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UPLC-MS\/MS identified CECs belonging to different categories such as pesticides, licit and illicit recreational drugs, and particularly pharmaceuticals. Concentrations of up to 6\u00a0\u00b5g\/L were identified but greatly varied spatially and temporally. Treated municipal wastewater was a harbinger for CECs (e.g., 6,055\u2009\u00b1\u2009434 ng\/L for efavirenz an HIV drug), while high CECs concentrations were also observed in river water (e.g., 3,228\u2009\u00b1\u2009114 ng\/L for acetaminophen). The high concentration for antiretroviral medication reflects the HIV\/AIDS crisis in Sub-Saharan Africa and likely medicine misuse for illicit drug (whoonga\/nyaope) manufacturing. Large intra-seasonal and intra-annual (seasonal) variations were observed (e.g., caffeine in dam water ranged from 73\u2009\u00b1\u20096 ng\/L to 1,492\u2009\u00b1\u200930 ng\/L), with overall high intra-seasonal and intra-annual variations (coefficient of variations up to 1.08 and 1.52, respectively) being observed. Individual risk quotients of up to 30 suggested high ecotoxicological risk potential. CECs pollution is apparent in South Africa, and likely across Sub-Saharan Africa and the Global South where similar problems persist, suggesting the need for effective wastewater treatment and policy intervention to curb CECs releases in freshwater.<\/jats:p>","DOI":"10.1038\/s41598-025-33703-2","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T12:33:09Z","timestamp":1770985989000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Spatial and temporal variability and distribution of emerging contaminants in South African freshwater and wastewater"],"prefix":"10.1038","volume":"16","author":[{"given":"Paki Israel","family":"Dikobe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Memory","family":"Tekere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vhahangwele","family":"Masindi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spyros","family":"Foteinis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,13]]},"reference":[{"key":"33703_CR1","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1080\/02508069808686730","volume":"23","author":"J Kuylenstierna","year":"1998","unstructured":"Kuylenstierna, J., Najlis, P. & Bj\u00f6rklund, G. 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