{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T14:32:00Z","timestamp":1794321120481,"version":"4.9.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T00:00:00Z","timestamp":1765584000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":31,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-31090-2","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T10:14:58Z","timestamp":1765620898000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Correlation between serum endocrine hormone levels and malignancy degree of prolactinoma and their predictive value for patient prognosis"],"prefix":"10.1038","volume":"16","author":[{"given":"Peimin","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengjin","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,13]]},"reference":[{"issue":"1","key":"31090_CR1","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1007\/s10143-023-02033-0","volume":"46","author":"M Ottenhausen","year":"2023","unstructured":"Ottenhausen, M., Conrad, J., Wolters, L. M. & Ringel, F. Surgery as first-line treatment for prolactinoma? Discussion of the literature and results of a consecutive series of surgically treated patients. Neurosurg. Rev. 46 (1), 128 (2023).","journal-title":"Neurosurg. Rev."},{"issue":"8","key":"31090_CR2","doi-asserted-by":"publisher","first-page":"4613","DOI":"10.1097\/MS9.0000000000002308","volume":"86","author":"F Yogeeta","year":"2024","unstructured":"Yogeeta, F. et al. Prolactinoma: Navigating the dual challenge of side effects and treatment strategies\u2014A comprehensive review. Ann. Med. Surg. (Lond). 86 (8), 4613\u20134623 (2024).","journal-title":"Ann. Med. Surg. (Lond)"},{"issue":"7","key":"31090_CR3","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1055\/a-1525-2131","volume":"53","author":"R Sari","year":"2021","unstructured":"Sari, R. et al. Treatment strategies for dopamine agonist-resistant and aggressive prolactinomas: A comprehensive analysis of the literature. Horm. Metab. Res. 53 (7), 413\u2013424 (2021).","journal-title":"Horm. Metab. Res."},{"issue":"1","key":"31090_CR4","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1159\/000499382","volume":"109","author":"J Trouillas","year":"2019","unstructured":"Trouillas, J. et al. Clinical, pathological, and molecular factors of aggressiveness in lactotroph tumours. Neuroendocrinology 109 (1), 70\u201376 (2019).","journal-title":"Neuroendocrinology"},{"issue":"1","key":"31090_CR5","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1007\/s12022-022-09703-7","volume":"33","author":"SL Asa","year":"2022","unstructured":"Asa, S. L., Mete, O., Perry, A. & Osamura, R. Y. Overview of the 2022 WHO classification of pituitary tumors. Endocr. Pathol. 33 (1), 6\u201326 (2022).","journal-title":"Endocr. Pathol."},{"key":"31090_CR6","doi-asserted-by":"publisher","first-page":"1363939","DOI":"10.3389\/fendo.2024.1363939","volume":"15","author":"S Hofbauer","year":"2024","unstructured":"Hofbauer, S. et al. Metabolic and inflammatory parameters in relation to baseline characterization and treatment outcome in patients with prolactinoma: Insights from a retrospective cohort study at a single tertiary center. Front. Endocrinol. (Lausanne). 15, 1363939 (2024).","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"31090_CR7","doi-asserted-by":"publisher","first-page":"1327404","DOI":"10.3389\/fendo.2023.1327404","volume":"14","author":"G Riley","year":"2024","unstructured":"Riley, G. et al. Prognostic indicators in pituitary adenoma surgery: A comprehensive analysis of surgical outcomes and complications. Front. Endocrinol. (Lausanne). 14, 1327404 (2024).","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"11","key":"31090_CR8","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.25122\/jml-2024-0015","volume":"17","author":"S Rouf","year":"2024","unstructured":"Rouf, S., Berrabeh, S., Zarraa, L. & Latrech, H. Knosp and revised Knosp classifications predict non-functioning pituitary adenoma outcomes: A single tertiary center experience. J. Med. Life. 17 (11), 1007\u20131011 (2024).","journal-title":"J. Med. Life"},{"issue":"3","key":"31090_CR9","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1111\/cen.14394","volume":"94","author":"VB Arya","year":"2021","unstructured":"Arya, V. B. et al. Prolactinoma in childhood and adolescence-tumour size at presentation predicts management strategy: Single centre series and a systematic review and meta-analysis. Clin. Endocrinol. (Oxf). 94 (3), 413\u2013423 (2021).","journal-title":"Clin. Endocrinol. (Oxf)"},{"issue":"3","key":"31090_CR10","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/s11102-024-01392-1","volume":"27","author":"M Castle-Kirszbaum","year":"2024","unstructured":"Castle-Kirszbaum, M., Biermasz, N., Kam, J. & Goldschlager, T. Quality of life in prolactinoma: A systematic review. Pituitary 27 (3), 239\u2013247 (2024).","journal-title":"Pituitary"},{"issue":"9","key":"31090_CR11","doi-asserted-by":"publisher","first-page":"2400","DOI":"10.1210\/clinem\/dgad174","volume":"108","author":"RS Auriemma","year":"2023","unstructured":"Auriemma, R. S. et al. Approach to the patient with prolactinoma. J. Clin. Endocrinol. Metab. 108 (9), 2400\u20132423 (2023).","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"31090_CR12","first-page":"dgae652","volume":"18","author":"VR van Trigt","year":"2024","unstructured":"van Trigt, V. R. et al. The changing treatment paradigm in prolactinoma\u2014A prospective series of 100 consecutive neurosurgical cases. J. Clin. Endocrinol. Metab. 18, dgae652 (2024).","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"8","key":"31090_CR13","doi-asserted-by":"publisher","first-page":"102919","DOI":"10.1016\/j.arcmed.2023.102919","volume":"54","author":"IM Zandbergen","year":"2023","unstructured":"Zandbergen, I. M. et al. Efficacy and safety of endoscopic transsphenoidal resection for prolactinoma: A retrospective multicenter Case-series. Arch. Med. Res. 54 (8), 102919 (2023).","journal-title":"Arch. Med. Res."},{"issue":"6","key":"31090_CR14","doi-asserted-by":"publisher","first-page":"2865","DOI":"10.1007\/s10278-024-01153-3","volume":"37","author":"H Li","year":"2024","unstructured":"Li, H. et al. Identification of prolactinoma in pituitary neuroendocrine tumors using radiomics analysis based on multiparameter MRI. J. Imaging Inf. Med. 37 (6), 2865\u20132873 (2024).","journal-title":"J. Imaging Inf. Med."},{"issue":"5","key":"31090_CR15","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1007\/s11102-024-01430-y","volume":"27","author":"VR van Trigt","year":"2024","unstructured":"van Trigt, V. R. et al. Clinical use of [18F]fluoro-ethyl-L-tyrosine PET co-registered with MRI for localizing prolactinoma remnants. Pituitary 27 (5), 614\u2013624 (2024).","journal-title":"Pituitary"},{"issue":"2","key":"31090_CR16","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1097\/GME.0000000000002303","volume":"31","author":"MS Carneiro","year":"2024","unstructured":"Carneiro, M. S., de Mira, T. A. A., Yela, D. A. & Benetti-Pinto, C. L. Prolactinoma in postmenopausal women: A systematic review. Menopause 31 (2), 160\u2013167 (2024).","journal-title":"Menopause"},{"issue":"8","key":"31090_CR17","doi-asserted-by":"publisher","first-page":"e1652","DOI":"10.1210\/clinem\/dgae087","volume":"109","author":"AS Papazoglou","year":"2024","unstructured":"Papazoglou, A. S. et al. Serum prolactin levels and mortality in adults without prolactinoma: A meta-analysis. J. Clin. Endocrinol. Metab. 109 (8), e1652\u2013e1664 (2024).","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"4","key":"31090_CR18","doi-asserted-by":"publisher","first-page":"357","DOI":"10.4103\/ijem.ijem_201_22","volume":"27","author":"MS Baba","year":"2023","unstructured":"Baba, M. S. et al. Metabolic Abnormalities, inflammatory markers and endothelial dysfunction in hyperprolactinemia due to prolactinoma before and after normalization of serum prolactin: A prospective case control study. Indian J. Endocrinol. Metab. 27 (4), 357\u2013364 (2023).","journal-title":"Indian J. Endocrinol. Metab."},{"issue":"2","key":"31090_CR19","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1159\/000494975","volume":"108","author":"N de Dios","year":"2019","unstructured":"de Dios, N. et al. JAK2\/STAT5 pathway mediates prolactin-induced apoptosis of lactotropes. Neuroendocrinology 108 (2), 84\u201397 (2019).","journal-title":"Neuroendocrinology"},{"issue":"6","key":"31090_CR20","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1158\/1535-7163.MCT-15-0891","volume":"15","author":"M Chanal","year":"2016","unstructured":"Chanal, M. et al. Differential effects of PI3K and dual PI3K\/mTOR inhibition in rat prolactin-secreting pituitary tumors. Mol. Cancer Ther. 15 (6), 1261\u20131270 (2016).","journal-title":"Mol. Cancer Ther."},{"issue":"22","key":"31090_CR21","doi-asserted-by":"publisher","first-page":"10327","DOI":"10.1111\/jcmm.16946","volume":"25","author":"Y Li","year":"2021","unstructured":"Li, Y., Kong, X., Xuan, L., Wang, Z. & Huang, Y. H. Prolactin and endocrine therapy resistance in breast cancer: The next potential hope for breast cancer treatment. J. Cell. Mol. Med. 25 (22), 10327\u201310348 (2021).","journal-title":"J. Cell. Mol. Med."},{"issue":"Pt 1","key":"31090_CR22","doi-asserted-by":"publisher","first-page":"128604","DOI":"10.1016\/j.chemosphere.2020.128604","volume":"264","author":"JC Chou","year":"2021","unstructured":"Chou, J. C. et al. Regulation of extracellular and intracellular prolactin on cell proliferation and survival rate through GHR\/JAK2\/STAT3 pathway in NSCLC. Chemosphere 264 (Pt 1), 128604 (2021).","journal-title":"Chemosphere"},{"issue":"1","key":"31090_CR23","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1089\/thy.2020.0022","volume":"31","author":"Y Tanizaki","year":"2021","unstructured":"Tanizaki, Y., Shibata, Y., Zhang, H. & Shi, Y. B. Analysis of thyroid hormone receptor \u03b1-Knockout tadpoles reveals that the activation of cell cycle program is involved in thyroid hormone-induced larval epithelial cell death and adult intestinal stem cell development during xenopus tropicalis metamorphosis. Thyroid 31 (1), 128\u2013142 (2021).","journal-title":"Thyroid"},{"issue":"12","key":"31090_CR24","doi-asserted-by":"publisher","first-page":"3417","DOI":"10.3390\/jcm11123417","volume":"11","author":"MV Deligiorgi","year":"2022","unstructured":"Deligiorgi, M. V. & Trafalis, D. T. The clinical relevance of hypothyroidism in patients with solid non-thyroid cancer: A tantalizing conundrum. J. Clin. Med. 11 (12), 3417 (2022).","journal-title":"J. Clin. Med."},{"issue":"21","key":"31090_CR25","doi-asserted-by":"publisher","first-page":"11434","DOI":"10.3390\/ijms252111434","volume":"25","author":"E Adamska-Fita","year":"2024","unstructured":"Adamska-Fita, E., \u015aliwka, P. W., Karbownik-Lewi\u0144ska, M., Lewi\u0144ski, A. & Stasiak, M. The absence of thyroid-stimulating hormone receptor expression on natural killer T cells: Implications for the immune-endocrine interaction. Int. J. Mol. Sci. 25 (21), 11434 (2024).","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"31090_CR26","doi-asserted-by":"publisher","first-page":"102893","DOI":"10.1016\/j.arcmed.2023.102893","volume":"54","author":"E Sosa-Eroza","year":"2023","unstructured":"Sosa-Eroza, E. & Espinosa-C\u00e1rdenas, E. Long-term discontinuation of dopamine agonist treatment in patients with prolactinomas revisited. Arch. Med. Res. 54 (8), 102893 (2023).","journal-title":"Arch. Med. Res."},{"issue":"1","key":"31090_CR27","first-page":"55","volume":"47","author":"G Ambwani","year":"2025","unstructured":"Ambwani, G., Shi, Z., Luo, K., Jeong, J. W. & Tan, S. Distinguishing laterality in brain injury in rabbit fetal magnetic resonance imaging using novel volume rendering techniques. Dev. Neurosci. 47 (1), 55\u201367 (2025).","journal-title":"Dev. Neurosci."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-31090-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-31090-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-31090-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T14:04:22Z","timestamp":1794319462000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-31090-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,13]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["31090"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-31090-2","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-7428081\/v1","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,13]]},"assertion":[{"value":"21 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 November 2026","order":6,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":7,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The original online version of this Article was revised: The Funding section in the original version of this Article was omitted. It now reads: \u201cThis work was supported by my supervisor\u2019s research project \u201cExploration and Expanded Application of Precise Glioma Surgery under Fluorescent 3D Neuroendoscopy.\u201d\u201d The original Article has been corrected.","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"1591"}}