{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T22:55:34Z","timestamp":1788216934653,"version":"build-2803163510"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":11,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-33243-9","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T22:16:41Z","timestamp":1766096201000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Hungarian cross-cultural adaptation of the MMQL-AF for measuring quality of life in adolescents with cancer"],"prefix":"10.1038","volume":"15","author":[{"given":"M\u00e1rton","family":"Szabados","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelli","family":"Farkas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Fleisz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kata","family":"Tak\u00e1cs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orsolya","family":"Juh\u00e1sz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rk","family":"Hern\u00e1df\u0151i","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitta","family":"Teutsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Cs\u00f3ka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Hegyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikl\u00f3s","family":"Garami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"issue":"15","key":"33243_CR1","doi-asserted-by":"publisher","first-page":"2625","DOI":"10.1200\/JCO.2009.27.4426","volume":"28","author":"MA Smith","year":"2010","unstructured":"Smith, M. A. et al. Outcomes for children and adolescents with cancer: challenges for the twenty-first century. J. Clin. Oncol. 28 (15), 2625\u20132634. https:\/\/doi.org\/10.1200\/JCO.2009.27.4426 (2010).","journal-title":"J. Clin. Oncol."},{"issue":"12","key":"33243_CR2","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1001\/jama.290.12.1583","volume":"290","author":"MM Hudson","year":"2003","unstructured":"Hudson, M. M. et al. Health status of adult long-term survivors of childhood cancer: A report from the childhood cancer survivor study. JAMA 290 (12), 1583\u20131592. https:\/\/doi.org\/10.1001\/jama.290.12.1583 (2003).","journal-title":"JAMA"},{"issue":"4","key":"33243_CR3","doi-asserted-by":"publisher","first-page":"208","DOI":"10.3322\/canjclin.54.4.208","volume":"54","author":"KC Oeffinger","year":"2004","unstructured":"Oeffinger, K. C. & Hudson, M. M. Long-term complications following childhood and adolescent cancer: foundations for providing risk-based health care for survivors. CA Cancer J. Clin. 54 (4), 208\u2013236. https:\/\/doi.org\/10.3322\/canjclin.54.4.208 (2004).","journal-title":"CA Cancer J. Clin."},{"issue":"24","key":"33243_CR4","doi-asserted-by":"publisher","first-page":"2705","DOI":"10.1001\/jama.297.24.2705","volume":"297","author":"MM Geenen","year":"2007","unstructured":"Geenen, M. M. et al. Medical assessment of adverse health outcomes in long-term survivors of childhood cancer. JAMA 297 (24), 2705\u20132715. https:\/\/doi.org\/10.1001\/jama.297.24.2705 (2007).","journal-title":"JAMA"},{"issue":"13","key":"33243_CR5","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1093\/jnci\/djp129","volume":"101","author":"GT Armstrong","year":"2009","unstructured":"Armstrong, G. T. et al. Long-term outcomes among adult survivors of childhood central nervous system malignancies in the childhood cancer survivor study. J. Natl. Cancer Inst. 101 (13), 946\u2013958. https:\/\/doi.org\/10.1093\/jnci\/djp129 (2009).","journal-title":"J. Natl. Cancer Inst."},{"issue":"28","key":"33243_CR6","doi-asserted-by":"publisher","first-page":"4401","DOI":"10.1200\/JCO.2008.16.3489","volume":"26","author":"EA Lown","year":"2008","unstructured":"Lown, E. A. et al. Psychological distress in adult survivors of childhood cancer: A report from the childhood cancer survivor study. J. Clin. Oncol. 26 (28), 4401\u20134409. https:\/\/doi.org\/10.1200\/JCO.2008.16.3489 (2008).","journal-title":"J. Clin. Oncol."},{"issue":"14","key":"33243_CR7","doi-asserted-by":"publisher","first-page":"2390","DOI":"10.1200\/JCO.2008.19.5482","volume":"27","author":"JG Gurney","year":"2009","unstructured":"Gurney, J. G. et al. Social outcomes in the childhood cancer survivor study cohort. J. Clin. Oncol. 27 (14), 2390\u20132395. https:\/\/doi.org\/10.1200\/JCO.2008.19.5482 (2009).","journal-title":"J. Clin. Oncol."},{"issue":"6","key":"33243_CR8","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1001\/jamapediatrics.2024.0642","volume":"178","author":"MV Hern\u00e1df\u0151i","year":"2024","unstructured":"Hern\u00e1df\u0151i, M. V. et al. Burden of childhood cancer and the social and economic challenges in adulthood: A systematic review and meta-analysis. JAMA Pediatr. 178 (6), 548\u2013566. https:\/\/doi.org\/10.1001\/jamapediatrics.2024.0642 (2024).","journal-title":"JAMA Pediatr."},{"issue":"14","key":"33243_CR9","doi-asserted-by":"publisher","first-page":"2396","DOI":"10.1200\/JCO.2008.20.3963","volume":"27","author":"LK Zeltzer","year":"2009","unstructured":"Zeltzer, L. K. et al. Psychological status in childhood cancer survivors: A report from the childhood cancer survivor study. J. Clin. Oncol. 27 (14), 2396\u20132404. https:\/\/doi.org\/10.1200\/JCO.2008.20.3963 (2009).","journal-title":"J. Clin. Oncol."},{"key":"33243_CR10","unstructured":"World Health Organization. WHOQOL: Measuring Quality of Life (WHO, 1997)."},{"issue":"5","key":"33243_CR11","doi-asserted-by":"publisher","first-page":"373","DOI":"10.3322\/caac.21351","volume":"65","author":"S Bhatia","year":"2015","unstructured":"Bhatia, S. & Landier, W. Evaluating survivors of pediatric cancer. CA Cancer J. Clin. 65 (5), 373\u2013400. https:\/\/doi.org\/10.3322\/caac.21351 (2015).","journal-title":"CA Cancer J. Clin."},{"issue":"13","key":"33243_CR12","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1056\/NEJM199603283341306","volume":"334","author":"MA Testa","year":"1996","unstructured":"Testa, M. A. & Simonson, D. C. Assessment of quality-of-life outcomes. N Engl. J. Med. 334 (13), 835\u2013840. https:\/\/doi.org\/10.1056\/NEJM199603283341306 (1996).","journal-title":"N Engl. J. Med."},{"issue":"24","key":"33243_CR13","doi-asserted-by":"publisher","first-page":"4692","DOI":"10.1200\/JCO.2002.04.067","volume":"20","author":"S Bhatia","year":"2002","unstructured":"Bhatia, S. et al. The Minneapolis-Manchester quality of life instrument: reliability and validity of the adolescent form. J. Clin. Oncol. 20 (24), 4692\u20134698. https:\/\/doi.org\/10.1200\/JCO.2002.04.067 (2002).","journal-title":"J. Clin. Oncol."},{"issue":"10","key":"33243_CR14","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1136\/adc.2006.098947","volume":"92","author":"HA Hutchings","year":"2007","unstructured":"Hutchings, H. A. et al. Adaptation of the Manchester\u2013Minneapolis quality of life instrument for use in the UK population. Arch. Dis. Child. 92 (10), 855\u2013860 (2007).","journal-title":"Arch. Dis. Child."},{"issue":"12","key":"33243_CR15","doi-asserted-by":"publisher","first-page":"1788","DOI":"10.3346\/jkms.2013.28.12.1788","volume":"28","author":"HJ Park","year":"2013","unstructured":"Park, H. J. et al. Cross-cultural adaptation of the Korean version of the Minneapolis-Manchester quality of life Instrument-Adolescent form. J. Korean Med. Sci. 28 (12), 1788\u20131795. https:\/\/doi.org\/10.3346\/jkms.2013.28.12.1788 (2013).","journal-title":"J. Korean Med. Sci."},{"key":"33243_CR16","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/1477-7525-11-79","volume":"11","author":"EL Einberg","year":"2013","unstructured":"Einberg, E. L., Nygren, J. M. & Jakobsson, U. Psychometric evaluation of a Swedish version of the Minneapolis-Manchester quality of life youth form and adolescent form. Health Qual. Life Outcomes. 11, 79. https:\/\/doi.org\/10.1186\/1477-7525-11-79 (2013).","journal-title":"Health Qual. Life Outcomes"},{"key":"33243_CR17","doi-asserted-by":"publisher","unstructured":"Iliescu, D. et al. The test adaptation reporting standards (TARES): reporting test adaptations. Int. J. Test. 1\u201323. https:\/\/doi.org\/10.1080\/15305058.2023.2294266 (2024).","DOI":"10.1080\/15305058.2023.2294266"},{"issue":"24","key":"33243_CR18","doi-asserted-by":"publisher","first-page":"3186","DOI":"10.1097\/00007632-200012150-00014","volume":"25","author":"DE Beaton","year":"2000","unstructured":"Beaton, D. E., Bombardier, C., Guillemin, F. & Ferraz, M. B. Guidelines for the process of cross-cultural adaptation of self-report measures. Spine 25 (24), 3186\u20133191. https:\/\/doi.org\/10.1097\/00007632-200012150-00014 (2000).","journal-title":"Spine"},{"key":"33243_CR19","unstructured":"Mokkink, L. B. et al. COSMIN Manual for Systematic Reviews of patient-reported Outcome Measures (PROMs) \u2013 User Manual, Version 1.0 (VU University Medical Center, 2018)."},{"key":"33243_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1477-7525-5-1","volume":"5","author":"JW Varni","year":"2007","unstructured":"Varni, J. W., Limbers, C. A. & Burwinkle, T. M. How young can children reliably and validly self-report their health-related quality of life? An analysis of 8,591 children across age subgroups with the PedsQL 4.0 generic core scales. Health Qual. Life Outcomes. 5, 1. https:\/\/doi.org\/10.1186\/1477-7525-5-1 (2007).","journal-title":"Health Qual. Life Outcomes"},{"issue":"1","key":"33243_CR21","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/1477-7525-8-14","volume":"8","author":"A Berkes","year":"2010","unstructured":"Berkes, A. et al. Measuring health-related quality of life in Hungarian children with heart disease: psychometric properties of the Hungarian version of the pediatric quality of life inventory 4.0 generic core scales and the cardiac module. Health Qual. Life Outcomes. 8 (1), 14. https:\/\/doi.org\/10.1186\/1477-7525-8-14 (2010).","journal-title":"Health Qual. Life Outcomes"},{"issue":"1","key":"33243_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/10705519909540118","volume":"6","author":"LT Hu","year":"1999","unstructured":"Hu, L. T. & Bentler, P. M. Cutoff criteria for fit indexes in covariance structure analysis: conventional criteria versus new alternatives. Struct. Equ Model. 6 (1), 1\u201355. https:\/\/doi.org\/10.1080\/10705519909540118 (1999).","journal-title":"Struct. Equ Model."},{"issue":"2","key":"33243_CR23","first-page":"23","volume":"8","author":"K Schermelleh-Engel","year":"2003","unstructured":"Schermelleh-Engel, K., Moosbrugger, H. & M\u00fcller, H. Evaluating the fit of structural equation models: tests of significance and descriptive goodness-of-fit measures. Methods Psychol. Res. Online. 8 (2), 23\u201374 (2003).","journal-title":"Methods Psychol. Res. Online"},{"key":"33243_CR24","unstructured":"Brown, T. A. Confirmatory Factor Analysis for Applied Research 2nd edn (Guilford Press, 2015)."},{"key":"33243_CR25","unstructured":"R Core Team. R: A language and environment for statistical computing. Version 4.3.3. Vienna, Austria: R Foundation for Statistical Computing. (2025). Available from: https:\/\/www.R-project.org\/"},{"issue":"4","key":"33243_CR26","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/S1470-2045(22)00085-0","volume":"23","author":"L Botta","year":"2022","unstructured":"Botta, L. et al. Long-term survival and cure fraction estimates for childhood cancer in Europe (EUROCARE-6): results from a population-based study. Lancet Oncol. 23 (4), 543\u2013552. https:\/\/doi.org\/10.1016\/S1470-2045(22)00085-0 (2022).","journal-title":"Lancet Oncol."},{"issue":"7","key":"33243_CR27","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1016\/S1470-2045(19)30187-7","volume":"20","author":"ZJ Ward","year":"2019","unstructured":"Ward, Z. J. et al. Global childhood cancer survival estimates and priority-setting: A simulation-based analysis. Lancet Oncol. 20 (7), 972\u2013983. https:\/\/doi.org\/10.1016\/S1470-2045(19)30187-7 (2019).","journal-title":"Lancet Oncol."},{"key":"33243_CR28","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.ejca.2021.01.008","volume":"156","author":"M Schindler","year":"2021","unstructured":"Schindler, M. et al. European PanCareFollowUp recommendations for surveillance of late effects of childhood, adolescent, and young adult cancer. Eur. J. Cancer. 156, 316\u2013334. https:\/\/doi.org\/10.1016\/j.ejca.2021.01.008 (2021).","journal-title":"Eur. J. Cancer"},{"key":"33243_CR29","unstructured":"Hair, J. F., Black, W. C., Babin, B. J. & Anderson, R. E. Multivariate Data Analysis 8th edn (Cengage Learning, 2019)."},{"issue":"5","key":"33243_CR30","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1016\/j.socscimed.2005.07.010","volume":"62","author":"L Sharpe","year":"2006","unstructured":"Sharpe, L. & Curran, L. Understanding the process of adjustment to illness. Soc. Sci. Med. 62 (5), 1153\u20131166. https:\/\/doi.org\/10.1016\/j.socscimed.2005.07.010 (2006).","journal-title":"Soc. Sci. Med."},{"issue":"8","key":"33243_CR31","doi-asserted-by":"publisher","first-page":"e26442","DOI":"10.1002\/pbc.26442","volume":"64","author":"F Schulte","year":"2017","unstructured":"Schulte, F. et al. Systematic review and meta-analysis of health-related quality of life in pediatric CNS tumor survivors. Pediatr. Blood Cancer. 64 (8), e26442. https:\/\/doi.org\/10.1002\/pbc.26442 (2017).","journal-title":"Pediatr. Blood Cancer"},{"issue":"5","key":"33243_CR32","doi-asserted-by":"publisher","first-page":"e169","DOI":"10.1210\/clinem\/dgad054","volume":"108","author":"M Nies","year":"2023","unstructured":"Nies, M., Kluijfhout, W. & Smit, J. Health-related quality of life at diagnosis for pediatric thyroid cancer patients compared to other pediatric cancer patients and healthy youth. J. Clin. Endocrinol. Metab. 108 (5), e169\u2013e178. https:\/\/doi.org\/10.1210\/clinem\/dgad054 (2023).","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"2","key":"33243_CR33","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1007\/s11060-015-1839-2","volume":"122","author":"AM Vranceanu","year":"2015","unstructured":"Vranceanu, A. M., Merker, V. L., Park, E. R. & Plotkin, S. R. Quality of life among children and adolescents with neurofibromatosis 1: A systematic review of the literature. J. Neurooncol. 122 (2), 219\u2013228. https:\/\/doi.org\/10.1007\/s11060-015-1839-2 (2015).","journal-title":"J. Neurooncol"},{"issue":"5","key":"33243_CR34","first-page":"579","volume":"11","author":"H Rennekampff","year":"2022","unstructured":"Rennekampff, H., Dahan-Oliel, N., Montpetit, K., Lavoie Smith, E. M. & Sultan, S. High prevalence of psychiatric disorders in young adults after treatment for pediatric bone tumors: A French National study. J. Adolesc. Young Adult Oncol. 11 (5), 579\u2013585 (2022).","journal-title":"J. Adolesc. Young Adult Oncol."},{"issue":"2","key":"33243_CR35","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1037\/fam0000076","volume":"29","author":"Y Kim","year":"2015","unstructured":"Kim, Y., Carver, C. S. & Cannady, R. S. Caregiving and emotional well-being: linking family support to better adjustment among cancer survivors. J. Fam Psychol. 29 (2), 282\u2013289. https:\/\/doi.org\/10.1037\/fam0000076 (2015).","journal-title":"J. Fam Psychol."},{"issue":"7","key":"33243_CR36","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1093\/jpepsy\/jsv024","volume":"40","author":"SM Santos","year":"2015","unstructured":"Santos, S. M., Diniz, S. G., Silva, M. R. & Costa, L. A. Family rituals and quality of life of children with cancer. J. Pediatr. Psychol. 40 (7), 664\u2013672. https:\/\/doi.org\/10.1093\/jpepsy\/jsv024 (2015).","journal-title":"J. Pediatr. Psychol."},{"issue":"9","key":"33243_CR37","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1007\/s11136-011-9946-7","volume":"20","author":"K Litzelman","year":"2011","unstructured":"Litzelman, K., Harper, H. M. & Stoeckel, M. C. Parental psychosocial distress and the health-related quality of life of children with cancer. Qual. Life Res. 20 (9), 1271\u20131278. https:\/\/doi.org\/10.1007\/s11136-011-9946-7 (2011).","journal-title":"Qual. Life Res."},{"issue":"30","key":"33243_CR38","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1200\/JCO.2018.78.7139","volume":"36","author":"S Hamner","year":"2018","unstructured":"Hamner, S., Denburg, A. F. & Shew, M. Parental chronic stress and quality of life in pediatric cancer patients. J. Clin. Oncol. 36 (30), 1159\u20131167. https:\/\/doi.org\/10.1200\/JCO.2018.78.7139 (2018).","journal-title":"J. Clin. Oncol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-33243-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-33243-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-33243-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:07:32Z","timestamp":1777396052000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-33243-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,18]]},"references-count":38,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["33243"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-33243-9","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-7593854\/v1","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,18]]},"assertion":[{"value":"11 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The study was approved by the Scientific and Research Ethics Committee (TUKEB) of the Health Science Council (ETT), under reference number BM\/16408-1\/2023. All procedures involving human participants in the study were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its subsequent amendments. Written informed consent was obtained from all participants, as well as from the parents or legal guardians of minors, prior to enrollment in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Due to ethical restrictions, the data supporting the findings of this study are not publicly available. However, they may be obtained from the corresponding author upon reasonable request and with appropriate institutional approvals.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data access statement"}},{"value":"The authors declare no conflicts of interest related to this study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data access statement"}}],"article-number":"45119"}}