{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:05:57Z","timestamp":1772136357861,"version":"3.50.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T00:00:00Z","timestamp":1765065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":33,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Jiangsu Maternal and Child Health Research Project","award":["F201863"],"award-info":[{"award-number":["F201863"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["62201141"],"award-info":[{"award-number":["62201141"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-30877-7","type":"journal-article","created":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T08:34:30Z","timestamp":1765096470000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Value of red blood cell distribution width in evaluating 2019-nCoV infection in neonates: a retrospective study"],"prefix":"10.1038","volume":"16","author":[{"given":"Han","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijuan","family":"Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lixing","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinyu","family":"Ge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,7]]},"reference":[{"issue":"8","key":"30877_CR1","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1097\/CCM.0b013e31821b85c6","volume":"39","author":"HS Bazick","year":"2011","unstructured":"Bazick, H. S., Chang, D., Mahadevappa, K., Gibbons, F. K. & Christopher, K. B. Red cell distribution width and all-cause mortality in critically ill patients. Crit. Care Med. 39 (8), 1913\u20131921 (2011).","journal-title":"Crit. Care Med."},{"issue":"3","key":"30877_CR2","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.amjmed.2011.08.021","volume":"125","author":"S Hunziker","year":"2012","unstructured":"Hunziker, S., Stevens, J. & Howell, M. D. Red cell distribution width and mortality in newly hospitalized patients. Am. J. Med. 125 (3), 283\u2013291 (2012).","journal-title":"Am. J. Med."},{"issue":"2","key":"30877_CR3","first-page":"1","volume":"e2264","author":"S Sarkar","year":"2021","unstructured":"Sarkar, S., Kannan, S., Khanna, P. & Singh, A. K. Role of red blood cell distribution width, as a prognostic indicator in COVID-19: A systematic review and meta-analysis. Rev. Med. Virol. e2264 (2), 1\u201310 (2021).","journal-title":"Rev. Med. Virol."},{"issue":"3","key":"30877_CR4","first-page":"222","volume":"44","author":"JN Feng","year":"2021","unstructured":"Feng, J. N., Wang, Y. P., Zhu, M. R., Jiang, Q. L. & Wu, H. Reference range of red blood cell parameters of radial artery within 24 hours after birth of premature infants with different gestational ages and genders. Clin. J. Lab. Med. 44 (3), 222\u2013227 (2021).","journal-title":"Clin. J. Lab. Med."},{"issue":"7","key":"30877_CR5","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1038\/jp.2014.241","volume":"35","author":"L Glasser","year":"2015","unstructured":"Glasser, L., Sutton, N., Schmeling, M. & Machan, J. T. A comprehensive study of umbilical cord blood cell developmental changes and reference ranges by gestation, gender and mode of delivery. J. Perinatol. 35 (7), 469\u2013475 (2015).","journal-title":"J. Perinatol."},{"issue":"12","key":"30877_CR6","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1515\/cclm-2015-0155","volume":"53","author":"JJ Hoffmann","year":"2015","unstructured":"Hoffmann, J. J., Nabbe, K. C. & Broek, N. M. Effect of age and gender on reference intervals of red blood cell distribution width (RDW) and mean red cell volume (MCV). Clin. Chem. Lab. Med. 53 (12), 2015\u20132019 (2015).","journal-title":"Clin. Chem. Lab. Med."},{"issue":"8","key":"30877_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/PEC.0000000000001319","volume":"36","author":"DD Ellahony","year":"2020","unstructured":"Ellahony, D. D., Mekkawy, M. S. & Farag, M. M. A study of red cell distribution width in neonatal sepsis. Pediatr. Emer Care. 36 (8), 1\u20136 (2020).","journal-title":"Pediatr. Emer Care"},{"issue":"12","key":"30877_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/14767058.2017.1421932","volume":"32","author":"SL Martin","year":"2019","unstructured":"Martin, S. L. et al. Red cell distribution width and its association with mortality in neonatal sepsis. J. Matern Fetal Neonatal Med. 32 (12), 1\u20135 (2019).","journal-title":"J. Matern Fetal Neonatal Med."},{"issue":"3","key":"30877_CR9","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.cell.2021.12.032","volume":"185","author":"M Hoffmann","year":"2022","unstructured":"Hoffmann, M. et al. The Omicron variant is highly resistant against antibody-mediated neutralization: implications for control of the COVID-19 pandemic. Cell 185 (3), 447\u2013456 (2022).","journal-title":"Cell"},{"issue":"7958","key":"30877_CR10","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1038\/d41586-023-01371-9","volume":"616","author":"C Willyard","year":"2023","unstructured":"Willyard, C. Are repeat COVID infections dangerous? What the science says. Nature 616 (7958), 650\u2013652 (2023).","journal-title":"Nature"},{"issue":"20","key":"30877_CR11","doi-asserted-by":"publisher","first-page":"2200372","DOI":"10.2807\/1560-7917.ES.2022.27.20.2200372","volume":"27","author":"C Sacco","year":"2022","unstructured":"Sacco, C. et al. Risk and protective factors for SARS-CoV-2 reinfections, surveillance data, Italy, August 2021 to March 2022. Euro. Surveill. 27 (20), 2200372 (2022).","journal-title":"Euro. Surveill"},{"issue":"1","key":"30877_CR12","first-page":"20","volume":"38","author":"RM Jiang","year":"2023","unstructured":"Jiang, R. M. et al. Diagnosis, treatment and prevention of 2019 novel coronavirus infection in children: experts\u2019 consensus statement (Fifth Edition). Chin. J. Appl. Clin. Pediatr. 38 (1), 20\u201330 (2023).","journal-title":"Chin. J. Appl. Clin. Pediatr."},{"key":"30877_CR13","unstructured":"Shao, X. M., Ye, H. M. & Qiu, X. S. (eds). Sepsis. In: Practical Neonatology, People\u2019s Medical Publishing House (2019)."},{"issue":"2","key":"30877_CR14","first-page":"145","volume":"41","author":"Chinese Center for Disease Control and Prevention","year":"2020","unstructured":"Chinese Center for Disease Control and Prevention. The epidemiological characteristics of an outbreak of 2019 novel coronavirus disease (COVID-19) in China. Chin. J. Epidemiol. 41 (2), 145\u2013151 (2020).","journal-title":"Chin. J. Epidemiol."},{"issue":"0","key":"30877_CR15","doi-asserted-by":"publisher","first-page":"206","DOI":"10.3389\/fped.2020.00206","volume":"8","author":"E Ciaglia","year":"2020","unstructured":"Ciaglia, E., Vecchione, C. & Puca, A. A. COVID-19 infection and Circulating ACE2 levels: protective role in women and children. Front. Pediatr. 8 (0), 206 (2020).","journal-title":"Front. Pediatr."},{"issue":"11","key":"30877_CR16","first-page":"1625","volume":"30","author":"J Liu","year":"2020","unstructured":"Liu, J. et al. Clinical and epidemiological characteristics of 91 children conformed with COVID-19. Chin. J. Nosocomiol. 30 (11), 1625\u20131629 (2020).","journal-title":"Chin. J. Nosocomiol"},{"issue":"24","key":"30877_CR17","first-page":"3767","volume":"32","author":"QN Chen","year":"2022","unstructured":"Chen, Q. N. et al. Clinical and epidemiological characteristics of 11 neonates with SARS-CoV-2 Omicron variant BA.5.1.3 infection in Sanya. Chin. J. Nosocomiol. 32 (24), 3767\u20133771 (2022).","journal-title":"Chin. J. Nosocomiol"},{"issue":"6","key":"30877_CR18","doi-asserted-by":"publisher","first-page":"367","DOI":"10.2174\/1570161121666230726123444","volume":"21","author":"LE Da Silva\u2002RM, Borges","year":"2023","unstructured":"Da Silva\u2002RM, Borges, L. E. Neutrophil-Lymphocyte ratio and red blood cell distribution width in patients with atrial fibrillation and rheumatic valve disease. Curr. Vasc Pharmacol. 21 (6), 367\u2013377 (2023).","journal-title":"Curr. Vasc Pharmacol."},{"issue":"0","key":"30877_CR19","first-page":"1","volume":"77","author":"DH Zhi","year":"2020","unstructured":"Zhi, D. H., Giuseppe, L. & Martina, M. Diagnostic and prognostic value of red blood cell distribution width in sepsis: A narrative review. Clin. Biochem. 77 (0), 1\u20136 (2020).","journal-title":"Clin. Biochem."},{"issue":"11","key":"30877_CR20","doi-asserted-by":"publisher","first-page":"4455","DOI":"10.1021\/acs.jproteome.0c00606","volume":"19","author":"T Thomas","year":"2020","unstructured":"Thomas, T. et al. Evidence of structural protein damage and membrane lipid remodeling in red blood cells from COVID-19 patients. J. Proteome Res. 19 (11), 4455\u20134469 (2020).","journal-title":"J. Proteome Res."},{"issue":"11","key":"30877_CR21","first-page":"1","volume":"33","author":"PL Prieto","year":"2020","unstructured":"Prieto, P. L. et al. Histiocytic hyperplasia with hemophagocytosis and acute alveolar damage in COVID-19 infection. Mod. Pathol. 33 (11), 1\u20138 (2020).","journal-title":"Mod. Pathol."},{"issue":"11","key":"30877_CR22","first-page":"2456","volume":"26","author":"XL Hu","year":"2016","unstructured":"Hu, X. L., Yao, Y. G., Wu, R. Z., Liu, S. X. & Zhao, Z. G. Clinical study on monocyte human leukocyte antigen-DR expression predicting multi-site infections in severe multiple trauma. Chin. J. Nosocomiol. 26 (11), 2456\u20132458 (2016).","journal-title":"Chin. J. Nosocomiol"},{"issue":"s01","key":"30877_CR23","first-page":"85","volume":"17","author":"R Tao","year":"2020","unstructured":"Tao, R. et al. Correlation between the ratio of different inflammatory markers and mild and severe cases of COVID-19. Lab. Med. Clin. 17 (s01), 85\u201388 (2020).","journal-title":"Lab. Med. Clin."},{"issue":"9","key":"30877_CR24","first-page":"1015","volume":"133","author":"LL Ren","year":"2020","unstructured":"Ren, L. L. et al. Identification of a novel corona-virus causing severe pneumonia in human: a descriptive study. Chin. Med. J(Engl). 133 (9), 1015\u20131024 (2020).","journal-title":"Chin. Med. J(Engl)"},{"issue":"10","key":"30877_CR25","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.3390\/v16101643","volume":"16","author":"XL Wang","year":"2024","unstructured":"Wang, X. L., Wang, X. & Ho, W. Z. Roles of macrophages in viral infections. Viruses 16 (10), 1643 (2024).","journal-title":"Viruses"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-30877-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-30877-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-30877-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T21:05:42Z","timestamp":1768165542000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-30877-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,7]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["30877"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-30877-7","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-7658577\/v1","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,7]]},"assertion":[{"value":"19 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1119"}}