{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:50:27Z","timestamp":1792785027650,"version":"4.5.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T00:00:00Z","timestamp":1764374400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":39,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Basic Research Project of Shanxi Province","award":["202203021212021"],"award-info":[{"award-number":["202203021212021"]}]},{"name":"Basic Research Project of Shanxi Province","award":["202203021222410"],"award-info":[{"award-number":["202203021222410"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82273539"],"award-info":[{"award-number":["82273539"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-30398-3","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T03:57:17Z","timestamp":1764388637000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["ADIPOQ regulates lipid metabolism by activating AMPK\/CPT-1 pathway to attenuate the proliferation of psoriasis lesions"],"prefix":"10.1038","volume":"16","author":[{"given":"Jianxiao","family":"Xing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aihong","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanjun","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junqin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,29]]},"reference":[{"issue":"4","key":"30398_CR1","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1111\/bjd.18245","volume":"182","author":"NJ Korman","year":"2020","unstructured":"Korman, N. J. Management of psoriasis as a systemic disease: what is the evidence? Br. J. Dermatol. 182 (4), 840\u2013848. https:\/\/doi.org\/10.1111\/bjd.18245 (2020).","journal-title":"Br. J. Dermatol."},{"key":"30398_CR2","doi-asserted-by":"publisher","unstructured":"Vaengebjerg, S., Skov, L., Egeberg, A. & Loft, N. D. Prevalence, incidence, and risk of cancer in patients with psoriasis and psoriatic arthritis: a systematic review and meta-analysis. JAMA dermatol. 156 (4), 421\u2013429. https:\/\/doi.org\/10.1001\/jamadermatol.2020.0024 (2020).","DOI":"10.1001\/jamadermatol.2020.0024"},{"issue":"5","key":"30398_CR3","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1007\/s40272-015-0137-1","volume":"17","author":"IM Bronckers","year":"2015","unstructured":"Bronckers, I. M., Paller, A. S., Geel, M. J. V., Kerkhof, P. C. M. V. & Seyger, M. M. B. Psoriasis in children and adolescents: diagnosis, management and comorbidities. Paediatr. Drugs. 17 (5), 373\u2013384. https:\/\/doi.org\/10.1007\/s40272-015-0137-1 (2015).","journal-title":"Paediatr. Drugs"},{"issue":"19","key":"30398_CR4","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1001\/jama.2020.4006","volume":"323","author":"AW Armstrong","year":"2020","unstructured":"Armstrong, A. W. & Read, C. Pathophysiology, clinical presentation, and treatment of psoriasis: a review. JAMA 323 (19), 1945\u20131960. https:\/\/doi.org\/10.1001\/jama.2020.4006 (2020).","journal-title":"JAMA"},{"key":"30398_CR5","doi-asserted-by":"publisher","unstructured":"Chen, L. et al. Psoriasis comorbid with atherosclerosis Meets in lipid metabolism. Front. Pharmacol. 2023:14:1308965. https:\/\/doi.org\/10.3389\/fphar.2023.1308965","DOI":"10.3389\/fphar.2023.1308965"},{"issue":"12","key":"30398_CR6","doi-asserted-by":"publisher","first-page":"e6369","DOI":"10.7759\/cureus.6369","volume":"11","author":"C Peralta","year":"2019","unstructured":"Peralta, C., Hamid, P., Batool, H., Al Achkar, Z. & Maximus, P. Psoriasis and metabolic syndrome: comorbidities and environmental and therapeutic implications. Cureus 11 (12), e6369. https:\/\/doi.org\/10.7759\/cureus.6369 (2019).","journal-title":"Cureus"},{"key":"30398_CR7","doi-asserted-by":"publisher","first-page":"535612","DOI":"10.1155\/2010\/535612","volume":"2010","author":"A Pietrzak","year":"2010","unstructured":"Pietrzak, A., Michalak-Stoma, A., Chodorowska, G. & Szepietowski, J. C. Lipid disturbances in psoriasis: an update. Mediators Inflamm. 2010, 535612. https:\/\/doi.org\/10.1155\/2010\/535612 (2010).","journal-title":"Mediators Inflamm."},{"issue":"13","key":"30398_CR8","doi-asserted-by":"publisher","first-page":"e150223","DOI":"10.1172\/jci.insight.150223","volume":"7","author":"X Zhang","year":"2022","unstructured":"Zhang, X. et al. Abnormal lipid metabolism in epidermal Langerhans cells mediates psoriasis-like dermatitis. JCI Insight. 7 (13), e150223. https:\/\/doi.org\/10.1172\/jci.insight.150223 (2022).","journal-title":"JCI Insight"},{"key":"30398_CR9","doi-asserted-by":"publisher","unstructured":"Zhang Q, et al. Advances in the mechanism of action of short-chain fatty acids in psoriasis. Int Immunopharmacol. 141, 112928. https:\/\/doi.org\/10.1016\/j.intimp.2024.112928. (2024).","DOI":"10.1016\/j.intimp.2024.112928"},{"key":"30398_CR10","doi-asserted-by":"publisher","unstructured":"Mathers, A. R. et al. Topical electrophilic nitro-fatty acids potentiate cutaneous inflammation. Free Radic Biol Med. 115, 31\u201342. (2018). 2017.11.009. https:\/\/doi.org\/10.1016\/j.freeradbiomed.","DOI":"10.1016\/j.freeradbiomed"},{"key":"30398_CR11","doi-asserted-by":"publisher","first-page":"8717369","DOI":"10.1155\/2017\/8717369","volume":"2017","author":"Y Gao","year":"2017","unstructured":"Gao, Y., Yi, X. & Ding, Y. Combined transcriptomic analysis revealed AKR1B10 played an important role in psoriasis through the dysregulated lipid pathway and overproliferation of keratinocyte. Biomed. Res. Int. 2017, 8717369. https:\/\/doi.org\/10.1155\/2017\/8717369 (2017).","journal-title":"Biomed. Res. Int."},{"key":"30398_CR12","doi-asserted-by":"publisher","first-page":"26746","DOI":"10.1074\/jbc.270.45.26746","volume":"270","author":"PE Scherer","year":"1995","unstructured":"Scherer, P. E., Williams, S., Fogliano, M., Baldini, G. & Lodish, H. F. A novel serum protein similar to C1q, produced exclusively in adipocytes. J. Biol. Chem. 270, 26746\u201326749. https:\/\/doi.org\/10.1074\/jbc.270.45.26746 (1995).","journal-title":"J. Biol. Chem."},{"key":"30398_CR13","doi-asserted-by":"publisher","first-page":"10697","DOI":"10.1074\/jbc.271.18.10697","volume":"271","author":"E Hu","year":"1996","unstructured":"Hu, E., Liang, P. & Spiegelman, B. M. AdipoQ is a novel Adipose-specific gene dysregulated in obesity. J. Biol. Chem. 271, 10697\u201310703. https:\/\/doi.org\/10.1074\/jbc.271.18.10697 (1996).","journal-title":"J. Biol. Chem."},{"key":"30398_CR14","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.2337\/db06-0263","volume":"55","author":"PE Scherer","year":"2006","unstructured":"Scherer, P. E. Adipose tissue: from lipid storage compartment to endocrine organ. Diabetes 55, 1537\u20131545. https:\/\/doi.org\/10.2337\/db06-0263 (2006).","journal-title":"Diabetes"},{"key":"30398_CR15","doi-asserted-by":"publisher","first-page":"2654","DOI":"10.1074\/jbc.M505311200","volume":"281","author":"AR Nawrocki","year":"2006","unstructured":"Nawrocki, A. R. et al. Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome Proliferator-activated receptor \u03b3 agonists. J. Biol. Chem. 281, 2654\u20132660. https:\/\/doi.org\/10.1074\/jbc.M505311200 (2006).","journal-title":"J. Biol. Chem."},{"key":"30398_CR16","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1007\/s00125-017-4516-8","volume":"61","author":"JY Xia","year":"2018","unstructured":"Xia, J. Y. et al. Acute loss of adipose tissue-derived adiponectin triggers immediate metabolic deterioration in mice. Diabetologia 61, 932\u2013941. https:\/\/doi.org\/10.1007\/s00125-017-4516-8 (2018).","journal-title":"Diabetologia"},{"key":"30398_CR17","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1210\/en.2003-1068","volume":"145","author":"TP Combs","year":"2004","unstructured":"Combs, T. P. et al. A Transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated Circulating adiponectin and improved insulin sensitivity. Endocrinology 145, 367\u2013383. https:\/\/doi.org\/10.1210\/en.2003-1068 (2004).","journal-title":"Endocrinology"},{"key":"30398_CR18","doi-asserted-by":"publisher","first-page":"2621","DOI":"10.1172\/JCI31021","volume":"117","author":"J-Y Kim","year":"2007","unstructured":"Kim, J-Y. et al. Obesity-associated improvements in metabolic profile through expansion of adipose tissue. J. Clin. Invest. 117, 2621\u20132637. https:\/\/doi.org\/10.1172\/JCI31021 (2007).","journal-title":"J. Clin. Invest."},{"key":"30398_CR19","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1038\/sj.bjc.6603051","volume":"94","author":"I Kelesidis","year":"2006","unstructured":"Kelesidis, I., Kelesidis, T. & Mantzoros, C. S. Adiponectin and cancer: a systematic review. Br. J. Cancer. 94, 1221\u20131225. https:\/\/doi.org\/10.1038\/sj.bjc.6603051 (2006).","journal-title":"Br. J. Cancer"},{"issue":"8","key":"30398_CR20","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1080\/15548627.2017.1332565","volume":"13","author":"SJ Chung","year":"2017","unstructured":"Chung, S. J. et al. ADIPOQ\/adiponectin induces cytotoxic autophagy in breast cancer cells through STK11\/LKB1-mediated activation of the AMPK-ULK1 axis. Autophagy 13 (8), 1386\u20131403. https:\/\/doi.org\/10.1080\/15548627.2017.1332565 (2017).","journal-title":"Autophagy"},{"key":"30398_CR21","doi-asserted-by":"publisher","first-page":"2035","DOI":"10.2147\/CCID.S385894","volume":"15","author":"X Li","year":"2022","unstructured":"Li, X. et al. The mRNA expression profile of psoriatic lesion distinct from Non-Lesion. Clin. Cosmet. Investig Dermatol. 15, 2035\u20132043. https:\/\/doi.org\/10.2147\/CCID.S385894 (2022).","journal-title":"Clin. Cosmet. Investig Dermatol."},{"issue":"8","key":"30398_CR22","doi-asserted-by":"publisher","first-page":"7053","DOI":"10.3390\/ijms24087053","volume":"24","author":"J Nowowiejska","year":"2023","unstructured":"Nowowiejska, J., Baran, A. & Flisiak, I. Lipid alterations and metabolism disturbances in selected inflammatory skin diseases. Int. J. Mol. Sci. 24 (8), 7053. https:\/\/doi.org\/10.3390\/ijms24087053 (2023).","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"30398_CR23","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1186\/s12974-019-1492-6","volume":"16","author":"M Jian","year":"2019","unstructured":"Jian, M., Kwan, J. S., Bunting, M., Ng, R. C. & Chan, K. H. Adiponectin suppresses amyloid-\u03b2 oligomer (A\u03b2O)-induced inflammatory response of microglia via AdipoR1-AMPK-NF-\u03baB signaling PathwayJ. Neuroinflammation 16 (1), 110. https:\/\/doi.org\/10.1186\/s12974-019-1492-6 (2019).","journal-title":"Neuroinflammation"},{"issue":"7","key":"30398_CR24","doi-asserted-by":"publisher","first-page":"440","DOI":"10.3858\/emm.2012.44.7.049","volume":"44","author":"YA Lee","year":"2012","unstructured":"Lee, Y. A. et al. Synergy between adiponectin and interleukin-1beta on the expression of interleukin-6, interleukin-8, and cyclooxygenase-2 in fibroblast-like synoviocytes. Exp. Mol. Med. 44 (7), 440\u2013447. https:\/\/doi.org\/10.3858\/emm.2012.44.7.049 (2012).","journal-title":"Exp. Mol. Med."},{"issue":"1","key":"30398_CR25","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.jdermsci.2022.03.003","volume":"106","author":"JH Suh","year":"2022","unstructured":"Suh, J. H. et al. Adiponectin-derived pentapeptide ameliorates psoriasiform skin inflammation by suppressing IL-17 production in gammadelta T cells. J. Dermatol. Sci. 106 (1), 45\u201352. https:\/\/doi.org\/10.1016\/j.jdermsci.2022.03.003 (2022).","journal-title":"J. Dermatol. Sci."},{"issue":"2","key":"30398_CR26","doi-asserted-by":"publisher","first-page":"663","DOI":"10.3390\/jcm12020663","volume":"12","author":"S S\u0142uczanowska-G\u0142abowska","year":"2023","unstructured":"S\u0142uczanowska-G\u0142abowska, S. et al. Adiponectin, leptin and resistin in patients with psoriasis. J. Clin. Med. 12 (2), 663. https:\/\/doi.org\/10.3390\/jcm12020663 (2023).","journal-title":"J. Clin. Med."},{"issue":"5","key":"30398_CR27","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1080\/09546634.2019.1621979","volume":"31","author":"S Gerdes","year":"2020","unstructured":"Gerdes, S., Pinter, A., Biermann, M., Papavassilis, C. & Reinhardt, M. Adiponectin levels in a large pooled plaque psoriasis study population. J. Dermatol. Treat. 31 (5), 531\u2013534. https:\/\/doi.org\/10.1080\/09546634.2019.1621979 (2020).","journal-title":"J. Dermatol. Treat."},{"key":"30398_CR28","doi-asserted-by":"publisher","unstructured":"Gisondi, P., Fostini, A. C., Foss\u00e0, I., Girolomoni, G. & Targher, G. Psoriasis and the metabolic syndrome. Clin. Dermatol.  36  (1), 21\u201328. https:\/\/doi.org\/10.1016\/j.clindermatol.2017.09.005 2018 Jan-Feb.","DOI":"10.1016\/j.clindermatol.2017.09.005"},{"key":"30398_CR29","doi-asserted-by":"publisher","first-page":"107883","DOI":"10.1016\/j.intimp.2021.107883","volume":"98","author":"KD Park","year":"2021","unstructured":"Park, K. D. et al. Protectin D1 reduces imiquimod-induced psoriasiform skin inflammation. Int. Immunopharmacol. 98, 107883. https:\/\/doi.org\/10.1016\/j.intimp.2021.107883 (2021).","journal-title":"Int. Immunopharmacol."},{"issue":"6","key":"30398_CR30","doi-asserted-by":"publisher","first-page":"2168","DOI":"10.7150\/ijbs.92514","volume":"20","author":"J Zhao","year":"2024","unstructured":"Zhao, J. et al. CYSLTR1 antagonist inhibits Th17 cell differentiation by regulating the NF-\u03baB signaling for the treatment of psoriasis. Int. J. Biol. Sci. 20 (6), 2168\u20132186. https:\/\/doi.org\/10.7150\/ijbs.92514 (2024).","journal-title":"Int. J. Biol. Sci."},{"key":"30398_CR31","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.1172\/JCI29126","volume":"116","author":"T Kadowaki","year":"2006","unstructured":"Kadowaki, T. et al. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J. Clin. Invest. 116, 1784\u20131792. https:\/\/doi.org\/10.1172\/JCI29126 (2006).","journal-title":"J. Clin. Invest."},{"key":"30398_CR32","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1002\/hep.20821","volume":"42","author":"M You","year":"2005","unstructured":"You, M., Considine, R. V., Leone, T. C., Kelly, D. P. & Crabb, D. W. Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice. Hepatology 42, 568\u2013577. https:\/\/doi.org\/10.1002\/hep.20821 (2005).","journal-title":"Hepatology"},{"key":"30398_CR33","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.cmet.2009.03.012","volume":"9","author":"BB Zhang","year":"2009","unstructured":"Zhang, B. B., Zhou, G. & Li, C. AMPK: an emerging drug target for diabetes and the metabolic syndrome. Cell. Metab. 9, 407\u2013416. https:\/\/doi.org\/10.1016\/j.cmet.2009.03.012 (2009).","journal-title":"Cell. Metab."},{"key":"30398_CR34","doi-asserted-by":"publisher","first-page":"2349","DOI":"10.1159\/000374037","volume":"35","author":"Y Xi","year":"2015","unstructured":"Xi, Y. et al. Baicalin attenuates high fat Diet-Induced obesity and liver dysfunction: Dose-Response and potential role of CaMKKbeta\/AMPK\/ACC pathway. Cell. Physiol. Biochem. 35, 2349\u20132359. https:\/\/doi.org\/10.1159\/000374037 (2015).","journal-title":"Cell. Physiol. Biochem."},{"key":"30398_CR35","doi-asserted-by":"publisher","first-page":"S43","DOI":"10.2337\/diabetes.53.2007.s43","volume":"53","author":"P Ferre","year":"2004","unstructured":"Ferre, P. The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivity. Diabetes 53, S43\u2013S50. https:\/\/doi.org\/10.2337\/diabetes.53.2007.s43 (2004).","journal-title":"Diabetes"},{"key":"30398_CR36","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1016\/j.bbalip.2011.10.016","volume":"1821","author":"A Tailleux","year":"2012","unstructured":"Tailleux, A., Wouters, K. & Staels, B. Roles of PPARs in NAFLD: potential therapeutic targets. Biochim. Biophys. Acta. 1821, 809\u2013818. https:\/\/doi.org\/10.1016\/j.bbalip.2011.10.016 (2012).","journal-title":"Biochim. Biophys. Acta"},{"issue":"11","key":"30398_CR37","doi-asserted-by":"publisher","first-page":"e111901","DOI":"10.15252\/embj.2022111901","volume":"42","author":"J Ngo","year":"2023","unstructured":"Ngo, J. et al. Mitochondrial morphology controls fatty acid utilization by changing CPT1 sensitivity to malonyl-CoA. EMBO J. 42 (11), e111901. https:\/\/doi.org\/10.15252\/embj.2022111901 (2023).","journal-title":"EMBO J."},{"key":"30398_CR38","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.bbrc.2005.12.011","volume":"340","author":"WJ Lee","year":"2006","unstructured":"Lee, W. J. et al. AMPK activation increases fatty acid oxidation in skeletal muscle by activating PPARalpha and PGC-1. Biochem. Biophys. Res. Commun. 340, 291\u2013295. https:\/\/doi.org\/10.1016\/j.bbrc.2005.12.011 (2006).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"30398_CR39","doi-asserted-by":"publisher","unstructured":"Feng, X. et al. ASS1 enhances Anoikis resistance via AMPK\/CPT1A-mediated fatty acid metabolism in ovarian cancer. Cancer Lett. 217082. https:\/\/doi.org\/10.1016\/j.canlet.2024.217082 (2024).","DOI":"10.1016\/j.canlet.2024.217082"},{"key":"30398_CR40","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1017\/S1461145711000976","volume":"15","author":"MK Kim","year":"2012","unstructured":"Kim, M. K. et al. The effect of clozapine on the AMPK-ACC-CPT1 pathway in the rat frontal cortex. Int. J. Neuropsychopharmacol. 15, 907\u2013917. https:\/\/doi.org\/10.1017\/S1461145711000976 (2012).","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"30398_CR41","doi-asserted-by":"publisher","first-page":"156699","DOI":"10.1016\/j.cyto.2024.156699","volume":"182","author":"YK Chen","year":"2024","unstructured":"Chen, Y. K. et al. The role of mesenchymal stem cells in the treatment and pathogenesis of psoriasis. Cytokine 182, 156699. https:\/\/doi.org\/10.1016\/j.cyto.2024.156699 (2024).","journal-title":"Cytokine"},{"issue":"4","key":"30398_CR42","doi-asserted-by":"publisher","first-page":"151550","DOI":"10.1016\/j.acthis.2020.151550","volume":"122","author":"Y Wang","year":"2020","unstructured":"Wang, Y. et al. Expression and functional regulation of gap junction protein connexin 43 in dermal mesenchymal stem cells from psoriasis patients. Acta Histochem. 122 (4), 151550. https:\/\/doi.org\/10.1016\/j.acthis.2020.151550 (2020).","journal-title":"Acta Histochem."},{"key":"30398_CR43","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.bbrep.2016.10.002","volume":"9","author":"YS Lee","year":"2016","unstructured":"Lee, Y. S. et al. Human umbilical cord blood-derived mesenchymal stem cells ameliorate psoriasis-like skin inflammation in mice. Biochem. Biophys. Rep. 9, 281\u2013288. https:\/\/doi.org\/10.1016\/j.bbrep.2016.10.002 (2016).","journal-title":"Biochem. Biophys. Rep."},{"issue":"8","key":"30398_CR44","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.3390\/medicina59081449","volume":"59","author":"A Rehman","year":"2023","unstructured":"Rehman, A. et al. Mesenchymal stem cells in soft tissue regenerative medicine: A comprehensive review. Med. (Kaunas). 59 (8), 1449. https:\/\/doi.org\/10.3390\/medicina59081449 (2023).","journal-title":"Med. (Kaunas)"},{"issue":"2","key":"30398_CR45","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1159\/000515767","volume":"238","author":"N Liang","year":"2022","unstructured":"Liang, N. et al. Dermal mesenchymal stem cells from psoriatic lesions stimulate HaCaT cell Proliferation, Differentiation, and migration via activating the PI3K\/AKT signaling pathway. Dermatology 238 (2), 283\u2013291. https:\/\/doi.org\/10.1159\/000515767 (2022).","journal-title":"Dermatology"},{"issue":"23","key":"30398_CR46","doi-asserted-by":"publisher","first-page":"15080","DOI":"10.3390\/ijms232315080","volume":"23","author":"F Diotallevi","year":"2022","unstructured":"Diotallevi, F. et al. Mesenchymal stem cells and psoriasis: systematic review. Int. J. Mol. Sci. 23 (23), 15080. https:\/\/doi.org\/10.3390\/ijms232315080 (2022).","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"30398_CR47","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.3390\/nu17071253","volume":"17","author":"D Jerab","year":"2025","unstructured":"Jerab, D. et al. Beneficial effects of Omega-3 fatty acids on obesity and related metabolic and chronic inflammatory diseases. Nutrients 17 (7), 1253. https:\/\/doi.org\/10.3390\/nu17071253 (2025).","journal-title":"Nutrients"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-30398-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-30398-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-30398-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T12:23:04Z","timestamp":1767788584000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-30398-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,29]]},"references-count":47,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["30398"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-30398-3","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,29]]},"assertion":[{"value":"1 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The authors declare no conflicts of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosure"}},{"value":"The study was approved by the institutional ethics committee of Taiyuan City Central Hospital. The study was carried out with the informed consent of the patients themselves and in accordance with the Declaration of Helsinki Principles.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics statement"}}],"article-number":"849"}}