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The research focuses on creating durable, antimicrobial coatings to prevent bacterial colonization on endotracheal tube surfaces. Using a 10-second exposure to solvents such as dimethylformamide (DMF) and tetrahydrofuran (THF), the study successfully demonstrated a robust coating on polyvinyl chloride (PVC) tubing. This coating inhibits the growth of Escherichia coli while maintaining biocompatibility and avoiding the toxic effects of traditional silver nitrate coatings. Quantitatively, the coatings achieved pH values of 5\u20135.5, viscosities of 0.6-1 mPa\u00b7s, and reduced microbial counts to 4 CFU\/\u00b5L, compared to 5 CFU\/\u00b5L in the controls. Biocompatibility remained high, with cell viability exceeding 98% for DMF and THF coatings. 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