{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:02:53Z","timestamp":1782950573363,"version":"3.54.5"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"vor","delay-in-days":28,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-33284-0","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T19:13:37Z","timestamp":1767035617000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Preoperative hemoglobin level and risk of new-onset atrial fibrillation and flutter after total joint arthroplasty: a retrospective analysis"],"prefix":"10.1038","volume":"16","author":[{"given":"Yi-Chen","family":"Lai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Sian","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo-Chuan","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Wei","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Ming","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I-Wen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,29]]},"reference":[{"key":"33284_CR1","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1097\/EJA.0000000000001265","volume":"37","author":"E Bjerrum","year":"2020","unstructured":"Bjerrum, E., Wahlstroem, K. L., G\u00f6genur, I., Burcharth, J. & Ekeloef, S. Postoperative atrial fibrillation following emergency noncardiothoracic surgery: A systematic review. Eur. J. Anaesthesiol. 37, 671\u2013679 (2020).","journal-title":"Eur. J. Anaesthesiol."},{"key":"33284_CR2","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1111\/anae.14118","volume":"73","author":"R Chebbout","year":"2018","unstructured":"Chebbout, R. et al. A systematic review of the incidence of and risk factors for postoperative atrial fibrillation following general surgery. Anaesthesia 73, 490\u2013498 (2018).","journal-title":"Anaesthesia"},{"key":"33284_CR3","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1038\/s41569-019-0166-5","volume":"16","author":"D Dobrev","year":"2019","unstructured":"Dobrev, D., Aguilar, M., Heijman, J., Guichard, J. B. & Nattel, S. Postoperative atrial fibrillation: mechanisms, manifestations and management. Nat. Rev. Cardiol. 16, 417\u2013436 (2019).","journal-title":"Nat. Rev. Cardiol."},{"key":"33284_CR4","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1053\/j.jvca.2015.08.003","volume":"30","author":"VV Lomivorotov","year":"2016","unstructured":"Lomivorotov, V. V., Efremov, S. M., Pokushalov, E. A. & Karaskov, A. M. New-Onset atrial fibrillation after cardiac surgery: Pathophysiology, Prophylaxis, and treatment. J. Cardiothorac. Vasc Anesth. 30, 200\u2013216 (2016).","journal-title":"J. Cardiothorac. Vasc Anesth."},{"key":"33284_CR5","first-page":"744424","volume":"74","author":"S Sari","year":"2024","unstructured":"Sari, S. et al. The association of hemoglobin with postoperative delirium and atrial fibrillation after cardiac surgery: a retrospective sub-study. Braz J. Anesthesiol. 74, 744424 (2024).","journal-title":"Braz J. Anesthesiol"},{"key":"33284_CR6","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1186\/s12872-021-02224-x","volume":"21","author":"EJ Seo","year":"2021","unstructured":"Seo, E. J., Hong, J., Lee, H. J. & Son, Y. J. Perioperative risk factors for new-onset postoperative atrial fibrillation after coronary artery bypass grafting: a systematic review. BMC Cardiovasc. Disord. 21, 418 (2021).","journal-title":"BMC Cardiovasc. Disord"},{"key":"33284_CR7","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1080\/13696998.2023.2267390","volume":"26","author":"TJ Park","year":"2023","unstructured":"Park, T. J. et al. Healthcare resource utilization and costs for patients with postoperative atrial fibrillation in the united States. J. Med. Econ. 26, 1417\u20131423 (2023).","journal-title":"J. Med. Econ."},{"key":"33284_CR8","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1161\/STROKEAHA.118.023921","volume":"50","author":"MH Lin","year":"2019","unstructured":"Lin, M. H. et al. Perioperative\/Postoperative atrial fibrillation and risk of subsequent stroke and\/or mortality. Stroke 50, 1364\u20131371 (2019).","journal-title":"Stroke"},{"key":"33284_CR9","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.ejim.2020.12.018","volume":"85","author":"A Albini","year":"2021","unstructured":"Albini, A. et al. Long-term outcomes of postoperative atrial fibrillation following Non cardiac surgery: A systematic review and metanalysis. Eur. J. Intern. Med. 85, 27\u201333 (2021).","journal-title":"Eur. J. Intern. Med."},{"key":"33284_CR10","doi-asserted-by":"publisher","first-page":"e007437","DOI":"10.1161\/CIRCEP.119.007437","volume":"13","author":"A AlTurki","year":"2020","unstructured":"AlTurki, A. et al. Major adverse cardiovascular events associated with postoperative atrial fibrillation after noncardiac surgery: A systematic review and Meta-Analysis. Circ. Arrhythm. Electrophysiol. 13, e007437 (2020).","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"33284_CR11","doi-asserted-by":"publisher","first-page":"1273547","DOI":"10.3389\/fcvm.2023.1273547","volume":"10","author":"S Jiang","year":"2023","unstructured":"Jiang, S., Liao, X., Chen, Y. & Li, B. Exploring postoperative atrial fibrillation after non-cardiac surgery: mechanisms, risk factors, and prevention strategies. Front. Cardiovasc. Med. 10, 1273547 (2023).","journal-title":"Front. Cardiovasc. Med."},{"key":"33284_CR12","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.ijcard.2018.10.020","volume":"287","author":"L Scott Jr","year":"2019","unstructured":"Scott, L. Jr., Li, N. & Dobrev, D. Role of inflammatory signaling in atrial fibrillation. Int. J. Cardiol. 287, 195\u2013200 (2019).","journal-title":"Int. J. Cardiol."},{"key":"33284_CR13","doi-asserted-by":"publisher","first-page":"3394","DOI":"10.1053\/j.jvca.2020.11.030","volume":"35","author":"J Boons","year":"2021","unstructured":"Boons, J. et al. Prevention, and treatment of atrial fibrillation after cardiac surgery: A narrative review. J. Cardiothorac. Vasc Anesth. 35, 3394\u20133403 (2021).","journal-title":"J. Cardiothorac. Vasc Anesth."},{"key":"33284_CR14","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1186\/s12872-021-01981-z","volume":"21","author":"ST Turkkolu","year":"2021","unstructured":"Turkkolu, S. T., Sel\u00e7uk, E. & K\u00f6ksal, C. Biochemical predictors of postoperative atrial fibrillation following cardiac surgery. BMC Cardiovasc. Disord. 21, 167 (2021).","journal-title":"BMC Cardiovasc. Disord"},{"key":"33284_CR15","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1007\/s10741-008-9088-8","volume":"13","author":"IS Anand","year":"2008","unstructured":"Anand, I. S. Heart failure and anemia: mechanisms and pathophysiology. Heart Fail. Rev. 13, 379\u2013386 (2008).","journal-title":"Heart Fail. Rev."},{"key":"33284_CR16","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1136\/hrt.70.4.357","volume":"70","author":"IS Anand","year":"1993","unstructured":"Anand, I. S., Chandrashekhar, Y., Ferrari, R., Poole-Wilson, P. A. & Harris, P. C. Pathogenesis of oedema in chronic severe anaemia: studies of body water and sodium, renal function, haemodynamic variables, and plasma hormones. Br. Heart J. 70, 357\u2013362 (1993).","journal-title":"Br. Heart J."},{"key":"33284_CR17","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1302\/2058-5241.6.200124","volume":"6","author":"ST Sinclair","year":"2021","unstructured":"Sinclair, S. T. et al. Comorbidity indices in orthopaedic surgery: a narrative review focused on hip and knee arthroplasty. EFORT Open. Rev. 6, 629\u2013640 (2021).","journal-title":"EFORT Open. Rev."},{"key":"33284_CR18","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s42836-022-00156-1","volume":"5","author":"I Patel","year":"2023","unstructured":"Patel, I., Nham, F., Zalikha, A. K. & El-Othmani, M. M. Epidemiology of total hip arthroplasty: demographics, comorbidities and outcomes. Arthroplasty 5, 2 (2023).","journal-title":"Arthroplasty"},{"key":"33284_CR19","doi-asserted-by":"publisher","first-page":"111574","DOI":"10.1016\/j.jclinane.2024.111574","volume":"98","author":"CN Ho","year":"2024","unstructured":"Ho, C. N. et al. Impact of preoperative QTc interval prolongation on short-term postoperative outcomes: A retrospective study. J. Clin. Anesth. 98, 111574 (2024).","journal-title":"J. Clin. Anesth."},{"key":"33284_CR20","doi-asserted-by":"publisher","first-page":"9757","DOI":"10.1038\/s41598-025-93807-7","volume":"15","author":"KC Hung","year":"2025","unstructured":"Hung, K. C. et al. Impact of vitamin D deficiency on postoperative outcomes in patients with chronic kidney disease undergoing surgery: a retrospective study. Sci. Rep. 15, 9757 (2025).","journal-title":"Sci. Rep."},{"key":"33284_CR21","doi-asserted-by":"publisher","first-page":"1617670","DOI":"10.3389\/fnut.2025.1617670","volume":"12","author":"KC Hung","year":"2025","unstructured":"Hung, K. C. et al. Preoperative vitamin D deficiency and postoperative delirium risk: multicenter retrospective study. Front. Nutr. 12, 1617670 (2025).","journal-title":"Front. Nutr."},{"key":"33284_CR22","doi-asserted-by":"publisher","first-page":"112407","DOI":"10.1016\/j.diabres.2025.112407","volume":"227","author":"WM Chen","year":"2025","unstructured":"Chen, W. M., Ng, H. J., Jao, A. T., Wu, S. Y. & Soong, R. S. GLP-1 receptor agonists and risk of hepatocellular carcinoma and all-cause mortality in patients with MASLD and type 2 diabetes: a propensity score-matched population-based cohort study. Diabetes Res. Clin. Pract. 227, 112407 (2025).","journal-title":"Diabetes Res. Clin. Pract."},{"key":"33284_CR23","doi-asserted-by":"publisher","first-page":"4402","DOI":"10.1007\/s11695-025-08262-0","volume":"35","author":"KC Hung","year":"2025","unstructured":"Hung, K. C. et al. Association between SGLT-2 inhibitors use and incidence of anemia in female patients undergoing metabolic and bariatric surgery: A retrospective study. Obes. Surg. 35, 4402\u20134410 (2025).","journal-title":"Obes. Surg."},{"key":"33284_CR24","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/j.arth.2021.12.042","volume":"37","author":"CS Sicat","year":"2022","unstructured":"Sicat, C. S. et al. Impact of preoperative anemia severity on primary total hip arthroplasty outcomes. J. Arthroplasty. 37, 721\u2013726 (2022).","journal-title":"J. Arthroplasty"},{"key":"33284_CR25","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1001\/jamacardio.2021.3702","volume":"6","author":"DE Singer","year":"2021","unstructured":"Singer, D. E., Ziegler, P. D., Koehler, J. L., Sarkar, S. & Passman, R. S. Temporal association between episodes of atrial fibrillation and risk of ischemic stroke. JAMA Cardiol. 6, 1364\u20131369 (2021).","journal-title":"JAMA Cardiol."},{"key":"33284_CR26","doi-asserted-by":"publisher","first-page":"644279","DOI":"10.3389\/fcvm.2021.644279","volume":"8","author":"S Costa","year":"2021","unstructured":"Costa, S. et al. The link between sex hormones and susceptibility to cardiac arrhythmias: from molecular basis to clinical implications. Front. Cardiovasc. Med. 8, 644279 (2021).","journal-title":"Front. Cardiovasc. Med."},{"key":"33284_CR27","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1093\/europace\/euy215","volume":"21","author":"KE Odening","year":"2019","unstructured":"Odening, K. E. et al. Mechanisms of sex differences in atrial fibrillation: role of hormones and differences in electrophysiology, structure, function, and remodelling. Europace 21, 366\u2013376 (2019).","journal-title":"Europace"},{"issue":"Suppl 3","key":"33284_CR28","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1093\/oxfordjournals.ndt.a027970","volume":"15","author":"F Metivier","year":"2000","unstructured":"Metivier, F., Marchais, S. J., Guerin, A. P., Pannier, B. & London, G. M. Pathophysiology of anaemia: focus on the heart and blood vessels. Nephrol. Dial Transpl. 15 (Suppl 3), 14\u201318 (2000).","journal-title":"Nephrol. Dial Transpl."},{"key":"33284_CR29","first-page":"S18","volume":"53","author":"T Grune","year":"2000","unstructured":"Grune, T., Sommerburg, O. & Siems, W. G. Oxidative stress in anemia. Clin. Nephrol. 53, S18\u201322 (2000).","journal-title":"Clin. Nephrol."},{"key":"33284_CR30","doi-asserted-by":"publisher","first-page":"313","DOI":"10.3389\/fphys.2016.00313","volume":"7","author":"G Tse","year":"2016","unstructured":"Tse, G., Yan, B. P., Chan, Y. W., Tian, X. Y. & Huang, Y. Reactive oxygen Species, Endoplasmic reticulum stress and mitochondrial dysfunction: the link with cardiac arrhythmogenesis. Front. Physiol. 7, 313 (2016).","journal-title":"Front. Physiol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-33284-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-33284-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-33284-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T01:03:33Z","timestamp":1769475813000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-33284-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,29]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["33284"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-33284-0","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,29]]},"assertion":[{"value":"22 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The study protocol was approved by the Institutional Review Board of Chi Mei Medical Center, which granted a waiver of informed consent in compliance with its observational research regulations (IRB number: 11403-E01).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was not required for this retrospective study, as it involved secondary analysis of pre-existing data without any interventions or direct participant interaction.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Patient consent statement"}}],"article-number":"3343"}}