{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:44:01Z","timestamp":1791233041335,"version":"4.1.0"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Zunyi Medical University Second Affiliated Hospital Master\u2019s Research Initiation Program","award":["SQ-2021-01"],"award-info":[{"award-number":["SQ-2021-01"]}]},{"name":"Zunyi Medical University Second Affiliated Hospital Master\u2019s Research Initiation Program","award":["SQ-2021-01"],"award-info":[{"award-number":["SQ-2021-01"]}]},{"name":"Zunyi Medical University Second Affiliated Hospital Master\u2019s Research Initiation Program","award":["SQ-2021-01"],"award-info":[{"award-number":["SQ-2021-01"]}]},{"name":"Zunyi Medical University Second Affiliated Hospital Master\u2019s Research Initiation Program","award":["SQ-2021-01"],"award-info":[{"award-number":["SQ-2021-01"]}]},{"name":"Guizhou Province Regular Institutions of Higher Learning Young Science and Technology Talent Development Program","award":["QianJiaoHe KY Zi [2022]286"],"award-info":[{"award-number":["QianJiaoHe KY Zi [2022]286"]}]},{"name":"Guizhou Province Regular Institutions of Higher Learning Young Science and Technology Talent Development Program","award":["QianJiaoHe KY Zi [2022]286"],"award-info":[{"award-number":["QianJiaoHe KY Zi [2022]286"]}]},{"name":"Guizhou Province Regular Institutions of Higher Learning Young Science and Technology Talent Development Program","award":["QianJiaoHe KY Zi [2022]286"],"award-info":[{"award-number":["QianJiaoHe KY Zi [2022]286"]}]},{"name":"Guizhou Province Regular Institutions of Higher Learning Young Science and Technology Talent Development Program","award":["QianJiaoHe KY Zi [2022]286"],"award-info":[{"award-number":["QianJiaoHe KY Zi [2022]286"]}]},{"name":"Guizhou Province Regular Institutions of Higher Learning Young Science and Technology Talent Development Program","award":["QianJiaoHe KY Zi [2022]286"],"award-info":[{"award-number":["QianJiaoHe KY Zi [2022]286"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-28087-2","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T12:21:04Z","timestamp":1766492464000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["LINC01116 promotes nascent protein synthesis and cellular stemness through the miR-432-5p\/FKBP7\/14 regulatory axis in melanoma"],"prefix":"10.1038","volume":"15","author":[{"given":"Ying","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZhenJuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HuiHuang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YuTing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LiSheng","family":"Ying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GengJian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,23]]},"reference":[{"key":"28087_CR1","doi-asserted-by":"publisher","first-page":"273","DOI":"10.4065\/72.3.273","volume":"72","author":"C Perniciaro","year":"1997","unstructured":"Perniciaro, C. Dermatopathologic variants of malignant melanoma. Mayo Clin. Proc. 72, 273\u2013279 (1997).","journal-title":"Mayo Clin. Proc."},{"key":"28087_CR2","doi-asserted-by":"publisher","first-page":"e103","DOI":"10.1016\/j.athoracsur.2020.09.088","volume":"112","author":"AE D\u2019Ambrosio","year":"2021","unstructured":"D\u2019Ambrosio, A. E. et al. Pleural melanoma metastasis. Ann. Thorac. Surg. 112, e103\u2013e105 (2021).","journal-title":"Ann. Thorac. Surg."},{"key":"28087_CR3","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.ejca.2021.04.029","volume":"152","author":"C Garbe","year":"2021","unstructured":"Garbe, C. et al. Epidemiology of cutaneous melanoma and keratinocyte cancer in white populations 1943\u20132036. Eur. J. Cancer. 152, 18\u201325 (2021).","journal-title":"Eur. J. Cancer"},{"key":"28087_CR4","doi-asserted-by":"crossref","unstructured":"Tawbi, H. A. et al. Three-Year overall survival with nivolumab plus relatlimab in advanced melanoma from RELATIVITY-047. Journal Clin. Oncology 43, (2025).","DOI":"10.1200\/JCO.24.01124"},{"key":"28087_CR5","doi-asserted-by":"crossref","unstructured":"Wolchok, J. D. et al. Final, 10-Year outcomes with nivolumab plus ipilimumab in advanced melanoma. New Engl. J. Med 392, (2025).","DOI":"10.1056\/NEJMe2411489"},{"key":"28087_CR6","first-page":"300","volume":"156","author":"M Bobos","year":"2021","unstructured":"Bobos, M. Histopathologic classification and prognostic factors of melanoma: a 2021 update. Ital. J. Dermatol. Venerol. 156, 300\u2013321 (2021).","journal-title":"Ital. J. Dermatol. Venerol"},{"key":"28087_CR7","doi-asserted-by":"publisher","first-page":"6199","DOI":"10.1200\/JCO.2009.23.4799","volume":"27","author":"CM Balch","year":"2009","unstructured":"Balch, C. M. et al. Final version of 2009 AJCC melanoma staging and classification. J. Clin. Oncol. 27, 6199\u20136206 (2009).","journal-title":"J. Clin. Oncol."},{"key":"28087_CR8","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1080\/14737140.2018.1489246","volume":"18","author":"EZ Keung","year":"2018","unstructured":"Keung, E. Z. & Gershenwald, J. E. The eighth edition American joint committee on cancer (AJCC) melanoma staging system: implications for melanoma treatment and care. Expert Rev. Anticancer Ther. 18, 775\u2013784 (2018).","journal-title":"Expert Rev. Anticancer Ther."},{"key":"28087_CR9","doi-asserted-by":"publisher","first-page":"6683","DOI":"10.1038\/ncomms7683","volume":"6","author":"A Verfaillie","year":"2015","unstructured":"Verfaillie, A. et al. Decoding the regulatory landscape of melanoma reveals TEADS as regulators of the invasive cell state. Nat. Commun. 6, 6683 (2015).","journal-title":"Nat. Commun."},{"key":"28087_CR10","doi-asserted-by":"publisher","first-page":"e2278","DOI":"10.1038\/cddis.2016.143","volume":"7","author":"R Dong","year":"2016","unstructured":"Dong, R. et al. Targeting long non-coding RNA-TUG1 inhibits tumor growth and angiogenesis in hepatoblastoma. Cell. Death Dis. 7, e2278 (2016).","journal-title":"Cell. Death Dis."},{"key":"28087_CR11","doi-asserted-by":"crossref","unstructured":"Lambrou, G. I., Hatziagapiou, K. & Zaravinos, A. The Non-Coding RNA GAS5 and its role in tumor Therapy-Induced resistance. Int J. Mol. Sci 21, (2020).","DOI":"10.3390\/ijms21207633"},{"key":"28087_CR12","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1186\/s12943-017-0714-8","volume":"16","author":"M Xue","year":"2017","unstructured":"Xue, M. et al. Hypoxic exosomes facilitate bladder tumor growth and development through transferring long non-coding RNA-UCA1. Mol. Cancer. 16, 143 (2017).","journal-title":"Mol. Cancer"},{"key":"28087_CR13","doi-asserted-by":"publisher","first-page":"2252","DOI":"10.1016\/j.molcel.2022.05.027","volume":"82","author":"AB Herman","year":"2022","unstructured":"Herman, A. B., Tsitsipatis, D. & Gorospe, M. Integrated LncRNA function upon genomic and epigenomic regulation. Mol. Cell. 82, 2252\u20132266 (2022).","journal-title":"Mol. Cell."},{"key":"28087_CR14","doi-asserted-by":"crossref","unstructured":"Bridges, M. C., Daulagala, A. C. & Kourtidis, A. LNCcation: LncRNA localization and function. J Cell. Biol 220, (2021).","DOI":"10.1083\/jcb.202009045"},{"key":"28087_CR15","doi-asserted-by":"publisher","first-page":"112801","DOI":"10.1016\/j.biopha.2022.112801","volume":"149","author":"T Li","year":"2022","unstructured":"Li, T. et al. LncRNA MNX1-AS1: A novel oncogenic propellant in cancers. Biomed. Pharmacother. 149, 112801 (2022).","journal-title":"Biomed. Pharmacother"},{"key":"28087_CR16","doi-asserted-by":"crossref","unstructured":"Zhang, P. et al. LncRNA-Mediated adipogenesis in different adipocytes. Int J. Mol. Sci 23, (2022).","DOI":"10.3390\/ijms23137488"},{"key":"28087_CR17","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.jnutbio.2017.01.001","volume":"42","author":"LM Beaver","year":"2017","unstructured":"Beaver, L. M. et al. Long noncoding RNAs and sulforaphane: a target for chemoprevention and suppression of prostate cancer. J. Nutr. Biochem. 42, 72\u201383 (2017).","journal-title":"J. Nutr. Biochem."},{"key":"28087_CR18","doi-asserted-by":"publisher","first-page":"114603","DOI":"10.18632\/oncotarget.23059","volume":"8","author":"C Xu","year":"2017","unstructured":"Xu, C. et al. LncNetP, a systematical LncRNA prioritization approach based on CeRNA and disease phenotype association assumptions. Oncotarget 8, 114603\u2013114612 (2017).","journal-title":"Oncotarget"},{"key":"28087_CR19","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1186\/s12885-024-13293-4","volume":"24","author":"ST Fan","year":"2024","unstructured":"Fan, S. T. et al. High linc01116 expression May contribute to a poor prognosis in various cancers based on systematic reviews and meta-analyses. BMC Cancer. 24, 1566 (2024).","journal-title":"BMC Cancer"},{"key":"28087_CR20","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.arcmed.2021.06.008","volume":"53","author":"K Wang","year":"2022","unstructured":"Wang, K. et al. LINC01116 facilitates melanoma 1 progression via sequestering miR-3612 and Up-regulating GDF11 and SDC3. Arch. Med. Res. 53, 44\u201350 (2022).","journal-title":"Arch. Med. Res."},{"key":"28087_CR21","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1158\/1078-0432.CCR-18-0704","volume":"25","author":"MF Garrido","year":"2019","unstructured":"Garrido, M. F. et al. Regulation of eIF4F translation initiation complex by the peptidyl Prolyl isomerase FKBP7 in Taxane-resistant prostate cancer. Clin. Cancer Res. 25, 710\u2013723 (2019).","journal-title":"Clin. Cancer Res."},{"key":"28087_CR22","doi-asserted-by":"publisher","first-page":"697534","DOI":"10.3389\/fonc.2021.697534","volume":"11","author":"Z Sun","year":"2021","unstructured":"Sun, Z., Qin, X., Fang, J., Tang, Y. & Fan, Y. Multi-Omics analysis of the expression and prognosis for FKBP gene family in renal cancer. Front. Oncol. 11, 697534 (2021).","journal-title":"Front. Oncol."},{"key":"28087_CR23","doi-asserted-by":"publisher","first-page":"651","DOI":"10.2174\/187152010794479816","volume":"10","author":"S Romano","year":"2010","unstructured":"Romano, S. et al. FK506 binding proteins as targets in anticancer therapy. Anticancer Agents Med. Chem. 10, 651\u2013656 (2010).","journal-title":"Anticancer Agents Med. Chem."},{"key":"28087_CR24","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.3389\/fphar.2018.01425","volume":"9","author":"JM Kolos","year":"2018","unstructured":"Kolos, J. M., Voll, A. M., Bauder, M. & Hausch, F. FKBP Ligands-Where we are and where to go? Front. Pharmacol. 9, 1425 (2018).","journal-title":"Front. Pharmacol."},{"key":"28087_CR25","doi-asserted-by":"publisher","first-page":"3078","DOI":"10.7150\/thno.18067","volume":"7","author":"W Zhu","year":"2017","unstructured":"Zhu, W. et al. FKBP3 promotes proliferation of Non-Small cell lung cancer cells through regulating Sp1\/HDAC2\/p27. Theranostics 7, 3078\u20133089 (2017).","journal-title":"Theranostics"},{"key":"28087_CR26","doi-asserted-by":"publisher","first-page":"3034","DOI":"10.1128\/MCB.18.5.3034","volume":"18","author":"P Vittorioso","year":"1998","unstructured":"Vittorioso, P., Cowling, R., Faure, J. D., Caboche, M. & Bellini, C. Mutation in the Arabidopsis PASTICCINO1 gene, which encodes a new FK506-binding protein-like protein, has a dramatic effect on plant development. Mol. Cell. Biol. 18, 3034\u20133043 (1998).","journal-title":"Mol. Cell. Biol."},{"key":"28087_CR27","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa, M. & Goto, S. KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28, 27\u201330 (2000).","journal-title":"Nucleic Acids Res."},{"key":"28087_CR28","doi-asserted-by":"publisher","first-page":"D457","DOI":"10.1093\/nar\/gkv1070","volume":"44","author":"M Kanehisa","year":"2016","unstructured":"Kanehisa, M., Sato, Y., Kawashima, M., Furumichi, M. & Tanabe, M. KEGG as a reference resource for gene and protein annotation. Nucleic Acids Res. 44, D457\u2013462 (2016).","journal-title":"Nucleic Acids Res."},{"key":"28087_CR29","doi-asserted-by":"crossref","unstructured":"Eddy, K. & Chen, S. Overcoming immune evasion in melanoma. Int J. Mol. Sci 21, (2020).","DOI":"10.3390\/ijms21238984"},{"key":"28087_CR30","unstructured":"Mogensen, M. et al. [Melanoma]. Ugeskr Laeger 187, (2025)."},{"key":"28087_CR31","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/S0140-6736(23)00821-8","volume":"402","author":"GV Long","year":"2023","unstructured":"Long, G. V., Swetter, S. M., Menzies, A. M. & Gershenwald, J. E. Scolyer, cutaneous melanoma. Lancet 402, 485\u2013502 (2023).","journal-title":"Lancet"},{"key":"28087_CR32","doi-asserted-by":"crossref","unstructured":"Teixido, C., Castillo, P., Martinez-Vila, C., Arance, A. & Alos, L. Molecular markers and targets in melanoma. Cells 10, (2021).","DOI":"10.3390\/cells10092320"},{"key":"28087_CR33","doi-asserted-by":"crossref","unstructured":"Timar, J. & Ladanyi, A. Molecular pathology of skin melanoma: Epidemiology, differential diagnostics, prognosis and therapy prediction. Int J. Mol. Sci 23, (2022).","DOI":"10.3390\/ijms23105384"},{"key":"28087_CR34","doi-asserted-by":"publisher","first-page":"13151","DOI":"10.2147\/OTT.S271346","volume":"13","author":"S Chen","year":"2020","unstructured":"Chen, S., Luo, L., Chen, H. & He, C. The current state of research regarding the role of Non-Coding RNAs in cutaneous squamous cell carcinoma. Onco Targets Ther. 13, 13151\u201313158 (2020).","journal-title":"Onco Targets Ther."},{"key":"28087_CR35","doi-asserted-by":"publisher","first-page":"615671","DOI":"10.3389\/fcell.2020.615671","volume":"8","author":"J Zhang","year":"2020","unstructured":"Zhang, J. et al. Identification of lncRNA-mRNA regulatory module to explore the pathogenesis and prognosis of melanoma. Front. Cell. Dev. Biol. 8, 615671 (2020).","journal-title":"Front. Cell. Dev. Biol."},{"key":"28087_CR36","doi-asserted-by":"publisher","first-page":"155262","DOI":"10.1016\/j.prp.2024.155262","volume":"256","author":"L Alos","year":"2024","unstructured":"Alos, L. et al. Melanoma on congenital melanocytic nevi. Pathol. Res. Pract. 256, 155262 (2024).","journal-title":"Pathol. Res. Pract."},{"key":"28087_CR37","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/j.hoc.2024.05.005","volume":"38","author":"Y Zhang","year":"2024","unstructured":"Zhang, Y., Ostrowski, S. M. & Fisher, D. E. Nevi and melanoma. Hematol. Oncol. Clin. North. Am. 38, 939\u2013952 (2024).","journal-title":"Hematol. Oncol. Clin. North. Am."},{"key":"28087_CR38","doi-asserted-by":"crossref","unstructured":"Gerard, L. et al. Identification of two novel heterodimeric ABC transporters in melanoma: ABCB5\u03b2\/B6 and ABCB5\u03b2\/B9. J. Biol. Chem. 300, (2024).","DOI":"10.1016\/j.jbc.2023.105594"},{"key":"28087_CR39","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1186\/s12935-021-01912-0","volume":"21","author":"Y Deng","year":"2021","unstructured":"Deng, Y., Zhang, L. & Luo, R. LINC01783 facilitates cell proliferation, migration and invasion in non-small cell lung cancer by targeting miR-432-5p to activate the Notch pathway. Cancer Cell. Int. 21, 234 (2021).","journal-title":"Cancer Cell. Int."},{"key":"28087_CR40","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/j.bbrc.2018.05.166","volume":"502","author":"Y Liu","year":"2018","unstructured":"Liu, Y., Lu, C., Zhou, Y., Zhang, Z. & Sun, L. Circular RNA hsa_circ_0008039 promotes breast cancer cell proliferation and migration by regulating miR-432-5p\/E2F3 axis. Biochem. Biophys. Res. Commun. 502, 358\u2013363 (2018).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"28087_CR41","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1038\/341758a0","volume":"341","author":"MW Harding","year":"1989","unstructured":"Harding, M. W., Galat, A., Uehling, D. E. & Schreiber, S. L. A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase. Nature 341, 758\u2013760 (1989).","journal-title":"Nature"},{"key":"28087_CR42","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1038\/341755a0","volume":"341","author":"JJ Siekierka","year":"1989","unstructured":"Siekierka, J. J., Hung, S. H., Poe, M., Lin, C. S. & Sigal, N. H. A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from Cyclophilin. Nature 341, 755\u2013757 (1989).","journal-title":"Nature"},{"key":"28087_CR43","doi-asserted-by":"publisher","first-page":"e578","DOI":"10.1038\/cddis.2013.109","volume":"4","author":"S Romano","year":"2013","unstructured":"Romano, S. et al. FK506 binding protein 51 positively regulates melanoma stemness and metastatic potential. Cell. Death Dis. 4, e578 (2013).","journal-title":"Cell. Death Dis."},{"key":"28087_CR44","doi-asserted-by":"publisher","first-page":"e24","DOI":"10.1371\/journal.pmed.1000024","volume":"6","author":"AP Crijns","year":"2009","unstructured":"Crijns, A. P. et al. Survival-related profile, pathways, and transcription factors in ovarian cancer. PLoS Med. 6, e24 (2009).","journal-title":"PLoS Med."},{"key":"28087_CR45","doi-asserted-by":"publisher","first-page":"71567","DOI":"10.18632\/oncotarget.12257","volume":"7","author":"M Hagedorn","year":"2016","unstructured":"Hagedorn, M., Siegfried, G., Hooks, K. B. & Khatib, A. M. Integration of zebrafish fin regeneration genes with expression data of human tumors in Silico uncovers potential novel melanoma markers. Oncotarget 7, 71567\u201371579 (2016).","journal-title":"Oncotarget"},{"key":"28087_CR46","doi-asserted-by":"publisher","first-page":"3878","DOI":"10.1073\/pnas.002025599","volume":"99","author":"M Kashani-Sabet","year":"2002","unstructured":"Kashani-Sabet, M. et al. Identification of gene function and functional pathways by systemic plasmid-based ribozyme targeting in adult mice. Proc. Natl. Acad. Sci. U S A. 99, 3878\u20133883 (2002).","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"28087_CR47","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.coph.2011.03.012","volume":"11","author":"J Solassol","year":"2011","unstructured":"Solassol, J., Mange, A. & Maudelonde, T. FKBP family proteins as promising new biomarkers for cancer. Curr. Opin. Pharmacol. 11, 320\u2013325 (2011).","journal-title":"Curr. Opin. Pharmacol."},{"key":"28087_CR48","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.5114\/ada.2022.122599","volume":"39","author":"K Nowogrodzka","year":"2022","unstructured":"Nowogrodzka, K. & Jankowska-Konsur, A. Emerging biomarker in carcinogenesis. Focus on Nestin. Postepy Dermatol. Alergol. 39, 1001\u20131007 (2022).","journal-title":"Postepy Dermatol. Alergol"},{"key":"28087_CR49","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1111\/j.1600-0560.2006.00627.x","volume":"34","author":"S Brychtova","year":"2007","unstructured":"Brychtova, S., Fiuraskova, M., Hlobilkova, A., Brychta, T. & Hirnak, J. Nestin expression in cutaneous melanomas and melanocytic nevi. J. Cutan. Pathol. 34, 370\u2013375 (2007).","journal-title":"J. Cutan. Pathol."},{"key":"28087_CR50","first-page":"354","volume":"54","author":"VA Florenes","year":"1994","unstructured":"Florenes, V. A., Holm, R., Myklebost, O., Lendahl, U. & Fodstad, O. Expression of the neuroectodermal intermediate filament Nestin in human melanomas. Cancer Res. 54, 354\u2013356 (1994).","journal-title":"Cancer Res."},{"key":"28087_CR51","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.jaad.2009.07.013","volume":"63","author":"K Sellheyer","year":"2010","unstructured":"Sellheyer, K. & Krahl, D. Spatiotemporal expression pattern of neuroepithelial stem cell marker Nestin suggests a role in dermal homeostasis, neovasculogenesis, and tumor stroma development: a study on embryonic and adult human skin. J. Am. Acad. Dermatol. 63, 93\u2013113 (2010).","journal-title":"J. Am. Acad. Dermatol."},{"key":"28087_CR52","doi-asserted-by":"publisher","first-page":"47156","DOI":"10.1074\/jbc.M308700200","volume":"278","author":"NY Frank","year":"2003","unstructured":"Frank, N. Y. et al. Regulation of progenitor cell fusion by ABCB5 P-glycoprotein, a novel human ATP-binding cassette transporter. J. Biol. Chem. 278, 47156\u201347165 (2003).","journal-title":"J. Biol. Chem."},{"key":"28087_CR53","doi-asserted-by":"publisher","first-page":"111483","DOI":"10.1016\/j.cellsig.2024.111483","volume":"125","author":"W Liu","year":"2025","unstructured":"Liu, W. et al. The BET inhibitor JQ1 suppresses tumor survival by ABCB5-mediated autophagy in uveal melanoma. Cell. Signal. 125, 111483 (2025).","journal-title":"Cell. Signal."},{"key":"28087_CR54","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1038\/nature06489","volume":"451","author":"T Schatton","year":"2008","unstructured":"Schatton, T. et al. Identification of cells initiating human melanomas. Nature 451, 345\u2013349 (2008).","journal-title":"Nature"},{"key":"28087_CR55","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/j.trecan.2022.07.001","volume":"8","author":"L Duvivier","year":"2022","unstructured":"Duvivier, L. & Gillet, J. P. Deciphering the roles of ABCB5 in normal and cancer cells. Trends Cancer. 8, 795\u2013798 (2022).","journal-title":"Trends Cancer"},{"key":"28087_CR56","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1111\/resp.14891","volume":"30","author":"C Donovan","year":"2025","unstructured":"Donovan, C. Beyond single cytokines: targeting Co-Receptor CD131 in Asthma-COPD overlap. Respirology 30, 274\u2013275 (2025).","journal-title":"Respirology"},{"key":"28087_CR57","doi-asserted-by":"crossref","unstructured":"Ciccone, V. et al. ALDH1A1 overexpression in melanoma cells promotes tumor angiogenesis by activating the IL\u20138\/Notch signaling cascade. Int J. Mol. Med 50, (2022).","DOI":"10.3892\/ijmm.2022.5155"},{"key":"28087_CR58","doi-asserted-by":"publisher","first-page":"114406","DOI":"10.1016\/j.celrep.2024.114406","volume":"43","author":"Y Lu","year":"2024","unstructured":"Lu, Y. et al. ALDH1A3-acetaldehyde metabolism potentiates transcriptional heterogeneity in melanoma. Cell. Rep. 43, 114406 (2024).","journal-title":"Cell. Rep."},{"key":"28087_CR59","doi-asserted-by":"crossref","unstructured":"Nguyen, A. L., Facey, C. O. B. & Boman, B. M. The significance of aldehyde dehydrogenase 1 in cancers. Int J. Mol. Sci 26, (2024).","DOI":"10.3390\/ijms26010251"},{"key":"28087_CR60","doi-asserted-by":"publisher","first-page":"795762","DOI":"10.3389\/fmed.2022.795762","volume":"9","author":"M Zanoni","year":"2022","unstructured":"Zanoni, M., Bravaccini, S., Fabbri, F. & Arienti, C. Emerging roles of aldehyde dehydrogenase isoforms in Anti-cancer therapy resistance. Front. Med. (Lausanne). 9, 795762 (2022).","journal-title":"Front. Med. (Lausanne)"},{"key":"28087_CR61","doi-asserted-by":"publisher","first-page":"1026278","DOI":"10.3389\/fonc.2022.1026278","volume":"12","author":"Y Wei","year":"2022","unstructured":"Wei, Y. et al. ALDH1: A potential therapeutic target for cancer stem cells in solid tumors. Front. Oncol. 12, 1026278 (2022).","journal-title":"Front. Oncol."},{"key":"28087_CR62","doi-asserted-by":"crossref","unstructured":"Mart\u00edn-Lluesma, S. et al. Efficacy of TIL therapy in advanced cutaneous melanoma in the current immuno-oncology era: updated systematic review and meta-analysis. Ann Oncol 35, (2024).","DOI":"10.1016\/j.annonc.2024.07.723"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-28087-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-28087-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-28087-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T01:04:13Z","timestamp":1766538253000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-28087-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,23]]},"references-count":62,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["28087"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-28087-2","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,23]]},"assertion":[{"value":"23 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All procedures involving human participants were conducted in accordance with the Declaration of Helsinki. This study was approved by the Ethics Committee of the Second Affiliated Hospital of Zunyi Medical University (Approval No. KYLL-2022-007).Written informed consent was obtained from all participants. Animal experiments were performed following the ARRIVE guidelines and approved by the Animal Care and Use Committee of Zunyi Medical University (Approval No. ZMU21-2405-001). Euthanasia was carried out via isoflurane inhalation followed by cervical dislocation to minimize suffering.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics statement"}}],"article-number":"44395"}}