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Subsequently, a carbon paste electrode (CPE) was modified with the Ag\n                    <jats:sub>2<\/jats:sub>\n                    WO\u2084 nanocomposite and an ionic liquid (IL) to exploit the synergistic effects of both materials, yielding a cost-effective and highly efficient platform for the electrochemical detection of Vortioxetine (VRT). The Ag\n                    <jats:sub>2<\/jats:sub>\n                    WO\u2084\/IL-modified CPE exhibited markedly enhanced electrochemical activity compared to the bare electrode, as evidenced by the increased oxidation currents and reduced charge-transfer resistance observed in cyclic voltammetry and electrochemical impedance spectroscopy analyses. The sensor demonstrated excellent linearity across a wide concentration range (0.03\u201360\u00a0\u00b5M) under optimized conditions, with a detection limit of 0.01\u00a0\u00b5M, indicating high sensitivity in adsorptive differential pulse voltammetry (AdsDPV) measurements. Additionally, the platform displayed excellent selectivity, stability, and reproducibility, with recovery values between 97.0 and 103.3% and relative standard deviation (RSD) values from 2.1 to 3.6%. The findings affirm the potential of the Ag\n                    <jats:sub>2<\/jats:sub>\n                    WO\u2084\/IL\/CPE sensor for precise quantification of VRT in biological fluids and pharmaceutical formulations. This work presents a promising electrochemical sensing strategy with potential extensions to other neuroactive drugs in clinical diagnostics.\n                  <\/jats:p>","DOI":"10.1038\/s41598-025-28420-9","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T10:07:03Z","timestamp":1764929223000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Green synthesis of silver tungstate\/ionic liquid-modified electrode for highly efficient electrochemical detection of the antidepressant Vortioxetine"],"prefix":"10.1038","volume":"15","author":[{"given":"Sahar","family":"Zinatloo-Ajabshir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Akbari Javar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadi","family":"Mahmoudi-Moghaddam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Azari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,5]]},"reference":[{"key":"28420_CR1","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1517\/14656566.2016.1133588","volume":"17","author":"KR Connolly","year":"2016","unstructured":"Connolly, K. 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