{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T14:35:13Z","timestamp":1793802913378,"version":"4.6.1"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":38,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-29334-2","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T05:35:54Z","timestamp":1763703354000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Integrative transcriptomics and network analysis reveals core genes driving meningioma pathogenesis and clinical outcomes"],"prefix":"10.1038","volume":"15","author":[{"given":"Youssef M","family":"Zohdy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali M","family":"Alawieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arman","family":"Jahangiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Siciliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Tariciotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Rodas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Maldonado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Hoang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edjah","family":"Nduom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian M","family":"Howard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel L","family":"Barrow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliaksandr","family":"Aksionau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stewart G","family":"Neill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhexing","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Pradilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Garzon-Muvdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,21]]},"reference":[{"issue":"Suppl 5","key":"29334_CR1","doi-asserted-by":"publisher","first-page":"v1","DOI":"10.1093\/neuonc\/noac202","volume":"24","author":"QT Ostrom","year":"2022","unstructured":"Ostrom, Q. T. et al. CBTRUS statistical report: Primary brain and other central nervous system tumors diagnosed in the united States in 2015\u20132019. Neuro Oncol. 24 (Suppl 5), v1\u2013v95 (2022).","journal-title":"Neuro Oncol."},{"issue":"6","key":"29334_CR2","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1007\/s00401-016-1545-1","volume":"131","author":"DN Louis","year":"2016","unstructured":"Louis, D. N. et al. The 2016 world health organization classification of tumors of the central nervous system: A summary. Acta Neuropathol. 131 (6), 803\u2013820 (2016).","journal-title":"Acta Neuropathol."},{"issue":"12","key":"29334_CR3","doi-asserted-by":"publisher","first-page":"3067","DOI":"10.1038\/s41591-023-02586-z","volume":"29","author":"WC Chen","year":"2023","unstructured":"Chen, W. C. et al. Targeted gene expression profiling predicts meningioma outcomes and radiotherapy responses. Nat. Med. 29 (12), 3067\u20133076 (2023).","journal-title":"Nat. Med."},{"issue":"1","key":"29334_CR4","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1093\/neuonc\/noac137","volume":"25","author":"CL Rogers","year":"2023","unstructured":"Rogers, C. L. et al. Low-risk meningioma: Initial outcomes from NRG Oncology\/RTOG 0539. Neuro Oncol. 25 (1), 137\u2013145 (2023).","journal-title":"Neuro Oncol."},{"issue":"4","key":"29334_CR5","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1016\/j.ijrobp.2019.11.028","volume":"106","author":"CL Rogers","year":"2020","unstructured":"Rogers, C. L. et al. High-risk meningioma: Initial outcomes from NRG Oncology\/RTOG 0539. Int. J. Radiat. Oncol. Biol. Phys. 106 (4), 790\u2013799 (2020).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"issue":"9","key":"29334_CR6","doi-asserted-by":"publisher","first-page":"2453","DOI":"10.1007\/s00701-022-05301-y","volume":"164","author":"SH Torp","year":"2022","unstructured":"Torp, S. H., Solheim, O. & Skjulsvik, A. J. The WHO 2021 classification of central nervous system tumours: A practical update on what neurosurgeons need to know-a minireview. Acta Neurochir. (Wien). 164 (9), 2453\u20132464 (2022).","journal-title":"Acta Neurochir. (Wien)"},{"issue":"5","key":"29334_CR7","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.3171\/2019.8.JNS191266","volume":"133","author":"MW Youngblood","year":"2019","unstructured":"Youngblood, M. W. et al. Correlations between genomic subgroup and clinical features in a cohort of more than 3000 meningiomas. J. Neurosurg. 133 (5), 1345\u20131354 (2019).","journal-title":"J. Neurosurg."},{"issue":"6123","key":"29334_CR8","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1126\/science.1233009","volume":"339","author":"VE Clark","year":"2013","unstructured":"Clark, V. E. et al. Genomic analysis of non-NF2 meningiomas reveals mutations in TRAF7, KLF4, AKT1, and SMO. Science 339 (6123), 1077\u20131080 (2013).","journal-title":"Science"},{"issue":"7874","key":"29334_CR9","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1038\/s41586-021-03850-3","volume":"597","author":"F Nassiri","year":"2021","unstructured":"Nassiri, F. et al. A clinically applicable integrative molecular classification of meningiomas. Nature 597 (7874), 119\u2013125 (2021).","journal-title":"Nature"},{"issue":"5","key":"29334_CR10","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1038\/s41588-022-01061-8","volume":"54","author":"A Choudhury","year":"2022","unstructured":"Choudhury, A. et al. Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities. Nat. Genet. 54 (5), 649\u2013659 (2022).","journal-title":"Nat. Genet."},{"issue":"5","key":"29334_CR11","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1093\/neuonc\/noab213","volume":"24","author":"J Driver","year":"2022","unstructured":"Driver, J. et al. A molecularly integrated grade for meningioma. Neuro Oncol. 24 (5), 796\u2013808 (2022).","journal-title":"Neuro Oncol."},{"issue":"3","key":"29334_CR12","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1038\/s41587-020-0439-x","volume":"38","author":"PA Ewels","year":"2020","unstructured":"Ewels, P. A. et al. The nf-core framework for community-curated bioinformatics pipelines. Nat. Biotechnol. 38 (3), 276\u2013278 (2020).","journal-title":"Nat. Biotechnol."},{"key":"29334_CR13","unstructured":"S. A. FastQC: a quality control tool for high throughput sequence data. Available online at: (2010). http:\/\/www.bioinformatics.babraham.ac.uk\/projects\/fastqc"},{"key":"29334_CR14","doi-asserted-by":"crossref","unstructured":"Martin, M. CUTADAPT removes adapter sequences from high-throughput sequencing reads. EMBnet Journal ; 17. (2011).","DOI":"10.14806\/ej.17.1.200"},{"issue":"1","key":"29334_CR15","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","volume":"29","author":"A Dobin","year":"2013","unstructured":"Dobin, A. et al. STAR: ultrafast universal RNA-seq aligner. Bioinformatics 29 (1), 15\u201321 (2013).","journal-title":"Bioinformatics"},{"issue":"4","key":"29334_CR16","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1038\/nmeth.4197","volume":"14","author":"R Patro","year":"2017","unstructured":"Patro, R., Duggal, G., Love, M. I., Irizarry, R. A. & Kingsford, C. Salmon provides fast and bias-aware quantification of transcript expression. Nat. Methods. 14 (4), 417\u2013419 (2017).","journal-title":"Nat. Methods"},{"issue":"12","key":"29334_CR17","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love, M. I., Huber, W. & Anders, S. Moderated Estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 15 (12), 550 (2014).","journal-title":"Genome Biol."},{"issue":"5","key":"29334_CR18","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","volume":"16","author":"G Yu","year":"2012","unstructured":"Yu, G., Wang, L. G., Han, Y. & He, Q. Y. ClusterProfiler: An R package for comparing biological themes among gene clusters. OMICS 16 (5), 284\u2013287 (2012).","journal-title":"OMICS"},{"key":"29334_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2105-9-559","volume":"9","author":"P Langfelder","year":"2008","unstructured":"Langfelder, P. & Horvath, S. WGCNA: An R package for weighted correlation network analysis. BMC Bioinform. 9, 1\u201313 (2008).","journal-title":"BMC Bioinform."},{"key":"29334_CR20","doi-asserted-by":"publisher","first-page":"34","DOI":"10.3389\/fbioe.2020.00034","volume":"8","author":"M Koutrouli","year":"2020","unstructured":"Koutrouli, M., Karatzas, E., Paez-Espino, D. & Pavlopoulos, G. A. A guide to conquer the biological network era using graph theory. Front. Bioeng. Biotechnol. 8, 34 (2020).","journal-title":"Front. Bioeng. Biotechnol."},{"key":"29334_CR21","unstructured":"Cs\u00e1rdi, G. et al. Igraph for R: R interface of the Igraph library for graph theory and network analysis. Zenodo (2024)."},{"issue":"1","key":"29334_CR22","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/comnet\/cnv013","volume":"4","author":"F Viger","year":"2015","unstructured":"Viger, F. & Latapy, M. Efficient and simple generation of random simple connected graphs with prescribed degree sequence. J. Complex. Networks. 4 (1), 15\u201337 (2015).","journal-title":"J. Complex. Networks"},{"issue":"2","key":"29334_CR23","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1038\/nphys209","volume":"2","author":"V Colizza","year":"2006","unstructured":"Colizza, V., Flammini, A., Serrano, M. A. & Vespignani, A. Detecting rich-club ordering in complex networks. Nat. Phys. 2 (2), 110\u2013115 (2006).","journal-title":"Nat. Phys."},{"key":"29334_CR24","unstructured":"Blighe, K. & Lun, A. PCAtools: everything principal components analysis. (2019). https:\/\/github.com\/kevinblighe\/PCAtools"},{"issue":"24","key":"29334_CR25","doi-asserted-by":"publisher","first-page":"5146","DOI":"10.1093\/bioinformatics\/btz447","volume":"35","author":"J Zyla","year":"2019","unstructured":"Zyla, J. et al. Gene set enrichment for reproducible science: Comparison of CERNO and eight other algorithms. Bioinformatics 35 (24), 5146\u20135154 (2019).","journal-title":"Bioinformatics"},{"issue":"4","key":"29334_CR26","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1111\/j.1750-3639.2009.00356.x","volume":"20","author":"Y Lee","year":"2010","unstructured":"Lee, Y. et al. Genomic landscape of meningiomas. Brain Pathol. 20 (4), 751\u2013762 (2010).","journal-title":"Brain Pathol."},{"issue":"43","key":"29334_CR27","doi-asserted-by":"publisher","first-page":"21715","DOI":"10.1073\/pnas.1912858116","volume":"116","author":"AJ Patel","year":"2019","unstructured":"Patel, A. J. et al. Molecular profiling predicts meningioma recurrence and reveals loss of DREAM complex repression in aggressive tumors. Proc. Natl. Acad. Sci. U S A. 116 (43), 21715\u201321726 (2019).","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"issue":"3","key":"29334_CR28","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1111\/j.1750-3639.2008.00191.x","volume":"19","author":"MD Tabernero","year":"2009","unstructured":"Tabernero, M. D. et al. Gene expression profiles of meningiomas are associated with tumor cytogenetics and patient outcome. Brain Pathol. 19 (3), 409\u2013420 (2009).","journal-title":"Brain Pathol."},{"issue":"12","key":"29334_CR29","doi-asserted-by":"publisher","first-page":"14551","DOI":"10.18632\/oncotarget.7396","volume":"7","author":"M Schmidt","year":"2016","unstructured":"Schmidt, M. et al. Transcriptomic analysis of aggressive meningiomas identifies PTTG1 and LEPR as prognostic biomarkers independent of WHO grade. Oncotarget 7 (12), 14551\u201314568 (2016).","journal-title":"Oncotarget"},{"issue":"1","key":"29334_CR30","doi-asserted-by":"publisher","first-page":"9065","DOI":"10.1038\/s41598-020-65365-7","volume":"10","author":"Z Zador","year":"2020","unstructured":"Zador, Z., Landry, A. P., Balas, M. & Cusimano, M. D. Landscape of immune cell gene expression is unique in predominantly WHO grade 1 skull base meningiomas when compared to convexity. Sci. Rep. 10 (1), 9065 (2020).","journal-title":"Sci. Rep."},{"key":"29334_CR31","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.3389\/fonc.2020.01491","volume":"10","author":"J Liu","year":"2020","unstructured":"Liu, J., Xia, C. & Wang, G. Multi-Omics analysis in initiation and progression of meningiomas: from pathogenesis to diagnosis. Front. Oncol. 10, 1491 (2020).","journal-title":"Front. Oncol."},{"issue":"34","key":"29334_CR32","doi-asserted-by":"publisher","first-page":"3839","DOI":"10.1200\/JCO.21.00784","volume":"39","author":"SLN Maas","year":"2021","unstructured":"Maas, S. L. N. et al. Integrated Molecular-Morphologic meningioma classification: A multicenter retrospective Analysis, retrospectively and prospectively validated. J. Clin. Oncol. 39 (34), 3839\u20133852 (2021).","journal-title":"J. Clin. Oncol."},{"issue":"1","key":"29334_CR33","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s40478-019-0690-x","volume":"7","author":"AN Viaene","year":"2019","unstructured":"Viaene, A. N. et al. Transcriptome signatures associated with meningioma progression. Acta Neuropathol. Commun. 7 (1), 67 (2019).","journal-title":"Acta Neuropathol. Commun."},{"issue":"6","key":"29334_CR34","doi-asserted-by":"publisher","first-page":"100566","DOI":"10.1016\/j.xgen.2024.100566","volume":"4","author":"HN Thirimanne","year":"2024","unstructured":"Thirimanne, H. N. et al. Meningioma transcriptomic landscape demonstrates novel subtypes with regional associated biology and patient outcome. Cell. Genom. 4 (6), 100566 (2024).","journal-title":"Cell. Genom"},{"issue":"3","key":"29334_CR35","doi-asserted-by":"publisher","first-page":"e335","DOI":"10.1371\/journal.pone.0000335","volume":"2","author":"S Wuchty","year":"2007","unstructured":"Wuchty, S. Rich-club phenomenon in the interactome of P. falciparum\u2013artifact or signature of a parasitic life style? PLoS One. 2 (3), e335 (2007).","journal-title":"PLoS One"},{"issue":"4","key":"29334_CR36","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/sj.embor.7400129","volume":"5","author":"P Aloy","year":"2004","unstructured":"Aloy, P. & Russell, R. B. Taking the mystery out of biological networks. EMBO Rep. 5 (4), 349\u2013350 (2004).","journal-title":"EMBO Rep."},{"issue":"6","key":"29334_CR37","doi-asserted-by":"publisher","first-page":"E3","DOI":"10.3171\/2013.10.FOCUS13326","volume":"35","author":"X Chang","year":"2013","unstructured":"Chang, X. et al. Genomic and transcriptome analysis revealing an oncogenic functional module in meningiomas. Neurosurg. Focus. 35 (6), E3 (2013).","journal-title":"Neurosurg. Focus"},{"key":"29334_CR38","doi-asserted-by":"publisher","first-page":"541928","DOI":"10.3389\/fonc.2020.541928","volume":"10","author":"Z Zador","year":"2020","unstructured":"Zador, Z., Landry, A. P., Saha, A. & Cusimano, M. D. Gene expression signatures identify biologically homogenous subgroups of grade 2 meningiomas. Front. Oncol. 10, 541928 (2020).","journal-title":"Front. Oncol."},{"issue":"6","key":"29334_CR39","first-page":"8245","volume":"15","author":"J Dai","year":"2018","unstructured":"Dai, J. et al. Identification of key genes and pathways in meningioma by bioinformatics analysis. Oncol. Lett. 15 (6), 8245\u20138252 (2018).","journal-title":"Oncol. Lett."},{"issue":"1","key":"29334_CR40","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1007\/s12032-022-01869-8","volume":"40","author":"L Zhang","year":"2022","unstructured":"Zhang, L., Wang, L., Tan, Y., Li, C. & Fang, C. Identification of key genes of anti-programmed death ligand 1 for meningioma immunotherapy by bioinformatic analysis. Med. Oncol. 40 (1), 54 (2022).","journal-title":"Med. Oncol."},{"issue":"1","key":"29334_CR41","doi-asserted-by":"publisher","first-page":"13513","DOI":"10.1038\/srep13513","volume":"5","author":"A Alawieh","year":"2015","unstructured":"Alawieh, A., Sabra, Z., Sabra, M., Tomlinson, S. & Zaraket, F. A. A rich-club organization in brain ischemia protein interaction network. Sci. Rep. 5 (1), 13513 (2015).","journal-title":"Sci. Rep."},{"key":"29334_CR42","doi-asserted-by":"publisher","first-page":"931371","DOI":"10.3389\/fonc.2022.931371","volume":"12","author":"JS Young","year":"2022","unstructured":"Young, J. S. et al. CDK 4\/6 inhibitors for the treatment of meningioma. Front. Oncol. 12, 931371 (2022).","journal-title":"Front. Oncol."},{"issue":"19","key":"29334_CR43","doi-asserted-by":"publisher","first-page":"3904","DOI":"10.4161\/cc.9.19.13585","volume":"9","author":"X Qiao","year":"2010","unstructured":"Qiao, X., Zhang, L., Gamper, A. M., Fujita, T. & Wan, Y. APC\/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity. Cell. Cycle. 9 (19), 3904\u20133912 (2010).","journal-title":"Cell. Cycle"},{"issue":"2","key":"29334_CR44","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.ymeth.2006.08.003","volume":"41","author":"JC Sible","year":"2007","unstructured":"Sible, J. C. & Tyson, J. J. Mathematical modeling as a tool for investigating cell cycle control networks. Methods 41 (2), 238\u2013247 (2007).","journal-title":"Methods"},{"issue":"11","key":"29334_CR45","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1097\/NEN.0b013e3181bc6642","volume":"68","author":"MD Johnson","year":"2009","unstructured":"Johnson, M. D., O\u2019Connell, M. J., Vito, F. & Pilcher, W. Bone morphogenetic protein 4 and its receptors are expressed in the leptomeninges and meningiomas and signal via the Smad pathway. J. Neuropathol. Exp. Neurol. 68 (11), 1177\u20131183 (2009).","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"2","key":"29334_CR46","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1111\/nan.12571","volume":"46","author":"H Kim","year":"2020","unstructured":"Kim, H. et al. Forkhead box M1 (FOXM1) transcription factor is a key oncogenic driver of aggressive human meningioma progression. Neuropathol. Appl. Neurobiol. 46 (2), 125\u2013141 (2020).","journal-title":"Neuropathol. Appl. Neurobiol."},{"issue":"10","key":"29334_CR47","doi-asserted-by":"publisher","first-page":"e0205846","DOI":"10.1371\/journal.pone.0205846","volume":"13","author":"MB Arnli","year":"2018","unstructured":"Arnli, M. B., Winther, T. L., Lydersen, S. & Torp, S. H. Prognostic value of ErbB2\/HER2 in human meningiomas. PLoS One. 13 (10), e0205846 (2018).","journal-title":"PLoS One"},{"issue":"1","key":"29334_CR48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/NEN.0b013e3182018f1c","volume":"70","author":"JE Stuart","year":"2011","unstructured":"Stuart, J. E. et al. Identification of gene markers associated with aggressive meningioma by filtering across multiple sets of gene expression arrays. J. Neuropathol. Exp. Neurol. 70 (1), 1\u201312 (2011).","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"5","key":"29334_CR49","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1038\/s41591-018-0014-x","volume":"24","author":"M Binnewies","year":"2018","unstructured":"Binnewies, M. et al. Understanding the tumor immune microenvironment (TIME) for effective therapy. Nat. Med. 24 (5), 541\u2013550 (2018).","journal-title":"Nat. Med."},{"issue":"7","key":"29334_CR50","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1038\/s41571-018-0003-5","volume":"15","author":"M Lim","year":"2018","unstructured":"Lim, M., Xia, Y., Bettegowda, C. & Weller, M. Current state of immunotherapy for glioblastoma. Nat. Rev. Clin. Oncol. 15 (7), 422\u2013442 (2018).","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"29334_CR51","doi-asserted-by":"publisher","first-page":"1321895","DOI":"10.3389\/fneur.2023.1321895","volume":"14","author":"V Aran","year":"2023","unstructured":"Aran, V. et al. Liquid biopsy evaluation of Circulating tumor DNA, miRNAs, and cytokines in meningioma patients. Front. Neurol. 14, 1321895 (2023).","journal-title":"Front. Neurol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-29334-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-29334-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-29334-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T14:05:09Z","timestamp":1777125909000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-29334-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,21]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["29334"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-29334-2","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,21]]},"assertion":[{"value":"31 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All collected tissues exceeded the amount required for pathological diagnosis and were specifically obtained for research purposes. The study protocol received approval by Emory University Institutional Review Board, and all research was performed in accordance with the Declaration of Helsinki. All participating patients provided informed consent for the collection of tumor tissue.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent of participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Core Genes Driving Meningioma Pathogenesis and outcomes.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Running title"}}],"article-number":"44982"}}