{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T15:37:45Z","timestamp":1777131465215,"version":"3.51.4"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"vor","delay-in-days":34,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100019266","name":"Korea Medical Device Development Fund","doi-asserted-by":"publisher","award":["202015X30"],"award-info":[{"award-number":["202015X30"]}],"id":[{"id":"10.13039\/100019266","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-29165-1","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:44:36Z","timestamp":1764117876000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Functional outcomes of hypothermic robot assisted radical prostatectomy using BELLOCOOL in a randomized controlled trial"],"prefix":"10.1038","volume":"15","author":[{"given":"Jang Hee","family":"Han","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang Wook","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Hoon","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minyong","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sangchul","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seok Soo","family":"Byun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheol","family":"Kwak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong Soo","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"29165_CR1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21708","volume":"72","author":"RL Siegel","year":"2022","unstructured":"Siegel, R. L., Miller, K. D., Fuchs, H. E. & Jemal, A. Cancer statistics, 2022. CA Cancer J. Clin. 72, 7\u201333. https:\/\/doi.org\/10.3322\/caac.21708 (2022).","journal-title":"CA Cancer J. Clin."},{"key":"29165_CR2","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1016\/j.eururo.2016.08.047","volume":"71","author":"PJ Gray","year":"2017","unstructured":"Gray, P. J., Lin, C. C., Cooperberg, M. R., Jemal, A. & Efstathiou, J. A. Temporal trends and the impact of Race, Insurance, and socioeconomic status in the management of localized prostate cancer. Eur. Urol. 71, 729\u2013737. https:\/\/doi.org\/10.1016\/j.eururo.2016.08.047 (2017).","journal-title":"Eur. Urol."},{"key":"29165_CR3","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.15585\/mmwr.mm6941a1","volume":"69","author":"DA Siegel","year":"2020","unstructured":"Siegel, D. A., O\u2019Neil, M. E., Richards, T. B., Dowling, N. F. & Weir, H. K. Prostate cancer incidence and Survival, by stage and Race\/Ethnicity - United States, 2001\u20132017. MMWR Morb Mortal. Wkly. Rep. 69, 1473\u20131480. https:\/\/doi.org\/10.15585\/mmwr.mm6941a1 (2020).","journal-title":"MMWR Morb Mortal. Wkly. Rep."},{"key":"29165_CR4","doi-asserted-by":"publisher","unstructured":"d\u2019Altilia, N. et al. A Matched-Pair analysis after robotic and retropubic radical prostatectomy: A new definition of continence and the impact of different surgical techniques. Cancers (Basel). 14. https:\/\/doi.org\/10.3390\/cancers14184350 (2022).","DOI":"10.3390\/cancers14184350"},{"key":"29165_CR5","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.eururo.2015.02.029","volume":"68","author":"E Haglind","year":"2015","unstructured":"Haglind, E. et al. Urinary incontinence and erectile dysfunction after robotic versus open radical prostatectomy: A prospective, controlled, nonrandomised trial. Eur. Urol. 68, 216\u2013225. https:\/\/doi.org\/10.1016\/j.eururo.2015.02.029 (2015).","journal-title":"Eur. Urol."},{"key":"29165_CR6","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/s41443-020-00374-8","volume":"33","author":"TFN Lima","year":"2021","unstructured":"Lima, T. F. N., Bitran, J., Frech, F. S. & Ramasamy, R. Prevalence of post-prostatectomy erectile dysfunction and a review of the recommended therapeutic modalities. Int. J. Impot. Res. 33, 401\u2013409. https:\/\/doi.org\/10.1038\/s41443-020-00374-8 (2021).","journal-title":"Int. J. Impot. Res."},{"key":"29165_CR7","doi-asserted-by":"publisher","first-page":"2291","DOI":"10.1097\/01.ju.0000181825.54480.eb","volume":"174","author":"M Menon","year":"2005","unstructured":"Menon, M. et al. Potency following robotic radical prostatectomy: a questionnaire based analysis of outcomes after conventional nerve sparing and prostatic fascia sparing techniques. J. Urol. 174, 2291\u20132296. https:\/\/doi.org\/10.1097\/01.ju.0000181825.54480.eb (2005). discussion 2296.","journal-title":"J. Urol."},{"key":"29165_CR8","doi-asserted-by":"publisher","first-page":"2313","DOI":"10.1089\/end.2008.9712","volume":"22","author":"A Mandhani","year":"2008","unstructured":"Mandhani, A. et al. Real time monitoring of temperature changes in neurovascular bundles during robotic radical prostatectomy: thermal map for nerve-sparing radical prostatectomy. J. Endourol. 22, 2313\u20132317. https:\/\/doi.org\/10.1089\/end.2008.9712 (2008).","journal-title":"J. Endourol"},{"key":"29165_CR9","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.eururo.2019.04.042","volume":"78","author":"WH Song","year":"2020","unstructured":"Song, W. H. et al. Establishment of novel intraoperative monitoring and mapping method for the cavernous nerve during Robot-assisted radical prostatectomy: results of the phase I\/II, First-in-human, feasibility study. Eur. Urol. 78, 221\u2013228. https:\/\/doi.org\/10.1016\/j.eururo.2019.04.042 (2020).","journal-title":"Eur. Urol."},{"key":"29165_CR10","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.urology.2007.11.084","volume":"72","author":"S Rais-Bahrami","year":"2008","unstructured":"Rais-Bahrami, S. et al. Optical coherence tomography of cavernous nerves: a step toward real-time intraoperative imaging during nerve-sparing radical prostatectomy. Urology 72, 198\u2013204. https:\/\/doi.org\/10.1016\/j.urology.2007.11.084 (2008).","journal-title":"Urology"},{"key":"29165_CR11","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1016\/j.euf.2020.08.004","volume":"7","author":"R Schiavina","year":"2021","unstructured":"Schiavina, R. et al. Real-time augmented reality Three-dimensional guided robotic radical prostatectomy: preliminary experience and evaluation of the impact on surgical planning. Eur. Urol. Focus. 7, 1260\u20131267. https:\/\/doi.org\/10.1016\/j.euf.2020.08.004 (2021).","journal-title":"Eur. Urol. Focus"},{"key":"29165_CR12","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1111\/bju.12663","volume":"114","author":"TE Ahlering","year":"2014","unstructured":"Ahlering, T. E. & Skarecky, D. W. Preserving sexual function after robotic radical prostatectomy: avoiding thermal energy near nerves. BJU Int. 114, 131\u2013132. https:\/\/doi.org\/10.1111\/bju.12663 (2014).","journal-title":"BJU Int."},{"key":"29165_CR13","doi-asserted-by":"publisher","first-page":"475","DOI":"10.4111\/icu.20220092","volume":"63","author":"WH Song","year":"2022","unstructured":"Song, W. H. et al. Feasibility study of a novel rectal cooling system for hypothermic radical prostatectomy in a swine model. Investig Clin. Urol. 63, 475\u2013481. https:\/\/doi.org\/10.4111\/icu.20220092 (2022).","journal-title":"Investig Clin. Urol."},{"key":"29165_CR14","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1089\/end.2022.0560","volume":"37","author":"JH Han","year":"2023","unstructured":"Han, J. H. et al. Feasibility, Safety, and functional outcomes of pelvic hypothermia induced using a rectal cooling device during Robot-Assisted radical prostatectomy: A phase I\/II trial. J. Endourol. 37, 407\u2013413. https:\/\/doi.org\/10.1089\/end.2022.0560 (2023).","journal-title":"J. Endourol"},{"key":"29165_CR15","doi-asserted-by":"publisher","first-page":"307","DOI":"10.21037\/tau.2019.07.03","volume":"8","author":"W Cui","year":"2019","unstructured":"Cui, W. et al. Efficacy and safety of novel low-intensity pulsed ultrasound (LIPUS) in treating mild to moderate erectile dysfunction: a multicenter, randomized, double-blind, sham-controlled clinical study. Transl Androl. Urol. 8, 307\u2013319. https:\/\/doi.org\/10.21037\/tau.2019.07.03 (2019).","journal-title":"Transl Androl. Urol."},{"key":"29165_CR16","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/j.urology.2008.09.085","volume":"73","author":"DS Finley","year":"2009","unstructured":"Finley, D. S., Osann, K., Skarecky, D. & Ahlering, T. E. Hypothermic nerve-sparing radical prostatectomy: rationale, feasibility, and effect on early continence. Urology 73, 691\u2013696. https:\/\/doi.org\/10.1016\/j.urology.2008.09.085 (2009).","journal-title":"Urology"},{"key":"29165_CR17","doi-asserted-by":"publisher","first-page":"16352","DOI":"10.1038\/s41598-018-34657-4","volume":"8","author":"LM Huynh","year":"2018","unstructured":"Huynh, L. M. et al. A randomized control trial of Anti-Inflammatory regional hypothermia on urinary continence during Robot-Assisted radical prostatectomy. Sci. Rep. 8, 16352. https:\/\/doi.org\/10.1038\/s41598-018-34657-4 (2018).","journal-title":"Sci. Rep."},{"key":"29165_CR18","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/sj.pcan.4501013","volume":"11","author":"S Namiki","year":"2008","unstructured":"Namiki, S. et al. Sexual function following radical prostatectomy: a prospective longitudinal study of cultural differences between Japanese and American men. Prostate Cancer Prostatic Dis. 11, 298\u2013302. https:\/\/doi.org\/10.1038\/sj.pcan.4501013 (2008).","journal-title":"Prostate Cancer Prostatic Dis."},{"key":"29165_CR19","doi-asserted-by":"publisher","first-page":"162","DOI":"10.5173\/ceju.2022.0279.R1","volume":"75","author":"A Philippi","year":"2022","unstructured":"Philippi, A. et al. Diabetes mellitus lowers the chance of short-term urinary continence recovery in prostate cancer patients undergoing radical prostatectomy. Cent. Eur. J. Urol. 75, 162\u2013168. https:\/\/doi.org\/10.5173\/ceju.2022.0279.R1 (2022).","journal-title":"Cent. Eur. J. Urol."},{"key":"29165_CR20","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1002\/nau.20314","volume":"26","author":"S Wille","year":"2007","unstructured":"Wille, S., Heidenreich, A., Hofmann, R. & Engelmann, U. Preoperative erectile function is one predictor for post prostatectomy incontinence. Neurourol. Urodyn. 26, 140\u2013143. https:\/\/doi.org\/10.1002\/nau.20314 (2007). discussion 144.","journal-title":"Neurourol. Urodyn."},{"key":"29165_CR21","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1016\/j.eururo.2011.07.053","volume":"60","author":"RC Rosen","year":"2011","unstructured":"Rosen, R. C., Allen, K. R., Ni, X. & Araujo, A. B. Minimal clinically important differences in the erectile function domain of the international index of erectile function scale. Eur. Urol. 60, 1010\u20131016. https:\/\/doi.org\/10.1016\/j.eururo.2011.07.053 (2011).","journal-title":"Eur. Urol."},{"key":"29165_CR22","doi-asserted-by":"publisher","first-page":"313","DOI":"10.4111\/icu.2018.59.5.313","volume":"59","author":"S Pak","year":"2018","unstructured":"Pak, S., Kim, M. & Ahn, H. Changes in health-related quality of life after radical prostatectomy for prostate cancer: A longitudinal cohort study in Korea. Investig Clin. Urol. 59, 313\u2013320. https:\/\/doi.org\/10.4111\/icu.2018.59.5.313 (2018).","journal-title":"Investig Clin. Urol."},{"key":"29165_CR23","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1111\/bju.15739","volume":"130","author":"JA Lane","year":"2022","unstructured":"Lane, J. A. et al. Functional and quality of life outcomes of localised prostate cancer treatments (Prostate testing for cancer and treatment [ProtecT] study). BJU Int. 130, 370\u2013380. https:\/\/doi.org\/10.1111\/bju.15739 (2022).","journal-title":"BJU Int."},{"key":"29165_CR24","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1111\/bju.14190","volume":"122","author":"LM Huynh","year":"2018","unstructured":"Huynh, L. M., Osann, K., Skarecky, D. & Ahlering, T. E. Predictive modelling of 2-year potency outcomes using a novel 90-day erection fullness scale after robot-assisted radical prostatectomy. BJU Int. 122, 249\u2013254. https:\/\/doi.org\/10.1111\/bju.14190 (2018).","journal-title":"BJU Int."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-29165-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-29165-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-29165-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T14:51:23Z","timestamp":1777128683000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-29165-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,26]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["29165"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-29165-1","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,26]]},"assertion":[{"value":"26 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"45366"}}