{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T02:07:42Z","timestamp":1764554862685,"version":"3.46.0"},"reference-count":138,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T00:00:00Z","timestamp":1763769600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T00:00:00Z","timestamp":1763769600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    To explore the changes in blood inflammatory cells (neutrophils, monocytes, platelets) and adaptive immune cells (lymphocytes) during chemotherapy, we retrospectively analysed medical records from 66 patients with unresectable Pancreatic Ductal Adenocarcinoma (PDAC) treated with the Gemcitabine-nab-Paclitaxel (GnP) regimen. Evaluations were conducted at baseline (pre-GnP, TA), after the first cycle (TB), and after the third cycle (TC) of treatment. In metastatic PDAC (mPDAC), the monocyte-to-lymphocyte ratio significantly increased at both TB and TC compared to TA, whereas no such change was observed in locally advanced PDAC (laPDAC) (interaction: p\u2009=\u20090.006). Platelet levels rose over time in both phenotypes, with a more pronounced increase in mPDAC (intergroup: p\u2009=\u20090.008). When stratified by gender, males with mPDAC showed an increase in monocyte percentages among total white blood cells (intergroup: p\u2009=\u20090.018), while both phenotypes exhibited rising platelet-to-lymphocyte ratios over time. In females, the platelet-to-lymphocyte ratio increased more significantly in laPDAC than in mPDAC (interaction: p\u2009=\u20090.046). GnP treatment notably increased circulating inflammatory cells and their relationships with lymphocytes in a manner dependent on both disease phenotype and gender. Pretreatment factors such as monocyte counts\u2009&lt;\u20090.6\u2009\u00d7\u200910\n                    <jats:sup>3<\/jats:sup>\n                    \/\u00b5l, lymphocyte counts\u2009&gt;\u20091\u2009\u00d7\u200910\n                    <jats:sup>3<\/jats:sup>\n                    \/\u00b5l, and a monocyte-to-lymphocyte ratio\u2009&lt;\u20090.43 were identified as independent predictors of survival.\n                  <\/jats:p>","DOI":"10.1038\/s41598-025-26219-2","type":"journal-article","created":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T04:53:47Z","timestamp":1763787227000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Immune cell changes following chemotherapy in advanced pancreatic cancer with variations based on gender"],"prefix":"10.1038","volume":"15","author":[{"given":"Roberto","family":"Aquilani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Corallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Maestri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Brugnatelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Iadarola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Viglio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Figini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatrice","family":"Filippi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domiziana","family":"Alaimo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvio","family":"Sporeni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Verri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Boschi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,22]]},"reference":[{"key":"26219_CR1","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1084\/jem.20170681","volume":"215","author":"ML Sulciner","year":"2018","unstructured":"Sulciner, M. L. et al. Resolvins suppress tumor growth and enhance cancer therapy. J. Exp. Med. 215, 115\u2013140. https:\/\/doi.org\/10.1084\/jem.20170681 (2018).","journal-title":"J. Exp. Med."},{"key":"26219_CR2","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1096\/fj.201800019RR","volume":"33","author":"J Chang","year":"2019","unstructured":"Chang, J. et al. Chemotherapy-generated cell debris stimulates colon carcinoma tumor growth via osteopontin. FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol. 33, 114\u2013125. https:\/\/doi.org\/10.1096\/fj.201800019RR (2019).","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"26219_CR3","doi-asserted-by":"publisher","first-page":"1698","DOI":"10.1073\/pnas.1803999116","volume":"116","author":"A Gartung","year":"2019","unstructured":"Gartung, A. et al. Suppression of chemotherapy-induced cytokine\/lipid mediator surge and ovarian cancer by a dual COX-2\/SEH inhibitor. Proc. Natl. Acad. Sci. USA. 116, 1698\u20131703. https:\/\/doi.org\/10.1073\/pnas.1803999116 (2019).","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"26219_CR4","doi-asserted-by":"publisher","first-page":"21576","DOI":"10.1073\/pnas.2007412117","volume":"117","author":"A Fishbein","year":"2020","unstructured":"Fishbein, A. et al. Resolution of eicosanoid\/cytokine storm prevents carcinogen and inflammation-initiated hepatocellular cancer progression. Proc. Natl. Acad. Sci. USA. 117, 21576\u201321587. https:\/\/doi.org\/10.1073\/pnas.2007412117 (2020).","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"26219_CR5","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1038\/s41416-019-0595-2","volume":"121","author":"Q Chen","year":"2019","unstructured":"Chen, Q. et al. Tumour cell-derived debris and IgG synergistically promote metastasis of pancreatic cancer by inducing inflammation via tumour-associated macrophages. Br. J. Cancer 121, 786\u2013795. https:\/\/doi.org\/10.1038\/s41416-019-0595-2 (2019).","journal-title":"Br. J. Cancer"},{"key":"26219_CR6","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/j.neo.2020.08.006","volume":"22","author":"SH Kim","year":"2020","unstructured":"Kim, S. H. et al. Breast cancer cell debris diminishes therapeutic efficacy through heme oxygenase-1-mediated inactivation of M1-like tumor-associated macrophages. Neoplasia N. Y. N 22, 606\u2013616. https:\/\/doi.org\/10.1016\/j.neo.2020.08.006 (2020).","journal-title":"Neoplasia N. Y. N"},{"key":"26219_CR7","doi-asserted-by":"publisher","first-page":"470","DOI":"10.3390\/antiox10030470","volume":"10","author":"SH Kim","year":"2021","unstructured":"Kim, S. H. et al. Reprograming of tumor-associated macrophages in breast tumor-bearing mice under chemotherapy by targeting heme oxygenase-1. Antioxid. Basel Switz. 10, 470. https:\/\/doi.org\/10.3390\/antiox10030470 (2021).","journal-title":"Antioxid. Basel Switz."},{"key":"26219_CR8","doi-asserted-by":"publisher","first-page":"e792s","DOI":"10.6061\/clinics\/2018\/e792s","volume":"73","author":"IA da Silva Junior","year":"2018","unstructured":"da Silva Junior, I. A., de Sousa Andrade, L. N., Jancar, S. & Chammas, R. Platelet activating factor receptor antagonists improve the efficacy of experimental chemo- and radiotherapy. Clin. Sao Paulo Braz. 73, e792s. https:\/\/doi.org\/10.6061\/clinics\/2018\/e792s (2018).","journal-title":"Clin. Sao Paulo Braz."},{"key":"26219_CR9","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/1476-4598-12-24","volume":"12","author":"K Abubaker","year":"2013","unstructured":"Abubaker, K. et al. Short-term single treatment of chemotherapy results in the enrichment of ovarian cancer stem cell-like cells leading to an increased tumor burden. Mol. Cancer 12, 24. https:\/\/doi.org\/10.1186\/1476-4598-12-24 (2013).","journal-title":"Mol. Cancer"},{"key":"26219_CR10","doi-asserted-by":"publisher","first-page":"5817","DOI":"10.2147\/OTT.S150456","volume":"10","author":"L Cui","year":"2017","unstructured":"Cui, L. et al. Chemotherapy induces ovarian cancer cell repopulation through the caspase 3-mediated arachidonic acid metabolic pathway. OncoTargets Ther. 10, 5817\u20135826. https:\/\/doi.org\/10.2147\/OTT.S150456 (2017).","journal-title":"OncoTargets Ther."},{"key":"26219_CR11","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1002\/1097-0142(20010201)91:3<578::AID-CNCR1037>3.0.CO;2-W","volume":"91","author":"KN Naresh","year":"2001","unstructured":"Naresh, K. N., Lakshminarayanan, K., Pai, S. A. & Borges, A. M. Apoptosis index is a predictor of metastatic phenotype in patients with early stage squamous carcinoma of the tongue: A hypothesis to support this paradoxical association. Cancer 91, 578\u2013584 (2001).","journal-title":"Cancer"},{"key":"26219_CR12","first-page":"177","volume":"1","author":"M Jalalinadoushan","year":"2004","unstructured":"Jalalinadoushan, M., Peivareh, H. & Azizzadeh Delshad, A. Correlation between apoptosis and histological grade of transitional cell carcinoma of urinary bladder. Urol. J. 1, 177\u2013179 (2004).","journal-title":"Urol. J."},{"key":"26219_CR13","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1054\/bjoc.1999.0928","volume":"82","author":"JS de Jong","year":"2000","unstructured":"de Jong, J. S., van Diest, P. J. & Baak, J. P. Number of apoptotic cells as a prognostic marker in invasive breast cancer. Br. J. Cancer 82, 368\u2013373. https:\/\/doi.org\/10.1054\/bjoc.1999.0928 (2000).","journal-title":"Br. J. Cancer"},{"key":"26219_CR14","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1097\/01.cej.0000198896.02185.68","volume":"15","author":"B Sun","year":"2006","unstructured":"Sun, B. et al. Extent, relationship and prognostic significance of apoptosis and cell proliferation in synovial sarcoma. Eur. J. Cancer Prev. Off. J. Eur. Cancer Prev. Organ. ECP 15, 258\u2013265. https:\/\/doi.org\/10.1097\/01.cej.0000198896.02185.68 (2006).","journal-title":"Eur. J. Cancer Prev. Off. J. Eur. Cancer Prev. Organ. ECP"},{"key":"26219_CR15","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/1472-6890-13-24","volume":"13","author":"J Alcaide","year":"2013","unstructured":"Alcaide, J. et al. The role and prognostic value of apoptosis in colorectal carcinoma. BMC Clin. Pathol. 13, 24. https:\/\/doi.org\/10.1186\/1472-6890-13-24 (2013).","journal-title":"BMC Clin. Pathol."},{"key":"26219_CR16","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1097\/COC.0000000000000798","volume":"44","author":"SB Holloway","year":"2021","unstructured":"Holloway, S. B., Colon, G. R., Zheng, W. & Lea, J. S. Tumor necrotic debris and high nuclear grade: Newly identified high-risk factors for early-stage endocervical adenocarcinoma. Am. J. Clin. Oncol. 44, 162\u2013168. https:\/\/doi.org\/10.1097\/COC.0000000000000798 (2021).","journal-title":"Am. J. Clin. Oncol."},{"key":"26219_CR17","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2107771118","volume":"118","author":"J Deng","year":"2021","unstructured":"Deng, J. et al. Eicosanoid regulation of debris-stimulated metastasis. Proc. Natl. Acad. Sci. USA. 118, e2107771118. https:\/\/doi.org\/10.1073\/pnas.2107771118 (2021).","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"26219_CR18","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.cmet.2019.06.001","volume":"30","author":"I Vitale","year":"2019","unstructured":"Vitale, I., Manic, G., Coussens, L. M., Kroemer, G. & Galluzzi, L. Macrophages and metabolism in the tumor microenvironment. Cell Metab. 30, 36\u201350. https:\/\/doi.org\/10.1016\/j.cmet.2019.06.001 (2019).","journal-title":"Cell Metab."},{"key":"26219_CR19","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1038\/nrclinonc.2016.217","volume":"14","author":"A Mantovani","year":"2017","unstructured":"Mantovani, A., Marchesi, F., Malesci, A., Laghi, L. & Allavena, P. Tumour-associated macrophages as treatment targets in oncology. Nat. Rev. Clin. Oncol. 14, 399\u2013416. https:\/\/doi.org\/10.1038\/nrclinonc.2016.217 (2017).","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"26219_CR20","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/j.immuni.2016.02.017","volume":"44","author":"L van de Laar","year":"2016","unstructured":"van de Laar, L. et al. Yolk sac macrophages, fetal liver, and adult monocytes can colonize an empty niche and develop into functional tissue-resident macrophages. Immunity 44, 755\u2013768. https:\/\/doi.org\/10.1016\/j.immuni.2016.02.017 (2016).","journal-title":"Immunity"},{"key":"26219_CR21","doi-asserted-by":"publisher","first-page":"2536","DOI":"10.1084\/jem.20180534","volume":"215","author":"P-L Loyher","year":"2018","unstructured":"Loyher, P.-L. et al. Macrophages of distinct origins contribute to tumor development in the lung. J. Exp. Med. 215, 2536\u20132553. https:\/\/doi.org\/10.1084\/jem.20180534 (2018).","journal-title":"J. Exp. Med."},{"key":"26219_CR22","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1089\/ars.2016.6704","volume":"25","author":"K Movahedi","year":"2016","unstructured":"Movahedi, K. & Van Ginderachter, J. A. The ontogeny and microenvironmental regulation of tumor-associated macrophages. Antioxid. Redox Signal. 25, 775\u2013791. https:\/\/doi.org\/10.1089\/ars.2016.6704 (2016).","journal-title":"Antioxid. Redox Signal."},{"key":"26219_CR23","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1158\/1078-0432.CCR-22-1031","volume":"29","author":"KB Kennel","year":"2023","unstructured":"Kennel, K. B., Bozlar, M., De Valk, A. F. & Greten, F. R. Cancer-associated fibroblasts in inflammation and antitumor immunity. Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res. 29, 1009\u20131016. https:\/\/doi.org\/10.1158\/1078-0432.CCR-22-1031 (2023).","journal-title":"Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res."},{"key":"26219_CR24","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1002\/eji.201142093","volume":"42","author":"D Sekar","year":"2012","unstructured":"Sekar, D., Hahn, C., Br\u00fcne, B., Roberts, E. & Weigert, A. Apoptotic tumor cells induce IL-27 release from human DCs to activate Treg cells that express CD69 and attenuate cytotoxicity. Eur. J. Immunol. 42, 1585\u20131598. https:\/\/doi.org\/10.1002\/eji.201142093 (2012).","journal-title":"Eur. J. Immunol."},{"key":"26219_CR25","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/0165-2478(94)00149-9","volume":"43","author":"RS Kornbluth","year":"1994","unstructured":"Kornbluth, R. S. The Immunological potential of apoptotic debris produced by tumor cells and during HIV infection. Immunol. Lett. 43, 125\u2013132. https:\/\/doi.org\/10.1016\/0165-2478(94)00149-9 (1994).","journal-title":"Immunol. Lett."},{"key":"26219_CR26","doi-asserted-by":"publisher","first-page":"2964","DOI":"10.1172\/JCI127282","volume":"129","author":"D Panigrahy","year":"2019","unstructured":"Panigrahy, D. et al. Preoperative stimulation of resolution and inflammation blockade eradicates micrometastases. J. Clin. Invest. 129, 2964\u20132979. https:\/\/doi.org\/10.1172\/JCI127282 (2019).","journal-title":"J. Clin. Invest."},{"key":"26219_CR27","doi-asserted-by":"publisher","first-page":"363","DOI":"10.3390\/cancers15020363","volume":"15","author":"FJ Hansen","year":"2023","unstructured":"Hansen, F. J. et al. Circulating monocytes serve as novel prognostic biomarker in pancreatic ductal adenocarcinoma patients. Cancers 15, 363. https:\/\/doi.org\/10.3390\/cancers15020363 (2023).","journal-title":"Cancers"},{"key":"26219_CR28","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.cell.2010.03.014","volume":"141","author":"B-Z Qian","year":"2010","unstructured":"Qian, B.-Z. & Pollard, J. W. Macrophage diversity enhances tumor progression and metastasis. Cell 141, 39\u201351. https:\/\/doi.org\/10.1016\/j.cell.2010.03.014 (2010).","journal-title":"Cell"},{"key":"26219_CR29","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/nn.4185","volume":"19","author":"D Hambardzumyan","year":"2016","unstructured":"Hambardzumyan, D., Gutmann, D. H. & Kettenmann, H. The role of microglia and macrophages in glioma maintenance and progression. Nat. Neurosci. 19, 20\u201327. https:\/\/doi.org\/10.1038\/nn.4185 (2016).","journal-title":"Nat. Neurosci."},{"key":"26219_CR30","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/0167-5699(92)90008-U","volume":"13","author":"A Mantovani","year":"1992","unstructured":"Mantovani, A., Bottazzi, B., Colotta, F., Sozzani, S. & Ruco, L. The origin and function of tumor-associated macrophages. Immunol. Today 13, 265\u2013270. https:\/\/doi.org\/10.1016\/0167-5699(92)90008-U (1992).","journal-title":"Immunol. Today"},{"key":"26219_CR31","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1002\/ijc.2910220617","volume":"22","author":"A Mantovani","year":"1978","unstructured":"Mantovani, A. Effects on in vitro tumor growth of murine macrophages isolated from sarcoma lines differing in immunogenicity and metastasizing capacity. Int. J. Cancer 22, 741\u2013746. https:\/\/doi.org\/10.1002\/ijc.2910220617 (1978).","journal-title":"Int. J. Cancer"},{"key":"26219_CR32","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/j.ccr.2013.09.014","volume":"24","author":"F Klug","year":"2013","unstructured":"Klug, F. et al. Low-dose irradiation programs macrophage differentiation to an INOS+\/M1 phenotype that orchestrates effective T cell immunotherapy. Cancer Cell 24, 589\u2013602. https:\/\/doi.org\/10.1016\/j.ccr.2013.09.014 (2013).","journal-title":"Cancer Cell"},{"key":"26219_CR33","doi-asserted-by":"publisher","first-page":"3336","DOI":"10.1182\/blood.V87.8.3336.bloodjournal8783336","volume":"87","author":"B Barleon","year":"1996","unstructured":"Barleon, B. et al. Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor Flt-1. Blood 87, 3336\u20133343 (1996).","journal-title":"Blood"},{"key":"26219_CR34","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/j.cell.2005.12.032","volume":"124","author":"P Zhu","year":"2006","unstructured":"Zhu, P. et al. Macrophage\/cancer cell interactions mediate hormone resistance by a nuclear receptor derepression pathway. Cell 124, 615\u2013629. https:\/\/doi.org\/10.1016\/j.cell.2005.12.032 (2006).","journal-title":"Cell"},{"key":"26219_CR35","doi-asserted-by":"publisher","first-page":"1918","DOI":"10.1111\/j.1464-410X.2010.09804.x","volume":"107","author":"N Nonomura","year":"2011","unstructured":"Nonomura, N. et al. Infiltration of tumour-associated macrophages in prostate biopsy specimens is predictive of disease progression after hormonal therapy for prostate cancer. BJU Int. 107, 1918\u20131922. https:\/\/doi.org\/10.1111\/j.1464-410X.2010.09804.x (2011).","journal-title":"BJU Int."},{"key":"26219_CR36","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1158\/0008-5472.CAN-14-0992","volume":"75","author":"J Escamilla","year":"2015","unstructured":"Escamilla, J. et al. CSF1 receptor targeting in prostate cancer reverses macrophage-mediated resistance to androgen blockade therapy. Cancer Res. 75, 950\u2013962. https:\/\/doi.org\/10.1158\/0008-5472.CAN-14-0992 (2015).","journal-title":"Cancer Res."},{"key":"26219_CR37","doi-asserted-by":"publisher","first-page":"1792","DOI":"10.1158\/0008-5472.CAN-15-1801-T","volume":"76","author":"L De Monte","year":"2016","unstructured":"De Monte, L. et al. Basophil recruitment into tumor-draining lymph nodes correlates with Th2 inflammation and reduced survival in pancreatic cancer patients. Cancer Res. 76, 1792\u20131803. https:\/\/doi.org\/10.1158\/0008-5472.CAN-15-1801-T (2016).","journal-title":"Cancer Res."},{"key":"26219_CR38","doi-asserted-by":"publisher","first-page":"3151","DOI":"10.1158\/1535-7163.MCT-09-0255","volume":"8","author":"CL Manthey","year":"2009","unstructured":"Manthey, C. L. et al. JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor\/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia. Mol. Cancer Ther. 8, 3151\u20133161. https:\/\/doi.org\/10.1158\/1535-7163.MCT-09-0255 (2009).","journal-title":"Mol. Cancer Ther."},{"key":"26219_CR39","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1309\/AJCPR92TDDFARISU","volume":"141","author":"YW Koh","year":"2014","unstructured":"Koh, Y. W., Park, C., Yoon, D. H., Suh, C. & Huh, J. CSF-1R expression in tumor-associated macrophages is associated with worse prognosis in classical Hodgkin lymphoma. Am. J. Clin. Pathol. 141, 573\u2013583. https:\/\/doi.org\/10.1309\/AJCPR92TDDFARISU (2014).","journal-title":"Am. J. Clin. Pathol."},{"key":"26219_CR40","doi-asserted-by":"publisher","first-page":"5278","DOI":"10.1158\/0008-5472.CAN-04-1853","volume":"65","author":"S Goswami","year":"2005","unstructured":"Goswami, S. et al. Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1\/epidermal growth factor paracrine loop. Cancer Res. 65, 5278\u20135283. https:\/\/doi.org\/10.1158\/0008-5472.CAN-04-1853 (2005).","journal-title":"Cancer Res."},{"key":"26219_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.105111","volume":"161","author":"S-Y Zhang","year":"2020","unstructured":"Zhang, S.-Y. et al. Tumor-associated macrophages: A promising target for a cancer immunotherapeutic strategy. Pharmacol. Res. 161, 105111. https:\/\/doi.org\/10.1016\/j.phrs.2020.105111 (2020).","journal-title":"Pharmacol. Res."},{"key":"26219_CR42","doi-asserted-by":"publisher","first-page":"4548","DOI":"10.1200\/JCO.2011.36.5742","volume":"29","author":"DD Von Hoff","year":"2011","unstructured":"Von Hoff, D. D. et al. Gemcitabine plus Nab-paclitaxel is an active regimen in patients with advanced pancreatic cancer: A phase I\/II trial. J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol. 29, 4548\u20134554. https:\/\/doi.org\/10.1200\/JCO.2011.36.5742 (2011).","journal-title":"J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol."},{"key":"26219_CR43","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1158\/2159-8290.CD-11-0242","volume":"2","author":"KK Frese","year":"2012","unstructured":"Frese, K. K. et al. Nab-paclitaxel potentiates gemcitabine activity by reducing cytidine deaminase levels in a mouse model of pancreatic cancer. Cancer Discov. 2, 260\u2013269. https:\/\/doi.org\/10.1158\/2159-8290.CD-11-0242 (2012).","journal-title":"Cancer Discov."},{"key":"26219_CR44","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1056\/NEJMoa1304369","volume":"369","author":"DD Von Hoff","year":"2013","unstructured":"Von Hoff, D. D. et al. Increased survival in pancreatic cancer with Nab-paclitaxel plus gemcitabine. N. Engl. J. Med. 369, 1691\u20131703. https:\/\/doi.org\/10.1056\/NEJMoa1304369 (2013).","journal-title":"N. Engl. J. Med."},{"key":"26219_CR45","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1164\/rccm.201406-1137OC","volume":"191","author":"A Schmall","year":"2015","unstructured":"Schmall, A. et al. Macrophage and cancer cell cross-talk via CCR2 and CX3CR1 is a fundamental mechanism driving lung cancer. Am. J. Respir. Crit. Care Med. 191, 437\u2013447. https:\/\/doi.org\/10.1164\/rccm.201406-1137OC (2015).","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"26219_CR46","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1038\/nature10138","volume":"475","author":"B-Z Qian","year":"2011","unstructured":"Qian, B.-Z. et al. CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis. Nature 475, 222\u2013225. https:\/\/doi.org\/10.1038\/nature10138 (2011).","journal-title":"Nature"},{"key":"26219_CR47","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1136\/gutjnl-2015-310514","volume":"66","author":"X Li","year":"2017","unstructured":"Li, X. et al. Targeting of tumour-infiltrating macrophages via CCL2\/CCR2 signalling as a therapeutic strategy against hepatocellular carcinoma. Gut 66, 157\u2013167. https:\/\/doi.org\/10.1136\/gutjnl-2015-310514 (2017).","journal-title":"Gut"},{"key":"26219_CR48","doi-asserted-by":"publisher","first-page":"5728","DOI":"10.1158\/0008-5472.CAN-09-4672","volume":"70","author":"K Movahedi","year":"2010","unstructured":"Movahedi, K. et al. Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes. Cancer Res. 70, 5728\u20135739. https:\/\/doi.org\/10.1158\/0008-5472.CAN-09-4672 (2010).","journal-title":"Cancer Res."},{"key":"26219_CR49","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1038\/nature13862","volume":"515","author":"L Bonapace","year":"2014","unstructured":"Bonapace, L. et al. Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis. Nature 515, 130\u2013133. https:\/\/doi.org\/10.1038\/nature13862 (2014).","journal-title":"Nature"},{"key":"26219_CR50","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1126\/science.aac9407","volume":"350","author":"RN Hanna","year":"2015","unstructured":"Hanna, R. N. et al. Patrolling monocytes control tumor metastasis to the lung. Science 350, 985\u2013990. https:\/\/doi.org\/10.1126\/science.aac9407 (2015).","journal-title":"Science"},{"key":"26219_CR51","doi-asserted-by":"publisher","first-page":"3404","DOI":"10.1158\/1078-0432.CCR-13-0525","volume":"19","author":"DE Sanford","year":"2013","unstructured":"Sanford, D. E. et al. Inflammatory monocyte mobilization decreases patient survival in pancreatic cancer: A role for targeting the CCL2\/CCR2 axis. Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res. 19, 3404\u20133415. https:\/\/doi.org\/10.1158\/1078-0432.CCR-13-0525 (2013).","journal-title":"Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res."},{"key":"26219_CR52","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1146\/annurev-immunol-042718-041607","volume":"37","author":"CN Morrell","year":"2019","unstructured":"Morrell, C. N., Pariser, D. N., Hilt, Z. T. & Vega Ocasio, D. The platelet napoleon complex-small cells, but big immune regulatory functions. Annu. Rev. Immunol. 37, 125\u2013144. https:\/\/doi.org\/10.1146\/annurev-immunol-042718-041607 (2019).","journal-title":"Annu. Rev. Immunol."},{"key":"26219_CR53","doi-asserted-by":"publisher","first-page":"7363","DOI":"10.1073\/pnas.0401567101","volume":"101","author":"NY Yount","year":"2004","unstructured":"Yount, N. Y. & Yeaman, M. R. Multidimensional signatures in antimicrobial peptides. Proc. Natl. Acad. Sci. USA. 101, 7363\u20137368. https:\/\/doi.org\/10.1073\/pnas.0401567101 (2004).","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"26219_CR54","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1126\/science.1256478","volume":"346","author":"V Sreeramkumar","year":"2014","unstructured":"Sreeramkumar, V. et al. Neutrophils scan for activated platelets to initiate inflammation. Science 346, 1234\u20131238. https:\/\/doi.org\/10.1126\/science.1256478 (2014).","journal-title":"Science"},{"key":"26219_CR55","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1111\/j.1574-695X.2012.00945.x","volume":"65","author":"AH Riaz","year":"2012","unstructured":"Riaz, A. H., Tasma, B. E., Woodman, M. E., Wooten, R. M. & Worth, R. G. Human platelets efficiently kill IgG-opsonized E. coli. FEMS Immunol. Med. Microbiol. 65, 78\u201383. https:\/\/doi.org\/10.1111\/j.1574-695X.2012.00945.x (2012).","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"26219_CR56","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1111\/hpb.12355","volume":"17","author":"L Stevens","year":"2015","unstructured":"Stevens, L. et al. Prognostic significance of pre-operative C-reactive protein and the neutrophil-lymphocyte ratio in resectable pancreatic cancer: A systematic review. HPB 17, 285\u2013291. https:\/\/doi.org\/10.1111\/hpb.12355 (2015).","journal-title":"HPB"},{"key":"26219_CR57","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1186\/s12885-020-07182-9","volume":"20","author":"DT Pointer","year":"2020","unstructured":"Pointer, D. T. et al. Neutrophil to lymphocyte ratio, not platelet to lymphocyte or lymphocyte to monocyte ratio, is predictive of patient survival after resection of early-stage pancreatic ductal adenocarcinoma. BMC Cancer 20, 750. https:\/\/doi.org\/10.1186\/s12885-020-07182-9 (2020).","journal-title":"BMC Cancer"},{"key":"26219_CR58","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.ijsu.2018.05.030","volume":"55","author":"D Tan","year":"2018","unstructured":"Tan, D., Fu, Y., Tong, W. & Li, F. Prognostic significance of lymphocyte to monocyte ratio in colorectal cancer: A meta-analysis. Int. J. Surg. Lond. Engl. 55, 128\u2013138. https:\/\/doi.org\/10.1016\/j.ijsu.2018.05.030 (2018).","journal-title":"Int. J. Surg. Lond. Engl."},{"key":"26219_CR59","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1080\/0284186X.2022.2053198","volume":"61","author":"K Kamposioras","year":"2022","unstructured":"Kamposioras, K. et al. Markers of tumor inflammation as prognostic factors for overall survival in patients with advanced pancreatic cancer receiving first-line FOLFIRINOX chemotherapy. Acta Oncol. Stockh. Swed. 61, 583\u2013590. https:\/\/doi.org\/10.1080\/0284186X.2022.2053198 (2022).","journal-title":"Acta Oncol. Stockh. Swed."},{"key":"26219_CR60","unstructured":"Toria, N., Kikodze, N., Rukhadze, R., Mizandari, M. & Chikovani, T. Inflammatory biomarkers in patients with unresectable pancreatic cancer: A retrospective study. Georgian Med. News 21\u201326 (2020)."},{"key":"26219_CR61","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"D Hanahan","year":"2011","unstructured":"Hanahan, D. & Weinberg, R. A. Hallmarks of cancer: The next generation. Cell 144, 646\u2013674. https:\/\/doi.org\/10.1016\/j.cell.2011.02.013 (2011).","journal-title":"Cell"},{"key":"26219_CR62","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.ccr.2011.09.009","volume":"20","author":"M Labelle","year":"2011","unstructured":"Labelle, M., Begum, S. & Hynes, R. O. Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis. Cancer Cell 20, 576\u2013590. https:\/\/doi.org\/10.1016\/j.ccr.2011.09.009 (2011).","journal-title":"Cancer Cell"},{"key":"26219_CR63","doi-asserted-by":"publisher","first-page":"E3053","DOI":"10.1073\/pnas.1411082111","volume":"111","author":"M Labelle","year":"2014","unstructured":"Labelle, M., Begum, S. & Hynes, R. O. Platelets guide the formation of early metastatic niches. Proc. Natl. Acad. Sci. USA. 111, E3053-3061. https:\/\/doi.org\/10.1073\/pnas.1411082111 (2014).","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"26219_CR64","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1186\/s13045-018-0669-2","volume":"11","author":"M Schlesinger","year":"2018","unstructured":"Schlesinger, M. Role of platelets and platelet receptors in cancer metastasis. J. Hematol. Oncol. J. Hematol. Oncol. 11, 125. https:\/\/doi.org\/10.1186\/s13045-018-0669-2 (2018).","journal-title":"J. Hematol. Oncol. J. Hematol. Oncol."},{"key":"26219_CR65","doi-asserted-by":"publisher","first-page":"3174","DOI":"10.1182\/blood.2019003976","volume":"137","author":"HG Roweth","year":"2021","unstructured":"Roweth, H. G. & Battinelli, E. M. Lessons to learn from tumor-educated platelets. Blood 137, 3174\u20133180. https:\/\/doi.org\/10.1182\/blood.2019003976 (2021).","journal-title":"Blood"},{"key":"26219_CR66","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1002\/ncp.10087","volume":"33","author":"DD Yeh","year":"2018","unstructured":"Yeh, D. D. et al. Serum levels of albumin and prealbumin do not correlate with nutrient delivery in surgical intensive care unit patients. Nutr. Clin. Pract. Off. Publ. Am. Soc. Parenter. Enter. Nutr. 33, 419\u2013425. https:\/\/doi.org\/10.1002\/ncp.10087 (2018).","journal-title":"Nutr. Clin. Pract. Off. Publ. Am. Soc. Parenter. Enter. Nutr."},{"key":"26219_CR67","doi-asserted-by":"publisher","first-page":"335","DOI":"10.3233\/CBM-160645","volume":"17","author":"V Formica","year":"2016","unstructured":"Formica, V. et al. Neutrophil\/lymphocyte ratio helps select metastatic pancreatic cancer patients benefitting from oxaliplatin. Cancer Biomark. Sect. Dis. Markers 17, 335\u2013345. https:\/\/doi.org\/10.3233\/CBM-160645 (2016).","journal-title":"Cancer Biomark. Sect. Dis. Markers"},{"key":"26219_CR68","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1634\/theoncologist.2018-0786","volume":"24","author":"P Rochefort","year":"2019","unstructured":"Rochefort, P. et al. Long-term survivors in metastatic pancreatic ductal adenocarcinoma: A retrospective and matched pair analysis. Oncologist 24, 1543\u20131548. https:\/\/doi.org\/10.1634\/theoncologist.2018-0786 (2019).","journal-title":"Oncologist"},{"key":"26219_CR69","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s12967-019-1782-x","volume":"17","author":"K Zhang","year":"2019","unstructured":"Zhang, K. et al. Systemic immune-inflammation index predicts prognosis of patients with advanced pancreatic cancer. J. Transl. Med. 17, 30. https:\/\/doi.org\/10.1186\/s12967-019-1782-x (2019).","journal-title":"J. Transl. Med."},{"key":"26219_CR70","doi-asserted-by":"publisher","first-page":"3903","DOI":"10.21037\/tcr-19-2777","volume":"9","author":"Q-X Shang","year":"2020","unstructured":"Shang, Q.-X. et al. Clinical and prognostic significance of preoperative lymphocyte-monocyte ratio, neutrophil-lymphocyte ratio and neutrophil-monocyte ratio on esophageal squamous cell carcinoma patients. Transl. Cancer Res. 9, 3903\u20133914. https:\/\/doi.org\/10.21037\/tcr-19-2777 (2020).","journal-title":"Transl. Cancer Res."},{"key":"26219_CR71","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/nri3024","volume":"11","author":"A Mantovani","year":"2011","unstructured":"Mantovani, A., Cassatella, M. A., Costantini, C. & Jaillon, S. Neutrophils in the activation and regulation of innate and adaptive immunity. Nat. Rev. Immunol. 11, 519\u2013531. https:\/\/doi.org\/10.1038\/nri3024 (2011).","journal-title":"Nat. Rev. Immunol."},{"key":"26219_CR72","doi-asserted-by":"publisher","first-page":"1817","DOI":"10.1056\/NEJMoa1011923","volume":"364","author":"T Conroy","year":"2011","unstructured":"Conroy, T. et al. FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N. Engl. J. Med. 364, 1817\u20131825. https:\/\/doi.org\/10.1056\/NEJMoa1011923 (2011).","journal-title":"N. Engl. J. Med."},{"key":"26219_CR73","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1186\/s12967-016-1037-z","volume":"14","author":"E Eriksson","year":"2016","unstructured":"Eriksson, E., Wenthe, J., Irenaeus, S., Loskog, A. & Ullenhag, G. Gemcitabine reduces MDSCs, Tregs and TGF\u03b2-1 while restoring the Teff\/Treg ratio in patients with pancreatic cancer. J. Transl. Med. 14, 282. https:\/\/doi.org\/10.1186\/s12967-016-1037-z (2016).","journal-title":"J. Transl. Med."},{"key":"26219_CR74","doi-asserted-by":"publisher","first-page":"1800","DOI":"10.1111\/j.1538-7836.2005.01377.x","volume":"3","author":"SR Coughlin","year":"2005","unstructured":"Coughlin, S. R. Protease-activated receptors in hemostasis, thrombosis and vascular biology. J. Thromb. Haemost. JTH 3, 1800\u20131814. https:\/\/doi.org\/10.1111\/j.1538-7836.2005.01377.x (2005).","journal-title":"J. Thromb. Haemost. JTH"},{"issue":"Suppl 1","key":"26219_CR75","doi-asserted-by":"publisher","first-page":"S186","DOI":"10.1016\/S0049-3848(16)30160-8","volume":"140","author":"MA Adesanya","year":"2016","unstructured":"Adesanya, M. A., Maraveyas, A. & Madden, L. A. PO-27\u2014Thrombin generation in pancreatic cancer and multiple myeloma with use of calibrated automated thrombography. Thromb. Res. 140(Suppl 1), S186. https:\/\/doi.org\/10.1016\/S0049-3848(16)30160-8 (2016).","journal-title":"Thromb. Res."},{"key":"26219_CR76","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/s10555-014-9498-0","volume":"33","author":"DG Menter","year":"2014","unstructured":"Menter, D. G. et al. Platelets and cancer: A casual or causal relationship: revisited. Cancer Metastasis Rev. 33, 231\u2013269. https:\/\/doi.org\/10.1007\/s10555-014-9498-0 (2014).","journal-title":"Cancer Metastasis Rev."},{"key":"26219_CR77","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1002\/ijc.29847","volume":"138","author":"N Li","year":"2016","unstructured":"Li, N. Platelets in cancer metastasis: to help the \u201cVillain\u201d to do evil. Int. J. Cancer 138, 2078\u20132087. https:\/\/doi.org\/10.1002\/ijc.29847 (2016).","journal-title":"Int. J. Cancer"},{"key":"26219_CR78","doi-asserted-by":"publisher","first-page":"4015","DOI":"10.1182\/blood-2011-07-368514","volume":"118","author":"B Shao","year":"2011","unstructured":"Shao, B. et al. Carcinoma mucins trigger reciprocal activation of platelets and neutrophils in a murine model of trousseau syndrome. Blood 118, 4015\u20134023. https:\/\/doi.org\/10.1182\/blood-2011-07-368514 (2011).","journal-title":"Blood"},{"key":"26219_CR79","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0071447","volume":"8","author":"N Faraday","year":"2013","unstructured":"Faraday, N. et al. Cathepsin G-dependent modulation of platelet thrombus formation in vivo by blood neutrophils. PLoS ONE 8, e71447. https:\/\/doi.org\/10.1371\/journal.pone.0071447 (2013).","journal-title":"PLoS ONE"},{"key":"26219_CR80","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3389\/fimmu.2019.01805","volume":"2019","author":"AL Palacios-Acedo","year":"1805","unstructured":"Palacios-Acedo, A. L. et al. Platelets, thrombo-inflammation, and cancer: Collaborating with the enemy. Front. Immunol. 2019, 10. https:\/\/doi.org\/10.3389\/fimmu.2019.01805 (1805).","journal-title":"Front. Immunol."},{"key":"26219_CR81","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/676731","volume":"2012","author":"G Bendas","year":"2012","unstructured":"Bendas, G. & Borsig, L. Cancer cell adhesion and metastasis: Selectins, integrins, and the inhibitory potential of heparins. Int. J. Cell Biol. 2012, 676731. https:\/\/doi.org\/10.1155\/2012\/676731 (2012).","journal-title":"Int. J. Cell Biol."},{"key":"26219_CR82","first-page":"1295","volume":"59","author":"B Nieswandt","year":"1999","unstructured":"Nieswandt, B., Hafner, M., Echtenacher, B. & M\u00e4nnel, D. N. Lysis of tumor cells by natural killer cells in mice is impeded by platelets. Cancer Res. 59, 1295\u20131300 (1999).","journal-title":"Cancer Res."},{"key":"26219_CR83","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1007\/BF01209121","volume":"122","author":"E Heinm\u00f6ller","year":"1996","unstructured":"Heinm\u00f6ller, E. et al. Studies on tumor-cell-induced platelet aggregation in human lung cancer cell lines. J. Cancer Res. Clin. Oncol. 122, 735\u2013744. https:\/\/doi.org\/10.1007\/BF01209121 (1996).","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"26219_CR84","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.3109\/00365529509096346","volume":"30","author":"E Heinm\u00f6ller","year":"1995","unstructured":"Heinm\u00f6ller, E. et al. Tumor cell-induced platelet aggregation in vitro by human pancreatic cancer cell lines. Scand. J. Gastroenterol. 30, 1008\u20131016. https:\/\/doi.org\/10.3109\/00365529509096346 (1995).","journal-title":"Scand. J. Gastroenterol."},{"key":"26219_CR85","doi-asserted-by":"publisher","first-page":"4336","DOI":"10.1073\/pnas.77.7.4336","volume":"77","author":"E Pearlstein","year":"1980","unstructured":"Pearlstein, E., Salk, P. L., Yogeeswaran, G. & Karpatkin, S. Correlation between spontaneous metastatic potential, platelet-aggregating activity of cell surface extracts, and cell surface sialylation in 10 metastatic-variant derivatives of a rat renal sarcoma cell line. Proc. Natl. Acad. Sci. USA 77, 4336\u20134339. https:\/\/doi.org\/10.1073\/pnas.77.7.4336 (1980).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"26219_CR86","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1080\/10408363.2016.1200008","volume":"53","author":"XR Xu","year":"2016","unstructured":"Xu, X. R. et al. Platelets are versatile cells: New discoveries in hemostasis, thrombosis, immune responses, tumor metastasis and beyond. Crit. Rev. Clin. Lab. Sci. 53, 409\u2013430. https:\/\/doi.org\/10.1080\/10408363.2016.1200008 (2016).","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"26219_CR87","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1182\/blood-2006-10-053736","volume":"110","author":"A Varki","year":"2007","unstructured":"Varki, A. Trousseau\u2019s syndrome: Multiple definitions and multiple mechanisms. Blood 110, 1723\u20131729. https:\/\/doi.org\/10.1182\/blood-2006-10-053736 (2007).","journal-title":"Blood"},{"key":"26219_CR88","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1160\/TH10-11-0757","volume":"105","author":"P Ferroni","year":"2011","unstructured":"Ferroni, P. et al. An activated protein c-dependent thrombin generation assay predicts chemotherapy-associated venous thromboembolism in cancer patients. Thromb. Haemost. 105, 931\u2013932. https:\/\/doi.org\/10.1160\/TH10-11-0757 (2011).","journal-title":"Thromb. Haemost."},{"key":"26219_CR89","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1007\/s10555-017-9677-x","volume":"36","author":"M Holinstat","year":"2017","unstructured":"Holinstat, M. Normal platelet function. Cancer Metastasis Rev. 36, 195\u2013198. https:\/\/doi.org\/10.1007\/s10555-017-9677-x (2017).","journal-title":"Cancer Metastasis Rev."},{"key":"26219_CR90","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1083\/jcb.201304054","volume":"201","author":"KR Machlus","year":"2013","unstructured":"Machlus, K. R. & Italiano, J. E. The incredible journey: From megakaryocyte development to platelet formation. J. Cell Biol. 201, 785\u2013796. https:\/\/doi.org\/10.1083\/jcb.201304054 (2013).","journal-title":"J. Cell Biol."},{"key":"26219_CR91","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1055\/s-0035-1564835","volume":"42","author":"T Gremmel","year":"2016","unstructured":"Gremmel, T., Frelinger, A. L. & Michelson, A. D. Platelet physiology. Semin. Thromb. Hemost. 42, 191\u2013204. https:\/\/doi.org\/10.1055\/s-0035-1564835 (2016).","journal-title":"Semin. Thromb. Hemost."},{"key":"26219_CR92","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.1182\/blood.V63.6.1372.1372","volume":"63","author":"CB Thompson","year":"1984","unstructured":"Thompson, C. B., Jakubowski, J. A., Quinn, P. G., Deykin, D. & Valeri, C. R. Platelet size and age determine platelet function independently. Blood 63, 1372\u20131375 (1984).","journal-title":"Blood"},{"key":"26219_CR93","doi-asserted-by":"publisher","first-page":"T05","DOI":"10.7860\/JCDR\/2015\/12028.6061","volume":"9","author":"AT Sayit","year":"2015","unstructured":"Sayit, A. T., Gunbey, P. H. & Terzi, Y. Is the mean platelet volume in patients with acute cholecystitis an inflammatory marker?. J. Clin. Diagn. Res. JCDR 9, T05-07. https:\/\/doi.org\/10.7860\/JCDR\/2015\/12028.6061 (2015).","journal-title":"J. Clin. Diagn. Res. JCDR"},{"key":"26219_CR94","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/s10555-017-9682-0","volume":"36","author":"DG Menter","year":"2017","unstructured":"Menter, D. G. et al. Platelet \u201cfirst responders\u201d in wound response, cancer, and metastasis. Cancer Metastasis Rev. 36, 199\u2013213. https:\/\/doi.org\/10.1007\/s10555-017-9682-0 (2017).","journal-title":"Cancer Metastasis Rev."},{"key":"26219_CR95","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1016\/S0140-6736(12)60209-8","volume":"379","author":"PM Rothwell","year":"2012","unstructured":"Rothwell, P. M. et al. Effect of daily aspirin on risk of cancer metastasis: A study of incident cancers during randomised controlled trials. Lancet Lond. Engl. 379, 1591\u20131601. https:\/\/doi.org\/10.1016\/S0140-6736(12)60209-8 (2012).","journal-title":"Lancet Lond. Engl."},{"key":"26219_CR96","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1160\/TH14-12-1068","volume":"114","author":"MR Thomas","year":"2015","unstructured":"Thomas, M. R. & Storey, R. F. Effect of P2Y12 inhibitors on inflammation and immunity. Thromb. Haemost. 114, 490\u2013497. https:\/\/doi.org\/10.1160\/TH14-12-1068 (2015).","journal-title":"Thromb. Haemost."},{"key":"26219_CR97","doi-asserted-by":"publisher","first-page":"4584","DOI":"10.1073\/pnas.78.7.4584","volume":"78","author":"TF Deuel","year":"1981","unstructured":"Deuel, T. F. et al. Platelet factor 4 is chemotactic for neutrophils and monocytes. Proc. Natl. Acad. Sci. USA 78, 4584\u20134587. https:\/\/doi.org\/10.1073\/pnas.78.7.4584 (1981).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"26219_CR98","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1182\/blood-2004-06-2475","volume":"105","author":"P von Hundelshausen","year":"2005","unstructured":"von Hundelshausen, P. et al. Heterophilic interactions of platelet factor 4 and RANTES promote monocyte arrest on endothelium. Blood 105, 924\u2013930. https:\/\/doi.org\/10.1182\/blood-2004-06-2475 (2005).","journal-title":"Blood"},{"key":"26219_CR99","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.cellimm.2015.01.018","volume":"294","author":"S Kovats","year":"2015","unstructured":"Kovats, S. Estrogen receptors regulate innate immune cells and signaling pathways. Cell. Immunol. 294, 63\u201369. https:\/\/doi.org\/10.1016\/j.cellimm.2015.01.018 (2015).","journal-title":"Cell. Immunol."},{"key":"26219_CR100","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.cellimm.2015.02.004","volume":"294","author":"A Trigunaite","year":"2015","unstructured":"Trigunaite, A., Dimo, J. & J\u00f8rgensen, T. N. Suppressive effects of androgens on the immune system. Cell. Immunol. 294, 87\u201394. https:\/\/doi.org\/10.1016\/j.cellimm.2015.02.004 (2015).","journal-title":"Cell. Immunol."},{"key":"26219_CR101","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.3389\/fimmu.2018.01653","volume":"9","author":"S Kadel","year":"2018","unstructured":"Kadel, S. & Kovats, S. Sex hormones regulate innate immune cells and promote sex differences in respiratory virus infection. Front. Immunol. 9, 1653. https:\/\/doi.org\/10.3389\/fimmu.2018.01653 (2018).","journal-title":"Front. Immunol."},{"key":"26219_CR102","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/0090-1229(79)90069-2","volume":"13","author":"S Mathur","year":"1979","unstructured":"Mathur, S., Mathur, R. S., Goust, J. M., Williamson, H. O. & Fudenberg, H. H. Cyclic variations in white cell subpopulations in the human menstrual cycle: Correlations with progesterone and estradiol. Clin. Immunol. Immunopathol. 13, 246\u2013253. https:\/\/doi.org\/10.1016\/0090-1229(79)90069-2 (1979).","journal-title":"Clin. Immunol. Immunopathol."},{"key":"26219_CR103","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1136\/bmj.2.5969.473","volume":"2","author":"BJ Bain","year":"1975","unstructured":"Bain, B. J. & England, J. M. Variations in leucocyte count during menstrual cycle. Br. Med. J. 2, 473\u2013475. https:\/\/doi.org\/10.1136\/bmj.2.5969.473 (1975).","journal-title":"Br. Med. J."},{"key":"26219_CR104","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1007\/s12288-012-0175-6","volume":"28","author":"S Chandra","year":"2012","unstructured":"Chandra, S., Tripathi, A. K., Mishra, S., Amzarul, M. & Vaish, A. K. Physiological changes in hematological parameters during pregnancy. Indian J. Hematol. Blood Transfus. Off. J. Indian Soc. Hematol. Blood Transfus. 28, 144\u2013146. https:\/\/doi.org\/10.1007\/s12288-012-0175-6 (2012).","journal-title":"Indian J. Hematol. Blood Transfus. Off. J. Indian Soc. Hematol. Blood Transfus."},{"issue":"51","key":"26219_CR105","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1046\/j.8755-8920.2003.00117.x","volume":"2004","author":"K Janis","year":"1989","unstructured":"Janis, K. et al. Estrogen decreases expression of chemokine receptors, and suppresses chemokine bioactivity in murine monocytes. Am. J. Reprod. Immunol. N. Y. N. 2004(51), 22\u201331. https:\/\/doi.org\/10.1046\/j.8755-8920.2003.00117.x (1989).","journal-title":"Am. J. Reprod. Immunol. N. Y. N."},{"key":"26219_CR106","doi-asserted-by":"publisher","first-page":"C35","DOI":"10.1152\/ajpcell.1999.277.1.C35","volume":"277","author":"MK Angele","year":"1999","unstructured":"Angele, M. K. et al. Sex steroids regulate pro- and anti-inflammatory cytokine release by macrophages after trauma-hemorrhage. Am. J. Physiol. 277, C35-42. https:\/\/doi.org\/10.1152\/ajpcell.1999.277.1.C35 (1999).","journal-title":"Am. J. Physiol."},{"key":"26219_CR107","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1111\/j.1749-6632.1999.tb07667.x","volume":"876","author":"P D\u2019Agostino","year":"1999","unstructured":"D\u2019Agostino, P. et al. Sex hormones modulate inflammatory mediators produced by macrophages. Ann. N. Y. Acad. Sci. 876, 426\u2013429. https:\/\/doi.org\/10.1111\/j.1749-6632.1999.tb07667.x (1999).","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"26219_CR108","first-page":"157","volume":"11","author":"ZG Li","year":"1993","unstructured":"Li, Z. G., Danis, V. A. & Brooks, P. M. Effect of gonadal steroids on the production of IL-1 and IL-6 by blood mononuclear cells in vitro. Clin. Exp. Rheumatol. 11, 157\u2013162 (1993).","journal-title":"Clin. Exp. Rheumatol."},{"key":"26219_CR109","doi-asserted-by":"publisher","first-page":"2279","DOI":"10.3389\/fimmu.2018.02279","volume":"9","author":"VR Moulton","year":"2018","unstructured":"Moulton, V. R. Sex Hormones in acquired immunity and autoimmune disease. Front. Immunol. 9, 2279. https:\/\/doi.org\/10.3389\/fimmu.2018.02279 (2018).","journal-title":"Front. Immunol."},{"issue":"179","key":"26219_CR110","doi-asserted-by":"publisher","first-page":"1776","DOI":"10.4049\/jimmunol.179.3.1776","volume":"2007","author":"R Dai","year":"1950","unstructured":"Dai, R., Phillips, R. A. & Ahmed, S. A. Despite inhibition of nuclear localization of NF-Kappa B P65, c-Rel, and RelB, 17-beta estradiol up-regulates NF-kappa B signaling in mouse splenocytes: The potential role of Bcl-3. J. Immunol. Baltim. Md 2007(179), 1776\u20131783. https:\/\/doi.org\/10.4049\/jimmunol.179.3.1776 (1950).","journal-title":"J. Immunol. Baltim. Md"},{"key":"26219_CR111","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.ctrv.2013.11.005","volume":"40","author":"K Sideras","year":"2014","unstructured":"Sideras, K. et al. Role of the immune system in pancreatic cancer progression and immune modulating treatment strategies. Cancer Treat. Rev. 40, 513\u2013522. https:\/\/doi.org\/10.1016\/j.ctrv.2013.11.005 (2014).","journal-title":"Cancer Treat. Rev."},{"key":"26219_CR112","doi-asserted-by":"publisher","first-page":"3280","DOI":"10.3390\/curroncol28050285","volume":"28","author":"R Aquilani","year":"2021","unstructured":"Aquilani, R. et al. Peripheral blood lymphocyte percentage may predict chemotolerance and survival in patients with advanced pancreatic cancer association between adaptive immunity and nutritional state. Curr. Oncol. Tor. Ont 28, 3280\u20133296. https:\/\/doi.org\/10.3390\/curroncol28050285 (2021).","journal-title":"Curr. Oncol. Tor. Ont"},{"key":"26219_CR113","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1097\/01.mpa.0000188305.90290.50","volume":"32","author":"P Fogar","year":"2006","unstructured":"Fogar, P. et al. Decreased total lymphocyte counts in pancreatic cancer: An index of adverse outcome. Pancreas 32, 22\u201328. https:\/\/doi.org\/10.1097\/01.mpa.0000188305.90290.50 (2006).","journal-title":"Pancreas"},{"key":"26219_CR114","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1016\/j.trecan.2023.07.015","volume":"9","author":"JH Kang","year":"2023","unstructured":"Kang, J. H. & Zappasodi, R. Modulating Treg stability to improve cancer immunotherapy. Trends Cancer 9, 911\u2013927. https:\/\/doi.org\/10.1016\/j.trecan.2023.07.015 (2023).","journal-title":"Trends Cancer"},{"key":"26219_CR115","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1186\/s40425-019-0628-7","volume":"7","author":"J Ogando","year":"2019","unstructured":"Ogando, J. et al. PD-1 signaling affects cristae morphology and leads to mitochondrial dysfunction in human CD8+ T lymphocytes. J. Immunother. Cancer 7, 151. https:\/\/doi.org\/10.1186\/s40425-019-0628-7 (2019).","journal-title":"J. Immunother. Cancer"},{"key":"26219_CR116","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.immuni.2016.07.009","volume":"45","author":"NE Scharping","year":"2016","unstructured":"Scharping, N. E. et al. The tumor microenvironment represses T cell mitochondrial biogenesis to drive intratumoral T cell metabolic insufficiency and dysfunction. Immunity 45, 374\u2013388. https:\/\/doi.org\/10.1016\/j.immuni.2016.07.009 (2016).","journal-title":"Immunity"},{"key":"26219_CR117","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1177\/0148607117695245","volume":"42","author":"Y-M Hu","year":"2018","unstructured":"Hu, Y.-M., Hsiung, Y.-C., Pai, M.-H. & Yeh, S.-L. Glutamine administration in early or late septic phase downregulates lymphocyte PD-1\/PD-L1 expression and the inflammatory response in mice with polymicrobial sepsis. JPEN J. Parenter. Enteral Nutr. 42, 538\u2013549. https:\/\/doi.org\/10.1177\/0148607117695245 (2018).","journal-title":"JPEN J. Parenter. Enteral Nutr."},{"key":"26219_CR118","doi-asserted-by":"publisher","first-page":"1771143","DOI":"10.1080\/2162402X.2020.1771143","volume":"9","author":"J Le Naour","year":"2020","unstructured":"Le Naour, J., Galluzzi, L., Zitvogel, L., Kroemer, G. & Vacchelli, E. Trial watch: TLR3 agonists in cancer therapy. Oncoimmunology 9, 1771143. https:\/\/doi.org\/10.1080\/2162402X.2020.1771143 (2020).","journal-title":"Oncoimmunology"},{"key":"26219_CR119","doi-asserted-by":"publisher","first-page":"136","DOI":"10.4049\/jimmunol.1301158","volume":"192","author":"DC Saucillo","year":"2014","unstructured":"Saucillo, D. C., Gerriets, V. A., Sheng, J., Rathmell, J. C. & MacIver, N. J. Leptin metabolically licenses T cells for activation to link nutrition and immunity. J. Immunol. 192, 136\u2013144. https:\/\/doi.org\/10.4049\/jimmunol.1301158 (2014).","journal-title":"J. Immunol."},{"key":"26219_CR120","doi-asserted-by":"publisher","first-page":"viii","DOI":"10.1016\/j.coi.2017.06.002","volume":"46","author":"NJ MacIver","year":"2017","unstructured":"MacIver, N. J. & Rathmell, J. C. Editorial overview: Metabolism of T cells: Integrating nutrients, signals, and cell fate. Curr. Opin. Immunol. 46, viii\u2013xi. https:\/\/doi.org\/10.1016\/j.coi.2017.06.002 (2017).","journal-title":"Curr. Opin. Immunol."},{"key":"26219_CR121","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1007\/s00432-009-0625-1","volume":"135","author":"M-H Chen","year":"2009","unstructured":"Chen, M.-H. et al. Prognostic significance of a pretreatment hematologic profile in patients with head and neck cancer. J. Cancer Res. Clin. Oncol. 135, 1783\u20131790. https:\/\/doi.org\/10.1007\/s00432-009-0625-1 (2009).","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"26219_CR122","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1002\/cam4.638","volume":"5","author":"F Kou","year":"2016","unstructured":"Kou, F. et al. Pretreatment lymphopenia is an easily detectable predictive and prognostic marker in patients with metastatic esophagus squamous cell carcinoma receiving first-line chemotherapy. Cancer Med. 5, 778\u2013786. https:\/\/doi.org\/10.1002\/cam4.638 (2016).","journal-title":"Cancer Med."},{"key":"26219_CR123","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1038\/35077246","volume":"411","author":"SA Rosenberg","year":"2001","unstructured":"Rosenberg, S. A. Progress in human tumour immunology and immunotherapy. Nature 411, 380\u2013384. https:\/\/doi.org\/10.1038\/35077246 (2001).","journal-title":"Nature"},{"key":"26219_CR124","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.immuni.2004.07.017","volume":"21","author":"GP Dunn","year":"2004","unstructured":"Dunn, G. P., Old, L. J. & Schreiber, R. D. The immunobiology of cancer immunosurveillance and immunoediting. Immunity 21, 137\u2013148. https:\/\/doi.org\/10.1016\/j.immuni.2004.07.017 (2004).","journal-title":"Immunity"},{"key":"26219_CR125","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1038\/nature07205","volume":"454","author":"A Mantovani","year":"2008","unstructured":"Mantovani, A., Allavena, P., Sica, A. & Balkwill, F. Cancer-related inflammation. Nature 454, 436\u2013444. https:\/\/doi.org\/10.1038\/nature07205 (2008).","journal-title":"Nature"},{"key":"26219_CR126","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/1471-2407-11-64","volume":"11","author":"J Kitayama","year":"2011","unstructured":"Kitayama, J., Yasuda, K., Kawai, K., Sunami, E. & Nagawa, H. Circulating lymphocyte is an important determinant of the effectiveness of preoperative radiotherapy in advanced rectal cancer. BMC Cancer 11, 64. https:\/\/doi.org\/10.1186\/1471-2407-11-64 (2011).","journal-title":"BMC Cancer"},{"key":"26219_CR127","doi-asserted-by":"publisher","first-page":"634","DOI":"10.4149\/BLL_2020_102","volume":"121","author":"E Ozgen","year":"2020","unstructured":"Ozgen, E. et al. The Relationship between neutrophil\/lymphocyte, monocyte\/lymphocyte, platelet\/lymphocyte ratios and clinical outcomes after ninety days in patients who were diagnosed as having acute ischemic stroke in the emergency room and underwent a mechanical thro. Bratisl. Lek. Listy 121, 634\u2013639. https:\/\/doi.org\/10.4149\/BLL_2020_102 (2020).","journal-title":"Bratisl. Lek. Listy"},{"key":"26219_CR128","doi-asserted-by":"publisher","first-page":"5758","DOI":"10.2174\/0929867328666210922160116","volume":"29","author":"D Marazziti","year":"2022","unstructured":"Marazziti, D. et al. Neutrophil\/lymphocyte, platelet\/lymphocyte, and monocyte\/lymphocyte ratios in mood disorders. Curr. Med. Chem. 29, 5758\u20135781. https:\/\/doi.org\/10.2174\/0929867328666210922160116 (2022).","journal-title":"Curr. Med. Chem."},{"key":"26219_CR129","doi-asserted-by":"publisher","first-page":"2644","DOI":"10.3390\/curroncol29040216","volume":"29","author":"T Yamai","year":"2022","unstructured":"Yamai, T. et al. 5-Fluorouracil\/L-leucovorin plus oxaliplatin (FOLFOX) regimen as salvage chemotherapy for patients with unresectable pancreatic cancer receiving gemcitabine and Nab-paclitaxel and 5-fluorouracil\/L-leucovorin plus nanoliposomal irinotecan: Preliminary results from clinical practice. Curr. Oncol. Tor. Ont 29, 2644\u20132649. https:\/\/doi.org\/10.3390\/curroncol29040216 (2022).","journal-title":"Curr. Oncol. Tor. Ont"},{"key":"26219_CR130","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1159\/000497748","volume":"9","author":"GM Virz\u00ec","year":"2019","unstructured":"Virz\u00ec, G. M., Clementi, A., Battaglia, G. G. & Ronco, C. Multi-omics approach: New potential key mechanisms implicated in cardiorenal syndromes. Cardiorenal. Med. 9, 201\u2013211. https:\/\/doi.org\/10.1159\/000497748 (2019).","journal-title":"Cardiorenal. Med."},{"key":"26219_CR131","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/j.clnu.2009.05.014","volume":"28","author":"PB Soeters","year":"2009","unstructured":"Soeters, P. B. & Grimble, R. F. Dangers, and benefits of the cytokine mediated response to injury and infection. Clin. Nutr. Edinb. Scotl. 28, 583\u2013596. https:\/\/doi.org\/10.1016\/j.clnu.2009.05.014 (2009).","journal-title":"Clin. Nutr. Edinb. Scotl."},{"key":"26219_CR132","doi-asserted-by":"publisher","first-page":"3201","DOI":"10.1182\/blood.2019003977","volume":"137","author":"DL Tao","year":"2021","unstructured":"Tao, D. L., Tassi Yunga, S., Williams, C. D. & McCarty, O. J. T. Aspirin and antiplatelet treatments in cancer. Blood 137, 3201\u20133211. https:\/\/doi.org\/10.1182\/blood.2019003977 (2021).","journal-title":"Blood"},{"key":"26219_CR133","doi-asserted-by":"publisher","first-page":"59","DOI":"10.2147\/OTT.S147715","volume":"11","author":"S Chen","year":"2018","unstructured":"Chen, S., Na, N. & Jian, Z. Pretreatment platelet count as a prognostic factor in patients with pancreatic cancer: A systematic review and meta-analysis. OncoTargets Ther. 11, 59\u201365. https:\/\/doi.org\/10.2147\/OTT.S147715 (2018).","journal-title":"OncoTargets Ther."},{"key":"26219_CR134","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s12893-020-00976-5","volume":"21","author":"T Yagyu","year":"2021","unstructured":"Yagyu, T. et al. Decreased mean platelet volume predicts poor prognosis in patients with pancreatic cancer. BMC Surg. 21, 8. https:\/\/doi.org\/10.1186\/s12893-020-00976-5 (2021).","journal-title":"BMC Surg."},{"key":"26219_CR135","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1016\/j.cell.2016.07.026","volume":"166","author":"A Wang","year":"2016","unstructured":"Wang, A. et al. Opposing effects of fasting metabolism on tissue tolerance in bacterial and viral inflammation. Cell 166, 1512-1525.e12. https:\/\/doi.org\/10.1016\/j.cell.2016.07.026 (2016).","journal-title":"Cell"},{"key":"26219_CR136","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1016\/j.cell.2019.07.050","volume":"178","author":"S Jordan","year":"2019","unstructured":"Jordan, S. et al. Dietary intake regulates the circulating inflammatory monocyte pool. Cell 178, 1102-1114.e17. https:\/\/doi.org\/10.1016\/j.cell.2019.07.050 (2019).","journal-title":"Cell"},{"key":"26219_CR137","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1055\/s-0034-1365839","volume":"40","author":"BJ McEwen","year":"2014","unstructured":"McEwen, B. J. The influence of diet and nutrients on platelet function. Semin. Thromb. Hemost. 40, 214\u2013226. https:\/\/doi.org\/10.1055\/s-0034-1365839 (2014).","journal-title":"Semin. Thromb. Hemost."},{"key":"26219_CR138","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/nri3845","volume":"15","author":"L Zitvogel","year":"2015","unstructured":"Zitvogel, L., Galluzzi, L., Kepp, O., Smyth, M. J. & Kroemer, G. Type I interferons in anticancer immunity. Nat. Rev. Immunol. 15, 405\u2013414. https:\/\/doi.org\/10.1038\/nri3845 (2015).","journal-title":"Nat. Rev. Immunol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-26219-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-26219-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-26219-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T02:02:00Z","timestamp":1764554520000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-26219-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,22]]},"references-count":138,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["26219"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-26219-2","relation":{},"ISSN":["2045-2322"],"issn-type":[{"type":"electronic","value":"2045-2322"}],"subject":[],"published":{"date-parts":[[2025,11,22]]},"assertion":[{"value":"26 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Informed consent was obtained from all subjects involved in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent statement"}},{"value":"This observational retrospective study was approved by the Ethical Committee of Policlinico S. Matteo (Pavia, Italy) (P-20210006621, 4 June 2021).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Institutional review board statement"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"42189"}}