{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T18:31:04Z","timestamp":1773081064337,"version":"3.50.1"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100009169","name":"Assiut University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009169","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Abnormal uterine bleeding (AUB) represents a notable sign for benign and\n                malignant uterine pathology. Differentiating adenomyosis from leiomyoma via\n                hysteroscopy aids in selecting appropriate surgical or medical management. Accurate\n                diagnosis is crucial for optimizing fertility outcomes and symptom control. The\n                current study evaluated the diagnostic accuracy of hysteroscopy in differentiating\n                between uterine adenomyosis and leiomymatosis. In addition to; compare between\n                continuous versus intermittent administration of Norethissterone to control both\n                uterine adenomyosis and leiomymatosis. A total of 100 premenopausal women present\n                with AUB. History takin and clinical evaluation was done. All women were subjected\n                to hysteroscopy. Two regimens were used by Norethindrone administration the 1st\n                regimen as continuous manner from day 5 to day 21 46 patients (46%). The 2nd manner\n                was the intermittent type from day 16 and for 10 days 54 patients (54%). Roc-curve\n                of hysteroscopy usage to predict diagnosis; adenomyosis sensitivity was 73.33% and\n                specificity 95.29% and fibroid sensitivity was 73.33% and specificity was 97.65%.\n                Both groups of therapy revealed; highly significant decrease in follow up\n                menorrhagia in continuous Norethindrone group (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001).By using ROC-curve analysis; Norethindrone administration\n                predicted decreased menorrhagia pain with AUC was 0.973. Hysteroscopy has effective\n                role in differentiating between adenomyosis and fibroids. Yet, long term follows up\n                of abnormal uterine bleeding cases with large sample size in future research are\n                still warranted.\n                  <\/jats:p>","DOI":"10.1038\/s41598-025-28540-2","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T07:14:59Z","timestamp":1764746099000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["RETRACTED ARTICLE: Management of uterine\n            leiomyoma and adenomyosis: role of hysteroscopy in diagnosis and norethindrone in the\n            treatment"],"prefix":"10.1038","volume":"15","author":[{"given":"Ahmed","family":"Ali","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alaaeldin","family":"Youssef","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali El","family":"Saman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisham Abou","family":"Taleb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,3]]},"reference":[{"issue":"2","key":"28540_CR1","first-page":"235","volume":"107","author":"E Lebduska","year":"2023","unstructured":"Lebduska, E., Beshear, D. & Spataro, B. M. Abnormal uterine\n                    bleeding. Med. Clin.\n                    107(2), 235\u2013246 (2023).","journal-title":"Med. Clin."},{"key":"28540_CR2","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.ejogrb.2023.06.021","volume":"287","author":"S Singh","year":"2023","unstructured":"Singh, S., Kumar, P., Rathore, S. S., Singh, Y. & Garg, N.\n                    Contemporary approaches in the management of uterine leiomyomas. Eur. J. Obstet. Gynecol. Reprod. Biol.\n                    287, 195\u2013210 (2023).","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"issue":"10","key":"28540_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogoh.2021.102228","volume":"50","author":"M Bourdon","year":"2021","unstructured":"Bourdon, M. et al. Adenomyosis: an update regarding its diagnosis\n                    and clinical features. J. Gynecol. Obstet. Hum.\n                        Reprod.\n                    50(10), 102228 (2021).","journal-title":"J. Gynecol. Obstet. Hum. Reprod."},{"issue":"1","key":"28540_CR4","first-page":"2518396","volume":"2017","author":"A Di Spiezio Sardo","year":"2017","unstructured":"Di Spiezio Sardo, A. et al. The role of hysteroscopy in the\n                    diagnosis and treatment of adenomyosis. BioMed Res.\n                        Int.\n                    2017(1), 2518396 (2017).","journal-title":"BioMed Res. Int."},{"issue":"3","key":"28540_CR5","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.fertnstert.2018.01.006","volume":"109","author":"S Gordts","year":"2018","unstructured":"Gordts, S., Grimbizis, G. & Campo, R. Symptoms and\n                    classification of uterine adenomyosis, including the place of hysteroscopy in\n                    diagnosis. Fertil. Steril.\n                    109(3), 380-388.e1 (2018).","journal-title":"Fertil. Steril."},{"issue":"5","key":"28540_CR6","doi-asserted-by":"publisher","first-page":"99","DOI":"10.31083\/j.ceog5005099","volume":"50","author":"M Gulisano","year":"2023","unstructured":"Gulisano, M. et al. Role of hysteroscopy on infertility: The\n                    eternal dilemma. Clin. Exp. Obstet. Gynecol.\n                    50(5), 99 (2023).","journal-title":"Clin. Exp. Obstet. Gynecol."},{"key":"28540_CR7","doi-asserted-by":"publisher","DOI":"10.7573\/dic.2024-4-1","author":"AM Boruah","year":"2024","unstructured":"Boruah, A. M. et al. Effect of norethindrone dose and duration in\n                    the management of abnormal uterine bleeding: a narrative review and case report.\n                        Drugs Context\n                    https:\/\/doi.org\/10.7573\/dic.2024-4-1\n                    (2024).","journal-title":"Drugs Context"},{"issue":"8","key":"28540_CR8","doi-asserted-by":"publisher","first-page":"181","DOI":"10.31083\/j.ceog4908181","volume":"49","author":"N Ignaszak-Kaus","year":"2022","unstructured":"Ignaszak-Kaus, N., Chmaj-Wierzchowska, K., Nowak, A., Wszo\u0142ek, K.\n                    & Wilczak, M. An Overview of Outpatient Hysteroscopy. Clin. Exp. Obstet. Gynecol.\n                    49(8), 181 (2022).","journal-title":"Clin. Exp. Obstet. Gynecol."},{"issue":"7","key":"28540_CR9","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1111\/1471-0528.16604","volume":"128","author":"P De Silva","year":"2021","unstructured":"De Silva, P., Wilson, L., Carnegy, A., Smith, P. & Clark, T.\n                    Cervical dilatation and preparation prior to outpatient hysteroscopy: a\n                    systematic review and meta-analysis. BJOG: Inte. J.\n                        Obstet. Gynaecol.\n                    128(7), 1112\u20131123 (2021).","journal-title":"BJOG: Inte. J. Obstet. Gynaecol."},{"issue":"1","key":"28540_CR10","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s12958-024-01191-0","volume":"22","author":"J-H Hou","year":"2024","unstructured":"Hou, J.-H., Lu, B.-J., Huang, Y.-L., Chen, C.-H. & Chen, C.-H.\n                    Outpatient hysteroscopy impact on subsequent assisted reproductive technology: a\n                    systematic review and meta-analysis in patients with normal transvaginal\n                    sonography or hysterosalpingography images. Reprod.\n                        Biol. Endocrinol.\n                    22(1), 18 (2024).","journal-title":"Reprod. Biol. Endocrinol."},{"key":"28540_CR11","doi-asserted-by":"publisher","first-page":"1489783","DOI":"10.3389\/fendo.2024.1489783","volume":"15","author":"Y Wang","year":"2024","unstructured":"Wang, Y., Tang, Z., Wang, C., Teng, X. & He, J. Whether\n                    hysteroscopy improves fertility outcomes in infertile women: a meta-analysis and\n                    systematic review. Front. Endocrinol.\n                    15, 1489783 (2024).","journal-title":"Front. Endocrinol."},{"issue":"4","key":"28540_CR12","doi-asserted-by":"publisher","first-page":"203","DOI":"10.4103\/GMIT.GMIT_125_20","volume":"10","author":"V Foreste","year":"2021","unstructured":"Foreste, V. et al. Hysteroscopy and retained products of\n                    conception: an update. Gynecol. Minim. Invasive\n                        Ther.\n                    10(4), 203\u2013209 (2021).","journal-title":"Gynecol. Minim. Invasive Ther."},{"issue":"8","key":"28540_CR13","doi-asserted-by":"publisher","first-page":"4339","DOI":"10.1007\/s00432-022-04343-0","volume":"149","author":"Y Ding","year":"2023","unstructured":"Ding, Y., Han, Y., Zhang, S. & Shi, X. The incidence of\n                    unexpected uterine malignancies in hysterectomies carried out for benign\n                    indications. J. Cancer Res. Clin. Oncol.\n                    149(8), 4339\u20134345 (2023).","journal-title":"J. Cancer Res. Clin. Oncol."},{"issue":"1","key":"28540_CR14","first-page":"33","volume":"90","author":"R Nicula","year":"2017","unstructured":"Nicula, R. et al. Accuracy of transvaginal ultrasonography compared\n                    to endometrial biopsy for the etiological diagnosis of abnormal perimenopausal\n                    bleeding. Clujul Med.\n                    90(1), 33 (2017).","journal-title":"Clujul Med."},{"issue":"8","key":"28540_CR15","doi-asserted-by":"publisher","first-page":"815","DOI":"10.15537\/smj.2019.8.24449","volume":"40","author":"AM Al Nemer","year":"2019","unstructured":"Al Nemer, A. M., Al Bayat, M. I. & Al Qahtani, N. H. The\n                    accuracy of endometrial sampling for the diagnosis of patterns of endometrial\n                    pathology in women presenting with abnormal uterine bleeding: More conservative\n                    therapeutic approaches. Saudi Med. J.\n                    40(8), 815 (2019).","journal-title":"Saudi Med. J."},{"issue":"4","key":"28540_CR16","doi-asserted-by":"publisher","first-page":"142","DOI":"10.3390\/diagnostics9040142","volume":"9","author":"P De Franciscis","year":"2019","unstructured":"De Franciscis, P. et al. Concordance between the hysteroscopic\n                    diagnosis of endometrial hyperplasia and histopathological examination.\n                        Diagnostics\n                    9(4), 142 (2019).","journal-title":"Diagnostics"},{"issue":"6","key":"28540_CR17","doi-asserted-by":"publisher","first-page":"128","DOI":"10.31083\/j.ceog5106128","volume":"51","author":"B Tuersun","year":"2024","unstructured":"Tuersun, B. & Zhang, Q. Application of vaginal ultrasound and\n                    hysteroscopy in the diagnosis of perimenopausal endometrial lesions. Clin. Exp. Obstet. Gynecol.\n                    51(6), 128 (2024).","journal-title":"Clin. Exp. Obstet. Gynecol."},{"issue":"1","key":"28540_CR18","doi-asserted-by":"crossref","first-page":"6951692","DOI":"10.1155\/2022\/9274098","volume":"2022","author":"Y Wang","year":"2022","unstructured":"Wang, Y. & Long, Q. Diagnostic value of vaginal ultrasound\n                    under improved clustering algorithm combined with hysteroscopy in abnormal\n                    uterine bleeding. Comput. Intell. Neurosci.\n                    2022(1), 6951692 (2022).","journal-title":"Comput. Intell. Neurosci."},{"issue":"1","key":"28540_CR19","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/S1074-3804(05)60024-2","volume":"11","author":"S Bettocchi","year":"2004","unstructured":"Bettocchi, S. et al. The role of office hysteroscopy in menopause.\n                        J. Am. Assoc. Gynecol. Laparosc.\n                    11(1), 103\u2013106 (2004).","journal-title":"J. Am. Assoc. Gynecol. Laparosc."}],"updated-by":[{"DOI":"10.1038\/s41598-026-43159-7","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000}}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-28540-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-28540-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-28540-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T11:04:33Z","timestamp":1773054273000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-28540-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,3]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["28540"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-28540-2","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,3]]},"assertion":[{"value":"7 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 March 2026","order":6,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":7,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This article has been retracted. Please see the Retraction Notice for more detail:","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1038\/s41598-026-43159-7","URL":"https:\/\/doi.org\/10.1038\/s41598-026-43159-7","order":9,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"43019"}}