{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T14:12:47Z","timestamp":1781619167765,"version":"3.54.5"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Halle (Saale)"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Despite the availability of numerous lymphedema treatments, integrating physical therapy for breast cancer-related lymphedema (BCRL) management has limited evidence. The objective is to evaluate the effect of a multimodal physical therapy approach in reducing upper limb (UL) lymphedema and improving shoulder range of motion (ROM) in women with BCRL. A retrospective study was conducted with 19 women diagnosed with BCRL. UL circumference and shoulder ROM were assessed before and after four weeks of therapy and showed significant improvement (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). The mean difference between baseline and 4-week intervention was 2.11\u00a0cm for UL circumference (95% CI: 1.54, 2.68; Cohen\u2019s d\u2009=\u20091.35), 46.31\n                    <jats:sup>o<\/jats:sup>\n                    for shoulder flexion (95% CI -57.5, -35.1; Cohen\u2019s d\u2009=\u20091.68), 10\n                    <jats:sup>o<\/jats:sup>\n                    for shoulder extension (95% CI -13.4, -6.59; Cohen\u2019s d\u2009=\u20091.74), 47.36\n                    <jats:sup>o<\/jats:sup>\n                    for shoulder abduction (95% CI -60.35, -34.38; Cohen\u2019s d\u2009=\u20091.67), 18.94\n                    <jats:sup>o<\/jats:sup>\n                    for shoulder internal rotation (95% CI -24.4, -13.4; Cohen\u2019s d\u2009=\u20091.37) and 16.05\n                    <jats:sup>o<\/jats:sup>\n                    for shoulder external rotation (95% CI -20.03, -12.07; Cohen\u2019s d\u2009=\u20091.51). Women with BCRL showed significant improvements in lymphedema and shoulder mobility following four weeks of therapy. Further, robust randomised clinical trials are required to substantiate these findings in Indian women.\n                  <\/jats:p>","DOI":"10.1038\/s41598-025-27786-0","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T09:21:41Z","timestamp":1763716901000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of a multimodal physical therapy approach on breast cancer-related lymphedema: a retrospective pre-post study"],"prefix":"10.1038","volume":"15","author":[{"given":"Divya varshini","family":"R","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahalakshmi","family":"Venugopalan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashokan","family":"Arumugam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7220-1221","authenticated-orcid":false,"given":"Filippo","family":"Migliorini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Maffulli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajkumar Kottayasamy","family":"Seenivasagam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,21]]},"reference":[{"issue":"12","key":"27786_CR1","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1001\/jamaoncol.2019.2996","volume":"5","author":"C Fitzmaurice","year":"2019","unstructured":"Fitzmaurice, C. et al. Global, regional, and National cancer incidence, mortality, years of life lost, years lived with disability, and disability-Adjusted life-years for 29 cancer groups, 1990 to 2017: A systematic analysis for the global burden of disease study. JAMA Oncol. 5 (12), 1749\u20131768 (2019).","journal-title":"JAMA Oncol."},{"issue":"1","key":"27786_CR2","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s13014-019-1243-y","volume":"14","author":"J Rupp","year":"2019","unstructured":"Rupp, J. et al. Frequency and risk factors for arm lymphedema after multimodal breast-conserving treatment of nodal positive breast Cancer - A long-term observation. Radiat. Oncol. 14(1), 39 https:\/\/doi.org\/10.1186\/s13014-019-1243-y (2019).","journal-title":"Radiat. Oncol."},{"key":"27786_CR3","doi-asserted-by":"crossref","unstructured":"Marchica, P. et al. Integrated Treatment of Breast cancer-related Lymphedema: A Descriptive Review of the State of the Art Vol. 41, p. 3233\u20133246 (Anticancer Research. International Institute of Anticancer Research, 2021).","DOI":"10.21873\/anticanres.15109"},{"key":"27786_CR4","doi-asserted-by":"publisher","unstructured":"Tandra, P., Kallam, A. & Krishnamurthy, J. Identification and Management of Lymphedema in Patients With Breast Cancer [Internet]. J Oncol Pract. 15, 255\u2013262 Available from: https:\/\/doi.org\/10.1200\/JOP.18.00141 (2019).","DOI":"10.1200\/JOP.18.00141"},{"key":"27786_CR5","doi-asserted-by":"crossref","unstructured":"Donahue, P. M. C., MacKenzie, A., Filipovic, A. & Koelmeyer, L. Advances in the Prevention and Treatment of Breast cancer-related Lymphedema Vol. 200, p. 1\u201314 (Springer, 2023). Breast Cancer Research and Treatment.","DOI":"10.1007\/s10549-023-06947-7"},{"key":"27786_CR6","doi-asserted-by":"crossref","unstructured":"Davies, C. C., Levenhagen, K., Ryans, K., Perdomo, M. & Gilchrist, L. An Executive Summary of the APTA Academy for Oncologic Physical Therapy Clinical Practice Guideline: Interventions for Breast Cancer-Related Lymphedema Vol. 38, p. 103\u2013109 (Lippincott Williams and Wilkins, 2020). Rehabilitation Oncology.","DOI":"10.1097\/01.REO.0000000000000223"},{"issue":"1","key":"27786_CR7","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1186\/s12891-022-05780-1","volume":"23","author":"M Hemmati","year":"2022","unstructured":"Hemmati, M., Rojhani-Shirazi, Z., Zakeri, Z. S., Akrami, M. & Salehi Dehno, N. The effect of the combined use of complex decongestive therapy with electrotherapy modalities for the treatment of breast cancer-related lymphedema: a randomized clinical trial. BMC Musculoskelet. Disord; 23(1), 837 (2022).","journal-title":"BMC Musculoskelet. 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