{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T01:15:48Z","timestamp":1782177348617,"version":"3.54.5"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":34,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Netherlands Heart Foundation","award":["2007B012"],"award-info":[{"award-number":["2007B012"]}]},{"name":"Netherlands Heart Institute-Interuniversity Cardiology Institute of the Netherlands","award":["071.01"],"award-info":[{"award-number":["071.01"]}]},{"name":"Working Group on Cardiovascular Research Netherlands"},{"name":"Eli Lilly, the Netherlands"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-30969-4","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T18:45:22Z","timestamp":1765392322000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sex-based differences in biomarker trajectories in acute coronary syndrome patients from the BIOMArCS study"],"prefix":"10.1038","volume":"16","author":[{"given":"Christiane","family":"G\u00e4rtner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique E. ten","family":"Haaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Martijn","family":"Akkerhuis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit M.","family":"Oemrawsingh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron H.","family":"van Schaik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda B.","family":"de Rijke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Kardys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolande","family":"Appelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Boersma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"issue":"13","key":"30969_CR1","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1093\/eurheartj\/ehz674","volume":"41","author":"A Haider","year":"2020","unstructured":"Haider, A. et al. Sex and gender in cardiovascular medicine: Presentation and outcomes of acute coronary syndrome. Eur. Heart J. 41(13), 1328\u20131336. https:\/\/doi.org\/10.1093\/eurheartj\/ehz674 (2020).","journal-title":"Eur. Heart J."},{"key":"30969_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13293-017-0152-8","volume":"8","author":"A Iorga","year":"2017","unstructured":"Iorga, A. et al. The protective role of estrogen and estrogen receptors in cardiovascular disease and the controversial use of estrogen therapy. Biol. Sex Differ. 8, 1\u201316. https:\/\/doi.org\/10.1186\/s13293-017-0152-8 (2017).","journal-title":"Biol. Sex Differ."},{"issue":"2 Suppl","key":"30969_CR3","doi-asserted-by":"publisher","first-page":"S62","DOI":"10.1067\/mhj.2001.109946","volume":"141","author":"AP Burke","year":"2001","unstructured":"Burke, A. P., Farb, A., Malcom, G. & Virmani, R. Effect of menopause on plaque morphologic characteristics in coronary atherosclerosis. Am. Heart J. 141(2 Suppl), S62. https:\/\/doi.org\/10.1067\/mhj.2001.109946 (2001).","journal-title":"Am. Heart J."},{"issue":"3 Suppl","key":"30969_CR4","doi-asserted-by":"publisher","first-page":"S72","DOI":"10.1016\/j.jcmg.2012.02.003","volume":"5","author":"AJ Lansky","year":"2012","unstructured":"Lansky, A. J. et al. Gender and the extent of coronary atherosclerosis, plaque composition, and clinical outcomes in acute coronary syndromes. JACC Cardiovasc. Imaging 5(3 Suppl), S72. https:\/\/doi.org\/10.1016\/j.jcmg.2012.02.003 (2012).","journal-title":"JACC Cardiovasc. Imaging"},{"issue":"8","key":"30969_CR5","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1038\/nrcardio.2016.89","volume":"13","author":"NJ Pagidipati","year":"2016","unstructured":"Pagidipati, N. J. & Peterson, E. D. Acute coronary syndromes in women and men. Nat. Rev. Cardiol. 13(8), 471\u2013480. https:\/\/doi.org\/10.1038\/nrcardio.2016.89 (2016).","journal-title":"Nat. Rev. Cardiol."},{"issue":"8","key":"30969_CR6","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1042\/CS20150586","volume":"130","author":"S Westerman","year":"2016","unstructured":"Westerman, S. & Wenger, N. K. Women and heart disease, the underrecognized burden: Sex differences, biases, and unmet clinical and research challenges. Clin. Sci. (London) 130(8), 551\u2013563. https:\/\/doi.org\/10.1042\/CS20150586 (2016).","journal-title":"Clin. Sci. (London)"},{"issue":"12","key":"30969_CR7","doi-asserted-by":"publisher","first-page":"e012929","DOI":"10.1136\/bmjopen-2016-012929","volume":"6","author":"RM Oemrawsingh","year":"2016","unstructured":"Oemrawsingh, R. M. et al. Cohort profile of BIOMArCS: The BIOMarker study to identify the Acute risk of a Coronary Syndrome\u2014a prospective multicentre biomarker study conducted in the Netherlands. BMJ Open 6(12), e012929. https:\/\/doi.org\/10.1136\/bmjopen-2016-012929 (2016).","journal-title":"BMJ Open"},{"issue":"22","key":"30969_CR8","doi-asserted-by":"publisher","first-page":"e1054","DOI":"10.1161\/CIR.0000000000000490","volume":"135","author":"SL Chow","year":"2017","unstructured":"Chow, S. L. et al. Role of biomarkers for the prevention, assessment, and management of heart failure: A scientific statement from the American Heart Association. Circulation 135(22), e1054\u2013e1091. https:\/\/doi.org\/10.1161\/CIR.0000000000000490 (2017).","journal-title":"Circulation"},{"issue":"10","key":"30969_CR9","doi-asserted-by":"publisher","first-page":"1992","DOI":"10.3390\/life13101992","volume":"13","author":"M Katsioupa","year":"2023","unstructured":"Katsioupa, M. et al. Novel biomarkers and their role in the diagnosis and prognosis of acute coronary syndrome. Life 13(10), 1992. https:\/\/doi.org\/10.3390\/life13101992 (2023).","journal-title":"Life"},{"issue":"23","key":"30969_CR10","doi-asserted-by":"publisher","first-page":"5508","DOI":"10.3390\/jcm10235508","volume":"10","author":"C Gaertner","year":"2021","unstructured":"Gaertner, C. et al. Revisited upper reference limits for highly sensitive cardiac troponin T in relation to age, sex, and renal function. J. Clin. Med. 10(23), 5508. https:\/\/doi.org\/10.3390\/jcm10235508 (2021).","journal-title":"J. Clin. Med."},{"issue":"11","key":"30969_CR11","doi-asserted-by":"publisher","first-page":"2046","DOI":"10.1515\/cclm-2023-0151","volume":"61","author":"R Gessner","year":"2023","unstructured":"Gessner, R. et al. Higher troponin T serum concentrations in hospital patients without diagnosed cardiac diseases compared to a population-based cohort. Clin. Chem. Lab. Med. 61(11), 2046\u20132052. https:\/\/doi.org\/10.1515\/cclm-2023-0151 (2023).","journal-title":"Clin. Chem. Lab. Med."},{"issue":"10","key":"30969_CR12","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1038\/nrcardio.2015.105","volume":"12","author":"LB Daniels","year":"2015","unstructured":"Daniels, L. B. & Maisel, A. S. Cardiovascular biomarkers and sex: The case for women. Nat. Rev. Cardiol. 12(10), 588\u2013596. https:\/\/doi.org\/10.1038\/nrcardio.2015.105 (2015).","journal-title":"Nat. Rev. Cardiol."},{"issue":"6","key":"30969_CR13","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1161\/CIRCULATIONAHA.116.024749","volume":"135","author":"J Lew","year":"2017","unstructured":"Lew, J. et al. Sex-based differences in cardiometabolic biomarkers. Circulation 135(6), 544\u2013555. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.116.024749 (2017).","journal-title":"Circulation"},{"issue":"12","key":"30969_CR14","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1016\/j.jacc.2019.07.068","volume":"74","author":"ES Lau","year":"2019","unstructured":"Lau, E. S. et al. Sex differences in circulating biomarkers of cardiovascular disease. J. Am. Coll. Cardiol. 74(12), 1543\u20131553. https:\/\/doi.org\/10.1016\/j.jacc.2019.07.068 (2019).","journal-title":"J. Am. Coll. Cardiol."},{"issue":"7","key":"30969_CR15","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1530\/EC-21-0273","volume":"11","author":"M Asrih","year":"2021","unstructured":"Asrih, M. et al. Sex-specific modulation of circulating growth differentiation factor-15 in patients with type 2 diabetes and\/or obesity. Endocr. Connect. 11(7), 643\u2013653. https:\/\/doi.org\/10.1530\/EC-21-0273 (2021).","journal-title":"Endocr. Connect."},{"issue":"6","key":"30969_CR16","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1515\/cclm-2024-0017","volume":"62","author":"KM Eggers","year":"2024","unstructured":"Eggers, K. M. et al. Temporal biomarker concentration patterns during the early course of acute coronary syndrome. Clin. Chem. Lab. Med. 62(6), 1167\u20131176. https:\/\/doi.org\/10.1515\/cclm-2024-0017 (2024).","journal-title":"Clin. Chem. Lab. Med."},{"issue":"1","key":"30969_CR17","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1161\/CIRCULATIONAHA.118.036349","volume":"139","author":"RM Oemrawsingh","year":"2019","unstructured":"Oemrawsingh, R. M. et al. High-frequency biomarker measurements of troponin, NT-proBNP, and C-reactive protein for prediction of new coronary events after acute coronary syndrome: BIOMArCS study. Circulation 139(1), 134\u2013136. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.118.036349 (2019).","journal-title":"Circulation"},{"key":"30969_CR18","doi-asserted-by":"publisher","first-page":"104750","DOI":"10.1016\/j.dib.2019.104750","volume":"27","author":"E Boersma","year":"2019","unstructured":"Boersma, E. et al. Details on high frequency blood collection, data analysis, available material and patient characteristics in BIOMArCS. Data Brief 27, 104750. https:\/\/doi.org\/10.1016\/j.dib.2019.104750 (2019).","journal-title":"Data Brief"},{"key":"30969_CR19","unstructured":"R Core Team. R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing. (2024)."},{"key":"30969_CR20","unstructured":"Pinheiro, J., Bates, D. & R Core Team. nlme: Linear and Nonlinear Mixed Effects Models [R package]. Version 3.1\u2013166. CRAN.R-project.org\/package=nlme (2024)."},{"issue":"6","key":"30969_CR21","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1161\/01.hyp.26.6.979","volume":"26","author":"G de Simone","year":"1995","unstructured":"de Simone, G., Devereux, R. B., Daniels, S. R. & Meyer, R. A. Gender differences in left ventricular growth. Hypertension 26(6), 979\u2013983. https:\/\/doi.org\/10.1161\/01.hyp.26.6.979 (1995).","journal-title":"Hypertension"},{"issue":"22","key":"30969_CR22","doi-asserted-by":"publisher","first-page":"2503","DOI":"10.1001\/jama.2010.1768","volume":"304","author":"JA De Lemos","year":"2010","unstructured":"De Lemos, J. A. et al. Association of troponin T detected with a highly sensitive assay and cardiac structure and mortality risk in the general population. JAMA 304(22), 2503\u20132512. https:\/\/doi.org\/10.1001\/jama.2010.1768 (2010).","journal-title":"JAMA"},{"issue":"2","key":"30969_CR23","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.jacc.2012.10.012","volume":"61","author":"IJ Neeland","year":"2013","unstructured":"Neeland, I. J. et al. Biomarkers of chronic cardiac injury and hemodynamic stress identify a malignant phenotype of left ventricular hypertrophy in the general population. J. Am. Coll. Cardiol. 61(2), 187\u2013195. https:\/\/doi.org\/10.1016\/j.jacc.2012.10.012 (2013).","journal-title":"J. Am. Coll. Cardiol."},{"issue":"1","key":"30969_CR24","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1373\/clinchem.2013.217927","volume":"60","author":"AS Jaffe","year":"2014","unstructured":"Jaffe, A. S. & Apple, F. S. High-sensitivity cardiac troponin assays: isn\u2019t it time for equality?. Clin. Chem. 60(1), 7\u20139. https:\/\/doi.org\/10.1373\/clinchem.2013.217927 (2014).","journal-title":"Clin. Chem."},{"issue":"2","key":"30969_CR25","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1161\/CIRCRESAHA.108.179903","volume":"104","author":"C Donaldson","year":"2009","unstructured":"Donaldson, C. et al. Estrogen attenuates left ventricular and cardiomyocyte hypertrophy via an estrogen receptor-dependent pathway that increases calcineurin degradation. Circ. Res. 104(2), 265\u2013275. https:\/\/doi.org\/10.1161\/CIRCRESAHA.108.179903 (2009).","journal-title":"Circ. Res."},{"issue":"11","key":"30969_CR26","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1016\/j.jacc.2009.09.065","volume":"55","author":"M Piro","year":"2010","unstructured":"Piro, M., Della Bona, R., Abbate, A., Biasucci, L. M. & Crea, F. Sex-related differences in myocardial remodeling. J. Am. Coll. Cardiol. 55(11), 1057\u20131065. https:\/\/doi.org\/10.1016\/j.jacc.2009.09.065 (2010).","journal-title":"J. Am. Coll. Cardiol."},{"issue":"12","key":"30969_CR27","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.1515\/cclm-2020-0415","volume":"58","author":"VJ van den Berg","year":"2020","unstructured":"van den Berg, V. J. et al. Stabilization patterns and variability of hs-CRP, NT-proBNP, and ST2 during 1 year after acute coronary syndrome admission: Results of the BIOMArCS study. Clin. Chem. Lab. Med. 58(12), 2099\u20132106. https:\/\/doi.org\/10.1515\/cclm-2020-0415 (2020).","journal-title":"Clin. Chem. Lab. Med."},{"issue":"17","key":"30969_CR28","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1161\/CIRCULATIONAHA.107.708529","volume":"116","author":"KM Eggers","year":"2007","unstructured":"Eggers, K. M., Lagerqvist, B., Venge, P., Wallentin, L. & Lindahl, B. Persistent cardiac troponin I elevation in stabilized patients after an episode of acute coronary syndrome predicts long-term mortality. Circulation 116(17), 1907\u20131914. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.107.708529 (2007).","journal-title":"Circulation"},{"issue":"14","key":"30969_CR29","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1093\/cvr\/cvx183","volume":"113","author":"KC Park","year":"2017","unstructured":"Park, K. C., Gaze, D. C., Collinson, P. O. & Marber, M. S. Cardiac troponins: from myocardial infarction to chronic disease. Cardiovasc. Res. 113(14), 1708\u20131718. https:\/\/doi.org\/10.1093\/cvr\/cvx183 (2017).","journal-title":"Cardiovasc. Res."},{"issue":"7","key":"30969_CR30","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1515\/cclm-2022-0510","volume":"61","author":"A Clerico","year":"2023","unstructured":"Clerico, A. et al. Variability of cardiac troponin levels in normal subjects and in patients with cardiovascular diseases: Analytical considerations and clinical relevance. Clin. Chem. Lab. Med. 61(7), 1209\u20131229. https:\/\/doi.org\/10.1515\/cclm-2022-0510 (2023).","journal-title":"Clin. Chem. Lab. Med."},{"issue":"8","key":"30969_CR31","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1002\/ejhf.1161","volume":"20","author":"N Suthahar","year":"2018","unstructured":"Suthahar, N. et al. Sex-specific associations of obesity and N-terminal pro-B-type natriuretic peptide levels in the general population. Eur. J. Heart Fail. 20(8), 1205\u20131214. https:\/\/doi.org\/10.1002\/ejhf.1161 (2018).","journal-title":"Eur. J. Heart Fail."},{"issue":"1","key":"30969_CR32","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/s0735-1097(02)02059-4","volume":"12","author":"MM Redfield","year":"2003","unstructured":"Redfield, M. M. et al. Plasma brain natriuretic peptide concentration: impact of age and gender. ACC Curr. J. Rev. 12(1), 44. https:\/\/doi.org\/10.1016\/s0735-1097(02)02059-4 (2003).","journal-title":"ACC Curr. J. Rev."},{"issue":"3","key":"30969_CR33","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1056\/NEJMoa020233","volume":"347","author":"AS Maisel","year":"2002","unstructured":"Maisel, A. S. et al. Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure. N. Engl. J. Med. 347(3), 161\u2013167. https:\/\/doi.org\/10.1056\/NEJMoa020233 (2002).","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"30969_CR34","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1093\/eurheartj\/eht463","volume":"35","author":"R Troughton","year":"2014","unstructured":"Troughton, R., Felker, G. M. & Januzzi, J. L. Jr. Natriuretic peptide-guided heart failure management. Eur. Heart J. 35(1), 16\u201324. https:\/\/doi.org\/10.1093\/eurheartj\/eht463 (2014).","journal-title":"Eur. Heart J."},{"issue":"7","key":"30969_CR35","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1161\/01.CIR.99.7.85","volume":"99","author":"LM Biasucci","year":"1999","unstructured":"Biasucci, L. M. et al. Elevated levels of c-reactive protein at discharge in patients with unstable angina predict recurrent instability. Circulation 99(7), 855\u2013860. https:\/\/doi.org\/10.1161\/01.CIR.99.7.85 (1999).","journal-title":"Circulation"},{"issue":"4","key":"30969_CR36","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1373\/49.4.669","volume":"49","author":"A Imhof","year":"2003","unstructured":"Imhof, A. et al. Distributions of C-reactive protein measured by high-sensitivity assays in apparently healthy men and women from different populations in Europe. Clin. Chem. 49(4), 669\u2013672. https:\/\/doi.org\/10.1373\/49.4.669 (2003).","journal-title":"Clin. Chem."},{"key":"30969_CR37","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2002.011","author":"JP McConnell","year":"2002","unstructured":"McConnell, J. P. et al. Gender differences in C-reactive protein concentrations-confirmation with two sensitive methods. Clin. Chem. Lab. Med. https:\/\/doi.org\/10.1515\/CCLM.2002.011 (2002).","journal-title":"Clin. Chem. Lab. Med."},{"key":"30969_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.ihj.2013.04.035","author":"S Gupta","year":"2013","unstructured":"Gupta, S., Gupta, V. K., Gupta, R., Arora, S. & Gupta, V. Relationship of high-sensitive C-reactive protein with cardiovascular risk factors, clinical presentation and angiographic profile in patients with acute coronary syndrome: An Indian perspective. Indian Heart J. https:\/\/doi.org\/10.1016\/j.ihj.2013.04.035 (2013).","journal-title":"Indian Heart J."},{"key":"30969_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.02.002","author":"CM Gijsberts","year":"2015","unstructured":"Gijsberts, C. M. et al. Severity of stable coronary artery disease and its biomarkers differ between men and women undergoing angiography. Atherosclerosis https:\/\/doi.org\/10.1016\/j.atherosclerosis.2015.02.002 (2015).","journal-title":"Atherosclerosis"},{"key":"30969_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.04.051","author":"A Khera","year":"2005","unstructured":"Khera, A. et al. Race and gender differences in C-reactive protein levels. J. Am. Coll. Cardiol. https:\/\/doi.org\/10.1016\/j.jacc.2005.04.051 (2005).","journal-title":"J. Am. Coll. Cardiol."},{"key":"30969_CR41","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1771","author":"N Suthahar","year":"2020","unstructured":"Suthahar, N., Meems, L. M., Ho, J. E. & de Boer, R. A. Sex-related differences in contemporary biomarkers for heart failure: a review. Eur. J. Heart Fail. https:\/\/doi.org\/10.1002\/ejhf.1771 (2020).","journal-title":"Eur. J. Heart Fail."},{"key":"30969_CR42","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002347","author":"M Nayor","year":"2015","unstructured":"Nayor, M. et al. Circulating galectin-3 is associated with cardiometabolic disease in the community. J. Am. Heart Assoc. https:\/\/doi.org\/10.1161\/JAHA.115.002347 (2015).","journal-title":"J. Am. Heart Assoc."},{"key":"30969_CR43","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-016-0490-3","author":"J Pang","year":"2016","unstructured":"Pang, J. et al. Relationship of galectin-3 with obesity, IL-6, and CRP in women. J. Endocrinol. Invest. https:\/\/doi.org\/10.1007\/s40618-016-0490-3 (2016).","journal-title":"J. Endocrinol. Invest."},{"key":"30969_CR44","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw272","author":"AL Catapano","year":"2016","unstructured":"Catapano, A. L. et al. ESC\/EAS guidelines for the management of dyslipidaemias. Eur. Heart J. https:\/\/doi.org\/10.1093\/eurheartj\/ehw272 (2016).","journal-title":"Eur. Heart J."},{"key":"30969_CR45","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2061","author":"X Wang","year":"2011","unstructured":"Wang, X., Magkos, F. & Mittendorfer, B. Sex differences in lipid and lipoprotein metabolism: it\u2019s not just about sex hormones. J. Clin. Endocrinol. Metab. https:\/\/doi.org\/10.1210\/jc.2010-2061 (2011).","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"30969_CR46","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae593","author":"Y Wang","year":"2024","unstructured":"Wang, Y. et al. Sex-specific prediction of cardiogenic shock after acute coronary syndromes: the SEX-SHOCK score. Eur. Heart J. https:\/\/doi.org\/10.1093\/eurheartj\/ehae593 (2024).","journal-title":"Eur. Heart J."},{"key":"30969_CR47","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2013.12199","author":"M Rubini Gimenez","year":"2014","unstructured":"Rubini Gimenez, M. et al. Sex-specific chest pain characteristics in the early diagnosis of acute myocardial infarction. JAMA Internal Med. https:\/\/doi.org\/10.1001\/jamainternmed.2013.12199 (2014).","journal-title":"JAMA Internal Med."},{"issue":"29","key":"30969_CR48","doi-asserted-by":"publisher","first-page":"2866","DOI":"10.1093\/eurheartj\/ehaf289","volume":"46","author":"S Kraler","year":"2025","unstructured":"Kraler, S. et al. Acute coronary syndromes: mechanisms, challenges, and new opportunities. Eur. Heart J. 46(29), 2866\u20132889. https:\/\/doi.org\/10.1093\/eurheartj\/ehaf289 (2025).","journal-title":"Eur. Heart J."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-30969-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-30969-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-30969-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T23:03:25Z","timestamp":1768345405000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-30969-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,10]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["30969"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-30969-4","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,10]]},"assertion":[{"value":"10 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"IK received travel reimbursement from Olink and SomaLogic. The other authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"BIOMArCS was conducted in accordance with the Declaration of Helsinki. The study protocol was approved by the institutional review board of the Erasmus MC (approval nr. MEC-2007-185), which decision was adopted by all other participating centers in accordance with Dutch law. All study participants provided written informed consent. BIOMArCS is registered in The Netherlands Trial Register under the unique identifiers NTR1106 and NTR1698.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}],"article-number":"1585"}}