{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T12:02:16Z","timestamp":1794484936774,"version":"4.9.1"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["RS-2023-KH139336"],"award-info":[{"award-number":["RS-2023-KH139336"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-28257-2","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T13:37:44Z","timestamp":1766583464000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Trichosanthes kirilowii Maximowicz attenuates dexamethasone induced atrophy in C2C12 myotubes through a Sirtuin 1 associated mechanism"],"prefix":"10.1038","volume":"15","author":[{"given":"Hyunseong","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Young","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhwan","family":"Yeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Jin","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junseon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Jae","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In-Hyuk","family":"Ha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,24]]},"reference":[{"key":"28257_CR1","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/s00223-014-9915-y","volume":"96","author":"WR Frontera","year":"2015","unstructured":"Frontera, W. R. & Ochala, J. Skeletal muscle: a brief review of structure and function. Calcif Tissue Int. 96, 183\u2013195. https:\/\/doi.org\/10.1007\/s00223-014-9915-y (2015).","journal-title":"Calcif Tissue Int."},{"key":"28257_CR2","doi-asserted-by":"publisher","first-page":"22837","DOI":"10.1038\/s41598-024-73903-w","volume":"14","author":"JW Choi","year":"2024","unstructured":"Choi, J. W. et al. Effect of low muscle mass on total mortality related to metabolic disease in chronic kidney disease patients. Sci. Rep. 14, 22837. https:\/\/doi.org\/10.1038\/s41598-024-73903-w (2024).","journal-title":"Sci. Rep."},{"key":"28257_CR3","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24032973","author":"L Jun","year":"2023","unstructured":"Jun, L., Robinson, M., Geetha, T., Broderick, T. L. & Babu, J. R. Prevalence and Mechanisms of Skeletal Muscle Atrophy in Metabolic Conditions. Int. J. Mol. Sci. https:\/\/doi.org\/10.3390\/ijms24032973 (2023).","journal-title":"Int. J. Mol. Sci."},{"key":"28257_CR4","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1210\/en.2016-1779","volume":"158","author":"AY Sato","year":"2017","unstructured":"Sato, A. Y. et al. Glucocorticoids induce bone and muscle atrophy by Tissue-Specific mechanisms upstream of E3 ubiquitin ligases. Endocrinology 158, 664\u2013677. https:\/\/doi.org\/10.1210\/en.2016-1779 (2017).","journal-title":"Endocrinology"},{"key":"28257_CR5","doi-asserted-by":"publisher","first-page":"2163","DOI":"10.1016\/j.biocel.2013.05.036","volume":"45","author":"O Schakman","year":"2013","unstructured":"Schakman, O., Kalista, S., Barbe, C., Loumaye, A. & Thissen, J. P. Glucocorticoid-induced skeletal muscle atrophy. Int. J. Biochem. Cell. Biol. 45, 2163\u20132172. https:\/\/doi.org\/10.1016\/j.biocel.2013.05.036 (2013).","journal-title":"Int. J. Biochem. Cell. Biol."},{"key":"28257_CR6","doi-asserted-by":"publisher","first-page":"3167","DOI":"10.1210\/jc.2002-021827","volume":"88","author":"BA Crawford","year":"2003","unstructured":"Crawford, B. A., Liu, P. Y., Kean, M. T., Bleasel, J. F. & Handelsman, D. J. Randomized placebo-controlled trial of androgen effects on muscle and bone in men requiring long-term systemic glucocorticoid treatment. J. Clin. Endocrinol. Metab. 88, 3167\u20133176. https:\/\/doi.org\/10.1210\/jc.2002-021827 (2003).","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"28257_CR7","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1210\/endrev\/bnad016","volume":"44","author":"R Pofi","year":"2023","unstructured":"Pofi, R., Caratti, G., Ray, D. W. & Tomlinson, J. W. Treating the side effects of exogenous Glucocorticoids; can we separate the good from the bad? Endocr. Rev. 44, 975\u20131011. https:\/\/doi.org\/10.1210\/endrev\/bnad016 (2023).","journal-title":"Endocr. Rev."},{"key":"28257_CR8","doi-asserted-by":"publisher","first-page":"e447","DOI":"10.1210\/clinem\/dgab590","volume":"107","author":"Corrigendum to","year":"2022","unstructured":"Corrigendum to. Thigh muscle fat infiltration is associated with impaired physical performance despite remission in cushing\u2019s syndrome. J. Clin. Endocrinol. Metab. 107, e447. https:\/\/doi.org\/10.1210\/clinem\/dgab590 (2022).","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"28257_CR9","doi-asserted-by":"publisher","first-page":"14752","DOI":"10.1038\/s41598-023-38843-x","volume":"13","author":"CG Juan","year":"2023","unstructured":"Juan, C. G., Matchett, K. B. & Davison, G. W. A systematic review and meta-analysis of the SIRT1 response to exercise. Sci. Rep. 13, 14752. https:\/\/doi.org\/10.1038\/s41598-023-38843-x (2023).","journal-title":"Sci. Rep."},{"key":"28257_CR10","doi-asserted-by":"publisher","first-page":"4281","DOI":"10.1172\/JCI58554","volume":"121","author":"S Schenk","year":"2011","unstructured":"Schenk, S. et al. Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction. J. Clin. Invest. 121, 4281\u20134288. https:\/\/doi.org\/10.1172\/JCI58554 (2011).","journal-title":"J. Clin. Invest."},{"key":"28257_CR11","doi-asserted-by":"publisher","DOI":"10.1038\/s41538-025-00432-9","author":"SM Kim","year":"2025","unstructured":"Kim, S. M. et al. Mealworm hydrolysate ameliorates dexamethasone-induced muscle atrophy via sirtuin 1-mediated signaling and Akt pathway. NPJ Sci. Food https:\/\/doi.org\/10.1038\/s41538-025-00432-9 (2025).","journal-title":"NPJ Sci. Food"},{"key":"28257_CR12","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10121957","author":"Y Zhao","year":"2021","unstructured":"Zhao, Y. et al. l-arginine alleviates LPS-induced oxidative stress and apoptosis via activating SIRT1-AKT-Nrf2 and SIRT1-FOXO3a signaling pathways in C2C12 myotube cells. Antioxid. (Basel) https:\/\/doi.org\/10.3390\/antiox10121957 (2021).","journal-title":"Antioxid. (Basel)"},{"key":"28257_CR13","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1080\/01635581.2023.2272345","volume":"75","author":"HJ Park","year":"2023","unstructured":"Park, H. J. & Park, S. H. Root extract of trichosanthes Kirilowii suppresses metastatic activity of EGFR TKI-Resistant human lung cancer cells by inhibiting Src-Mediated EMT. Nutr. Cancer. 75, 1945\u20131957. https:\/\/doi.org\/10.1080\/01635581.2023.2272345 (2023).","journal-title":"Nutr. Cancer"},{"key":"28257_CR14","doi-asserted-by":"publisher","first-page":"109201","DOI":"10.1016\/j.foodcont.2022.109201","volume":"142","author":"L Xu","year":"2022","unstructured":"Xu, L. et al. Influence of different extraction methods on the chemical composition, antioxidant activity, and overall quality attributes of oils from trichosanthes Kirilowii Maxim seed. Food Control. 142, 109201. https:\/\/doi.org\/10.1016\/j.foodcont.2022.109201 (2022).","journal-title":"Food Control"},{"key":"28257_CR15","doi-asserted-by":"publisher","first-page":"2861","DOI":"10.1016\/j.ijbiomac.2020.08.072","volume":"164","author":"Z Hu","year":"2020","unstructured":"Hu, Z. et al. Microwave-assisted extraction, characterization and Immunomodulatory activity on RAW264.7 cells of polysaccharides from trichosanthes Kirilowii Maxim seeds. Int. J. Biol. Macromol. 164, 2861\u20132872. https:\/\/doi.org\/10.1016\/j.ijbiomac.2020.08.072 (2020).","journal-title":"Int. J. Biol. Macromol."},{"key":"28257_CR16","doi-asserted-by":"publisher","first-page":"718","DOI":"10.3390\/cimb44020050","volume":"44","author":"JH Lee","year":"2022","unstructured":"Lee, J. H., Kim, B., Ko, S. G. & Kim, W. Analgesic effect of SH003 and trichosanthes Kirilowii Maximowicz in Paclitaxel-Induced neuropathic pain in mice. Curr. Issues Mol. Biol. 44, 718\u2013730. https:\/\/doi.org\/10.3390\/cimb44020050 (2022).","journal-title":"Curr. Issues Mol. Biol."},{"key":"28257_CR17","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s13020-019-0263-8","volume":"14","author":"SM Park","year":"2019","unstructured":"Park, S. M. et al. Anti-tumor effects of the ethanolic extract of trichosanthes Kirilowii seeds in colorectal cancer. Chin. Med. 14, 43. https:\/\/doi.org\/10.1186\/s13020-019-0263-8 (2019).","journal-title":"Chin. Med."},{"key":"28257_CR18","doi-asserted-by":"publisher","DOI":"10.21769\/BioProtoc.2237","author":"B Castro","year":"2017","unstructured":"Castro, B. & Kuang, S. Evaluation of muscle performance in mice by treadmill exhaustion test and whole-limb grip strength assay. Bio Protoc. https:\/\/doi.org\/10.21769\/BioProtoc.2237 (2017).","journal-title":"Bio Protoc."},{"key":"28257_CR19","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1248\/cpb.42.1101","volume":"42","author":"T Akihisa","year":"1994","unstructured":"Akihisa, T. et al. Five D:C-friedo-oleanane triterpenes from the seeds of trichosanthes Kirilowii Maxim. And their anti-inflammatory effects. Chem. Pharm. Bull. (Tokyo). 42, 1101\u20131105. https:\/\/doi.org\/10.1248\/cpb.42.1101 (1994).","journal-title":"Chem. Pharm. Bull. (Tokyo)"},{"key":"28257_CR20","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1021\/np900820p","volume":"73","author":"NT Dat","year":"2010","unstructured":"Dat, N. T., Jin, X., Hong, Y. S. & Lee, J. J. An Isoaurone and other constituents from trichosanthes Kirilowii seeds inhibit hypoxia-inducible factor-1 and nuclear factor-kappaB. J. Nat. Prod. 73, 1167\u20131169. https:\/\/doi.org\/10.1021\/np900820p (2010).","journal-title":"J. Nat. Prod."},{"key":"28257_CR21","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1515\/znc-2000-3-409","volume":"55","author":"Y Huang","year":"2000","unstructured":"Huang, Y., He, P., Bader, K. P., Radunz, A. & Schmid, G. H. Seeds of trichosanthes kirilowii, an energy-rich diet. Z. Naturforsch C J. Biosci. 55, 189\u2013194. https:\/\/doi.org\/10.1515\/znc-2000-3-409 (2000).","journal-title":"Z. Naturforsch C J. Biosci."},{"key":"28257_CR22","doi-asserted-by":"publisher","first-page":"7264","DOI":"10.1016\/j.bmc.2008.06.032","volume":"16","author":"SS Moon","year":"2008","unstructured":"Moon, S. S., Rahman, A. A., Kim, J. Y. & Kee, S. H. Hanultarin, a cytotoxic Lignan as an inhibitor of actin cytoskeleton polymerization from the seeds of trichosanthes Kirilowii. Bioorg. Med. Chem. 16, 7264\u20137269. https:\/\/doi.org\/10.1016\/j.bmc.2008.06.032 (2008).","journal-title":"Bioorg. Med. Chem."},{"key":"28257_CR23","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.jfda.2013.12.005","volume":"22","author":"S Wu","year":"2014","unstructured":"Wu, S., Xu, T. & Akoh, C. C. Effect of roasting on the volatile constituents of trichosanthes Kirilowii seeds. J. Food Drug Anal. 22, 310\u2013317. https:\/\/doi.org\/10.1016\/j.jfda.2013.12.005 (2014).","journal-title":"J. Food Drug Anal."},{"key":"28257_CR24","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.jep.2018.05.034","volume":"224","author":"X Yu","year":"2018","unstructured":"Yu, X. et al. Trichosanthis fructus: botany, traditional uses, phytochemistry and Pharmacology. J. Ethnopharmacol. 224, 177\u2013194. https:\/\/doi.org\/10.1016\/j.jep.2018.05.034 (2018).","journal-title":"J. Ethnopharmacol."},{"key":"28257_CR25","doi-asserted-by":"publisher","first-page":"434","DOI":"10.7150\/ijms.18427","volume":"14","author":"DS Han","year":"2017","unstructured":"Han, D. S., Yang, W. S. & Kao, T. W. Dexamethasone treatment at the myoblast stage enhanced C2C12 myocyte differentiation. Int. J. Med. Sci. 14, 434\u2013443. https:\/\/doi.org\/10.7150\/ijms.18427 (2017).","journal-title":"Int. J. Med. Sci."},{"key":"28257_CR26","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1002\/jcsm.12393","volume":"10","author":"S Shen","year":"2019","unstructured":"Shen, S. et al. Myricanol rescues dexamethasone-induced muscle dysfunction via a Sirtuin 1-dependent mechanism. J. Cachexia Sarcopenia Muscle. 10, 429\u2013444. https:\/\/doi.org\/10.1002\/jcsm.12393 (2019).","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"28257_CR27","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1016\/j.exger.2006.08.011","volume":"41","author":"E Marzetti","year":"2006","unstructured":"Marzetti, E. & Leeuwenburgh, C. Skeletal muscle apoptosis, sarcopenia and frailty at old age. Exp. Gerontol. 41, 1234\u20131238. https:\/\/doi.org\/10.1016\/j.exger.2006.08.011 (2006).","journal-title":"Exp. Gerontol."},{"key":"28257_CR28","doi-asserted-by":"publisher","first-page":"7463","DOI":"10.3748\/wjg.v12.i46.7463","volume":"12","author":"EE Dupont-Versteegden","year":"2006","unstructured":"Dupont-Versteegden, E. E. Apoptosis in skeletal muscle and its relevance to atrophy. World J. Gastroenterol. 12, 7463\u20137466. https:\/\/doi.org\/10.3748\/wjg.v12.i46.7463 (2006).","journal-title":"World J. Gastroenterol."},{"key":"28257_CR29","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.3389\/fphys.2018.01887","volume":"9","author":"LM Schwartz","year":"2018","unstructured":"Schwartz, L. M. Skeletal muscles do not undergo apoptosis during either atrophy or programmed cell Death-Revisiting the myonuclear domain hypothesis. Front. Physiol. 9, 1887. https:\/\/doi.org\/10.3389\/fphys.2018.01887 (2018).","journal-title":"Front. Physiol."},{"key":"28257_CR30","doi-asserted-by":"publisher","first-page":"188430","DOI":"10.1016\/j.bbcan.2020.188430","volume":"1874","author":"D Clarisse","year":"2020","unstructured":"Clarisse, D., Offner, F. & De Bosscher, K. Latest perspectives on glucocorticoid-induced apoptosis and resistance in lymphoid malignancies. Biochim. Biophys. Acta Rev. Cancer. 1874, 188430. https:\/\/doi.org\/10.1016\/j.bbcan.2020.188430 (2020).","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"28257_CR31","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.3324\/haematol.10543","volume":"92","author":"E Laane","year":"2007","unstructured":"Laane, E. et al. Dexamethasone-induced apoptosis in acute lymphoblastic leukemia involves differential regulation of Bcl-2 family members. Haematologica 92, 1460\u20131469. https:\/\/doi.org\/10.3324\/haematol.10543 (2007).","journal-title":"Haematologica"},{"key":"28257_CR32","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.4049\/jimmunol.176.3.1695","volume":"176","author":"D Wang","year":"2006","unstructured":"Wang, D., Muller, N., McPherson, K. G. & Reichardt, H. M. Glucocorticoids engage different signal transduction pathways to induce apoptosis in thymocytes and mature T cells. J. Immunol. 176, 1695\u20131702. https:\/\/doi.org\/10.4049\/jimmunol.176.3.1695 (2006).","journal-title":"J. Immunol."},{"key":"28257_CR33","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s12576-020-00768-9","volume":"70","author":"Y Kitajima","year":"2020","unstructured":"Kitajima, Y., Yoshioka, K. & Suzuki, N. The ubiquitin-proteasome system in regulation of the skeletal muscle homeostasis and atrophy: from basic science to disorders. J. Physiol. Sci. 70, 40. https:\/\/doi.org\/10.1186\/s12576-020-00768-9 (2020).","journal-title":"J. Physiol. Sci."},{"key":"28257_CR34","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1007\/s12020-012-9751-7","volume":"43","author":"JP Gumucio","year":"2013","unstructured":"Gumucio, J. P. & Mendias, C. L. Atrogin-1, MuRF-1, and sarcopenia. Endocrine 43, 12\u201321. https:\/\/doi.org\/10.1007\/s12020-012-9751-7 (2013).","journal-title":"Endocrine"},{"key":"28257_CR35","doi-asserted-by":"publisher","first-page":"4117","DOI":"10.1007\/s00018-013-1330-4","volume":"70","author":"N Zanou","year":"2013","unstructured":"Zanou, N. & Gailly, P. Skeletal muscle hypertrophy and regeneration: interplay between the myogenic regulatory factors (MRFs) and insulin-like growth factors (IGFs) pathways. Cell. Mol. Life Sci. 70, 4117\u20134130. https:\/\/doi.org\/10.1007\/s00018-013-1330-4 (2013).","journal-title":"Cell. Mol. Life Sci."},{"key":"28257_CR36","doi-asserted-by":"publisher","first-page":"116917","DOI":"10.1016\/j.biopha.2024.116917","volume":"177","author":"L Yang","year":"2024","unstructured":"Yang, L. et al. SIRT1 signaling pathways in sarcopenia: novel mechanisms and potential therapeutic targets. Biomed. Pharmacother. 177, 116917. https:\/\/doi.org\/10.1016\/j.biopha.2024.116917 (2024).","journal-title":"Biomed. Pharmacother"},{"key":"28257_CR37","doi-asserted-by":"publisher","first-page":"293","DOI":"10.3389\/fphys.2015.00293","volume":"6","author":"TK Sin","year":"2015","unstructured":"Sin, T. K. et al. SIRT1-dependent myoprotective effects of Resveratrol on muscle injury induced by compression. Front. Physiol. 6, 293. https:\/\/doi.org\/10.3389\/fphys.2015.00293 (2015).","journal-title":"Front. Physiol."},{"key":"28257_CR38","doi-asserted-by":"publisher","first-page":"111590","DOI":"10.1016\/j.biopha.2021.111590","volume":"139","author":"L Zhiyin","year":"2021","unstructured":"Zhiyin, L., Jinliang, C., Qiunan, C., Yunfei, Y. & Qian, X. Fucoxanthin rescues dexamethasone induced C2C12 myotubes atrophy. Biomed. Pharmacother. 139, 111590. https:\/\/doi.org\/10.1016\/j.biopha.2021.111590 (2021).","journal-title":"Biomed. Pharmacother"},{"key":"28257_CR39","doi-asserted-by":"publisher","first-page":"E2772","DOI":"10.1073\/pnas.1303628110","volume":"110","author":"M Gertz","year":"2013","unstructured":"Gertz, M. et al. Ex-527 inhibits sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism. Proc. Natl. Acad. Sci. U S A. 110, E2772\u20132781. https:\/\/doi.org\/10.1073\/pnas.1303628110 (2013).","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"28257_CR40","doi-asserted-by":"publisher","first-page":"735044","DOI":"10.3389\/fphar.2021.735044","volume":"12","author":"JY Hong","year":"2021","unstructured":"Hong, J. Y. & Lin, H. Sirtuin modulators in cellular and animal models of human diseases. Front. Pharmacol. 12, 735044. https:\/\/doi.org\/10.3389\/fphar.2021.735044 (2021).","journal-title":"Front. Pharmacol."},{"key":"28257_CR41","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1128\/MCB.26.1.28-38.2006","volume":"26","author":"JM Solomon","year":"2006","unstructured":"Solomon, J. M. et al. Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol. Cell. Biol. 26, 28\u201338. https:\/\/doi.org\/10.1128\/MCB.26.1.28-38.2006 (2006).","journal-title":"Mol. Cell. Biol."},{"key":"28257_CR42","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1038\/nature08918","volume":"464","author":"VV Deshpande","year":"2010","unstructured":"Deshpande, V. V., Bockrath, M., Glazman, L. I. & Yacoby, A. Electron liquids and solids in one dimension. Nature 464, 209\u2013216. https:\/\/doi.org\/10.1038\/nature08918 (2010).","journal-title":"Nature"},{"key":"28257_CR43","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1016\/j.cell.2008.03.034","volume":"133","author":"C Maurange","year":"2008","unstructured":"Maurange, C., Cheng, L. & Gould, A. P. Temporal transcription factors and their targets schedule the end of neural proliferation in drosophila. Cell 133, 891\u2013902. https:\/\/doi.org\/10.1016\/j.cell.2008.03.034 (2008).","journal-title":"Cell"},{"key":"28257_CR44","first-page":"625","volume":"18","author":"CK Zhoh","year":"2007","unstructured":"Zhoh, C. K., Uhm, T. Y. & Kim, J. C. Antioxidants effectiveness of trichosanthes Kirilowii Maximowicz extracts. J. Korean Industrial Eng. Chem. 18, 625\u2013629 (2007).","journal-title":"J. Korean Industrial Eng. Chem."},{"key":"28257_CR45","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.abb.2010.05.003","volume":"501","author":"S Chung","year":"2010","unstructured":"Chung, S. et al. Regulation of SIRT1 in cellular functions: role of polyphenols. Arch. Biochem. Biophys. 501, 79\u201390. https:\/\/doi.org\/10.1016\/j.abb.2010.05.003 (2010).","journal-title":"Arch. Biochem. Biophys."},{"key":"28257_CR46","doi-asserted-by":"publisher","first-page":"126","DOI":"10.2174\/1570159X15666170703113212","volume":"16","author":"F Sarubbo","year":"2018","unstructured":"Sarubbo, F., Esteban, S., Miralles, A. & Moranta, D. Effects of Resveratrol and other polyphenols on Sirt1: relevance to brain function during aging. Curr. Neuropharmacol. 16, 126\u2013136. https:\/\/doi.org\/10.2174\/1570159X15666170703113212 (2018).","journal-title":"Curr. Neuropharmacol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-28257-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-28257-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-28257-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:07:27Z","timestamp":1777388847000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-28257-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,24]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["28257"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-28257-2","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,24]]},"assertion":[{"value":"1 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"44601"}}