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Reliability of these parameters is limited by projection errors and landmark ambiguity. Using 3D models allows more precise quantification of these parameters. This study validated an algorithm for measuring volar tilt and radial inclination on 3D virtual models of malunited and healthy radii. The algorithm establishes a 3D coordinate system and anatomical landmarks replicating conventional 2D definitions to maintain clinical compatibility. Automatic 3D measurements on models from 16 participants were compared with manual measurements on 2D radiographs (by three surgeons in consensus) and on 3D models (by two independent raters). Agreement was assessed using Bland\u2013Altman analysis, and landmark discrepancies were quantified. Mean differences between automatic 3D and manual 2D measurements were small: for volar tilt, 2.0\u00b0 in malunited and 3.5\u00b0 in healthy radii; for radial inclination, 1.5\u00b0 and 2.3\u00b0, respectively. Strong agreement was also found between automatic and manual 3D measurements. Landmark deviations ranged from 0.5 to 2.8\u00a0mm, with an average longitudinal axis difference of 2.5\u00b0. This open-source algorithm provides a reproducible 3D assessment of distal radius alignment. By closely matching 2D standards, the algorithm has a high potential for clinical integration.<\/jats:p>","DOI":"10.1038\/s41598-025-33737-6","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T16:15:08Z","timestamp":1767716108000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Automatic measurements of volar tilt and radial inclination of the distal radius on 3D models: validation against manual methods"],"prefix":"10.1038","volume":"16","author":[{"given":"Emilia","family":"Gryska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katleen","family":"Libberecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte Stor","family":"Swinkels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Axelsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Bj\u00f6rkman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"33737_CR1","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/s11751-017-0284-8","volume":"12","author":"RJO de Muinck Keizer","year":"2017","unstructured":"de Muinck Keizer, R. 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