{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:26:39Z","timestamp":1791822399372,"version":"4.3.4"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100017634","name":"Henan University of Chinese Medicine","doi-asserted-by":"publisher","award":["HSRP-DFCTCM-2023-1-09"],"award-info":[{"award-number":["HSRP-DFCTCM-2023-1-09"]}],"id":[{"id":"10.13039\/100017634","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-32707-2","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T19:23:36Z","timestamp":1766431416000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Peptidomics analysis of serum in patients suffered from generalized anxiety disorder"],"prefix":"10.1038","volume":"15","author":[{"given":"Jing","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weibiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuexia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangrong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianhui","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,22]]},"reference":[{"issue":"9553","key":"32707_CR1","doi-asserted-by":"publisher","first-page":"2156","DOI":"10.1016\/S0140-6736(06)69865-6","volume":"368","author":"P Tyrer","year":"2006","unstructured":"Tyrer, P. & Baldwin, D. Generalised anxiety disorder. Lancet 368(9553), 2156\u201366 (2006).","journal-title":"Lancet"},{"issue":"5","key":"32707_CR2","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1001\/jamapediatrics.2022.0052","volume":"176","author":"MM Gleason","year":"2022","unstructured":"Gleason, M. M. & Thompson, L. A. Depression and anxiety disorder in children and adolescents. JAMA Pediatr. 176(5), 532 (2022).","journal-title":"JAMA Pediatr."},{"issue":"3","key":"32707_CR3","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.chc.2023.02.001","volume":"32","author":"EN Warner","year":"2023","unstructured":"Warner, E. N. et al. Developmental epidemiology of pediatric anxiety disorders. Child Adolesc. Psychiatr. Clin. N. Am. 32(3), 511\u2013530 (2023).","journal-title":"Child Adolesc. Psychiatr. Clin. N. Am."},{"issue":"10258","key":"32707_CR4","first-page":"1204","volume":"396","author":"GBD 2019 Diseases and Injuries Collaborators","year":"2019","unstructured":"GBD 2019 Diseases and Injuries Collaborators. Global burden of 369 diseases and injuries in 204 countries and territories, 1990\u20132019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet 396(10258), 1204\u20131222 (2019).","journal-title":"Lancet"},{"issue":"10","key":"32707_CR5","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1097\/NMD.0000000000001534","volume":"210","author":"ME Demirkol","year":"2022","unstructured":"Demirkol, M. E., Tamam, L., Namli, Z., Karaytu\u011f, M. O. & Ye\u015filo\u011flu, C. The relationship among anxiety sensitivity, psychache, and suicidality in patients with generalized anxiety disorder. J. Nerv. Ment. Dis. 210(10), 760\u2013766 (2022).","journal-title":"J. Nerv. Ment. Dis."},{"issue":"37","key":"32707_CR6","first-page":"611","volume":"155","author":"A Str\u00f6hle","year":"2018","unstructured":"Str\u00f6hle, A., Gensichen, J. & Domschke, K. The diagnosis and treatment of anxiety disorders. Dtsch. Arztebl. Int. 155(37), 611\u2013620 (2018).","journal-title":"Dtsch. Arztebl. Int."},{"issue":"5","key":"32707_CR7","doi-asserted-by":"publisher","first-page":"574","DOI":"10.2174\/1570159X15666170913110426","volume":"16","author":"YK Kim","year":"2018","unstructured":"Kim, Y. K. & Jeon, S. W. Neuroinflammation and the immune-kynurenine pathway in anxiety disorders. Curr. Neuropharmacol. 16(5), 574\u2013582 (2018).","journal-title":"Curr. Neuropharmacol."},{"issue":"4","key":"32707_CR8","doi-asserted-by":"publisher","first-page":"355","DOI":"10.17219\/acem\/147441","volume":"31","author":"C Chen","year":"2022","unstructured":"Chen, C. Recent advances in the study of the comorbidity of depressive and anxiety disorders. Adv. Clin. Exp. Med. 31(4), 355\u2013358 (2022).","journal-title":"Adv. Clin. Exp. Med."},{"issue":"12","key":"32707_CR9","doi-asserted-by":"publisher","first-page":"2381","DOI":"10.1002\/jclp.23360","volume":"78","author":"V Trenoska Basile","year":"2022","unstructured":"Trenoska Basile, V., Newton-John, T. & Wootton, B. M. Remote cognitive-behavioral therapy for generalized anxiety disorder: A preliminary meta-analysis. J. Clin. Psychol. 78(12), 2381\u20132395 (2022).","journal-title":"J. Clin. Psychol."},{"key":"32707_CR10","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/978-981-32-9705-0_20","volume":"1191","author":"R Balon","year":"2020","unstructured":"Balon, R. & Starcevic, V. Role of benzodiazepines in anxiety disorders. Adv. Exp. Med. Biol. 1191, 367\u2013388 (2020).","journal-title":"Adv. Exp. Med. Biol."},{"issue":"7","key":"32707_CR11","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1016\/j.jpsychires.2010.12.010","volume":"45","author":"P Gormanns","year":"2011","unstructured":"Gormanns, P. et al. Phenome-transcriptome correlation unravels anxiety and depression related pathways. J. Psychiatr. Res. 45(7), 973\u20139 (2011).","journal-title":"J. Psychiatr. Res."},{"issue":"2","key":"32707_CR12","doi-asserted-by":"publisher","first-page":"166.e1","DOI":"10.1016\/j.ajog.2023.01.012","volume":"229","author":"E Accortt","year":"2023","unstructured":"Accortt, E. et al. Perinatal mood and anxiety disorders: biomarker discovery using plasma proteomics. Am. J. Obstet. Gynecol. 229(2), 166.e1-166.e16 (2023).","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"533","key":"32707_CR13","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.cca.2022.06.022","volume":"1","author":"H Kui","year":"2022","unstructured":"Kui, H. et al. Serum metabolomics study of anxiety disorder patients based on LC\u2013MS. Clin. Chim. Acta. 1(533), 131\u2013143 (2022).","journal-title":"Clin. Chim. Acta."},{"issue":"13","key":"32707_CR14","doi-asserted-by":"publisher","first-page":"3414","DOI":"10.1002\/pmic.200401219","volume":"5","author":"H Tammen","year":"2005","unstructured":"Tammen, H. et al. Peptidomic analysis of human blood specimens: comparison between plasma specimens and serum by differential peptide display. Proteomics 5(13), 3414\u201322 (2005).","journal-title":"Proteomics"},{"issue":"5\u20136","key":"32707_CR15","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1002\/pmic.201400310","volume":"15","author":"DC Dallas","year":"2015","unstructured":"Dallas, D. C. et al. Current peptidomics: applications, purification, identification, quantification, and functional analysis. Proteomics 15(5\u20136), 1026\u201338 (2015).","journal-title":"Proteomics"},{"issue":"8","key":"32707_CR16","doi-asserted-by":"publisher","first-page":"3782","DOI":"10.1021\/acs.jproteome.1c00295","volume":"20","author":"RE Foreman","year":"2021","unstructured":"Foreman, R. E., George, A. L., Reimann, F., Gribble, F. M. & Kay, R. G. Peptidomics: A review of clinical applications and methodologies. J. Proteome Res. 20(8), 3782\u20133797 (2021).","journal-title":"J. Proteome Res."},{"issue":"3","key":"32707_CR17","doi-asserted-by":"publisher","first-page":"327","DOI":"10.31887\/DCNS.2015.17.3\/bbandelow","volume":"17","author":"B Bandelow","year":"2015","unstructured":"Bandelow, B. & Michaelis, S. Epidemiology of anxiety disorders in the 21st century. Dialogues Clin Neurosci. 17(3), 327\u201335 (2015).","journal-title":"Dialogues Clin Neurosci."},{"key":"32707_CR18","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/978-3-031-50624-6_6","volume":"1443","author":"L Rodrigues-Ribeiro","year":"2024","unstructured":"Rodrigues-Ribeiro, L. et al. Neuroproteomics: Unveiling the molecular insights of psychiatric disorders with a focus on anxiety disorder and depression. Adv. Exp. Med. Biol. 1443, 103\u2013128 (2024).","journal-title":"Adv. Exp. Med. Biol."},{"issue":"3 Suppl 2","key":"32707_CR19","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1053\/srao.2002.34863","volume":"12","author":"SP Ethier","year":"2002","unstructured":"Ethier, S. P. Signal transduction pathways: the molecular basis for targeted therapies. Semin. Radiat Oncol. 12(3 Suppl 2), 3\u201310 (2002).","journal-title":"Semin. Radiat Oncol."},{"issue":"7","key":"32707_CR20","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202103052","volume":"220","author":"TC S\u00fcdhof","year":"2021","unstructured":"S\u00fcdhof, T. C. The cell biology of synapse formation. J. Cell Biol. 220(7), e202103052 (2021).","journal-title":"J. Cell Biol."},{"issue":"3 Suppl","key":"32707_CR21","doi-asserted-by":"publisher","first-page":"101","DOI":"10.3233\/JAD-2006-9S312","volume":"9","author":"SW Scheff","year":"2006","unstructured":"Scheff, S. W. & Price, D. A. Alzheimer\u2019s disease-related alterations in synaptic density: neocortex and hippocampus. J. Alzheimers Dis. 9(3 Suppl), 101\u201315 (2006).","journal-title":"J. Alzheimers Dis."},{"key":"32707_CR22","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/S0074-7696(08)60527-6","volume":"192","author":"K Luby-Phelps","year":"2000","unstructured":"Luby-Phelps, K. Cytoarchitecture and physical properties of cytoplasm: volume, viscosity, diffusion, intracellular surface area. Int. Rev. Cytol. 192, 189\u2013221 (2000).","journal-title":"Int. Rev. Cytol."},{"issue":"6627","key":"32707_CR23","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1038\/386779a0","volume":"386","author":"EA Nigg","year":"1997","unstructured":"Nigg, E. A. Nucleocytoplasmic transport: signals, mechanisms and regulation. Nature 386(6627), 779\u201387 (1997).","journal-title":"Nature"},{"issue":"17","key":"32707_CR24","doi-asserted-by":"publisher","first-page":"2593","DOI":"10.1091\/mbc.e12-08-0617","volume":"24","author":"K Luby-Phelps","year":"2013","unstructured":"Luby-Phelps, K. The physical chemistry of cytoplasm and its influence on cell function: an update. Mol. Biol. Cell. 24(17), 2593\u20136 (2013).","journal-title":"Mol. Biol. Cell."},{"issue":"4","key":"32707_CR25","doi-asserted-by":"publisher","first-page":"152","DOI":"10.7150\/ijbs.1.152","volume":"1","author":"S Li","year":"2005","unstructured":"Li, S. Mechanisms of cellular signal transduction. Int. J. Biol. Sci. 1(4), 152 (2005).","journal-title":"Int. J. Biol. Sci."},{"issue":"6","key":"32707_CR26","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1007\/s11920-000-0006-6","volume":"2","author":"HK Manji","year":"2000","unstructured":"Manji, H. K. & Chen, G. Post-receptor signaling pathways in the pathophysiology and treatment of mood disorders. Curr. Psychiatry Rep. 2(6), 479\u201389 (2000).","journal-title":"Curr. Psychiatry Rep."},{"issue":"5","key":"32707_CR27","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1002\/jnr.23960","volume":"95","author":"LP Shapiro","year":"2017","unstructured":"Shapiro, L. P., Parsons, R. G., Koleske, A. J. & Gourley, S. L. Differential expression of cytoskeletal regulatory factors in the adolescent prefrontal cortex: Implications for cortical development. J. Neurosci. Res. 95(5), 1123\u20131143 (2017).","journal-title":"J. Neurosci. Res."},{"issue":"19","key":"32707_CR28","doi-asserted-by":"publisher","first-page":"4808","DOI":"10.3390\/cancers15194808","volume":"15","author":"A Tojjari","year":"2023","unstructured":"Tojjari, A., Giles, F. J., Vilbert, M., Saeed, A. & Cavalcante, L. SLAM modification as an immune-modulatory therapeutic approach in cancer. Cancers (Basel) 15(19), 4808 (2023).","journal-title":"Cancers (Basel)"},{"issue":"14","key":"32707_CR29","doi-asserted-by":"publisher","first-page":"1174138","DOI":"10.3389\/fimmu.2023.1174138","volume":"11","author":"P Farhangnia","year":"2023","unstructured":"Farhangnia, P. et al. SLAM-family receptors come of age as a potential molecular target in cancer immunotherapy. Front. Immunol. 11(14), 1174138 (2023).","journal-title":"Front. Immunol."},{"issue":"12","key":"32707_CR30","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.654839","volume":"16","author":"Y Gartshteyn","year":"2021","unstructured":"Gartshteyn, Y., Askanase, A. D. & Mor, A. SLAM associated protein signaling in T cells: Tilting the balance toward autoimmunity. Front. Immunol. 16(12), 654839 (2021).","journal-title":"Front. Immunol."},{"key":"32707_CR31","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.777390","volume":"9","author":"K Atitey","year":"2022","unstructured":"Atitey, K. & Anchang, B. Mathematical modeling of proliferative immune response initiated by interactions between classical antigen-presenting cells under joint antagonistic IL-2 and IL-4 signaling. Front. Mol. Biosci. 9, 777390 (2022).","journal-title":"Front. Mol. Biosci."},{"key":"32707_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2023.106893","volume":"195","author":"X Gao","year":"2023","unstructured":"Gao, X. et al. Treg cell: Critical role of regulatory T-cells in depression. Pharmacol. Res. 195, 106893 (2023).","journal-title":"Pharmacol. Res."},{"key":"32707_CR33","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.clim.2018.10.011","volume":"204","author":"M Claus","year":"2019","unstructured":"Claus, M., Urlaub, D., Fasbender, F. & Watzl, C. SLAM family receptors in natural killer cells: Mediators of adhesion, activation and inhibition via cis and trans interactions. Clin. Immunol. 204, 37\u201342 (2019).","journal-title":"Clin. Immunol."},{"issue":"8","key":"32707_CR34","doi-asserted-by":"publisher","first-page":"2137","DOI":"10.4049\/jimmunol.1901483","volume":"205","author":"M Zhang","year":"2020","unstructured":"Zhang, M. et al. Revisiting the pig IGHC gene locus in different breeds uncovers nine distinct IGHG genes. J. Immunol. 205(8), 2137\u20132145 (2020).","journal-title":"J. Immunol."},{"issue":"1","key":"32707_CR35","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1007\/s12672-024-01593-x","volume":"15","author":"S Li","year":"2024","unstructured":"Li, S. et al. TLN1: an oncogene associated with tumorigenesis and progression. Discov. Oncol. 15(1), 716 (2024).","journal-title":"Discov. Oncol."},{"issue":"5","key":"32707_CR36","doi-asserted-by":"publisher","first-page":"60","DOI":"10.3892\/ijmm.2022.5116","volume":"49","author":"Y Zhao","year":"2022","unstructured":"Zhao, Y., Lykov, N. & Tzeng, C. Talin 1 interaction network in cellular mechanotransduction (Review). Int. J. Mol. Med. 49(5), 60 (2022).","journal-title":"Int. J. Mol. Med."},{"key":"32707_CR37","doi-asserted-by":"publisher","first-page":"4696","DOI":"10.1021\/acs.biochem.9b00453","volume":"58","author":"Y Wang","year":"2019","unstructured":"Wang, Y., Yan, J. & Goult, B. T. Force-dependent binding constants. Biochemistry 58, 4696\u20134709 (2019).","journal-title":"Biochemistry"},{"issue":"1","key":"32707_CR38","doi-asserted-by":"publisher","first-page":"209","DOI":"10.4103\/1673-5374.391301","volume":"20","author":"SY Sun","year":"2025","unstructured":"Sun, S. Y. et al. The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons. Neural Regen. Res. 20(1), 209\u2013223 (2025).","journal-title":"Neural Regen. Res."},{"key":"32707_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2023.106490","volume":"166","author":"Y Wang","year":"2024","unstructured":"Wang, Y. et al. Talin mechanotransduction in disease. Int. J. Biochem. Cell Biol. 166, 106490 (2024).","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"32707_CR40","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.bbi.2019.11.015","volume":"84","author":"A Eguchi","year":"2020","unstructured":"Eguchi, A. et al. Identification of actin network proteins, talin-1 and filamin-A, in circulating extracellular vesicles as blood biomarkers for human myalgic encephalomyelitis\/chronic fatigue syndrome. Brain Behav. Immun. 84, 106\u2013114 (2020).","journal-title":"Brain Behav. Immun."},{"issue":"1","key":"32707_CR41","doi-asserted-by":"publisher","first-page":"6086","DOI":"10.1038\/s41467-021-26366-w","volume":"12","author":"A Menny","year":"2021","unstructured":"Menny, A. et al. Structural basis of soluble membrane attack complex packaging for clearance. Nat. Commun. 12(1), 6086 (2021).","journal-title":"Nat. Commun."},{"key":"32707_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2021.101032","volume":"89","author":"MR Wilson","year":"2022","unstructured":"Wilson, M. R. et al. Clusterin, other extracellular chaperones, and eye disease. Prog. Retin Eye Res. 89, 101032 (2022).","journal-title":"Prog. Retin Eye Res."},{"issue":"4","key":"32707_CR43","doi-asserted-by":"publisher","first-page":"887","DOI":"10.7150\/ijms.107159","volume":"22","author":"X Du","year":"2025","unstructured":"Du, X., Chen, Z. & Shui, W. Clusterin: structure, function and roles in disease. Int. J. Med. Sci. 22(4), 887\u2013896 (2025).","journal-title":"Int. J. Med. Sci."},{"issue":"2","key":"32707_CR44","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1001\/jamaneurol.2013.4560","volume":"71","author":"RS Desikan","year":"2014","unstructured":"Desikan, R. S. et al. The role of clusterin in amyloid-$$\\beta$$-associated neurodegeneration. JAMA Neurol. 71(2), 180\u20137 (2014).","journal-title":"JAMA Neurol."},{"issue":"13","key":"32707_CR45","doi-asserted-by":"publisher","first-page":"164","DOI":"10.3389\/fnins.2019.00164","volume":"28","author":"EM Foster","year":"2019","unstructured":"Foster, E. M., Dangla-Valls, A., Lovestone, S., Ribe, E. M. & Buckley, N. J. Clusterin in Alzheimer\u2019s disease: Mechanisms, genetics, and lessons from other pathologies. Front. Neurosci. 28(13), 164 (2019).","journal-title":"Front. Neurosci."},{"issue":"23","key":"32707_CR46","first-page":"912","volume":"9","author":"P Sultana","year":"2024","unstructured":"Sultana, P. & Novotny, J. Clusterin: a double-edged sword in cancer and neurological disorders. EXCLI J. 9(23), 912\u2013936 (2024).","journal-title":"EXCLI J."},{"issue":"13","key":"32707_CR47","doi-asserted-by":"publisher","first-page":"164","DOI":"10.3389\/fnins.2019.00164","volume":"28","author":"EM Foster","year":"2019","unstructured":"Foster, E. M., Dangla-Valls, A., Lovestone, S., Ribe, E. M. & Buckley, N. J. Clusterin in Alzheimer\u2019s disease: Mechanisms, genetics, and lessons from other pathologies. Front. Neurosci. 28(13), 164 (2019).","journal-title":"Front. Neurosci."},{"issue":"1","key":"32707_CR48","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s13024-025-00840-1","volume":"20","author":"X Zhao","year":"2025","unstructured":"Zhao, X. et al. Alzheimer\u2019s disease protective allele of Clusterin modulates neuronal excitability through lipid-droplet-mediated neuron-glia communication. Mol. Neurodegener. 20(1), 51 (2025).","journal-title":"Mol. Neurodegener."},{"issue":"8","key":"32707_CR49","doi-asserted-by":"publisher","first-page":"2137","DOI":"10.4049\/jimmunol.1901483","volume":"205","author":"M Zhang","year":"2020","unstructured":"Zhang, M. et al. Revisiting the pig IGHC gene locus in different breeds uncovers nine distinct IGHG genes. J. Immunol. 205(8), 2137\u20132145 (2020).","journal-title":"J. Immunol."},{"issue":"5","key":"32707_CR50","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1111\/jdi.14144","volume":"15","author":"Q Hu","year":"2024","unstructured":"Hu, Q., Yang, Q., Gao, H., Tian, J. & Che, G. Immunoglobulin heavy constant gamma 1 silencing decreases tonicity-responsive enhancer-binding protein expression to alleviate diabetic nephropathy. J. Diabetes Investig. 15(5), 572\u2013583 (2024).","journal-title":"J. Diabetes Investig."},{"issue":"5","key":"32707_CR51","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1097\/MPA.0b013e318213d51b","volume":"40","author":"X Li","year":"2011","unstructured":"Li, X. et al. The presence of IGHG1 in human pancreatic carcinomas is associated with immune evasion mechanisms. Pancreas 40(5), 753\u201361 (2011).","journal-title":"Pancreas"},{"issue":"5","key":"32707_CR52","doi-asserted-by":"publisher","first-page":"779","DOI":"10.2174\/1570159X01666160930121647","volume":"15","author":"K Manoutcharian","year":"2017","unstructured":"Manoutcharian, K., Perez-Garmendia, R. & Gevorkian, G. Recombinant antibody fragments for neurodegenerative diseases. Curr. Neuropharmacol. 15(5), 779\u2013788 (2017).","journal-title":"Curr. Neuropharmacol."},{"key":"32707_CR53","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2020.104235","volume":"358","author":"J Odales","year":"2020","unstructured":"Odales, J., Guzman Valle, J., Mart\u00ednez-Cort\u00e9s, F. & Manoutcharian, K. Immunogenic properties of immunoglobulin superfamily members within complex biological networks. Cell Immunol. 358, 104235 (2020).","journal-title":"Cell Immunol."},{"issue":"5","key":"32707_CR54","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1111\/jdi.14144","volume":"15","author":"Q Hu","year":"2024","unstructured":"Hu, Q., Yang, Q., Gao, H., Tian, J. & Che, G. Immunoglobulin heavy constant gamma 1 silencing decreases tonicity-responsive enhancer-binding protein expression to alleviate diabetic nephropathy. J. Diabetes Investig. 15(5), 572\u2013583 (2024).","journal-title":"J. Diabetes Investig."},{"issue":"21","key":"32707_CR55","doi-asserted-by":"publisher","first-page":"4258","DOI":"10.1128\/MCB.05547-11","volume":"31","author":"Y Zheng","year":"2011","unstructured":"Zheng, Y. et al. Ras-induced and extracellular signal-regulated kinase 1 and 2 phosphorylation-dependent isomerization of protein tyrosine phosphatase (PTP)-PEST by PIN1 promotes FAK dephosphorylation by PTP-PEST. Mol. Cell Biol. 31(21), 4258\u201369 (2011).","journal-title":"Mol. Cell Biol."},{"issue":"26","key":"32707_CR56","doi-asserted-by":"publisher","first-page":"24422","DOI":"10.1074\/jbc.M011080200","volume":"276","author":"PD Lyons","year":"2001","unstructured":"Lyons, P. D., Dunty, J. M., Schaefer, E. M. & Schaller, M. D. Inhibition of the catalytic activity of cell adhesion kinase beta by protein-tyrosine phosphatase-PEST-mediated dephosphorylation. J. Biol. Chem. 276(26), 24422\u201331 (2001).","journal-title":"J. Biol. Chem."},{"issue":"6","key":"32707_CR57","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1016\/j.celrep.2016.04.016","volume":"15","author":"H Li","year":"2016","unstructured":"Li, H. et al. Crystal structure and substrate specificity of PTPN12. Cell Rep. 15(6), 1345\u201358 (2016).","journal-title":"Cell Rep."},{"issue":"5","key":"32707_CR58","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1038\/ni.2246","volume":"13","author":"I Rhee","year":"2012","unstructured":"Rhee, I. & Veillette, A. Protein tyrosine phosphatases in lymphocyte activation and autoimmunity. Nat. Immunol. 13(5), 439\u201347 (2012).","journal-title":"Nat. Immunol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-32707-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-32707-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-32707-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T14:04:54Z","timestamp":1777125894000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-32707-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,22]]},"references-count":58,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["32707"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-32707-2","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,22]]},"assertion":[{"value":"10 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"45072"}}