{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T20:00:20Z","timestamp":1783627220745,"version":"3.55.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2023KY997"],"award-info":[{"award-number":["2023KY997"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2023KY997"],"award-info":[{"award-number":["2023KY997"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Health Science and Technology Project of Hangzhou","award":["ZD20230118"],"award-info":[{"award-number":["ZD20230118"]}]},{"name":"Health Science and Technology Project of Hangzhou","award":["ZD20230118"],"award-info":[{"award-number":["ZD20230118"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    To investigate factors influencing cervical cancer and precancerous lesions by collecting and analyzing clinical data and pathological results from 2,998 patients undergoing cervical biopsy; Pathological results and clinical data of 2,998 patients who underwent cervical biopsy at the gynecology outpatient clinic of a tertiary hospital in Hangzhou (January 2022\u2013January 2023) were collected. Univariate analysis and multivariate unconditional logistic regression models were used to analyze relevant influencing factors; The results of univariate and multivariate analyses showed that cervical lesions were related to Human Papillomavirus (HPV) infection and the number of deliveries (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05) but were not related to age, number of pregnancies, number of abortions, use of condoms for contraception, and smoking (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&gt;\u20090.05); Cervical cancer and precancerous lesions are associated with HPV infection and number of deliveries. It is imperative to implement a series of prevention and treatment measures to inhibit the onset and progression of cervical diseases, thereby reducing their incidence and mortality rates.\n                  <\/jats:p>","DOI":"10.1038\/s41598-025-32215-3","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T08:22:27Z","timestamp":1773044547000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Analysis of factors associated with cervical cancer and precancerous lesions"],"prefix":"10.1038","volume":"16","author":[{"given":"Danhong","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengnan","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangqian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoqin","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,9]]},"reference":[{"issue":"3","key":"32215_CR1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","volume":"74","author":"F Bray","year":"2022","unstructured":"Bray, F. et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. Cancer J. Clin. 74 (3), 229\u2013263 (2022).","journal-title":"Cancer J. Clin."},{"key":"32215_CR2","doi-asserted-by":"crossref","unstructured":"Rayner, M. et al. Cervical cancer screening recommendations: now and for the future. Healthcare 11 (16), 2273. (2023).","DOI":"10.3390\/healthcare11162273"},{"issue":"04","key":"32215_CR3","first-page":"443","volume":"23","author":"L Bi Hui","year":"2022","unstructured":"Bi Hui, L. et al. Chinese expert consensus on the management of cervical Low-Grade squamous intraepithelial lesions. Chin. J. Clin. Obstet. Gynecol. 23 (04), 443\u2013445 (2022).","journal-title":"Chin. J. Clin. Obstet. Gynecol."},{"issue":"11","key":"32215_CR4","first-page":"2244","volume":"31","author":"C Zhang Shan","year":"2023","unstructured":"Zhang Shan, C. & Guangyan, F. W. Interaction between abnormal expression of P53 and CD44v6 in tissue samples of patients with cervical precancerous lesions and HPV infection. Chin. J. Prenatal Genetic Med. 31 (11), 2244\u20132248 (2023).","journal-title":"Chin. J. Prenatal Genetic Med."},{"issue":"07","key":"32215_CR5","first-page":"588","volume":"36","author":"Zhang","year":"2020","unstructured":"Zhang, Yumin & Zhang Shiqian. Management of persistent High-Risk human papillomavirus (HPV) infection. Chin. J. Practical Obstet. Gynecol. 36 (07), 588\u2013592 (2020).","journal-title":"Chin. J. Practical Obstet. Gynecol."},{"issue":"21","key":"32215_CR6","first-page":"3283","volume":"52","author":"W Wang Longyi","year":"2023","unstructured":"Wang Longyi, W. et al. Analysis of related influencing factors of High-Risk HPV infection and cervical pathological progression. Chongqing Med. 52 (21), 3283\u20133286 (2023).","journal-title":"Chongqing Med."},{"issue":"1","key":"32215_CR7","first-page":"47","volume":"4","author":"B Han","year":"2024","unstructured":"Han, B. et al. Cancer incidence and mortality in China, 2022. J. Natl. Cancer Cent. 4 (1), 47\u201353 (2024).","journal-title":"J. Natl. Cancer Cent."},{"issue":"11","key":"32215_CR8","first-page":"1185","volume":"35","author":"H Jin Youcun","year":"2022","unstructured":"Jin Youcun, H. et al. Predictive value of combined high-risk HPV-DNA and TCT testing for recurrence of high-grade cervical squamous intraepithelial lesions after LEEP. J. Postgraduates Med. 35 (11), 1185\u20131189 (2022).","journal-title":"J. Postgraduates Med."},{"issue":"3","key":"32215_CR9","first-page":"147","volume":"62","author":"D Saslow","year":"2012","unstructured":"Saslow, D. et al. American cancer society, American society for colposcopy and cervical pathology, and American society for clinical pathology screening guidelines for the prevention and early detection of cervical cancer. CA 62 (3), 147\u2013172 (2012).","journal-title":"CA"},{"key":"32215_CR10","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1002\/ijc.22357","volume":"120","author":"International Collaboration of Epidemiological Studies of Cervical Cancer, corp-author","year":"2007","unstructured":"International Collaboration of Epidemiological Studies of Cervical Cancer, corp-author. Comparison of risk factors for invasive squamous cell carcinoma and adenocarcinoma of the cervix: collaborative reanalysis of individual data on 8,097 women with squamous cell carcinoma and 1,374 women with adenocarcinoma from 12 epidemiological studies. Int. J. Cancer. 120, 885\u2013891 (2007).","journal-title":"Int. J. 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Res."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-32215-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-32215-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-32215-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T23:05:46Z","timestamp":1774307146000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-32215-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,9]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["32215"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-32215-3","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,9]]},"assertion":[{"value":"29 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Studies involving human participants were reviewed and approved by the Medical Ethics Committee of Hangzhou First People\u2019s Hospital (Batch number ZN-2024353-01). All research was performed under relevant guidelines and regulations. Additionally, the data used in this study were obtained from previous clinical diagnoses and treatments, and do not involve medical records and specimens that patients have previously explicitly refused to use. This study will not have any adverse effects on the rights (including the right to privacy) and health of the subjects, and does not involve commercial interests. So, the need to obtain informed consent was waived by the Hangzhou First People\u2019s Hospital Ethics Committee. For details, see the attachment.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}],"article-number":"9600"}}