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This prospective cross-sectional study included 31 patients (61 eyes) with ODD and 21 age-matched controls (42 eyes), aged 6\u201318 years. pRNFL thickness was measured with Spectralis SD-OCT at 3.5\u00a0mm and 4.7\u00a0mm peripapillary rings; rGCL was assessed at the posterior pole. ODD were graded by OCT and ultrasound criteria as follows: A; deep ODD detectable by ultrasound, exclusively. B; deep ODD detectable by OCT and located below Bruch\u00b4s membrane (BM), C; superficial\u2009\u2264\u20095, and D; superficial\u2009&gt;\u20095 ODD above BM, respectively. At 3.5\u00a0mm, stage D ODD showed significant pRNFL thinning in the temporal superior (TS), nasal superior (NS) and nasal (N) sector, while stage C showed significant thickening TS, NS, temporal inferior (TI), and globally. At 4.7\u00a0mm, stage D ODD showed thinning in all sectors, most pronounced TS, NS and TI; the temporal sector was most preserved. Stage C did not differ from controls here. rGCL was thickened in stage B superior (S), NS, nasal inferior (NS)\u00a0and globally, and in stage C in all sectors but TI. Stage D showed significant global thinning in all sectors, most temporal, least nasal. Thus, rGCL thickening preceded pRNFL changes; 3.5\u00a0mm detected early congestion, 4.7\u00a0mm revealed atrophy; the papillomacular bundle was relatively preserved. In pediatric patients deep drusen and those advancing toward the optic nerve head surface first cause sector-specific swelling of both pRNFL and rGCL followed by atrophy in the very same sectors. Larger patient cohorts and prospective longitudinal studies are needed to define whether these findings occur in a chronological order. If so, such data may become of prognostic value for visual functions in ODD patients.<\/jats:p>","DOI":"10.1038\/s41598-025-25161-7","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:45:55Z","timestamp":1762505155000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Retinal peripapillary nerve fiber and retinal ganglion cell layer thickening preceed atrophy in children and teenagers with optic disc drusen"],"prefix":"10.1038","volume":"15","author":[{"given":"L.","family":"Rudolph","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Baldassarre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Halfter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Lottspeich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Rudolph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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