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These target heterocycles were obtained by reacting the hydrazide with several carbon-based electrophilic reagents, including chloroacetyl chloride, benzoyl chloride, acetic anhydride, carbon disulfide, and pyrazole aldehyde. The synthesized compounds were evaluated for their antiproliferative activity against colon (HCT-116) and breast (MCF-7) cancer cell lines, which implied the more selective toxicity of these derivatives toward cancer cell lines rather than normal cell line (WI-38), signifying the safety of the tested compounds. Biological screening results demonstrated that compounds\n                    <jats:bold>5<\/jats:bold>\n                    ,\n                    <jats:bold>8<\/jats:bold>\n                    ,\n                    <jats:bold>9<\/jats:bold>\n                    , and\n                    <jats:bold>10<\/jats:bold>\n                    exhibited significant cytotoxic activity against both cell lines. Among molecular docking simulation, the ligand binding energies were like those of doxorubicin (as an anticancer drug) and RRC (as a CDK2 inhibitor), as the most interacting amino acids were common, proposing being CDK2 inhibitor. The superlative docking score was given by compound\n                    <jats:bold>9<\/jats:bold>\n                    (S= -9.5080\u00a0kcal\/mol), which was higher than that of doxorubicin and co-crystallized ligand (RRC). This work may develop the innovative, highly effective agents against cancer in the future.\n                  <\/jats:p>","DOI":"10.1038\/s41598-025-27006-9","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T14:37:13Z","timestamp":1763995033000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Synthesis, antiproliferative screening, and molecular docking of some heterocycles derived from N-(1-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-3-hydrazineyl-3-oxoprop-1-en-2-yl)benzamide"],"prefix":"10.1038","volume":"15","author":[{"given":"Eman A. 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