{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:08:05Z","timestamp":1772136485311,"version":"3.50.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":32,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R44CA257303"],"award-info":[{"award-number":["R44CA257303"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["NSF CAREER 2339554"],"award-info":[{"award-number":["NSF CAREER 2339554"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Intracervical injections directly deliver therapies into the cervix. We previously explored ethyl cellulose (EC)-ethanol intracervical injections as a treatment for cervical dysplasia in low- and middle-income countries. Here we: (1) compared swine and human cervices to assess swine as a model for intracervical injections, and (2) evaluated two speculum-compatible injectors: a custom single needle injector and an extender injector, assembled from off-the-shelf components, to determine what parameters produced optimal distribution. Mechanical properties of swine and human cervices were compared. Swine cervices were injected with EC-ethanol iohexol using both injectors. Distribution and leakage volumes in tissue were visualized with microCT and quantified with 3D Slicer. Mechanical testing showed swine and human cervical tissue yielded comparable storage and loss moduli (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&gt;\u20090.05). Ex vivo studies showed injections\u2009\u2265\u200910\u00a0mm deep and &lt;\u20092 mL significantly reduced backflow and crack formation for both injectors. Additionally, the extender injector produced significantly less crack formation than the single needle injector. These findings indicate swine cervices are a clinically relevant model for intracervical injection studies. The extender device when inserted\u2009\u2265\u200910\u00a0mm and delivering\u2009&lt;\u20092 mL of EC-ethanol achieved the most consistent results across intracervical delivery protocols.\n                  <\/jats:p>","DOI":"10.1038\/s41598-025-32627-1","type":"journal-article","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T08:32:59Z","timestamp":1766219579000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Optimization of injections with speculum-compatible devices to deliver ethyl cellulose-ethanol into the cervix to treat cervical dysplasia"],"prefix":"10.1038","volume":"16","author":[{"given":"Taya","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ven\u00e9","family":"Richardson-Powell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gatha","family":"Adhikari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Crouch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nimmi","family":"Ramanujam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenna L.","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,20]]},"reference":[{"key":"32627_CR1","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1097\/LGT.0000000000000292","volume":"21","author":"M Kiviharju","year":"2017","unstructured":"Kiviharju, M. et al. Pain sensation during colposcopy and cervical Biopsy, with or without local anesthesia: A randomized trial. J. Low Genit. Tract. Dis. 21, 102 (2017).","journal-title":"J. Low Genit. Tract. Dis."},{"key":"32627_CR2","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1097\/AOG.0000000000002790","volume":"132","author":"SK Mody","year":"2018","unstructured":"Mody, S. K., Farala, J. P., Jimenez, B., Nishikawa, M. & Ngo, L. L. Paracervical block for intrauterine device placement among nulliparous women: A randomized controlled trial. Obstet. Gynecol. 132, 575\u2013582 (2018).","journal-title":"Obstet. 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