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However, changes on cardiac function on very early phase (within 48\u00a0h) has not been thoroughly investigated. This study aimed to evaluate the acute effects of CA on cardiac function and morphology immediately post-procedural (\u2264\u200948\u00a0h). We prospectively enrolled 117 consecutive patients. Hemodynamic parameters including biatrial pressure and echocardiographic data were acquired pre- and post-ablation. (i) All bi-atrial pressures significantly elevated post-ablation (p\u2009&lt;\u20090.002). (ii) Bi-atrial function including ejection fraction, reservoir strain and conduit strain improved immediately after ablation (p\u2009&lt;\u20090.01). Persistent atrial fibrillation (AF) improved more than paroxysmal AF. (iii) Biventricular systolic function improved early but left ventricular diastolic function was stunned within 48\u00a0h (p\u2009&lt;\u20090.01). Whereas all chambers\u2019 volume did not change significantly (p\u2009&gt;\u20090.05). (iv) No statistically significant differences in pre- versus post-procedural pressure changed between patients with persistent AF and those with paroxysmal AF in biatrial pressure elevation (p\u2009&gt;\u20090.05). (v) Echocardiographic parameters including LA reservoir strain, RA reservoir strain, peak A of mitral valve, peak E of tricuspid valve and inferior vena cava diameters increased more in persistent AF groups (p\u2009&lt;\u20090.05). This prospective study suggested all chambers\u2019 systolic functions improved in early period post-ablation with left ventricular diastolic function stunning. Mechanical improvements preceding structural remodeling in AF patients early after ablation.<\/jats:p>","DOI":"10.1038\/s41598-025-28591-5","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T14:12:09Z","timestamp":1767017529000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Very early cardiac hemodynamic changes after atrial fibrillation ablation"],"prefix":"10.1038","volume":"15","author":[{"given":"Wanyu","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiquan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yankai","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bowen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,29]]},"reference":[{"key":"28591_CR1","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1161\/CIR.0000000000001193","volume":"149","author":"JA Joglar","year":"2024","unstructured":"Joglar, J. 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