{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:23:22Z","timestamp":1792023802676,"version":"4.4.0"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T00:00:00Z","timestamp":1765843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":37,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82470686"],"award-info":[{"award-number":["82470686"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82370666"],"award-info":[{"award-number":["82370666"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-32785-2","type":"journal-article","created":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T16:35:00Z","timestamp":1765902900000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Single-cell analysis indicating CCR8 modulates CD8+ tissue-resident memory T cells to attenuates rejection in transplantation"],"prefix":"10.1038","volume":"16","author":[{"given":"Xueteng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinqiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailun","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoyu","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruidong","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiying","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shipeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dahong","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinzhen","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,16]]},"reference":[{"key":"32785_CR1","doi-asserted-by":"publisher","first-page":"2341","DOI":"10.1097\/tp.0000000000004572","volume":"107","author":"S Short","year":"2023","unstructured":"Short, S., Lewik, G. & Issa, F. An immune atlas of T cells in transplant rejection: pathways and therapeutic opportunities. Transplantation 107, 2341\u20132352. https:\/\/doi.org\/10.1097\/tp.0000000000004572 (2023).","journal-title":"Transplantation"},{"key":"32785_CR2","doi-asserted-by":"publisher","unstructured":"Marino, J., Paster, J. & Benichou, G. Allorecognition by T lymphocytes and allograft rejection. Front. Immunol. 7 https:\/\/doi.org\/10.3389\/fimmu.2016.00582 (2016).","DOI":"10.3389\/fimmu.2016.00582"},{"key":"32785_CR3","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1038\/s41422-024-01049-5","volume":"35","author":"Y Liu","year":"2025","unstructured":"Liu, Y. et al. Donor MHC-specific thymus vaccination allows for immunocompatible allotransplantation. Cell Res. 35, 132\u2013144. https:\/\/doi.org\/10.1038\/s41422-024-01049-5 (2025).","journal-title":"Cell Res."},{"key":"32785_CR4","doi-asserted-by":"publisher","unstructured":"Ohm, B. et al. Chimerism and immunological tolerance in solid organ transplantation. Semin. Immunopathol. 47 https:\/\/doi.org\/10.1007\/s00281-025-01052-x (2025).","DOI":"10.1007\/s00281-025-01052-x"},{"key":"32785_CR5","doi-asserted-by":"publisher","first-page":"109141","DOI":"10.1016\/j.celrep.2021.109141","volume":"35","author":"A Prosser","year":"2021","unstructured":"Prosser, A. et al. Dynamic changes to tissue-resident immunity after MHC-matched and MHC-mismatched solid organ transplantation. Cell. Rep. 35, 109141. https:\/\/doi.org\/10.1016\/j.celrep.2021.109141 (2021).","journal-title":"Cell. Rep."},{"key":"32785_CR6","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1146\/annurev-immunol-042617-053214","volume":"37","author":"D Masopust","year":"2019","unstructured":"Masopust, D. & Soerens, A. G. Tissue-resident T cells and other resident leukocytes. Annu. Rev. Immunol. 37, 521\u2013546. https:\/\/doi.org\/10.1146\/annurev-immunol-042617-053214 (2019).","journal-title":"Annu. Rev. Immunol."},{"key":"32785_CR7","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/j.it.2015.07.002","volume":"36","author":"N Iijima","year":"2015","unstructured":"Iijima, N. & Iwasaki, A. Tissue instruction for migration and retention of TRM cells. Trends Immunol. 36, 556\u2013564. https:\/\/doi.org\/10.1016\/j.it.2015.07.002 (2015).","journal-title":"Trends Immunol."},{"key":"32785_CR8","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/nature02284","volume":"427","author":"M Matloubian","year":"2004","unstructured":"Matloubian, M. et al. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 427, 355\u2013360. https:\/\/doi.org\/10.1038\/nature02284 (2004).","journal-title":"Nature"},{"key":"32785_CR9","doi-asserted-by":"publisher","first-page":"4844","DOI":"10.7150\/thno.96928","volume":"14","author":"X Li","year":"2024","unstructured":"Li, X. et al. Single cell RNA-sequencing delineates CD8(+) tissue resident memory T cells maintaining rejection in liver transplantation. Theranostics 14, 4844\u20134860. https:\/\/doi.org\/10.7150\/thno.96928 (2024).","journal-title":"Theranostics"},{"key":"32785_CR10","doi-asserted-by":"publisher","unstructured":"Wakim, L. M. et al. The molecular signature of tissue resident memory CD8 T cells isolated from the brain. J. Immunol. 189, 3462\u20133471. https:\/\/doi.org\/10.4049\/jimmunol.1201305 (2012).","DOI":"10.4049\/jimmunol.1201305"},{"key":"32785_CR11","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1038\/ni.2744","volume":"14","author":"LK Mackay","year":"2013","unstructured":"Mackay, L. K. et al. The developmental pathway for CD103(+)CD8\u2009+\u2009tissue-resident memory T cells of skin. Nat. Immunol. 14, 1294\u20131301. https:\/\/doi.org\/10.1038\/ni.2744 (2013).","journal-title":"Nat. Immunol."},{"key":"32785_CR12","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/nri.2015.3","volume":"16","author":"SN Mueller","year":"2016","unstructured":"Mueller, S. N. & Mackay, L. K. Tissue-resident memory T cells: local specialists in immune defence. Nat. Rev. Immunol. 16, 79\u201389. https:\/\/doi.org\/10.1038\/nri.2015.3 (2016).","journal-title":"Nat. Rev. Immunol."},{"key":"32785_CR13","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1038\/ni.3108","volume":"16","author":"T Bergsbaken","year":"2015","unstructured":"Bergsbaken, T. & Bevan, M. J. Proinflammatory microenvironments within the intestine regulate the differentiation of tissue-resident CD8\u207a T cells responding to infection. Nat. Immunol. 16, 406\u2013414. https:\/\/doi.org\/10.1038\/ni.3108 (2015).","journal-title":"Nat. Immunol."},{"key":"32785_CR14","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1038\/s41423-019-0359-1","volume":"17","author":"SC Sasson","year":"2020","unstructured":"Sasson, S. C., Gordon, C. L., Christo, S. N., Klenerman, P. & Mackay, L. K. Local heroes or villains: tissue-resident memory T cells in human health and disease. Cell Mol. Immunol. 17, 113\u2013122. https:\/\/doi.org\/10.1038\/s41423-019-0359-1 (2020).","journal-title":"Cell Mol. Immunol."},{"key":"32785_CR15","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1097\/tp.0000000000004000","volume":"106","author":"J Fu","year":"2022","unstructured":"Fu, J. & Sykes, M. Emerging concepts of tissue-resident memory T cells in transplantation. Transplantation 106, 1132\u20131142. https:\/\/doi.org\/10.1097\/tp.0000000000004000 (2022).","journal-title":"Transplantation"},{"key":"32785_CR16","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1038\/s41590-022-01395-9","volume":"24","author":"MML Poon","year":"2023","unstructured":"Poon, M. M. L. et al. Tissue adaptation and clonal segregation of human memory T cells in barrier sites. Nat. Immunol. 24, 309\u2013319. https:\/\/doi.org\/10.1038\/s41590-022-01395-9 (2023).","journal-title":"Nat. Immunol."},{"key":"32785_CR17","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1097\/tp.0000000000004647","volume":"108","author":"KL Alexander","year":"2024","unstructured":"Alexander, K. L. & Ford, M. L. The entangled world of memory T cells and implications in transplantation. Transplantation 108, 137\u2013147. https:\/\/doi.org\/10.1097\/tp.0000000000004647 (2024).","journal-title":"Transplantation"},{"key":"32785_CR18","doi-asserted-by":"publisher","first-page":"eabk0270","DOI":"10.1126\/sciadv.abk0270","volume":"8","author":"Q Tian","year":"2022","unstructured":"Tian, Q. et al. Skin and heart allograft rejection solely by long-lived alloreactive T(RM) cells in skin of severe combined immunodeficient mice. Sci. Adv. 8, eabk0270. https:\/\/doi.org\/10.1126\/sciadv.abk0270 (2022).","journal-title":"Sci. Adv."},{"key":"32785_CR19","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1007\/s00281-022-00927-7","volume":"44","author":"N Asada","year":"2022","unstructured":"Asada, N., Ginsberg, P., Gagliani, N., Mittrucker, H. W. & Panzer, U. Tissue-resident memory T cells in the kidney. Semin Immunopathol. 44, 801\u2013811. https:\/\/doi.org\/10.1007\/s00281-022-00927-7 (2022).","journal-title":"Semin Immunopathol."},{"key":"32785_CR20","doi-asserted-by":"publisher","unstructured":"Snyder, M. E. et al. Generation and persistence of human tissue-resident memory T cells in lung transplantation. Sci. Immunol. 4 https:\/\/doi.org\/10.1126\/sciimmunol.aav5581 (2019).","DOI":"10.1126\/sciimmunol.aav5581"},{"key":"32785_CR21","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1038\/nri1781","volume":"6","author":"Y Takahama","year":"2006","unstructured":"Takahama, Y. Journey through the thymus: stromal guides for T-cell development and selection. Nat. Rev. Immunol. 6, 127\u2013135. https:\/\/doi.org\/10.1038\/nri1781 (2006).","journal-title":"Nat. Rev. Immunol."},{"key":"32785_CR22","doi-asserted-by":"publisher","first-page":"25184","DOI":"10.1074\/jbc.M603912200","volume":"281","author":"TT Murooka","year":"2006","unstructured":"Murooka, T. T. et al. CCL5-CCR5-mediated apoptosis in T cells: requirement for glycosaminoglycan binding and CCL5 aggregation. J. Biol. Chem. 281, 25184\u201325194. https:\/\/doi.org\/10.1074\/jbc.M603912200 (2006).","journal-title":"J. Biol. Chem."},{"key":"32785_CR23","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1038\/31269","volume":"393","author":"YR Zou","year":"1998","unstructured":"Zou, Y. R., Kottmann, A. H., Kuroda, M., Taniuchi, I. & Littman, D. R. Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature 393, 595\u2013599. https:\/\/doi.org\/10.1038\/31269 (1998).","journal-title":"Nature"},{"key":"32785_CR24","doi-asserted-by":"publisher","first-page":"27348","DOI":"10.1074\/jbc.270.45.27348","volume":"270","author":"RM Strieter","year":"1995","unstructured":"Strieter, R. M. et al. The functional role of the ELR motif in CXC chemokine-mediated angiogenesis. J. Biol. Chem. 270, 27348\u201327357. https:\/\/doi.org\/10.1074\/jbc.270.45.27348 (1995).","journal-title":"J. Biol. Chem."},{"key":"32785_CR25","doi-asserted-by":"publisher","first-page":"1378359","DOI":"10.3389\/fimmu.2024.1378359","volume":"15","author":"G Liu","year":"2024","unstructured":"Liu, G., Wang, Z. & Li, S. Heterogeneity and plasticity of tissue-resident memory T cells in skin diseases and homeostasis: a review. Front. Immunol. 15, 1378359. https:\/\/doi.org\/10.3389\/fimmu.2024.1378359 (2024).","journal-title":"Front. Immunol."},{"key":"32785_CR26","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/ni.1984","volume":"12","author":"SA Islam","year":"2011","unstructured":"Islam, S. A. et al. Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5\u2009+\u2009T(H)2 cells. Nat. Immunol. 12, 167\u2013177. https:\/\/doi.org\/10.1038\/ni.1984 (2011).","journal-title":"Nat. Immunol."},{"key":"32785_CR27","doi-asserted-by":"publisher","first-page":"eadj7500","DOI":"10.1126\/sciadv.adj7500","volume":"10","author":"S Jiang","year":"2024","unstructured":"Jiang, S. et al. Unveiling the structural mechanisms of nonpeptide ligand recognition and activation in human chemokine receptor CCR8. Sci. Adv. 10, eadj7500. https:\/\/doi.org\/10.1126\/sciadv.adj7500 (2024).","journal-title":"Sci. Adv."},{"key":"32785_CR28","doi-asserted-by":"publisher","unstructured":"Moser, B. Chemokine Receptor-Targeted therapies: special case for CCR8. Cancers 14 https:\/\/doi.org\/10.3390\/cancers14030511 (2022).","DOI":"10.3390\/cancers14030511"},{"key":"32785_CR29","doi-asserted-by":"publisher","first-page":"C1178","DOI":"10.1152\/ajpcell.00368.2024","volume":"327","author":"X Feng","year":"2024","unstructured":"Feng, X. et al. CD8(+) tissue-resident memory T cells are essential in bleomycin-induced pulmonary fibrosis. Am. J. Physiol. Cell Physiol. 327, C1178\u2013c1191. https:\/\/doi.org\/10.1152\/ajpcell.00368.2024 (2024).","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"32785_CR30","doi-asserted-by":"publisher","first-page":"3030","DOI":"10.1016\/j.cell.2025.03.022","volume":"188","author":"Y Hou","year":"2025","unstructured":"Hou, Y. et al. Optimizing stem cell infusion timing in the prevention of acute graft-versus-host disease. Cell 188, 3030\u20133044e3017. https:\/\/doi.org\/10.1016\/j.cell.2025.03.022 (2025).","journal-title":"Cell"},{"key":"32785_CR31","doi-asserted-by":"publisher","first-page":"2348","DOI":"10.1111\/ajt.17107","volume":"22","author":"P Wang","year":"2022","unstructured":"Wang, P. et al. Oral alloantigen exposure promotes donor-specific tolerance in a mouse model of minor-mismatched skin transplantation. Am. J. Transpl. 22, 2348\u20132359. https:\/\/doi.org\/10.1111\/ajt.17107 (2022).","journal-title":"Am. J. Transpl."},{"key":"32785_CR32","doi-asserted-by":"publisher","unstructured":"Hao, Y. et al. Integrated analysis of multimodal single-cell data. Cell. 184, 3573\u20133587.e3529. https:\/\/doi.org\/10.1016\/j.cell.2021.04.048 (2021).","DOI":"10.1016\/j.cell.2021.04.048"},{"key":"32785_CR33","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1038\/s41419-024-06834-z","volume":"15","author":"LX Zhou","year":"2024","unstructured":"Zhou, L. X. et al. Myeloid-derived suppressor cells-induced exhaustion of CD8\u2009+\u2009T-cell participates in rejection after liver transplantation. Cell. Death Dis. 15, 507. https:\/\/doi.org\/10.1038\/s41419-024-06834-z (2024).","journal-title":"Cell. Death Dis."},{"key":"32785_CR34","doi-asserted-by":"publisher","first-page":"113604","DOI":"10.1016\/j.intimp.2024.113604","volume":"143","author":"P Jiang","year":"2024","unstructured":"Jiang, P. et al. PTX3 exacerbates hepatocyte pyroptosis in hepatic ischemia-reperfusion injury by promoting macrophage M1 polarization. Int. Immunopharmacol. 143, 113604. https:\/\/doi.org\/10.1016\/j.intimp.2024.113604 (2024).","journal-title":"Int. Immunopharmacol."},{"key":"32785_CR35","doi-asserted-by":"publisher","first-page":"2077","DOI":"10.1007\/s10753-024-02026-1","volume":"47","author":"X Li","year":"2024","unstructured":"Li, X. et al. Integrated single cell analysis reveals an atlas of tumor associated macrophages in hepatocellular carcinoma. Inflammation 47, 2077\u20132093. https:\/\/doi.org\/10.1007\/s10753-024-02026-1 (2024).","journal-title":"Inflammation"},{"key":"32785_CR36","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1038\/s41590-018-0276-y","volume":"20","author":"D Aran","year":"2019","unstructured":"Aran, D. et al. Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage. Nat. Immunol. 20, 163\u2013172. https:\/\/doi.org\/10.1038\/s41590-018-0276-y (2019).","journal-title":"Nat. Immunol."},{"key":"32785_CR37","doi-asserted-by":"publisher","first-page":"100141","DOI":"10.1016\/j.xinn.2021.100141","volume":"2","author":"T Wu","year":"2021","unstructured":"Wu, T. et al. ClusterProfiler 4.0: A universal enrichment tool for interpreting omics data. Innov. (Camb). 2, 100141. https:\/\/doi.org\/10.1016\/j.xinn.2021.100141 (2021).","journal-title":"Innov. (Camb)"},{"key":"32785_CR38","doi-asserted-by":"publisher","first-page":"D672","DOI":"10.1093\/nar\/gkae909","volume":"53","author":"M Kanehisa","year":"2025","unstructured":"Kanehisa, M., Furumichi, M., Sato, Y., Matsuura, Y. & Ishiguro-Watanabe, M. KEGG: biological systems database as a model of the real world. Nucleic Acids Res. 53, D672\u2013d677. https:\/\/doi.org\/10.1093\/nar\/gkae909 (2025).","journal-title":"Nucleic Acids Res."},{"key":"32785_CR39","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1002\/pro.3715","volume":"28","author":"M Kanehisa","year":"2019","unstructured":"Kanehisa, M. Toward understanding the origin and evolution of cellular organisms. Protein Science: Publication Protein Soc. 28, 1947\u20131951. https:\/\/doi.org\/10.1002\/pro.3715 (2019).","journal-title":"Protein Science: Publication Protein Soc."},{"key":"32785_CR40","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa, M. & Goto, S. KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28, 27\u201330. https:\/\/doi.org\/10.1093\/nar\/28.1.27 (2000).","journal-title":"Nucleic Acids Res."},{"key":"32785_CR41","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","volume":"12","author":"S Jin","year":"2021","unstructured":"Jin, S. et al. Inference and analysis of cell-cell communication using cellchat. Nat. Commun. 12, 1088. https:\/\/doi.org\/10.1038\/s41467-021-21246-9 (2021).","journal-title":"Nat. Commun."},{"key":"32785_CR42","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1111\/imr.12801","volume":"292","author":"JM Gauthier","year":"2019","unstructured":"Gauthier, J. M., Harrison, M. S., Krupnick, A. S., Gelman, A. E. & Kreisel, D. The emerging role of regulatory T cells following lung transplantation. Immunol. Rev. 292, 194\u2013208. https:\/\/doi.org\/10.1111\/imr.12801 (2019).","journal-title":"Immunol. Rev."},{"key":"32785_CR43","doi-asserted-by":"publisher","DOI":"10.23876\/j.krcp.23.317","author":"H Lee","year":"2024","unstructured":"Lee, H. et al. Single-cell RNA sequencing revealed the role of the Th17 pathway in the development of anti- human leukocyte antigen antibodies in a highly sensitized mouse model. Kidney Res. Clin. Pract. https:\/\/doi.org\/10.23876\/j.krcp.23.317 (2024).","journal-title":"Kidney Res. Clin. Pract."},{"key":"32785_CR44","doi-asserted-by":"publisher","unstructured":"Li, X. et al. Landscape of immune cells heterogeneity in liver transplantation by single-cell RNA sequencing analysis. Front. Immunol. 13 https:\/\/doi.org\/10.3389\/fimmu.2022.890019 (2022).","DOI":"10.3389\/fimmu.2022.890019"},{"key":"32785_CR45","doi-asserted-by":"publisher","unstructured":"Abou-Daya, K. I. et al. Resident memory T cells form during persistent antigen exposure leading to allograft rejection. Sci. Immunol. 6 https:\/\/doi.org\/10.1126\/sciimmunol.abc8122 (2021).","DOI":"10.1126\/sciimmunol.abc8122"},{"key":"32785_CR46","doi-asserted-by":"publisher","unstructured":"Rubino, V. et al. T(R3-56) and Treg regulatory T cell subsets as potential indicators of graft tolerance control in kidney transplant recipients. Int. J. Mol. Sci. 25 https:\/\/doi.org\/10.3390\/ijms251910610 (2024).","DOI":"10.3390\/ijms251910610"},{"key":"32785_CR47","doi-asserted-by":"publisher","first-page":"141","DOI":"10.20517\/evcna.2024.52","volume":"6","author":"X Li","year":"2025","unstructured":"Li, X. et al. Impact of exosomes derived from adipose stem cells on lymphocyte proliferation and phenotype in mouse skin grafts. Extracell. Vesicles Circ. Nucl. Acids. 6, 141\u2013157. https:\/\/doi.org\/10.20517\/evcna.2024.52 (2025).","journal-title":"Extracell. Vesicles Circ. Nucl. Acids"},{"key":"32785_CR48","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1038\/s41423-019-0253-x","volume":"17","author":"H Huang","year":"2020","unstructured":"Huang, H. et al. The time-dependent shift in the hepatic graft and recipient macrophage pool following liver transplantation. Cell Mol. Immunol. 17, 412\u2013414. https:\/\/doi.org\/10.1038\/s41423-019-0253-x (2020).","journal-title":"Cell Mol. Immunol."},{"key":"32785_CR49","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.it.2025.01.001","volume":"46","author":"Y Wen","year":"2025","unstructured":"Wen, Y., Xia, Y., Yang, X., Li, H. & Gao, Q. CCR8: a promising therapeutic target against tumor-infiltrating regulatory T cells. Trends Immunol. 46, 153\u2013165. https:\/\/doi.org\/10.1016\/j.it.2025.01.001 (2025).","journal-title":"Trends Immunol."},{"key":"32785_CR50","doi-asserted-by":"publisher","first-page":"5082","DOI":"10.4049\/jimmunol.174.8.5082","volume":"174","author":"M Gombert","year":"2005","unstructured":"Gombert, M. et al. CCL1-CCR8 interactions: an axis mediating the recruitment of T cells and Langerhans-type dendritic cells to sites of atopic skin inflammation. J. Immunol.. 174, 5082\u20135091. https:\/\/doi.org\/10.4049\/jimmunol.174.8.5082 (2005).","journal-title":"J. Immunol."},{"key":"32785_CR51","doi-asserted-by":"publisher","first-page":"1876","DOI":"10.1681\/asn.2022020139","volume":"33","author":"A Dangi","year":"2022","unstructured":"Dangi, A. et al. Blocking CCL8-CCR8-mediated early allograft inflammation improves kidney transplant function. J. Am. Soc. Nephrology: JASN. 33, 1876\u20131890. https:\/\/doi.org\/10.1681\/asn.2022020139 (2022).","journal-title":"J. Am. Soc. Nephrology: JASN"},{"key":"32785_CR52","doi-asserted-by":"publisher","first-page":"2451","DOI":"10.4049\/jimmunol.1700571","volume":"199","author":"A Zaid","year":"2017","unstructured":"Zaid, A. et al. Chemokine receptor-dependent control of skin tissue-resident memory T cell formation. J. Immunol. (Baltimore Md. : 1950). 199, 2451\u20132459. https:\/\/doi.org\/10.4049\/jimmunol.1700571 (2017).","journal-title":"J. Immunol. (Baltimore Md. : 1950)"},{"key":"32785_CR53","doi-asserted-by":"publisher","unstructured":"Moghbeli, K. et al. NKG2D Blockade impairs tissue-resident memory T cell accumulation and reduces chronic lung allograft dysfunction. JCI Insight. 10 https:\/\/doi.org\/10.1172\/jci.insight.184048 (2025).","DOI":"10.1172\/jci.insight.184048"},{"key":"32785_CR54","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1084\/jem.20162115","volume":"214","author":"LJ Pallett","year":"2017","unstructured":"Pallett, L. J. et al. IL-2(high) tissue-resident T cells in the human liver: sentinels for hepatotropic infection. J. Exp. Med. 214, 1567\u20131580. https:\/\/doi.org\/10.1084\/jem.20162115 (2017).","journal-title":"J. Exp. Med."},{"key":"32785_CR55","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1038\/ni.2079","volume":"12","author":"S Feau","year":"2011","unstructured":"Feau, S., Arens, R., Togher, S. & Schoenberger, S. P. Autocrine IL-2 is required for secondary population expansion of CD8(+) memory T cells. Nat. Immunol. 12, 908\u2013913. https:\/\/doi.org\/10.1038\/ni.2079 (2011).","journal-title":"Nat. Immunol."},{"key":"32785_CR56","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/ajt.12510","volume":"14","author":"JA Bradley","year":"2014","unstructured":"Bradley, J. A. Transplant tolerance by Treg therapy. Am. J. Transplantation: Official J. Am. Soc. Transplantation Am. Soc. Transpl. Surg. 14, 5\u20136. https:\/\/doi.org\/10.1111\/ajt.12510 (2014).","journal-title":"Am. J. Transplantation: Official J. Am. Soc. Transplantation Am. Soc. Transpl. Surg."},{"key":"32785_CR57","doi-asserted-by":"publisher","unstructured":"Bernaldo-de-Quir\u00f3s, E. et al. First-in-human therapy with Treg produced from thymic tissue (thyTreg) in a heart transplant infant. J. Exp. Med. 220 https:\/\/doi.org\/10.1084\/jem.20231045 (2023).","DOI":"10.1084\/jem.20231045"},{"key":"32785_CR58","doi-asserted-by":"publisher","first-page":"2505","DOI":"10.1172\/jci90598","volume":"127","author":"Q Tang","year":"2017","unstructured":"Tang, Q. & Vincenti, F. Transplant trials with tregs: perils and promises. J. Clin. Investig. 127, 2505\u20132512. https:\/\/doi.org\/10.1172\/jci90598 (2017).","journal-title":"J. Clin. Investig."},{"key":"32785_CR59","doi-asserted-by":"publisher","first-page":"746889","DOI":"10.3389\/fimmu.2022.746889","volume":"13","author":"T Juneja","year":"2022","unstructured":"Juneja, T., Kazmi, M., Mellace, M. & Saidi, R. F. Utilization of Treg cells in solid organ transplantation. Front. Immunol. 13, 746889. https:\/\/doi.org\/10.3389\/fimmu.2022.746889 (2022).","journal-title":"Front. Immunol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-32785-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-32785-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-32785-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T02:07:46Z","timestamp":1769220466000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-32785-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,16]]},"references-count":59,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["32785"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-32785-2","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,16]]},"assertion":[{"value":"14 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"2936"}}