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Thus, finding novel antimicrobial agents is urgent for the solution. The objective was to characterize a newly isolated\n                    <jats:italic>Epseptimavirus<\/jats:italic>\n                    phage with antimicrobial activity against multidrug-resistant\n                    <jats:italic>S.<\/jats:italic>\n                    Infantis strains.\n                    <jats:italic>Salmonella<\/jats:italic>\n                    phage vB_SalS-SIY1lw (or SIY1lw) is a new member of the phages belonging to the\n                    <jats:italic>Epseptimavirus<\/jats:italic>\n                    genus. SIY1lw contained the receptor binding protein (ORF 23) and tail fiber protein (ORF 43) genes\u2014both associated with bacterial host recognition and binding\u2014similar to that in\n                    <jats:italic>Salmonella<\/jats:italic>\n                    phage OSY-STA (the\n                    <jats:italic>Epseptimavirus<\/jats:italic>\n                    genus) and\n                    <jats:italic>Escherichia<\/jats:italic>\n                    phage DaisyDussoix (the\n                    <jats:italic>Tequintavirus<\/jats:italic>\n                    genus), respectively. For biological traits, SIY1lw has a latent period of 30\u00a0min and an estimated burst size of 42 PFU\/CFU. The phage was polyvalent against\n                    <jats:italic>S.<\/jats:italic>\n                    <jats:italic>enterica<\/jats:italic>\n                    (Infantis and Newport) and non-pathogenic\n                    <jats:italic>E. coli<\/jats:italic>\n                    strains. The in vitro antimicrobial activity test showed that the phage with MOI of\u20091,000 is the most effective in reducing\n                    <jats:italic>S.<\/jats:italic>\n                    Infantis FSIS7823 and FSIS4921 by 1 and 0.8 log, respectively, over the 6-h treatment at 25\u00a0\u00b0C. These findings indicate that the new\n                    <jats:italic>Epseptimavirus<\/jats:italic>\n                    phage SIY1lw has future potential to develop an antimicrobial alternative to multidrug-resistant\n                    <jats:italic>S.<\/jats:italic>\n                    Infantis strains.\n                  <\/jats:p>","DOI":"10.1038\/s41598-025-31311-8","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T05:05:45Z","timestamp":1770267945000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A new Epseptimavirus bacteriophage vB_SalS-SIY1lw as a potential antimicrobial alternative to multidrug-resistant Salmonella Infantis"],"prefix":"10.1038","volume":"16","author":[{"given":"Yen-Te","family":"Liao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Voelker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail R.","family":"Arellano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie A.","family":"Harden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Salvador","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian C. 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