{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T19:37:48Z","timestamp":1782848268744,"version":"3.54.5"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":35,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16H06277"],"award-info":[{"award-number":["16H06277"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22H04923"],"award-info":[{"award-number":["22H04923"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Japanese Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"crossref","award":["17015018"],"award-info":[{"award-number":["17015018"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001700","name":"Japanese Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"crossref","award":["221S0001"],"award-info":[{"award-number":["221S0001"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-32665-9","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T11:04:08Z","timestamp":1765969448000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["ME-BYO index as a formative construct for healthy ageing: a cross-sectional PLS-SEM analysis"],"prefix":"10.1038","volume":"16","author":[{"given":"Sho","family":"Nakamura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaname","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Choy-Lye","family":"Chei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaisy Xinhong","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai Xuan","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ung-il","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroto","family":"Narimatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"32665_CR1","unstructured":"World Health Organization. Decade of Healthy Ageing: Baseline Report (World Health Organization, 2020)."},{"key":"32665_CR2","unstructured":"World Health Organization. World Report on Ageing and Health: Summary. Contract No.: WHO\/FWC\/ALC\/15.01 (World Health Organization, 2015)."},{"key":"32665_CR3","doi-asserted-by":"publisher","first-page":"1142281","DOI":"10.3389\/fpubh.2023.1142281","volume":"11","author":"S Nakamura","year":"2023","unstructured":"Nakamura, S. et al. The ME-BYO index: A development and validation project of a novel comprehensive health index. Front. Public Health. 11, 1142281 (2023).","journal-title":"Front. Public. Health"},{"key":"32665_CR4","doi-asserted-by":"publisher","first-page":"e79109","DOI":"10.2196\/79109","volume":"27","author":"CL Chei","year":"2025","unstructured":"Chei, C. L., Nakamura, S., Watanabe, K. & Narimatsu, H. User engagement, demographics, and health status of the my ME-BYO record, A personal health management mobile app: retrospective study. J. Med. Internet Res. 27, e79109 (2025).","journal-title":"J. Med. Internet Res."},{"key":"32665_CR5","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1186\/s13104-022-06101-4","volume":"15","author":"Y Saito","year":"2022","unstructured":"Saito, Y. et al. Checking the validity and reliability of the Japanese version of the Mini-Cog using a smartphone application. BMC Res. Notes. 15, 222 (2022).","journal-title":"BMC Res. Notes"},{"key":"32665_CR6","doi-asserted-by":"publisher","first-page":"904924","DOI":"10.3389\/fspor.2022.904924","volume":"4","author":"Y Saito","year":"2022","unstructured":"Saito, Y. et al. Evaluation of the validity and reliability of the 10-meter walk test using a smartphone application among Japanese older adults. Front. Sports Act. Living. 4, 904924 (2022).","journal-title":"Front. Sports Act. Living"},{"key":"32665_CR7","doi-asserted-by":"publisher","first-page":"660","DOI":"10.2188\/jea.JE20200147","volume":"31","author":"K Takeuchi","year":"2021","unstructured":"Takeuchi, K. et al. Study profile of the Japan multi-institutional collaborative cohort (J-MICC) study. J. Epidemiol. 31, 660\u2013668 (2021).","journal-title":"J. Epidemiol."},{"key":"32665_CR8","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s00776-011-0193-5","volume":"17","author":"A Seichi","year":"2012","unstructured":"Seichi, A. et al. Development of a screening tool for risk of locomotive syndrome in the elderly: the 25-question geriatric locomotive function scale. J. Orthop. Sci. 17, 163\u2013172 (2012).","journal-title":"J. Orthop. Sci."},{"issue":"Suppl 1","key":"32665_CR9","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1002\/mpr.310","volume":"19","author":"RC Kessler","year":"2010","unstructured":"Kessler, R. C. et al. Screening for serious mental illness in the general population with the K6 screening scale: results from the WHO world mental health (WMH) survey initiative. Int. J. Methods Psychiatr Res. 19 (Suppl 1), 4\u201322 (2010).","journal-title":"Int. J. Methods Psychiatr Res."},{"key":"32665_CR10","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1002\/mpr.257","volume":"17","author":"TA Furukawa","year":"2008","unstructured":"Furukawa, T. A. et al. The performance of the Japanese version of the K6 and K10 in the world mental health survey Japan. Int. J. Methods Psychiatr Res. 17, 152\u2013158 (2008).","journal-title":"Int. J. Methods Psychiatr Res."},{"key":"32665_CR11","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1016\/j.jval.2016.03.1834","volume":"19","author":"T Shiroiwa","year":"2016","unstructured":"Shiroiwa, T. et al. Comparison of value set based on DCE and\/or TTO data: scoring for EQ-5D-5L health States in Japan. Value Health. 19, 648\u2013654 (2016).","journal-title":"Value Health"},{"key":"32665_CR12","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1007\/s11136-020-02688-y","volume":"30","author":"YS Feng","year":"2021","unstructured":"Feng, Y. S., Kohlmann, T., Janssen, M. F. & Buchholz, I. Psychometric properties of the EQ-5D-5L: a systematic review of the literature. Qual. Life Res. 30, 647\u2013673 (2021).","journal-title":"Qual. Life Res."},{"key":"32665_CR13","first-page":"40","volume":"5","author":"S Tokudome","year":"2004","unstructured":"Tokudome, S. et al. Development of a data-based short food frequency questionnaire for assessing nutrient intake by middle-aged Japanese. Asian Pac. J. Cancer Prev. 5, 40\u201343 (2004).","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"32665_CR14","doi-asserted-by":"publisher","first-page":"100","DOI":"10.2188\/jea.17.100","volume":"17","author":"N Imaeda","year":"2007","unstructured":"Imaeda, N. et al. Reproducibility of a short food frequency questionnaire for Japanese general population. J. Epidemiol. 17, 100\u2013107 (2007).","journal-title":"J. Epidemiol."},{"key":"32665_CR15","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.alcohol.2020.09.002","volume":"89","author":"I Shimoshikiryo","year":"2020","unstructured":"Shimoshikiryo, I. et al. Association between alcohol intake pattern and metabolic syndrome components and simulated change by alcohol intake reduction: a cross-sectional study from the Japan Multi-Institutional collaborative cohort study. Alcohol 89, 129\u2013138 (2020).","journal-title":"Alcohol"},{"key":"32665_CR16","doi-asserted-by":"publisher","first-page":"101169","DOI":"10.1016\/j.pmedr.2020.101169","volume":"20","author":"H Kikuchi","year":"2020","unstructured":"Kikuchi, H. et al. Intensity-specific validity and reliability of the Japan public health Center-based prospective study-physical activity questionnaire. Prev. Med. Rep. 20, 101169 (2020).","journal-title":"Prev. Med. Rep."},{"key":"32665_CR17","unstructured":"R Core Team. R: A Language and Environment for Statistical Computing (R Foundation for Statistical Computing, 2023)."},{"key":"32665_CR18","unstructured":"Hair, J. F., Sarstedt, M., Ringle, C. M. & Gudergan, S. Advanced Issues in Partial Least Squares Structural Equation Modeling (Sage, 2023)."},{"key":"32665_CR19","doi-asserted-by":"crossref","unstructured":"Hair, J. F., Hult, G. T. M., Ringle, C. M. & Sarstedt, M. A Primer on Partial Least Squares Structural Equation Modeling (PLS-SEM), 3 edn (Sage, 2022).","DOI":"10.1007\/978-3-030-80519-7"},{"key":"32665_CR20","first-page":"1","volume":"15","author":"K Tokunaga","year":"1991","unstructured":"Tokunaga, K. et al. Ideal body weight estimated from the body mass index with the lowest morbidity. Int. J. Obes. 15, 1\u20135 (1991).","journal-title":"Int. J. Obes."},{"key":"32665_CR21","doi-asserted-by":"publisher","first-page":"2322","DOI":"10.1108\/EJM-02-2019-0189","volume":"53","author":"G Shmueli","year":"2019","unstructured":"Shmueli, G. et al. Predictive model assessment in PLS-SEM: guidelines for using PLSpredict. Eur. J. Mark. 53, 2322\u20132347 (2019).","journal-title":"Eur. J. Mark."},{"key":"32665_CR22","unstructured":"Chua, Y. P. A step-by-step guide to SMARTPLS. In CB-SEM, Process and Regression. Kuala Lumpur: Researchtree Independently Published 4:  Data Analysis Using PLS-SEM (2024)."},{"key":"32665_CR23","doi-asserted-by":"crossref","unstructured":"Hair, J. F. et al. Partial Least Squares Structural Equation Modeling (PLS-SEM) Using R. Classroom Companion: A Workbook (Springer, 2021).","DOI":"10.1007\/978-3-030-80519-7"},{"key":"32665_CR24","unstructured":"Ray, S., Danks, N. & Calero, V. A. seminr. Building and Estimating Structural Equation Models. R Package Version 2.3.4 ed2024."},{"key":"32665_CR25","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1093\/tbm\/ibz198","volume":"10","author":"DX Marquez","year":"2020","unstructured":"Marquez, D. X. et al. A systematic review of physical activity and quality of life and well-being. Transl Behav. Med. 10, 1098\u20131109 (2020).","journal-title":"Transl Behav. Med."},{"issue":"Suppl 2","key":"32665_CR26","doi-asserted-by":"publisher","first-page":"S231","DOI":"10.4103\/indianjpsychiatry.indianjpsychiatry_707_23","volume":"66","author":"S Gautam","year":"2024","unstructured":"Gautam, S. et al. Concept of mental health and mental well-being, it\u2019s determinants and coping strategies. Indian J. Psychiatry. 66 (Suppl 2), S231\u2013S244 (2024).","journal-title":"Indian J. Psychiatry"},{"key":"32665_CR27","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1007\/s11482-019-09776-3","volume":"16","author":"K Zawisza","year":"2021","unstructured":"Zawisza, K., Tobiasz-Adamczyk, B., Galas, A., Jab\u0142o\u0144ska, K. & Grodzicki, T. Changes in body mass index and quality of life\u2014population-based follow-up study COURAGE and COURAGE-POLFUS, Poland. Appl. Res. Qual. Life. 16, 501\u2013526 (2021).","journal-title":"Appl. Res. Qual. Life"},{"issue":"Suppl 1","key":"32665_CR28","doi-asserted-by":"publisher","first-page":"e227","DOI":"10.1097\/01.hjh.0001021788.95421.3f","volume":"42","author":"A Inamdar","year":"2024","unstructured":"Inamdar, A. Correlation of body mass index (BMI) with systolic and diastolic blood pressure in rural Indian patients. J. Hypertens. 42 (Suppl 1), e227\u2013e228 (2024).","journal-title":"J. Hypertens."},{"key":"32665_CR29","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1093\/geront\/gnt073","volume":"54","author":"DJ Martin","year":"2014","unstructured":"Martin, D. J. & Gillen, L. L. Revisiting gerontology\u2019s scrapbook: from Metchnikoff to the spectrum model of aging. Gerontologist 54, 51\u201358 (2014).","journal-title":"Gerontologist"},{"key":"32665_CR30","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1093\/gerona\/gly011","volume":"73","author":"M Cesari","year":"2018","unstructured":"Cesari, M. et al. Evidence for the domains supporting the construct of intrinsic capacity. J. Gerontol. Biol. Sci. Med. Sci. 73, 1653\u20131660 (2018).","journal-title":"J. Gerontol. Biol. Sci. Med. Sci."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-32665-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-32665-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-32665-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T00:11:08Z","timestamp":1769213468000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-32665-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,17]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["32665"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-32665-9","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,17]]},"assertion":[{"value":"30 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The ME-BYO cohort and analyses performed in this study were approved by the Ethics Committee of Kanagawa Cancer Center (Yokohama, Japan; approval no. 28KEN-36), and written informed consent was obtained from all participants.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}}],"article-number":"2766"}}