{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:54:34Z","timestamp":1787003674688,"version":"build-2736575974"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100004385","name":"Universiteit Gent","doi-asserted-by":"publisher","award":["BOF.GOA.2021.0004"],"award-info":[{"award-number":["BOF.GOA.2021.0004"]}],"id":[{"id":"10.13039\/501100004385","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-29937-9","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T16:34:00Z","timestamp":1767717240000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A rare 5\u2019UTR variant in SEC24D reveals translational dysfunction in osteogenesis imperfecta: a roadmap for RNA therapeutic rescue"],"prefix":"10.1038","volume":"16","author":[{"given":"Osama","family":"Essawi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Jarayseh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piyanoot","family":"Tapaneeyaphan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manon","family":"Bouckaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Naessens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fransiska","family":"Malfait","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frauke","family":"Coppieters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Coucke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"29937_CR1","doi-asserted-by":"crossref","unstructured":"Sillence, D. O., Senn, A. & Danks, D. M. Genetic heterogeneity in osteogenesis imperfecta. J Med. Genet 16, 101-116 (1979).","DOI":"10.1136\/jmg.16.2.101"},{"key":"29937_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00728-X","author":"A Forlino","year":"2016","unstructured":"Forlino, A. & Marini, J. C. Osteogenesis imperfecta. The Lancet https:\/\/doi.org\/10.1016\/S0140-6736(15)00728-X (2016).","journal-title":"The Lancet"},{"key":"29937_CR3","doi-asserted-by":"publisher","first-page":"Preprintathttps","DOI":"10.1038\/nrdp.2017.52","volume":"3","author":"J Marini","year":"2017","unstructured":"Marini, J. et al. (ed, C.) Osteogenesis imperfecta. Nat. Rev. Dis. Primers 3 Preprintathttpsdoiorg101038nrdp201752 (2017).","journal-title":"Nat. Rev. Dis. Primers"},{"key":"29937_CR4","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-024-01266-5","author":"M Jovanovic","year":"2024","unstructured":"Jovanovic, M. & Marini, J. C. Update on the genetics of osteogenesis imperfecta. Calcif Tissue Int. https:\/\/doi.org\/10.1007\/s00223-024-01266-5 (2024).","journal-title":"Calcif Tissue Int."},{"key":"29937_CR5","doi-asserted-by":"crossref","unstructured":"Viljoen, D., Versfeld, G. & Beighton, P. Osteogenesis imperfecta with congenital joint contractures (Bruck Syndrome). Clin. Genet. 36, 122-126 (1989).","DOI":"10.1111\/j.1399-0004.1989.tb03174.x"},{"key":"29937_CR6","doi-asserted-by":"crossref","unstructured":"Beighton, P., Winship, I. & Behari, D. The ocular form of osteogenesis imperfecta: a new autosomal recessive syndrome. Clin. Genet. 28, 69-75 (1985).","DOI":"10.1111\/j.1399-0004.1985.tb01220.x"},{"key":"29937_CR7","doi-asserted-by":"crossref","unstructured":"Cole, D. & Carpenter, T. O. E. C. Bone fragility, craniosynostosis, ocular proptosis, hydrocephalus, and distinctive facial features: A newly recognized type of osteogenesis imperfecta. J. Pediatr. 110, 76-80 (1987).","DOI":"10.1016\/S0022-3476(87)80292-5"},{"key":"29937_CR8","doi-asserted-by":"crossref","unstructured":"Rauch, F. et al. Cole-carpenter syndrome is caused by a heterozygous missense mutation in P4HB. Am J. Hum. Genet 96, 425-431 (2015).","DOI":"10.1016\/j.ajhg.2014.12.027"},{"key":"29937_CR9","doi-asserted-by":"crossref","unstructured":"Garbes, L. et al. Mutations in SEC24D, encoding a component of the COPII machinery, cause a syndromic form of osteogenesis imperfecta. Am J. Hum. Genet 96, 432-439(2015).","DOI":"10.1016\/j.ajhg.2015.01.002"},{"key":"29937_CR10","doi-asserted-by":"publisher","first-page":"Preprintathttps","DOI":"10.1111\/cge.12678","volume":"89","author":"S Moosa","year":"2016","unstructured":"Moosa, S. et al. Mutations in SEC24D cause autosomal recessive osteogenesis imperfecta. Clin. Genet. 89, Preprintathttpsdoiorg101111cge12678 (2016).","journal-title":"Clin. Genet."},{"key":"29937_CR11","doi-asserted-by":"crossref","unstructured":"Zhang, H. et al. Novel mutations in the SEC24D gene in Chinese families with autosomal recessive osteogenesis imperfecta. Osteoporosis Int. 28, 1473-1480 (2017).","DOI":"10.1007\/s00198-016-3866-2"},{"key":"29937_CR12","doi-asserted-by":"crossref","unstructured":"Takeyari, S. et al. Japanese patient with Cole-carpenter syndrome with compound heterozygous variants of SEC24D. Am J. Med. Genet. A 176, 2882-2886 (2018).","DOI":"10.1002\/ajmg.a.40643"},{"key":"29937_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2013.04.005","author":"EA Miller","year":"2013","unstructured":"Miller, E. A. & Schekman, R. COPII - a flexible vesicle formation system. Curr. Opin. Cell Biol. https:\/\/doi.org\/10.1016\/j.ceb.2013.04.005 (2013).","journal-title":"Curr. Opin. Cell Biol."},{"key":"29937_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2013.08.005","author":"R Venditti","year":"2014","unstructured":"Venditti, R., Wilson, C. & De Matteis, M. A. Exiting the ER: what we know and what we don\u2019t. Trends Cell. Biol. https:\/\/doi.org\/10.1016\/j.tcb.2013.08.005 (2014).","journal-title":"Trends Cell. Biol."},{"key":"29937_CR15","doi-asserted-by":"publisher","first-page":"1796","DOI":"10.1038\/s41431-021-00959-x","volume":"29","author":"IFAC Fokkema","year":"2021","unstructured":"Fokkema, I. F. A. C. et al. The LOVD3 platform: efficient genome-wide sharing of genetic variants. Eur. J. Hum. Genet. 29, 1796\u20131803 (2021).","journal-title":"Eur. J. Hum. Genet."},{"key":"29937_CR16","doi-asserted-by":"publisher","first-page":"D980","DOI":"10.1093\/nar\/gkt1113","volume":"42","author":"MJ Landrum","year":"2014","unstructured":"Landrum, M. J. et al. ClinVar: public archive of relationships among sequence variation and human phenotype. Nucleic Acids Res. 42, D980\u2013D985 (2014).","journal-title":"Nucleic Acids Res."},{"key":"29937_CR17","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1007\/s00439-020-02199-3","volume":"139","author":"PD Stenson","year":"2020","unstructured":"Stenson, P. D. et al. The human gene mutation database (HGMD\u00ae): optimizing its use in a clinical diagnostic or research setting. Hum. Genet. 139, 1197\u20131207 (2020).","journal-title":"Hum. Genet."},{"key":"29937_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.01.042","author":"N Sonenberg","year":"2009","unstructured":"Sonenberg, N. & Hinnebusch, A. G. Regulation of translation initiation in Eukaryotes: Mechanisms and biological targets. Cell https:\/\/doi.org\/10.1016\/j.cell.2009.01.042 (2009).","journal-title":"Cell"},{"key":"29937_CR19","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.841032","author":"O Soukarieh","year":"2022","unstructured":"Soukarieh, O. et al. Common and rare 5\u2032UTR variants altering upstream open reading frames in cardiovascular genomics. Front. Cardiovasc. Med. https:\/\/doi.org\/10.3389\/fcvm.2022.841032 (2022).","journal-title":"Front. Cardiovasc. Med."},{"key":"29937_CR20","unstructured":"Whiffin, N. et al. Characterising the loss-of-function impact of 5\u2019 untranslated region variants in 15,708 individuals. Nat. Commun. 11, 2523 (2020)."},{"key":"29937_CR21","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s13073-023-01277-1","volume":"16","author":"A Due\u00f1as Rey","year":"2024","unstructured":"Due\u00f1as Rey, A. et al. Combining a prioritization strategy and functional studies nominates 5\u2019UTR variants underlying inherited retinal disease. Genome Med. 16, 7 (2024).","journal-title":"Genome Med."},{"key":"29937_CR22","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.ajhg.2012.06.005","volume":"91","author":"TJ Cho","year":"2012","unstructured":"Cho, T. J. et al. A single recurrent mutation in the 5\u2032-UTR of IFITM5 causes osteogenesis imperfecta type V. Am. J. Hum. Genet. 91, 343\u2013348 (2012).","journal-title":"Am. J. Hum. Genet."},{"key":"29937_CR23","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.ajhg.2012.06.011","volume":"91","author":"O Semler","year":"2012","unstructured":"Semler, O. et al. A mutation in the 5\u2032-UTR of IFITM5 creates an In-Frame start codon and causes Autosomal-Dominant osteogenesis imperfecta type V with hyperplastic callus. Am. J. Hum. Genet. 91, 349\u2013357 (2012).","journal-title":"Am. J. Hum. Genet."},{"key":"29937_CR24","doi-asserted-by":"crossref","unstructured":"Wu, D., Wang, Y. & Huang, H. A novel variant of the IFITM5 gene within the 5\u2032-UTR causes neonatal transverse clavicular fracture: expanding the genetic spectrum. Mol Genet. Genomic Med 8, e1287 (2020).","DOI":"10.1002\/mgg3.1287"},{"key":"29937_CR25","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1016\/j.ymthe.2019.06.016","volume":"27","author":"S Sasaki","year":"2019","unstructured":"Sasaki, S. et al. Steric Inhibition of 5\u2032 UTR regulatory elements results in upregulation of human CFTR. Mol. Ther. 27, 1749\u20131757 (2019).","journal-title":"Mol. Ther."},{"key":"29937_CR26","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1038\/nbt.3589","volume":"34","author":"X Liang","year":"2016","unstructured":"Liang, X. et al. Translation efficiency of mRNAs is increased by antisense oligonucleotides targeting upstream open reading frames. Nat. Biotechnol. 34, 875\u2013880 (2016).","journal-title":"Nat. Biotechnol."},{"key":"29937_CR27","doi-asserted-by":"crossref","unstructured":"Essawi, O. et al. Genetic analysis of osteogenesis imperfecta in the Palestinian population: molecular screening of 49 affected families. Mol Genet. Genomic Med 6, 15-26 (2018).","DOI":"10.1002\/mgg3.331"},{"key":"29937_CR28","doi-asserted-by":"publisher","first-page":"W593","DOI":"10.1093\/nar\/gkp369","volume":"37","author":"D Seelow","year":"2009","unstructured":"Seelow, D., Schuelke, M., Hildebrandt, F. & Nurnberg, P. HomozygosityMapper\u2013an interactive approach to homozygosity mapping. Nucleic Acids Res. 37, W593\u2013W599 (2009).","journal-title":"Nucleic Acids Res."},{"key":"29937_CR29","doi-asserted-by":"crossref","unstructured":"Silberstein, M. et al. A system for exact and approximate genetic linkage analysis of SNP data in large pedigrees. Bioinformatics 29, 197-205 (2013).","DOI":"10.1093\/bioinformatics\/bts658"},{"key":"29937_CR30","first-page":"D65","volume":"48","author":"P Meylan","year":"2020","unstructured":"Meylan, P., Dreos, R., Ambrosini, G., Groux, R. & Bucher, P. EPD in 2020: enhanced data visualization and extension to NcRNA promoters. Nucleic Acids Res. 48, D65\u2013D69 (2020).","journal-title":"Nucleic Acids Res."},{"key":"29937_CR31","doi-asserted-by":"publisher","first-page":"D92","DOI":"10.1093\/nar\/gku1111","volume":"43","author":"R Dreos","year":"2015","unstructured":"Dreos, R., Ambrosini, G., P\u00e9rier, R. C. & Bucher, P. The eukaryotic promoter database: expansion of EPDnew and new promoter analysis tools. Nucleic Acids Res. 43, D92\u2013D96 (2015).","journal-title":"Nucleic Acids Res."},{"key":"29937_CR32","unstructured":"Research Environment User Guide - Genomics England Research Environment - Genomics England Research Environment. (accessed December 1 2023). https:\/\/research-help.genomicsengland.co.uk\/display\/GERE\/Research+Environment+User+Guide."},{"key":"29937_CR33","doi-asserted-by":"publisher","first-page":"782","DOI":"10.2144\/01304st04","volume":"30","author":"PM Martensen","year":"2001","unstructured":"Martensen, P. M. & Justesen, J. Specific inhibitors prevent proteolytic degradation of Recombinant proteins expressed in high Five\u2122 cells. Biotechniques 30, 782\u2013792 (2001).","journal-title":"Biotechniques"},{"key":"29937_CR34","doi-asserted-by":"crossref","unstructured":"Miao, Y. et al. Case report: clinical manifestations and genotype analysis of a child with PTPN11 and SEC24D mutations. Front. Pediatr. 10, 973920 (2022).","DOI":"10.3389\/fped.2022.973920"},{"key":"29937_CR35","doi-asserted-by":"crossref","unstructured":"Li, S. et al. Genotypic and phenotypic analysis in Chinese cohort with autosomal recessive osteogenesis imperfecta. Front. Genet. 11\u00a0(2020).","DOI":"10.3389\/fgene.2020.00984"},{"key":"29937_CR36","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1101\/gr.GR-1460R","volume":"10","author":"RV Davuluri","year":"2000","unstructured":"Davuluri, R. V. CART classification of human 5\u2019 UTR sequences. Genome Res. 10, 1807\u20131816 (2000).","journal-title":"Genome Res."},{"key":"29937_CR37","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.tibs.2019.12.009","volume":"45","author":"A Bogaert","year":"2020","unstructured":"Bogaert, A., Fernandez, E. & Gevaert, K. N-Terminal proteoforms in human disease. Trends Biochem. Sci. 45, 308\u2013320 (2020).","journal-title":"Trends Biochem. Sci."},{"key":"29937_CR38","doi-asserted-by":"crossref","unstructured":"Zhang, X., Wakeling, M., Ware, J. & Whiffin, N. Annotating high-impact 5\u2032untranslated region variants with the utrannotator. Bioinformatics 37, 1171-1173 (2021).","DOI":"10.1093\/bioinformatics\/btaa783"},{"key":"29937_CR39","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2838","author":"RJ Jackson","year":"2010","unstructured":"Jackson, R. J., Hellen, C. U. T. & Pestova, T. V. The mechanism of eukaryotic translation initiation and principles of its regulation. Nat. Rev. Mol. Cell Biol. https:\/\/doi.org\/10.1038\/nrm2838 (2010).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"29937_CR40","doi-asserted-by":"publisher","unstructured":"Araujo, P. R. et al. Before it gets started: Regulating translation at the 5\u2032; UTR. Comp Funct Genomics. https:\/\/doi.org\/10.1155\/2012\/475731 (2012).","DOI":"10.1155\/2012\/475731"},{"key":"29937_CR41","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks068","author":"A Bugaut","year":"2012","unstructured":"Bugaut, A. & Balasubramanian, S. 5\u2032-UTR RNA G-quadruplexes: translation regulation and targeting. Nucleic Acids Res. https:\/\/doi.org\/10.1093\/nar\/gks068 (2012).","journal-title":"Nucleic Acids Res."},{"key":"29937_CR42","doi-asserted-by":"publisher","DOI":"10.1038\/s41431-025-01886-x","author":"H Lindel\u00f6f","year":"2025","unstructured":"Lindel\u00f6f, H. et al. Genome sequencing in a cohort of 32 fetuses with genetic skeletal disorders. Eur. J. Hum. Genet. https:\/\/doi.org\/10.1038\/s41431-025-01886-x (2025).","journal-title":"Eur. J. Hum. Genet."},{"key":"29937_CR43","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1089\/nat.2021.0039","volume":"32","author":"M Synofzik","year":"2022","unstructured":"Synofzik, M. et al. Preparing n-of-1 antisense oligonucleotide treatments for rare neurological diseases in europe: Genetic, Regulatory, and ethical perspectives. Nucleic Acid Ther. 32, 83\u201394 (2022).","journal-title":"Nucleic Acid Ther."},{"key":"29937_CR44","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1016\/j.jcf.2021.06.003","volume":"20","author":"YS Oren","year":"2021","unstructured":"Oren, Y. S. et al. Antisense oligonucleotide-based drug development for cystic fibrosis patients carrying the 3849\u2009+\u200910\u00a0kb C-to-T splicing mutation. J. Cyst. Fibros. 20, 865\u2013875 (2021).","journal-title":"J. Cyst. Fibros."},{"key":"29937_CR45","doi-asserted-by":"publisher","first-page":"2057","DOI":"10.1016\/j.cell.2022.04.031","volume":"185","author":"LE Marasco","year":"2022","unstructured":"Marasco, L. E. et al. Counteracting chromatin effects of a splicing-correcting antisense oligonucleotide improves its therapeutic efficacy in spinal muscular atrophy. Cell 185, 2057-2070.e15 (2022).","journal-title":"Cell"},{"key":"29937_CR46","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1681\/ASN.2022060644","volume":"34","author":"A Kidwell","year":"2023","unstructured":"Kidwell, A. et al. Translation rescue by targeting Ppp1r15a through its upstream open reading frame in Sepsis-Induced acute kidney injury in a murine model. J. Am. Soc. Nephrol. 34, 220\u2013240 (2023).","journal-title":"J. Am. Soc. Nephrol."},{"key":"29937_CR47","doi-asserted-by":"publisher","first-page":"W43","DOI":"10.1093\/nar\/gkm234","volume":"35","author":"WA Kibbe","year":"2007","unstructured":"Kibbe, W. A. OligoCalc: an online oligonucleotide properties calculator. Nucleic Acids Res. 35, W43\u2013W46 (2007).","journal-title":"Nucleic Acids Res."},{"key":"29937_CR48","doi-asserted-by":"crossref","unstructured":"Mathews, D. H. RNA secondary structure analysis using rnastructure. Curr Protoc. Bioinform. 13\u00a0(2006).","DOI":"10.1002\/0471250953.bi1206s13"},{"key":"29937_CR49","doi-asserted-by":"publisher","first-page":"3406","DOI":"10.1093\/nar\/gkg595","volume":"31","author":"M Zuker","year":"2003","unstructured":"Zuker, M. Mfold web server for nucleic acid folding and hybridization prediction. Nucleic Acids Res. 31, 3406\u20133415 (2003).","journal-title":"Nucleic Acids Res."},{"key":"29937_CR50","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1038\/nbt.3765","volume":"35","author":"A Khvorova","year":"2017","unstructured":"Khvorova, A. & Watts, J. K. The chemical evolution of oligonucleotide therapies of clinical utility. Nat. Biotechnol. 35, 238\u2013248 (2017).","journal-title":"Nat. Biotechnol."},{"key":"29937_CR51","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/978-1-61779-767-5_8","volume":"867","author":"A Aartsma-Rus","year":"2012","unstructured":"Aartsma-Rus, A. Overview on AON design. Methods Mol. Biol. 867, 117\u2013129. https:\/\/doi.org\/10.1007\/978-1-61779-767-5_8 (2012).","journal-title":"Methods Mol. Biol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-29937-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-29937-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-29937-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:03:02Z","timestamp":1767830582000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-29937-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,6]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["29937"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-29937-9","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,6]]},"assertion":[{"value":"27 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"687"}}