{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T03:46:30Z","timestamp":1791603990119,"version":"4.3.4"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-27433-8","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T11:45:17Z","timestamp":1765799117000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Ceftazidime prescription and antibiotic resistance patterns in a tertiary care hospital"],"prefix":"10.1038","volume":"15","author":[{"given":"Banan M.","family":"Aiesh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shama","family":"Amoudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leena","family":"Bassalat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abeer","family":"Yousef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dania","family":"Abuhalima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adham","family":"Abutaha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samah W.","family":"Al-Jabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Sabateen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sa\u2019ed H.","family":"Zyoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,15]]},"reference":[{"key":"27433_CR1","first-page":"277","volume":"40","author":"CL Ventola","year":"2015","unstructured":"Ventola, C. L. The antibiotic resistance crisis: part 1: causes and threats. P T. 40, 277\u2013283 (2015).","journal-title":"P T"},{"key":"27433_CR2","unstructured":"World Health Organization. Antimicrobial resistance, (2023). https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/antimicrobial-resistance"},{"key":"27433_CR3","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1080\/22221751.2022.2030196","volume":"11","author":"O Ayobami","year":"2022","unstructured":"Ayobami, O., Brinkwirth, S., Eckmanns, T. & Markwart, R. Antibiotic resistance in hospital-acquired ESKAPE-E infections in low- and lower-middle-income countries: a systematic review and meta-analysis. Emerg. Microbes Infect. 11, 443\u2013451. https:\/\/doi.org\/10.1080\/22221751.2022.2030196 (2022).","journal-title":"Emerg. Microbes Infect."},{"key":"27433_CR4","doi-asserted-by":"publisher","first-page":"107275","DOI":"10.1016\/j.micpath.2024.107275","volume":"200","author":"MS Aljohni","year":"2025","unstructured":"Aljohni, M. S., Harun-Ur-Rashid, M. & Selim, S. Emerging threats: antimicrobial resistance in extended-spectrum beta-lactamase and carbapenem-resistant Escherichia coli. Microb. Pathog. 200, 107275. https:\/\/doi.org\/10.1016\/j.micpath.2024.107275 (2025).","journal-title":"Microb. Pathog"},{"key":"27433_CR5","doi-asserted-by":"publisher","first-page":"1928","DOI":"10.3201\/eid2510.181626","volume":"25","author":"A Chamieh","year":"2019","unstructured":"Chamieh, A. et al. Control and elimination of extensively Drug-Resistant acinetobacter baumanii in an intensive care unit. Emerg. Infect. Dis. 25, 1928\u20131931. https:\/\/doi.org\/10.3201\/eid2510.181626 (2019).","journal-title":"Emerg. Infect. Dis."},{"key":"27433_CR6","doi-asserted-by":"publisher","unstructured":"Aqel, A. A. et al. Monitoring of antibiotic resistance patterns within Al-Karak governmental Hospital, Jordan, in 2022. Antibiot. (Basel). 13,\u00a0https:\/\/doi.org\/10.3390\/antibiotics13121172 (2024).","DOI":"10.3390\/antibiotics13121172"},{"key":"27433_CR7","doi-asserted-by":"publisher","first-page":"e31695","DOI":"10.7759\/cureus.31695","volume":"14","author":"AY Hakami","year":"2022","unstructured":"Hakami, A. Y. et al. Antibacterial resistance patterns among common infections in a tertiary care hospital in Saudi Arabia. Cureus 14, e31695. https:\/\/doi.org\/10.7759\/cureus.31695 (2022).","journal-title":"Cureus"},{"key":"27433_CR8","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1186\/s12879-022-07375-6","volume":"22","author":"R Rabayah","year":"2022","unstructured":"Rabayah, R. et al. Microbial spectrum and drug resistance profile in solid malignancies in a large tertiary hospital from Palestine. BMC Infect. Dis. 22, 385. https:\/\/doi.org\/10.1186\/s12879-022-07375-6 (2022).","journal-title":"BMC Infect. Dis."},{"key":"27433_CR9","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1186\/s12879-023-08058-6","volume":"23","author":"N Joudeh","year":"2023","unstructured":"Joudeh, N. et al. Epidemiology and source of infection in cancer patients with febrile neutropenia: an experience from a developing country. BMC Infect. Dis. 23, 106. https:\/\/doi.org\/10.1186\/s12879-023-08058-6 (2023).","journal-title":"BMC Infect. Dis."},{"key":"27433_CR10","doi-asserted-by":"publisher","first-page":"115","DOI":"10.2147\/dhps.S226505","volume":"11","author":"TG Gebremichael","year":"2019","unstructured":"Gebremichael, T. G., Gebreyesus, H. H. & Gebremariam, A. Assessment of the appropriateness of Ceftazidime use in a tertiary teaching Hospital, Northern Ethiopia. Drug Healthc. Patient Saf. 11, 115\u2013123. https:\/\/doi.org\/10.2147\/dhps.S226505 (2019).","journal-title":"Drug Healthc. Patient Saf."},{"key":"27433_CR11","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s40360-016-0057-x","volume":"17","author":"A Sileshi","year":"2016","unstructured":"Sileshi, A., Tenna, A., Feyissa, M. & Shibeshi, W. Evaluation of ceftriaxone utilization in medical and emergency wards of Tikur Anbessa specialized hospital: a prospective cross-sectional study. BMC Pharmacol. Toxicol. 17, 7. https:\/\/doi.org\/10.1186\/s40360-016-0057-x (2016).","journal-title":"BMC Pharmacol. Toxicol."},{"key":"27433_CR12","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1186\/s13756-023-01355-4","volume":"12","author":"S Shbaita","year":"2023","unstructured":"Shbaita, S. et al. Antibiotic resistance profiles and associated factors of Pseudomonas infections among patients admitted to large tertiary care hospital from a developing country. Antimicrob. Resist. Infect. Control. 12, 149. https:\/\/doi.org\/10.1186\/s13756-023-01355-4 (2023).","journal-title":"Antimicrob. Resist. Infect. Control"},{"key":"27433_CR13","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1186\/s12879-023-08643-9","volume":"23","author":"BM Aiesh","year":"2023","unstructured":"Aiesh, B. M. et al. Epidemiology and clinical characteristics of patients with carbapenem-resistant enterobacterales infections: experience from a large tertiary care center in a developing country. BMC Infect. Dis. 23, 644. https:\/\/doi.org\/10.1186\/s12879-023-08643-9 (2023).","journal-title":"BMC Infect. Dis."},{"key":"27433_CR14","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1186\/s12879-024-09749-4","volume":"24","author":"BM Aiesh","year":"2024","unstructured":"Aiesh, B. M. et al. Patterns of fluoroquinolone utilization and resistance in a tertiary care hospital: a retrospective cross-sectional analysis study from a developing country. BMC Infect. Dis. 24, 856. https:\/\/doi.org\/10.1186\/s12879-024-09749-4 (2024).","journal-title":"BMC Infect. Dis."},{"key":"27433_CR15","doi-asserted-by":"publisher","first-page":"3022","DOI":"10.1038\/s41598-024-53596-x","volume":"14","author":"BM Aiesh","year":"2024","unstructured":"Aiesh, B. M. et al. Epidemiology and clinical characteristics of patients with healthcare-acquired multidrug-resistant Gram-negative bacilli: a retrospective study from a tertiary care hospital. Sci. Rep. 14, 3022. https:\/\/doi.org\/10.1038\/s41598-024-53596-x (2024).","journal-title":"Sci. Rep."},{"key":"27433_CR16","doi-asserted-by":"publisher","unstructured":"Bone, R. C. et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP\/SCCM Consensus Conference Committee. American College of Chest Physicians\/Society of Critical Care Medicine. Chest 101, 1644\u20131655, (1992). https:\/\/doi.org\/10.1378\/chest.101.6.1644","DOI":"10.1378\/chest.101.6.1644"},{"key":"27433_CR17","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1200\/JCO.2017.77.6211","volume":"36","author":"RA Taplitz","year":"2018","unstructured":"Taplitz, R. A. et al. Outpatient management of fever and neutropenia in adults treated for malignancy: American society of clinical oncology and infectious diseases society of America clinical practice guideline update. J. Clin. Oncol. 36, 1443\u20131453. https:\/\/doi.org\/10.1200\/JCO.2017.77.6211 (2018).","journal-title":"J. Clin. Oncol."},{"key":"27433_CR18","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1200\/JOP.18.00269","volume":"15","author":"AJ Zimmer","year":"2019","unstructured":"Zimmer, A. J. & Freifeld, A. G. Optimal management of neutropenic fever in patients with cancer. J. Oncol. Pract. 15, 19\u201324. https:\/\/doi.org\/10.1200\/JOP.18.00269 (2019).","journal-title":"J. Oncol. Pract."},{"key":"27433_CR19","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1080\/14787210.2019.1573670","volume":"17","author":"M Schmidt-Hieber","year":"2019","unstructured":"Schmidt-Hieber, M., Teschner, D., Maschmeyer, G. & Schalk, E. Management of febrile neutropenia in the perspective of antimicrobial de-escalation and discontinuation. Expert Rev. Anti Infect. Ther. 17, 983\u2013995. https:\/\/doi.org\/10.1080\/14787210.2019.1573670 (2019).","journal-title":"Expert Rev. Anti Infect. Ther."},{"key":"27433_CR20","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1128\/AAC.27.4.605","volume":"27","author":"GL Drusano","year":"1985","unstructured":"Drusano, G. L. et al. Pharmacokinetics of ceftazidime, alone or in combination with Piperacillin or tobramycin, in the Sera of cancer patients. Antimicrob. Agents Chemother. 27, 605\u2013607. https:\/\/doi.org\/10.1128\/AAC.27.4.605 (1985).","journal-title":"Antimicrob. Agents Chemother."},{"key":"27433_CR21","doi-asserted-by":"publisher","unstructured":"Fainstein, V. et al. A randomized study of Ceftazidime compared to Ceftazidime and tobramycin for the treatment of infections in cancer patients. J Antimicrob. Chemother Suppl. A. 12 101\u2013110. https:\/\/doi.org\/10.1093\/jac\/12.suppl_a.101 (1983).","DOI":"10.1093\/jac\/12.suppl_a.101"},{"key":"27433_CR22","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.mcna.2020.02.011","volume":"104","author":"MD Font","year":"2020","unstructured":"Font, M. D., Thyagarajan, B. & Khanna, A. K. Sepsis and septic Shock - Basics of diagnosis, pathophysiology and clinical decision making. Med. Clin. North. Am. 104, 573\u2013585. https:\/\/doi.org\/10.1016\/j.mcna.2020.02.011 (2020).","journal-title":"Med. Clin. North. Am."},{"key":"27433_CR23","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/s0140-6736(18)30696-2","volume":"392","author":"M Cecconi","year":"2018","unstructured":"Cecconi, M., Evans, L., Levy, M. & Rhodes, A. Sepsis and septic shock. Lancet 392, 75\u201387. https:\/\/doi.org\/10.1016\/s0140-6736(18)30696-2 (2018).","journal-title":"Lancet"},{"key":"27433_CR24","doi-asserted-by":"publisher","unstructured":"Singer, M. et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA 315, 801\u2013810, https:\/\/doi.org\/10.1001\/jama.2016.0287%JJAMA (2016).","DOI":"10.1001\/jama.2016.0287%JJAMA"},{"issue":"Suppl 1","key":"27433_CR25","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1086\/590062","volume":"47","author":"DL Paterson","year":"2008","unstructured":"Paterson, D. L. Impact of antibiotic resistance in gram-negative bacilli on empirical and definitive antibiotic therapy. Clin. Infect. Dis. 47 (Suppl 1), 14\u201320. https:\/\/doi.org\/10.1086\/590062 (2008).","journal-title":"Clin. Infect. Dis."},{"key":"27433_CR26","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/S1473-3099(16)30004-4","volume":"16","author":"Y Carmeli","year":"2016","unstructured":"Carmeli, Y. et al. Ceftazidime-avibactam or best available therapy in patients with ceftazidime-resistant Enterobacteriaceae and Pseudomonas aeruginosa complicated urinary tract infections or complicated intra-abdominal infections (REPRISE): a randomised, pathogen-directed, phase 3 study. Lancet Infect. Dis. 16, 661\u2013673. https:\/\/doi.org\/10.1016\/S1473-3099(16)30004-4 (2016).","journal-title":"Lancet Infect. Dis."},{"key":"27433_CR27","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1179\/joc.2005.17.5.470","volume":"17","author":"J Koprnova","year":"2005","unstructured":"Koprnova, J. et al. Bacteremia due to Pseudomonas aeruginosa: results from a 3-year National study in the Slovak Republic. J. Chemother. 17, 470\u2013476. https:\/\/doi.org\/10.1179\/joc.2005.17.5.470 (2005).","journal-title":"J. Chemother."},{"key":"27433_CR28","doi-asserted-by":"publisher","first-page":"443","DOI":"10.2147\/ijgm.S145133","volume":"10","author":"W Wanla","year":"2017","unstructured":"Wanla, W., Katip, W., Supakul, S., Apiwatnakorn, P. & Khamsarn, S. Effects of an antimicrobial restriction system on appropriate carbapenem use in a hospital without infectious diseases consultation. Int. J. Gen. Med. 10, 443\u2013449. https:\/\/doi.org\/10.2147\/ijgm.S145133 (2017).","journal-title":"Int. J. Gen. Med."},{"key":"27433_CR29","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/j.jiph.2024.03.010","volume":"17","author":"W Katip","year":"2024","unstructured":"Katip, W. et al. Comparative effectiveness and mortality of colistin monotherapy versus colistin-fosfomycin combination therapy for the treatment of carbapenem-resistant Enterobacteriaceae (CRE) infections: A propensity score analysis. J. Infect. Public. Health. 17, 727\u2013734. https:\/\/doi.org\/10.1016\/j.jiph.2024.03.010 (2024).","journal-title":"J. Infect. Public. Health"},{"key":"27433_CR30","doi-asserted-by":"publisher","unstructured":"Katip, W. et al. High-Loading-Dose colistin with nebulized administration for Carbapenem-Resistant acinetobacter baumannii pneumonia in critically ill patients: A retrospective cohort study. Antibiot. (Basel). 13, https:\/\/doi.org\/10.3390\/antibiotics13030287 (2024).","DOI":"10.3390\/antibiotics13030287"},{"key":"27433_CR31","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1016\/j.jiph.2023.05.024","volume":"16","author":"W Katip","year":"2023","unstructured":"Katip, W., Rayanakorn, A., Oberdorfer, P., Taruangsri, P. & Nampuan, T. Short versus long course of colistin treatment for carbapenem-resistant A. baumannii in critically ill patients: A propensity score matching study. J. Infect. Public. Health. 16, 1249\u20131255. https:\/\/doi.org\/10.1016\/j.jiph.2023.05.024 (2023).","journal-title":"J. Infect. Public. Health"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-27433-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-27433-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-27433-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T14:09:04Z","timestamp":1766066944000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-27433-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,15]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["27433"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-27433-8","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,15]]},"assertion":[{"value":"18 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"43763"}}