{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T22:58:10Z","timestamp":1788044290296,"version":"build-2784847793"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":36,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-29458-5","type":"journal-article","created":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T02:14:09Z","timestamp":1764468849000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Lower mortality in calcimimetic users compared to non-users in dialysis patients with serum parathyroid hormone levels within the target range"],"prefix":"10.1038","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0725-2688","authenticated-orcid":false,"given":"Kazuyoshi","family":"Okada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Tashiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumiyo","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6453-3824","authenticated-orcid":false,"given":"Takahiro","family":"Kuragano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Minakuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,30]]},"reference":[{"key":"29458_CR1","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1111\/1744-9987.12058","volume":"17","author":"M Fukagawa","year":"2013","unstructured":"Fukagawa, M. et al. Clinical practice guideline for the management of chronic kidney Disease-Mineral and bone disorder. Ther. Aphr Dial. 17, 247\u2013288. https:\/\/doi.org\/10.1111\/1744-9987.12058 (2013).","journal-title":"Ther. Aphr Dial"},{"key":"29458_CR2","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1093\/ndt\/gfad213","volume":"39","author":"S Goto","year":"2024","unstructured":"Goto, S. et al. Hypocalcemia and cardiovascular mortality in Cinacalcet users. Nephrol. Dial Transpl. 39, 637\u2013647. https:\/\/doi.org\/10.1093\/ndt\/gfad213 (2024).","journal-title":"Nephrol. Dial Transpl."},{"key":"29458_CR3","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1111\/1744-9987.12030","volume":"17","author":"M Taniguchi","year":"2013","unstructured":"Taniguchi, M. et al. Serum phosphate and calcium should be primarily and consistently controlled in prevalent Hemodialysis patients. Ther. Apher Dial. 17, 221\u2013228. https:\/\/doi.org\/10.1111\/1744-9987.12030 (2013).","journal-title":"Ther. Apher Dial"},{"key":"29458_CR4","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1681\/ASN.2014040414","volume":"26","author":"SM Moe","year":"2015","unstructured":"Moe, S. M. et al. Effects of Cinacalcet on fracture events in patients receiving hemodialysis: the EVOLVE trial. J. Am. Soc. Nephrol. 26, 1466\u20131375. https:\/\/doi.org\/10.1681\/ASN.2014040414 (2015).","journal-title":"J. Am. Soc. Nephrol."},{"key":"29458_CR5","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.2215\/CJN.0000000000000254","volume":"18","author":"P Khairallah","year":"2023","unstructured":"Khairallah, P. et al. Changes in bone quality after treatment with Etelcalcetide. Clin. J. Am. Soc. Nephro L. 18, 1456\u20131465. https:\/\/doi.org\/10.2215\/CJN.0000000000000254 (2023).","journal-title":"Clin. J. Am. Soc. Nephro L"},{"key":"29458_CR6","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1007\/s00774-024-01500-y","volume":"42","author":"T Wakamatsu","year":"2024","unstructured":"Wakamatsu, T. et al. Effectiveness of calcimimetics on fractures in Dialysis patients with secondary hyperparathyroidism: meta-analysis of randomized trials. J. Bone Min. Metab. 42, 316\u2013325. https:\/\/doi.org\/10.1007\/s00774-024-01500-y (2024).","journal-title":"J. Bone Min. Metab."},{"key":"29458_CR7","doi-asserted-by":"publisher","first-page":"2956","DOI":"10.1016\/j.ekir.2024.07.008","volume":"9","author":"H Komaba","year":"2024","unstructured":"Komaba, H. et al. Lower parathyroid hormone levels are associated with reduced fracture risk in Japanese patients on hemodialysis. Kidney Int. Rep. 9, 2956\u20132569. https:\/\/doi.org\/10.1016\/j.ekir.2024.07.008 (2024) (2956\u2009\u2013\u20092569).","journal-title":"Kidney Int. Rep."},{"key":"29458_CR8","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/s41100-021-00385-1","volume":"7","author":"K Okada","year":"2021","unstructured":"Okada, K. et al. Effects of Japanese-style online hemodiafiltration on survival and cardiovascular events. Ren. Replace. Ther. 7, 70. https:\/\/doi.org\/10.1186\/s41100-021-00385-1 (2021).","journal-title":"Ren. Replace. Ther."},{"key":"29458_CR9","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1002\/pst.433","volume":"10","author":"PC Austin","year":"2011","unstructured":"Austin, P. C. Optimal caliper widths for propensity-score matching when estimating differences in means and differences in proportions in observational studies. Pharm. Stat. 10, 150\u2013161. https:\/\/doi.org\/10.1002\/pst.433 (2011).","journal-title":"Pharm. Stat."},{"key":"29458_CR10","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1093\/ckj\/sfab177","volume":"15","author":"M Abe","year":"2021","unstructured":"Abe, M. et al. Super high-flux membrane dialyzers improve mortality in patients on hemodialysis: a 3-year nationwide cohort study. Clin. Kidney J. 15, 473\u2013483. https:\/\/doi.org\/10.1093\/ckj\/sfab177 (2021).","journal-title":"Clin. Kidney J."},{"key":"29458_CR11","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s41100-023-00490-3","volume":"9","author":"K Okada","year":"2023","unstructured":"Okada, K. et al. Comparison of survival for super high-flux hemodialysis (SHF-HD) with high albumin leakage versus online hemodiafiltration or SHF-HD with low albumin leakage: the SUPERB study. Ren. Replace. Ther 9, 32. https:\/\/doi.org\/10.1186\/s41100-023-00490-3 (2023).","journal-title":"Ren. Replace. Ther"},{"key":"29458_CR12","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s41100-022-00440-5","volume":"8","author":"K Okada","year":"2022","unstructured":"Okada, K. et al. Effects of high albumin leakage on survival between online hemodiafiltration and super high-flux hemodialysis: the HISTORY study. Ren. Replace. Ther. 8, 52. https:\/\/doi.org\/10.1186\/s41100-022-00440-5 (2022).","journal-title":"Ren. Replace. Ther."},{"key":"29458_CR13","doi-asserted-by":"publisher","first-page":"2482","DOI":"10.1056\/NEJMoa1205624","volume":"367","author":"GM Chertow","year":"2012","unstructured":"Chertow, G. M. et al. Effect of Cinacalcet on cardiovascular disease in patients undergoing Dialysis. N Engl. J. Med. 367, 2482\u20132494. https:\/\/doi.org\/10.1056\/NEJMoa1205624 (2012).","journal-title":"N Engl. J. Med."},{"key":"29458_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.kisu.2017.10.001","volume":"7","author":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD Update Work group","year":"2017","unstructured":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD Update Work group. KDIGO 2017 clinical practice guideline update for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease-mineral and bone disorder (CKD-MBD). Kidney Int. Suppl. 7, 1\u201359. https:\/\/doi.org\/10.1016\/j.kisu.2017.10.001 (2017).","journal-title":"Kidney Int. Suppl."},{"key":"29458_CR15","doi-asserted-by":"publisher","first-page":"98","DOI":"10.2215\/CJN.12941213","volume":"10","author":"F Tentori","year":"2015","unstructured":"Tentori, F. et al. Recent changes in therapeutic approaches and association with outcomes among patients with secondary hyperparathyroidism on chronic hemodialysis: the DOPPS study. Clin. J. Am. Soc. Nephrol. 10, 98\u2013109. https:\/\/doi.org\/10.2215\/CJN.12941213 (2015).","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"29458_CR16","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1016\/j.kint.2023.01.008","volume":"103","author":"T Imaizumi","year":"2023","unstructured":"Imaizumi, T. et al. Excess risk of cardiovascular events in patients in the united States vs. Japan with chronic kidney disease is mediated mainly by left ventricular structure and function. Kidney Int. 103, 949\u2013961. https:\/\/doi.org\/10.1016\/j.kint.2023.01.008 (2023).","journal-title":"Kidney Int."},{"key":"29458_CR17","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1038\/ki.2013.252","volume":"85","author":"B Robinson","year":"2014","unstructured":"Robinson, B. et al. World-wide, mortality is a high risk soon after initiation of Hemodialysis. Kidney Int. 85, 158\u2013165. https:\/\/doi.org\/10.1038\/ki.2013.252 (2014).","journal-title":"Kidney Int."},{"key":"29458_CR18","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.semnephrol.2018.02.005","volume":"38","author":"K Lim","year":"2018","unstructured":"Lim, K., Hamano, T. & Thadhani, R. Vitamin D and calcimimetics in cardiovascular disease. Semin Nephrol. 38, 251\u2013266. https:\/\/doi.org\/10.1016\/j.semnephrol.2018.02.005 (2018).","journal-title":"Semin Nephrol."},{"key":"29458_CR19","doi-asserted-by":"publisher","first-page":"599","DOI":"10.2215\/CJN.16601020","volume":"16","author":"T Shoji","year":"2021","unstructured":"Shoji, T. et al. Comparative effects of Etelcalcetide and maxacalcitol on serum calcification propensity in secondary hyperparathyroidism: A randomized clinical trial. Clin. J. Am. Soc. Nephrol. 16, 599\u2013612. https:\/\/doi.org\/10.2215\/CJN.16601020 (2021).","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"29458_CR20","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1038\/ki.2013.279","volume":"85","author":"F Tentori","year":"2014","unstructured":"Tentori, F. et al. High rates of death and hospitalization follow bone fracture among Hemodialysis patients. Kidney Int. 85, 166\u2013173. https:\/\/doi.org\/10.1038\/ki.2013.279 (2014).","journal-title":"Kidney Int."},{"key":"29458_CR21","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s41100-024-00543-1","volume":"10","author":"K Okada","year":"2024","unstructured":"Okada, K. et al. Improved survival on super high flux-albumin leaking Hemodialysis and online hemodiafiltration with high albumin leakage in patients with mild hypoalbuminemia: evidence and a hypothesis. Ren. Replace. Ther. 10, 27. https:\/\/doi.org\/10.1186\/s41100-024-00543-1 (2024).","journal-title":"Ren. Replace. Ther."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-29458-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-29458-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-29458-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T03:02:23Z","timestamp":1767668543000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-29458-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,30]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["29458"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-29458-5","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,30]]},"assertion":[{"value":"19 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"241"}}