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The aim of the present study was to investigate the role of virtual reality technology in decreasing psychological distress and increasing pregnancy rates in women diagnosed with infertility undergoing intrauterine insemination (IUI). This randomised controlled trial study was conducted at Kosar University Hospital in Urmia, Iran, in 2024, involving 114 women diagnosed with infertility. Participants were randomly allocated to either the intervention group (n\u2009=\u200957), which viewed a selected video with 360-degree virtual reality glasses for 20 min before and 10 min during the IUI procedure, or the control group (n\u2009=\u200957), which received standard care. Psychological outcomes were assessed using the Hospital Anxiety and Depression Scale (HADS) and the Pennsylvania State Worry Questionnaire (PSWQ). The clinical pregnancy rates, a secondary outcome, was evaluated 14 days post-IUI using a Beta hCG test. Results indicated that the intervention group exhibited significantly lower median scores (interquartile range) for worry, anxiety, and depression compared to the control group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Furthermore, the odds of a positive pregnancy test were 2.76 times higher in the intervention group (95% CI,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). These findings suggest that virtual reality technology is an effective intervention for reducing psychological distress and improving pregnancy outcomes in women undergoing IUI.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Trial Registration<\/jats:italic>\n                    : The study was registered in the Iranian Registry of Clinical Trials (IRCT Id:\n                    <jats:bold>IRCT20231013059702N2<\/jats:bold>\n                    Registration date:\u00a0\n                    <jats:bold>2024-02-11<\/jats:bold>\n                    ).\n                  <\/jats:p>","DOI":"10.1038\/s41598-025-32620-8","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T11:22:55Z","timestamp":1770290575000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The use of virtual reality technology among women undergoing intrauterine insemination: a randomized controlled study"],"prefix":"10.1038","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0476-5752","authenticated-orcid":false,"given":"Ghazaleh","family":"Gholami","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1634-7685","authenticated-orcid":false,"given":"Tahereh Behroozi","family":"lak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7122-8035","authenticated-orcid":false,"given":"Roghieh","family":"Bayrami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4756-2137","authenticated-orcid":false,"given":"Maryam","family":"Mesgarzadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,5]]},"reference":[{"key":"32620_CR1","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1080\/13691058.2017.1359672","volume":"20","author":"MA Daibes","year":"2018","unstructured":"Daibes, M. 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