":"10.1371\/journal.pone.0095730","volume":"9","author":"BG Kim","year":"2014","unstructured":"Kim, B. G. et al. Developmental changes of ENaC expression and function in the inner ear of pendrin knock-out mice as a perspective on the development of endolymphatic hydrops. PLoS One 9, e95730 (2014).","journal-title":"PLoS One"},{"key":"24549_CR33","doi-asserted-by":"publisher","first-page":"e26851","DOI":"10.7554\/eLife.26851","volume":"6","author":"K Honda","year":"2017","unstructured":"Honda, K. et al. Molecular architecture underlying fluid absorption by the developing inner ear. eLife 6, e26851 (2017).","journal-title":"eLife"},{"key":"24549_CR34","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1177\/019459988309100111","volume":"91","author":"HJ Koskas","year":"1983","unstructured":"Koskas, H. J., Linthicum, F. H. Jr & House, W. F. Membranous ruptures in meniere\u2019s disease: existence, location, and incidence. Otolaryngol. Head Neck Surg. 91, 61\u201367 (1983).","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"24549_CR35","first-page":"41","volume-title":"Meniere\u2019s Disease","author":"HF Schuknecht","year":"1999","unstructured":"Schuknecht, H. F. Histopathology of meniere\u2019s disease. In Meniere\u2019s Disease (ed. Harris, J. P.) 41\u201352 (Kugler, 1999)."},{"key":"24549_CR36","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/BF00238469","volume":"36","author":"AN Salt","year":"1979","unstructured":"Salt, A. N. & Stopp, P. E. The effect of Raising the scala tympani potassium concentration on the tone-induced cochlear responses of the Guinea pig. Exp. Brain Res. 36, 87\u201398 (1979).","journal-title":"Exp. Brain Res."},{"key":"24549_CR37","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1080\/00016480600621722","volume":"126","author":"WL Valk","year":"2006","unstructured":"Valk, W. L., Wit, H. P. & Albers, F. W. Rupture of reissner\u2019s membrane during acute endolymphatic hydrops in the Guinea pig: a model for M\u00e9ni\u00e8re\u2019s disease? Acta Otolaryngol. 126, 1030\u20131035 (2006).","journal-title":"Acta Otolaryngol."},{"key":"24549_CR38","first-page":"24","volume-title":"Schuknecht\u2019s Pathology of the Ear","author":"SN Merchant","year":"2010","unstructured":"Merchant, S. N. & Nadol, J. B. Jr. Method of removal, preparation, and study \u2013 artifacts. In Schuknecht\u2019s Pathology of the Ear 24\u201326 (People\u2019s Medical Publishing House, 2010)."},{"key":"24549_CR39","doi-asserted-by":"publisher","first-page":"105294","DOI":"10.1016\/j.ebiom.2024.105294","volume":"107","author":"ZL Li","year":"2024","unstructured":"Li, Z. L. et al. Renal tubular epithelial cells response to injury in acute kidney injury. EBioMedicine 107, 105294 (2024).","journal-title":"EBioMedicine"},{"key":"24549_CR40","doi-asserted-by":"publisher","first-page":"F595","DOI":"10.1152\/ajprenal.00134.2023","volume":"325","author":"RL Chevalier","year":"2023","unstructured":"Chevalier, R. L. Why is chronic kidney disease progressive? Evolutionary adaptations and maladaptations. Am. J. Physiol. Ren. Physiol. 325, F595\u2013F617 (2023).","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"24549_CR41","doi-asserted-by":"publisher","first-page":"1764","DOI":"10.3748\/wjg.v23.i10.1764","volume":"23","author":"F Marongiu","year":"2017","unstructured":"Marongiu, F. et al. Hyperplasia vs hypertrophy in tissue regeneration after extensive liver resection. World J. Gastroenterol. 23, 1764\u20131770 (2017).","journal-title":"World J. Gastroenterol."},{"key":"24549_CR42","doi-asserted-by":"publisher","first-page":"bqad095","DOI":"10.1210\/endocr\/bqad136","volume":"164","author":"M Romitti","year":"2023","unstructured":"Romitti, M. & Costagliola, S. Progress toward and challenges remaining for thyroid tissue regeneration. Endocrinology 164, bqad095 (2023).","journal-title":"Endocrinology"},{"key":"24549_CR43","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1038\/nrneph.2015.3","volume":"11","author":"DA Ferenbach","year":"2015","unstructured":"Ferenbach, D. A. & Bonventre, J. V. Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD. Nat. Rev. Nephrol. 11, 264\u2013276 (2015).","journal-title":"Nat. Rev. Nephrol."},{"key":"24549_CR44","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/s00467-013-2494-8","volume":"29","author":"HW Schnaper","year":"2014","unstructured":"Schnaper, H. W. Remnant nephron physiology and the progression of chronic kidney disease. Pediatr. Nephrol. 29, 193\u2013202 (2014).","journal-title":"Pediatr. Nephrol."},{"key":"24549_CR45","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/0378-5955(94)90180-5","volume":"74","author":"AN Salt","year":"1994","unstructured":"Salt, A. N. & DeMott, J. Endolymph calcium increases with time after surgical induction of hydrops in guinea-pigs. Hear. Res. 74, 115\u2013121 (1994).","journal-title":"Hear. Res."},{"key":"24549_CR46","first-page":"1002","volume":"105","author":"H Silverstein","year":"1996","unstructured":"Silverstein, H. Endolymphatic ion concentration in meniere\u2019s disease. Ann. Otol Rhinol Laryngol. 105, 1002\u20131002 (1996).","journal-title":"Ann. Otol Rhinol Laryngol"},{"key":"24549_CR47","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1288\/00005537-199204000-00011","volume":"102","author":"I Sziklai","year":"1992","unstructured":"Sziklai, I., Ferrary, E., Horner, K. C., Sterkers, O. & Amiel, C. Time-related alteration of endolymph composition in an experimental model of endolymphatic hydrops. Laryngoscope 102, 431\u2013438 (1992).","journal-title":"Laryngoscope"},{"key":"24549_CR48","doi-asserted-by":"publisher","first-page":"18","DOI":"10.3109\/00016488809125131","volume":"460","author":"Meyer zum Gottesberge AM","year":"1988","unstructured":"Meyer zum Gottesberge AM. Imbalanced calcium homeostasis and endolymphatic hydrops. Acta Otolaryngol. Suppl. 460, 18\u201327 (1988).","journal-title":"Acta Otolaryngol. Suppl."},{"key":"24549_CR49","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1177\/000348949410300607","volume":"103","author":"I Ichimiya","year":"1994","unstructured":"Ichimiya, I., Adams, J. C. & Kimura, R. S. Changes in immunostaining of cochleas with experimentally induced endolymphatic hydrops. Ann. Otol Rhinol Laryngol. 103, 457\u2013468 (1994).","journal-title":"Ann. Otol Rhinol Laryngol"},{"key":"24549_CR50","volume-title":"Schuknecht\u2019s Pathology of the Ear","author":"SN Merchant","year":"2010","unstructured":"Merchant, S. N. Schuknecht\u2019s Pathology of the Ear (PMPH-USA, 2010)."},{"key":"24549_CR51","doi-asserted-by":"publisher","first-page":"16878","DOI":"10.1038\/s41598-017-17204-5","volume":"7","author":"P Bankhead","year":"2017","unstructured":"Bankhead, P. et al. QuPath: Open source software for digital pathology image analysis. Sci. Rep. 7, 16878 (2017).","journal-title":"Sci. Rep."},{"key":"24549_CR52","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1186\/s12859-017-1934-z","volume":"18","author":"CT Rueden","year":"2017","unstructured":"Rueden, C. T. et al. ImageJ2: ImageJ for the next generation of scientific image data. BMC Bioinform. 18, 529 (2017).","journal-title":"BMC Bioinform."},{"key":"24549_CR53","doi-asserted-by":"publisher","first-page":"22560","DOI":"10.1038\/s41598-025-06083-w","volume":"15","author":"J Telischi","year":"2025","unstructured":"Telischi, J. et al. MRI-based measurement of inner ear fluids reveals increased endolymph volume variability in patients with endolymphatic hydrops and hearing instability. Sci. Rep. 15, 22560 (2025).","journal-title":"Sci. Rep."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-24549-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-24549-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-24549-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T13:04:02Z","timestamp":1763557442000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-24549-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,19]]},"references-count":53,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["24549"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-24549-9","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2025.03.11.642574","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,19]]},"assertion":[{"value":"15 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"40801"}}