{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:06:58Z","timestamp":1772136418397,"version":"3.50.1"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Research Project of Basic Science (Natural Science) in Colleges and Universities of Jiangsu Province","award":["NO. 23KJD350004"],"award-info":[{"award-number":["NO. 23KJD350004"]}]},{"name":"Research Project of Basic Science (Natural Science) in Colleges and Universities of Jiangsu Province","award":["NO. 23KJD350004"],"award-info":[{"award-number":["NO. 23KJD350004"]}]},{"name":"Research Project of Basic Science (Natural Science) in Colleges and Universities of Jiangsu Province","award":["NO. 23KJD350004"],"award-info":[{"award-number":["NO. 23KJD350004"]}]},{"name":"Research Project of Basic Science (Natural Science) in Colleges and Universities of Jiangsu Province","award":["NO. 23KJD350004"],"award-info":[{"award-number":["NO. 23KJD350004"]}]},{"name":"2024 Taizhou Vocational Education Federation (Taizhou Vocational Education Group) - Taizhou Polytechnic College Joint Research Project","award":["NO. 2024BZD02"],"award-info":[{"award-number":["NO. 2024BZD02"]}]},{"name":"2024 Taizhou Vocational Education Federation (Taizhou Vocational Education Group) - Taizhou Polytechnic College Joint Research Project","award":["NO. 2024BZD02"],"award-info":[{"award-number":["NO. 2024BZD02"]}]},{"name":"2024 Taizhou Vocational Education Federation (Taizhou Vocational Education Group) - Taizhou Polytechnic College Joint Research Project","award":["NO. 2024BZD02"],"award-info":[{"award-number":["NO. 2024BZD02"]}]},{"name":"2024 Taizhou Vocational Education Federation (Taizhou Vocational Education Group) - Taizhou Polytechnic College Joint Research Project","award":["NO. 2024BZD02"],"award-info":[{"award-number":["NO. 2024BZD02"]}]},{"name":"2023 Jiangsu Province University \u201cBlue Project\u201d Excellent Teaching Team"},{"name":"2024 College Students\u2019 Innovation and Entrepreneurship Cultivation Plan Project","award":["TZY2024024"],"award-info":[{"award-number":["TZY2024024"]}]},{"name":"2024 College Students\u2019 Innovation and Entrepreneurship Cultivation Plan Project","award":["TZY2024024"],"award-info":[{"award-number":["TZY2024024"]}]},{"name":"2024 College Students\u2019 Innovation and Entrepreneurship Cultivation Plan Project","award":["TZY2024024"],"award-info":[{"award-number":["TZY2024024"]}]},{"name":"2024 College Students\u2019 Innovation and Entrepreneurship Cultivation Plan Project","award":["TZY2024024"],"award-info":[{"award-number":["TZY2024024"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-25907-3","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T15:29:30Z","timestamp":1764084570000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Design, synthesis, and antifungal activity of 14-aryloxy\/amide substituted andrographolide derivatives"],"prefix":"10.1038","volume":"15","author":[{"given":"Zhuyun","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jierui","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunying","family":"Sha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuyan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuqing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lizhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"issue":"1","key":"25907_CR1","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1094\/PDIS-06-23-1164-PDN","volume":"108","author":"Y Wang","year":"2024","unstructured":"Wang, Y. et al. First report of fusarium tricinctum causing root rot on Chinese Dwarf Cherry (Cerasus humilis) in China. Plant. Dis. 108 (1), 213 (2024).","journal-title":"Plant. Dis."},{"key":"25907_CR2","doi-asserted-by":"publisher","first-page":"1363460","DOI":"10.3389\/ffunb.2024.1363460","volume":"5","author":"M Mishra","year":"2024","unstructured":"Mishra, M., Srivastava, A., Singh, A., Pandey, G. C. & Srivastava, G. An overview of symbiotic and pathogenic interactions at the fungi-plant interface under environmental constraints. Front. Fungal Biol. 5, 1363460 (2024).","journal-title":"Front. Fungal Biol."},{"key":"25907_CR3","doi-asserted-by":"publisher","first-page":"113323","DOI":"10.1016\/j.postharvbio.2024.113323","volume":"221","author":"D Luciano-Rosario","year":"2025","unstructured":"Luciano-Rosario, D. et al. Mold in, mold out: harvest bins harbor viable inoculum that can be reduced using novel sanitation methods to manage blue mold decay of apples. Postharvest Biol. Tec. 221, 113323 (2025).","journal-title":"Postharvest Biol. Tec."},{"key":"25907_CR4","doi-asserted-by":"publisher","first-page":"104564","DOI":"10.1016\/j.fm.2024.104564","volume":"122","author":"M Dwivedi","year":"2024","unstructured":"Dwivedi, M., Singh, P. & Pandey, A. K. Botrytis fruit rot management: what have we achieved so far? Food Microbiol. 122, 104564 (2024).","journal-title":"Food Microbiol."},{"issue":"5","key":"25907_CR5","doi-asserted-by":"publisher","first-page":"055001","DOI":"10.1289\/EHP7484","volume":"129","author":"M Toda","year":"2021","unstructured":"Toda, M., Beer, K. D., Kuivila, K. M., Chiller, T. M. & Jackson, B. R. Trends in agricultural Triazole fungicide use in the united states, 1992\u20132016 and possible implications for antifungal-resistant fungi in human disease. Environ. Health Persp. 129 (5), 055001 (2021).","journal-title":"Environ. Health Persp"},{"key":"25907_CR6","doi-asserted-by":"publisher","first-page":"117433","DOI":"10.1016\/j.ecoenv.2024.117433","volume":"289","author":"ZK Wang","year":"2025","unstructured":"Wang, Z. K. et al. Effect of fungicides on soil respiration, microbial community, and enzyme activity: A global meta-analysis (1975\u20132024). Ecotoxicol. Environ. Saf. 289, 117433 (2025).","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"2","key":"25907_CR7","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1021\/acs.jmedchem.4c02757","volume":"68","author":"PZ Sun","year":"2025","unstructured":"Sun, P. Z., Sun, S. X., Kong, W. L. & Li, S. K. In pursuit of lead innovation: pharmaceutically important and distinct amide-free succinate dehydrogenase inhibitors. J. Med. Chem. 68 (2), 1051\u20131067 (2025).","journal-title":"J. Med. Chem."},{"key":"25907_CR8","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.indcrop.2017.11.013","volume":"112","author":"F Abed-Ashtiani","year":"2017","unstructured":"Abed-Ashtiani, F. et al. Plant tonic, a plant-derived bioactive natural product, exhibits antifungal activity against rice blast disease. Ind. Crop Prod. 112, 105\u2013112 (2017).","journal-title":"Ind. Crop Prod."},{"issue":"16","key":"25907_CR9","doi-asserted-by":"publisher","first-page":"6236","DOI":"10.1021\/acs.jafc.2c09037","volume":"71","author":"YB Bai","year":"2023","unstructured":"Bai, Y. B. et al. Synthesis and antifungal activity of derivatives of the natural product Griseofulvin against phytopathogenic fungi. J. Agric. Food Chem. 71 (16), 6236\u20136248 (2023).","journal-title":"J. Agric. Food Chem."},{"issue":"11","key":"25907_CR10","doi-asserted-by":"publisher","first-page":"5983","DOI":"10.1021\/acs.jafc.3c06032","volume":"72","author":"P Dai","year":"2024","unstructured":"Dai, P. et al. Design, synthesis, antifungal activity, and 3D-QASR of novel oxime ether-containing coumarin derivatives as potential fungicides. J. Agric. Food Chem. 72 (11), 5983\u20135992 (2024).","journal-title":"J. Agric. Food Chem."},{"key":"25907_CR11","doi-asserted-by":"publisher","first-page":"126867","DOI":"10.1016\/j.micres.2021.126867","volume":"252","author":"ES Armengol","year":"2021","unstructured":"Armengol, E. S., Harmanci, M. & Laffleur, F. Current strategies to determine antifungal and antimicrobial activity of natural compounds. Microbiol. Res. 252, 126867 (2021).","journal-title":"Microbiol. Res."},{"issue":"17","key":"25907_CR12","doi-asserted-by":"publisher","first-page":"4210","DOI":"10.3390\/molecules29174210","volume":"29","author":"AM Orellana-Paucar","year":"2024","unstructured":"Orellana-Paucar, A. M. Turmeric essential oil constituents as potential drug candidates: a comprehensive overview of their individual bioactivities. Molecules 29 (17), 4210 (2024).","journal-title":"Molecules"},{"issue":"17","key":"25907_CR13","doi-asserted-by":"publisher","first-page":"5562","DOI":"10.3390\/molecules27175562","volume":"27","author":"JJ Liang","year":"2022","unstructured":"Liang, J. J. et al. Biological activities and secondary metabolites from sophora tonkinensis and its endophytic fungi. Molecules 27 (17), 5562 (2022).","journal-title":"Molecules"},{"key":"25907_CR14","doi-asserted-by":"publisher","first-page":"154266","DOI":"10.1016\/j.phymed.2022.154266","volume":"104","author":"HX Xiao","year":"2022","unstructured":"Xiao, H. X. et al. Lycorine and organ protection: review of its potential effects and molecular mechanisms. Phytomedicine 104, 154266 (2022).","journal-title":"Phytomedicine"},{"issue":"17","key":"25907_CR15","doi-asserted-by":"publisher","first-page":"9440","DOI":"10.1039\/C8RA01063C","volume":"8","author":"F Li","year":"2018","unstructured":"Li, F. et al. Discovery and preliminary SAR of 14-aryloxy-andrographolide derivatives as antibacterial agents with immunosuppressant activity. RSC Adv. 8 (17), 9440\u20139456 (2018).","journal-title":"RSC Adv."},{"key":"25907_CR16","doi-asserted-by":"publisher","first-page":"e2408028","DOI":"10.4014\/jmb.2408.08028","volume":"35","author":"GS Dafur","year":"2025","unstructured":"Dafur, G. S., Harun, A., Kub, T. N. T., Bakar, R. A. & Harun, A. A systematic review on the antimicrobial activity of Andrographolide. J. Microbiol. Biotechnol. 35, e2408028 (2025).","journal-title":"J. Microbiol. Biotechnol."},{"key":"25907_CR17","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.bioorg.2019.01.020","volume":"86","author":"M Xu","year":"2019","unstructured":"Xu, M. et al. Evaluation of andrographolide-based analogs derived from Andrographis paniculata against Mythimna separata walker and Tetranychus cinnabarinus boisduval. Bioorg. Chem. 86, 28\u201333 (2019).","journal-title":"Bioorg. Chem."},{"issue":"12","key":"25907_CR18","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1038\/s41419-019-2195-8","volume":"10","author":"J Gao","year":"2019","unstructured":"Gao, J. et al. Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced lung inflammation and fibrosis. Cell. Death Dis. 10 (12), 957 (2019).","journal-title":"Cell. Death Dis."},{"issue":"1","key":"25907_CR19","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1142\/S0192415X23500088","volume":"51","author":"CC Yen","year":"2023","unstructured":"Yen, C. C. et al. W. Andrographolide attenuates oxidized LDL-induced activation of the NLRP3 inflammasome in bone marrow-derived macrophages and mitigates HFCCD-induced atherosclerosis in mice. AM. J. Chin. Med. 51 (1), 129\u2013147 (2023).","journal-title":"AM. J. Chin. Med."},{"key":"25907_CR20","doi-asserted-by":"publisher","first-page":"100134","DOI":"10.1016\/j.bioflm.2023.100134","volume":"5","author":"JC \u017diemyt\u0117 Migl\u0117, Rodr\u00edguez-D\u00edaz","year":"2023","unstructured":"\u017diemyt\u0117 Migl\u0117, Rodr\u00edguez-D\u00edaz, J. C., Ventero-Mart\u00edn Mar\u00eda, P., Alex, M. & Ferrer, M. D. Real-time monitoring of biofilm growth identifies Andrographolide as a potent antifungal compound eradicating Candida biofilms. Biofilm 5, 100134 (2023).","journal-title":"Biofilm"},{"issue":"6","key":"25907_CR21","doi-asserted-by":"publisher","first-page":"35","DOI":"10.22270\/jddt.v13i6.5847","volume":"13","author":"AG Mansuk","year":"2023","unstructured":"Mansuk, A. G. & Pachpute, T. S. Comprehensive assessment of transcorneal permeation, antimicrobial, and antifungal activities of andrographolide-loaded nanosuspension: in vitro and in vivo studies. J. Drug Deliv Ther. 13 (6), 35\u201342 (2023).","journal-title":"J. Drug Deliv Ther."},{"key":"25907_CR22","doi-asserted-by":"publisher","first-page":"e19544","DOI":"10.7717\/peerj.19544","volume":"13","author":"GS Dafur","year":"2025","unstructured":"Dafur, G. S. et al. Antifungal effects of Andrographolide and its combination with amphotericin B against selected fungal pathogens. PeerJ 13, e19544 (2025).","journal-title":"PeerJ"},{"issue":"26","key":"25907_CR23","doi-asserted-by":"publisher","first-page":"13533","DOI":"10.1039\/C3RA46715E","volume":"4","author":"ZY Liu","year":"2014","unstructured":"Liu, Z. Y. et al. Synthesis and discovery of Andrographolide derivatives as non-steroidal farnesoid X receptor (FXR) antagonists. RSC Adv. 4 (26), 13533\u201313545 (2014).","journal-title":"RSC Adv."},{"key":"25907_CR24","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/j.bcp.2019.03.019","volume":"163","author":"BJ Guo","year":"2019","unstructured":"Guo, B. J. et al. Andrographolide derivative ameliorates dextran sulfate sodium-induced experimental colitis in mice. Biochem. Pharmacol. 163, 416\u2013424 (2019).","journal-title":"Biochem. Pharmacol."},{"key":"25907_CR25","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.phytol.2024.11.010","volume":"65","author":"SS Yang","year":"2025","unstructured":"Yang, S. S. et al. Design, synthesis, and antifungal activity of hydrazone schiff bases containing cinnamaldehyde moieties. Phytochem Lett. 65, 53\u201357 (2025).","journal-title":"Phytochem Lett."},{"issue":"8","key":"25907_CR26","doi-asserted-by":"publisher","first-page":"3681","DOI":"10.1021\/acs.jafc.2c07712","volume":"71","author":"YH Zhang","year":"2023","unstructured":"Zhang, Y. H. et al. Discovery of N-phenylpropiolamide as a novel succinate dehydrogenase inhibitor scaffold with broad-spectrum antifungal activity on phytopathogenic fungi. J. Agric. Food Chem. 71 (8), 3681\u20133693 (2023).","journal-title":"J. Agric. Food Chem."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-25907-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-25907-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-25907-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T15:29:31Z","timestamp":1764084571000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-25907-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,25]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["25907"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-25907-3","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-7031196\/v1","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,25]]},"assertion":[{"value":"2 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"41906"}}