{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T17:03:36Z","timestamp":1781629416195,"version":"3.54.5"},"reference-count":89,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":19,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["FS\/17\/60\/33474"],"award-info":[{"award-number":["FS\/17\/60\/33474"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["FS\/17\/60\/33474"],"award-info":[{"award-number":["FS\/17\/60\/33474"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["FS\/17\/60\/33474"],"award-info":[{"award-number":["FS\/17\/60\/33474"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Granulocyte-macrophage colony-stimulating factor (GM-CSF; CSF2) has emerged as an important regulator of pro-inflammatory macrophage polarisation, with pro-inflammatory responses recognised to influence cardiac remodelling and repair after cardiac injury. We hypothesised that selective inhibition of CSF2RA, responsible for mediating CSF2 signalling in monocyte\/macrophages, could promote reparative responses after cardiac injury through modulating macrophage\/fibroblast communication. We demonstrate for the first time that pharmacological CSF2RA inhibition alters the inflammatory response and cardiac remodelling in response to injury, through promoting pro-fibrotic macrophages and beneficial effects upon cardiac fibroblast differentiation, limiting border zone fibrosis, and encouraging scar maturation, culminating in improved cardiac function. Proteomic and in vitro analyses revealed that loss of CSF2-mediated signalling promotes pro-fibrotic macrophages, which facilitate myofibroblast dedifferentiation, in part through decreased CTSZ expression and concomitant augmented CXCL10\/CXCR3 signalling. Providing translational potential, we establish that pharmacological CSF2RA inhibition modulates macrophage responses and associated fibroblast function to promote cardiac remodelling, repair, and recovery. These actions may also be applicable to other inflammatory conditions, non-resolving fibrosis, and wound healing.<\/jats:p>","DOI":"10.1038\/s41598-025-33936-1","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T09:35:56Z","timestamp":1767951356000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Suppression of CSF2RA macrophage polarisation impacts pathological cardiac remodelling in mice"],"prefix":"10.1038","volume":"16","author":[{"given":"Georgios","family":"Kremastiotis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Bond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daire","family":"Shanahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina Di","family":"Gregoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alastair W.","family":"Poole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J.","family":"George","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason L.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,9]]},"reference":[{"key":"33936_CR1","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1007\/s10554-020-02136-5","volume":"37","author":"MR Sinn","year":"2021","unstructured":"Sinn, M. R. et al. Prognosis of early pre-discharge and late left ventricular dilatation by cardiac magnetic resonance imaging after acute myocardial infarction. Int. J. Cardiovasc. Imaging. 37, 1711\u20131720. https:\/\/doi.org\/10.1007\/s10554-020-02136-5 (2021).","journal-title":"Int. J. Cardiovasc. Imaging"},{"key":"33936_CR2","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.jchf.2019.08.014","volume":"8","author":"P van der Bijl","year":"2020","unstructured":"van der Bijl, P. et al. Left ventricular Post-Infarct remodeling: implications for systolic function improvement and outcomes in the modern era. JACC Heart Fail. 8, 131\u2013140. https:\/\/doi.org\/10.1016\/j.jchf.2019.08.014 (2020).","journal-title":"JACC Heart Fail."},{"key":"33936_CR3","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.jcmg.2010.10.008","volume":"4","author":"MA Konstam","year":"2011","unstructured":"Konstam, M. A., Kramer, D. G., Patel, A. R., Maron, M. S. & Udelson, J. E. Left ventricular remodeling in heart failure: current concepts in clinical significance and assessment. JACC Cardiovasc. Imaging. 4, 98\u2013108. https:\/\/doi.org\/10.1016\/j.jcmg.2010.10.008 (2011).","journal-title":"JACC Cardiovasc. Imaging"},{"key":"33936_CR4","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1136\/heartjnl-2014-305646","volume":"100","author":"MJ Goumans","year":"2014","unstructured":"Goumans, M. J., Maring, J. A. & Smits, A. M. A straightforward guide to the basic science behind cardiovascular cell-based therapies. Heart 100, 1153\u20131157. https:\/\/doi.org\/10.1136\/heartjnl-2014-305646 (2014).","journal-title":"Heart"},{"key":"33936_CR5","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.matbio.2017.12.001","volume":"75\u201376","author":"SH Nielsen","year":"2019","unstructured":"Nielsen, S. H. et al. Understanding cardiac extracellular matrix remodeling to develop biomarkers of myocardial infarction outcomes. Matrix Biol. 75\u201376, 43\u201357. https:\/\/doi.org\/10.1016\/j.matbio.2017.12.001 (2019).","journal-title":"Matrix Biol."},{"key":"33936_CR6","doi-asserted-by":"publisher","first-page":"3037","DOI":"10.1084\/jem.20070885","volume":"204","author":"M Nahrendorf","year":"2007","unstructured":"Nahrendorf, M. et al. The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J. Exp. Med. 204, 3037\u20133047. https:\/\/doi.org\/10.1084\/jem.20070885 (2007).","journal-title":"J. Exp. Med."},{"key":"33936_CR7","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1038\/s41591-018-0059-x","volume":"24","author":"G Bajpai","year":"2018","unstructured":"Bajpai, G. et al. The human heart contains distinct macrophage subsets with divergent origins and functions. Nat. Med. 24, 1234\u20131245. https:\/\/doi.org\/10.1038\/s41591-018-0059-x (2018).","journal-title":"Nat. Med."},{"key":"33936_CR8","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.1161\/CIRCRESAHA.114.303204","volume":"114","author":"I Hilgendorf","year":"2014","unstructured":"Hilgendorf, I. et al. Ly-6Chigh monocytes depend on Nr4a1 to balance both inflammatory and reparative phases in the infarcted myocardium. Circ. Res. 114, 1611\u20131622. https:\/\/doi.org\/10.1161\/CIRCRESAHA.114.303204 (2014).","journal-title":"Circ. Res."},{"key":"33936_CR9","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1093\/cvr\/cvu062","volume":"102","author":"S Van Linthout","year":"2014","unstructured":"Van Linthout, S., Miteva, K. & Tsch\u00f6pe, C. Crosstalk between fibroblasts and inflammatory cells. Cardiovasc. Res. 102, 258\u2013269. https:\/\/doi.org\/10.1093\/cvr\/cvu062 (2014).","journal-title":"Cardiovasc. Res."},{"key":"33936_CR10","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1038\/nri2356","volume":"8","author":"JA Hamilton","year":"2008","unstructured":"Hamilton, J. A. Colony-stimulating factors in inflammation and autoimmunity. Nat. Rev. Immunol. 8, 533\u2013544. https:\/\/doi.org\/10.1038\/nri2356 (2008).","journal-title":"Nat. Rev. Immunol."},{"key":"33936_CR11","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.2353\/ajpath.2008.070513","volume":"172","author":"SW Waldo","year":"2008","unstructured":"Waldo, S. W. et al. Heterogeneity of human macrophages in culture and in atherosclerotic plaques. Am. J. Pathol. 172, 1112\u20131126. https:\/\/doi.org\/10.2353\/ajpath.2008.070513 (2008).","journal-title":"Am. J. Pathol."},{"key":"33936_CR12","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1097\/MOL.0b013e328357ca6e","volume":"23","author":"K Di Gregoli","year":"2012","unstructured":"Di Gregoli, K. & Johnson, J. L. Role of colony-stimulating factors in atherosclerosis. Curr. Opin. Lipidol. 23, 412\u2013421. https:\/\/doi.org\/10.1097\/MOL.0b013e328357ca6e (2012).","journal-title":"Curr. Opin. Lipidol."},{"key":"33936_CR13","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20170689","author":"A Anzai","year":"2017","unstructured":"Anzai, A. et al. The infarcted myocardium solicits GM-CSF for the detrimental oversupply of inflammatory leukocytes. J. Exp. Med. https:\/\/doi.org\/10.1084\/jem.20170689 (2017).","journal-title":"J. Exp. Med."},{"key":"33936_CR14","first-page":"139","volume":"15","author":"JT Parissis","year":"2004","unstructured":"Parissis, J. T. et al. Plasma profiles of Circulating granulocyte-macrophage colony-stimulating factor and soluble cellular adhesion molecules in acute myocardial infarction. Contribution to post-infarction left ventricular dysfunction. Eur. Cytokine Netw. 15, 139\u2013144 (2004).","journal-title":"Eur. Cytokine Netw."},{"key":"33936_CR15","doi-asserted-by":"publisher","first-page":"H483","DOI":"10.1152\/ajpheart.01016.2002","volume":"285","author":"NG Frangogiannis","year":"2003","unstructured":"Frangogiannis, N. G. et al. MCSF expression is induced in healing myocardial infarcts and May regulate monocyte and endothelial cell phenotype. Am. J. Physiol. Heart Circ. Physiol. 285, H483\u2013492. https:\/\/doi.org\/10.1152\/ajpheart.01016.2002 (2003).","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"33936_CR16","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1177\/0003319711409742","volume":"63","author":"G Novo","year":"2012","unstructured":"Novo, G. et al. The role of macrophage colony-stimulating factor in patients with acute myocardial infarction: a pilot study. Angiology 63, 127\u2013130. https:\/\/doi.org\/10.1177\/0003319711409742 (2012).","journal-title":"Angiology"},{"key":"33936_CR17","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.ejheart.2007.11.009","volume":"10","author":"S Frantz","year":"2008","unstructured":"Frantz, S. et al. Impact of different bone marrow cell preparations on left ventricular remodelling after experimental myocardial infarction. Eur. J. Heart Fail. 10, 119\u2013124. https:\/\/doi.org\/10.1016\/j.ejheart.2007.11.009 (2008).","journal-title":"Eur. J. Heart Fail."},{"key":"33936_CR18","doi-asserted-by":"publisher","first-page":"109816","DOI":"10.1016\/j.cellsig.2020.109816","volume":"77","author":"MJ Daseke","year":"2021","unstructured":"Daseke, M. J. et al. Neutrophil signaling during myocardial infarction wound repair. Cell. Signal. 77, 109816. https:\/\/doi.org\/10.1016\/j.cellsig.2020.109816 (2021).","journal-title":"Cell. Signal."},{"key":"33936_CR19","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1093\/cvr\/cvw024","volume":"110","author":"Y Ma","year":"2016","unstructured":"Ma, Y. et al. Temporal neutrophil polarization following myocardial infarction. Cardiovasc. Res. 110, 51\u201361. https:\/\/doi.org\/10.1093\/cvr\/cvw024 (2016).","journal-title":"Cardiovasc. Res."},{"key":"33936_CR20","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1182\/blood-2008-12-164004","volume":"114","author":"TR Hercus","year":"2009","unstructured":"Hercus, T. R. et al. The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease. Blood 114, 1289\u20131298. https:\/\/doi.org\/10.1182\/blood-2008-12-164004 (2009).","journal-title":"Blood"},{"key":"33936_CR21","doi-asserted-by":"publisher","first-page":"5838","DOI":"10.1073\/pnas.91.13.5838","volume":"91","author":"TR Hercus","year":"1994","unstructured":"Hercus, T. R. et al. Specific human granulocyte-macrophage colony-stimulating factor antagonists. Proc. Natl. Acad. Sci. U S A. 91, 5838\u20135842. https:\/\/doi.org\/10.1073\/pnas.91.13.5838 (1994).","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"33936_CR22","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1161\/01.CIR.0000074225.62168.68","volume":"108","author":"K Hayakawa","year":"2003","unstructured":"Hayakawa, K. et al. Inhibition of granulation tissue cell apoptosis during the subacute stage of myocardial infarction improves cardiac remodeling and dysfunction at the chronic stage. Circulation 108, 104\u2013109. https:\/\/doi.org\/10.1161\/01.CIR.0000074225.62168.68 (2003).","journal-title":"Circulation"},{"key":"33936_CR23","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1016\/j.bbadis.2012.11.004","volume":"1832","author":"H Sahin","year":"2013","unstructured":"Sahin, H. & Wasmuth, H. E. Chemokines in tissue fibrosis. Biochim. Biophys. Acta. 1832, 1041\u20131048. https:\/\/doi.org\/10.1016\/j.bbadis.2012.11.004 (2013).","journal-title":"Biochim. Biophys. Acta"},{"key":"33936_CR24","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s00395-017-0622-5","volume":"112","author":"M Jung","year":"2017","unstructured":"Jung, M. et al. IL-10 improves cardiac remodeling after myocardial infarction by stimulating M2 macrophage polarization and fibroblast activation. Basic. Res. Cardiol. 112, 33. https:\/\/doi.org\/10.1007\/s00395-017-0622-5 (2017).","journal-title":"Basic. Res. Cardiol."},{"key":"33936_CR25","doi-asserted-by":"publisher","unstructured":"Di Gregoli, K. et al. Galectin-3 identifies a subset of macrophages with a potential beneficial role in atherosclerosis. Arterioscler. Thromb. Vasc Biol. ATVBAHA120314252 https:\/\/doi.org\/10.1161\/ATVBAHA.120.314252 (2020).","DOI":"10.1161\/ATVBAHA.120.314252"},{"key":"33936_CR26","doi-asserted-by":"publisher","first-page":"1990","DOI":"10.1161\/ATVBAHA.114.304088","volume":"34","author":"K Di Gregoli","year":"2014","unstructured":"Di Gregoli, K. et al. MicroRNA-24 regulates macrophage behavior and retards atherosclerosis. Arterioscler. Thromb. Vasc Biol. 34, 1990\u20132000. https:\/\/doi.org\/10.1161\/ATVBAHA.114.304088 (2014).","journal-title":"Arterioscler. Thromb. Vasc Biol."},{"key":"33936_CR27","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1161\/CIRCRESAHA.116.309321","volume":"120","author":"K Di Gregoli","year":"2017","unstructured":"Di Gregoli, K. et al. MicroRNA-181b controls atherosclerosis and aneurysms through regulation of TIMP-3 and Elastin. Circ. Res. 120, 49\u201365. https:\/\/doi.org\/10.1161\/CIRCRESAHA.116.309321 (2017).","journal-title":"Circ. Res."},{"key":"33936_CR28","doi-asserted-by":"publisher","first-page":"e0148873","DOI":"10.1371\/journal.pone.0148873","volume":"11","author":"A Tsaousi","year":"2016","unstructured":"Tsaousi, A. et al. Plaque size is decreased but M1 macrophage polarization and rupture related metalloproteinase expression are maintained after deleting T-Bet in ApoE null mice. PLoS One. 11, e0148873. https:\/\/doi.org\/10.1371\/journal.pone.0148873 (2016).","journal-title":"PLoS One"},{"key":"33936_CR29","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1093\/cvr\/cvv268","volume":"109","author":"K Di Gregoli","year":"2016","unstructured":"Di Gregoli, K., George, S. J., Jackson, C. L., Newby, A. C. & Johnson, J. L. Differential effects of tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2 on atherosclerosis and monocyte\/macrophage invasion. Cardiovasc. Res. 109, 318\u2013330. https:\/\/doi.org\/10.1093\/cvr\/cvv268 (2016).","journal-title":"Cardiovasc. Res."},{"key":"33936_CR30","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.jacbts.2019.02.006","volume":"4","author":"C Humeres","year":"2019","unstructured":"Humeres, C. & Frangogiannis, N. G. Fibroblasts in the Infarcted, Remodeling, and failing heart. JACC Basic. Transl Sci. 4, 449\u2013467. https:\/\/doi.org\/10.1016\/j.jacbts.2019.02.006 (2019).","journal-title":"JACC Basic. Transl Sci."},{"key":"33936_CR31","doi-asserted-by":"publisher","first-page":"2267","DOI":"10.1016\/j.jacc.2019.02.049","volume":"73","author":"CK Nagaraju","year":"2019","unstructured":"Nagaraju, C. K. et al. Myofibroblast phenotype and reversibility of fibrosis in patients with end-stage heart failure. J. Am. Coll. Cardiol. 73, 2267\u20132282 (2019).","journal-title":"J. Am. Coll. Cardiol."},{"key":"33936_CR32","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1165\/rcmb.2019-0092OC","volume":"62","author":"K Kato","year":"2020","unstructured":"Kato, K. et al. Impaired myofibroblast dedifferentiation contributes to nonresolving fibrosis in aging. Am. J. Respir Cell. Mol. Biol. 62, 633\u2013644. https:\/\/doi.org\/10.1165\/rcmb.2019-0092OC (2020).","journal-title":"Am. J. Respir Cell. Mol. Biol."},{"key":"33936_CR33","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1016\/0735-1097(89)90360-4","volume":"13","author":"KT Weber","year":"1989","unstructured":"Weber, K. T. Cardiac interstitium in health and disease: the fibrillar collagen network. J. Am. Coll. Cardiol. 13, 1637\u20131652. https:\/\/doi.org\/10.1016\/0735-1097(89)90360-4 (1989).","journal-title":"J. Am. Coll. Cardiol."},{"key":"33936_CR34","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.bbadis.2016.11.006","volume":"1863","author":"AV Shinde","year":"2017","unstructured":"Shinde, A. V., Humeres, C. & Frangogiannis, N. G. The role of \u03b1-smooth muscle actin in fibroblast-mediated matrix contraction and remodeling. Biochim. Biophys. Acta Mol. Basis Dis. 1863, 298\u2013309. https:\/\/doi.org\/10.1016\/j.bbadis.2016.11.006 (2017).","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"33936_CR35","doi-asserted-by":"publisher","first-page":"19389","DOI":"10.1074\/jbc.M800266200","volume":"283","author":"JH Cox","year":"2008","unstructured":"Cox, J. H., Dean, R. A., Roberts, C. R. & Overall, C. M. Matrix metalloproteinase processing of CXCL11\/I-TAC results in loss of chemoattractant activity and altered glycosaminoglycan binding. J. Biol. Chem. 283, 19389\u201319399. https:\/\/doi.org\/10.1074\/jbc.M800266200 (2008).","journal-title":"J. Biol. Chem."},{"key":"33936_CR36","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1016\/j.bbrc.2003.09.098","volume":"310","author":"PE Van den Steen","year":"2003","unstructured":"Van den Steen, P. E., Husson, S. J., Proost, P., Van Damme, J. & Opdenakker, G. Carboxyterminal cleavage of the chemokines MIG and IP-10 by gelatinase B and neutrophil collagenase. Biochem. Biophys. Res. Commun. 310, 889\u2013896. https:\/\/doi.org\/10.1016\/j.bbrc.2003.09.098 (2003).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"33936_CR37","doi-asserted-by":"publisher","first-page":"13800","DOI":"10.1074\/jbc.M115.638395","volume":"290","author":"U Repnik","year":"2015","unstructured":"Repnik, U., Starr, A. E., Overall, C. M. & Turk, B. Cysteine cathepsins activate ELR chemokines and inactivate Non-ELR chemokines. J. Biol. Chem. 290, 13800\u201313811. https:\/\/doi.org\/10.1074\/jbc.M115.638395 (2015).","journal-title":"J. Biol. Chem."},{"key":"33936_CR38","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1007\/s10555-019-09807-3","volume":"38","author":"H Bronger","year":"2019","unstructured":"Bronger, H., Magdolen, V., Goettig, P. & Dreyer, T. Proteolytic chemokine cleavage as a regulator of lymphocytic infiltration in solid tumors. Cancer Metastasis Rev. 38, 417\u2013430. https:\/\/doi.org\/10.1007\/s10555-019-09807-3 (2019).","journal-title":"Cancer Metastasis Rev."},{"key":"33936_CR39","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.bbrc.2009.02.164","volume":"382","author":"H Denney","year":"2009","unstructured":"Denney, H., Clench, M. R. & Woodroofe, M. N. Cleavage of chemokines CCL2 and CXCL10 by matrix metalloproteinases-2 and \u2013\u20099: implications for chemotaxis. Biochem. Biophys. Res. Commun. 382, 341\u2013347. https:\/\/doi.org\/10.1016\/j.bbrc.2009.02.164 (2009).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"33936_CR40","doi-asserted-by":"publisher","first-page":"13402","DOI":"10.1074\/jbc.M312814200","volume":"279","author":"PJ Hensbergen","year":"2004","unstructured":"Hensbergen, P. J. et al. Furin is a chemokine-modifying enzyme: in vitro and in vivo processing of CXCL10 generates a C-terminally truncated chemokine retaining full activity. J. Biol. Chem. 279, 13402\u201313411. https:\/\/doi.org\/10.1074\/jbc.M312814200 (2004).","journal-title":"J. Biol. Chem."},{"key":"33936_CR41","doi-asserted-by":"publisher","first-page":"4138","DOI":"10.1172\/JCI57559","volume":"121","author":"AJ Murphy","year":"2011","unstructured":"Murphy, A. J. et al. ApoE regulates hematopoietic stem cell proliferation, monocytosis, and monocyte accumulation in atherosclerotic lesions in mice. J. Clin. Invest. 121, 4138\u20134149 (2011).","journal-title":"J. Clin. Invest."},{"key":"33936_CR42","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1016\/j.jacc.2009.08.089","volume":"55","author":"P Panizzi","year":"2010","unstructured":"Panizzi, P. et al. Impaired infarct healing in atherosclerotic mice with Ly-6Chi monocytosis. J. Am. Coll. Cardiol. 55, 1629\u20131638 (2010).","journal-title":"J. Am. Coll. Cardiol."},{"key":"33936_CR43","doi-asserted-by":"publisher","first-page":"2357","DOI":"10.1016\/j.jacc.2011.08.034","volume":"58","author":"EA Liehn","year":"2011","unstructured":"Liehn, E. A., Postea, O., Curaj, A. & Marx, N. Repair after myocardial Infarction, between fantasy and reality. JACC 58, 2357\u20132362. https:\/\/doi.org\/10.1016\/j.jacc.2011.08.034 (2011).","journal-title":"JACC"},{"key":"33936_CR44","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1007\/s12265-010-9241-3","volume":"4","author":"GM Fomovsky","year":"2011","unstructured":"Fomovsky, G. M., Macadangdang, J. R., Ailawadi, G. & Holmes, J. W. Model-based design of mechanical therapies for myocardial infarction. J. Cardiovasc. Transl Res. 4, 82\u201391. https:\/\/doi.org\/10.1007\/s12265-010-9241-3 (2011).","journal-title":"J. Cardiovasc. Transl Res."},{"key":"33936_CR45","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1007\/s00395-018-0686-x","volume":"113","author":"AJ Mouton","year":"2018","unstructured":"Mouton, A. J. et al. Mapping macrophage polarization over the myocardial infarction time continuum. Basic. Res. Cardiol. 113, 26. https:\/\/doi.org\/10.1007\/s00395-018-0686-x (2018).","journal-title":"Basic. Res. Cardiol."},{"key":"33936_CR46","doi-asserted-by":"publisher","first-page":"23081","DOI":"10.1038\/s41598-021-02508-4","volume":"11","author":"G Kremastiotis","year":"2021","unstructured":"Kremastiotis, G., Handa, I., Jackson, C., George, S. & Johnson, J. Disparate effects of MMP and TIMP modulation on coronary atherosclerosis and associated myocardial fibrosis. Sci. Rep. 11, 23081. https:\/\/doi.org\/10.1038\/s41598-021-02508-4 (2021).","journal-title":"Sci. Rep."},{"key":"33936_CR47","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1093\/cvr\/cvt158","volume":"100","author":"H Chen","year":"2013","unstructured":"Chen, H. et al. Cathepsin S-mediated fibroblast trans-differentiation contributes to left ventricular remodelling after myocardial infarction. Cardiovasc. Res. 100, 84\u201394. https:\/\/doi.org\/10.1093\/cvr\/cvt158 (2013).","journal-title":"Cardiovasc. Res."},{"key":"33936_CR48","doi-asserted-by":"publisher","first-page":"680279","DOI":"10.3389\/fimmu.2021.680279","volume":"12","author":"M Peri\u0161i\u0107 Nanut","year":"2021","unstructured":"Peri\u0161i\u0107 Nanut, M., Pe\u010dar Fonovi\u0107, U., Jako\u0161, T. & Kos, J. The role of cysteine peptidases in hematopoietic stem cell differentiation and modulation of immune system function. Front. Immunol. 12, 680279. https:\/\/doi.org\/10.3389\/fimmu.2021.680279 (2021).","journal-title":"Front. Immunol."},{"key":"33936_CR49","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1515\/bchm3.1995.376.4.225","volume":"376","author":"B Turk","year":"1995","unstructured":"Turk, B. et al. Regulation of the activity of lysosomal cysteine proteinases by pH-induced inactivation and\/or endogenous protein inhibitors, cystatins. Biol. Chem. Hoppe Seyler. 376, 225\u2013230. https:\/\/doi.org\/10.1515\/bchm3.1995.376.4.225 (1995).","journal-title":"Biol. Chem. Hoppe Seyler"},{"key":"33936_CR50","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1021\/bi00052a046","volume":"32","author":"B Turk","year":"1993","unstructured":"Turk, B., Dolenc, I., Turk, V. & Bieth, J. G. Kinetics of the pH-induced inactivation of human cathepsin L. Biochemistry 32, 375\u2013380. https:\/\/doi.org\/10.1021\/bi00052a046 (1993).","journal-title":"Biochemistry"},{"key":"33936_CR51","doi-asserted-by":"publisher","unstructured":"Gohbara, M. et al. Association between acidosis soon after reperfusion and Contrast-Induced nephropathy in patients with a First-Time ST-Segment elevation myocardial infarction. J. Am. Heart Assoc. 6 https:\/\/doi.org\/10.1161\/JAHA.117.006380 (2017).","DOI":"10.1161\/JAHA.117.006380"},{"key":"33936_CR52","doi-asserted-by":"publisher","unstructured":"Vidak, E., Javor\u0161ek, U., Vizovi\u0161ek, M. & Turk, B. Cysteine cathepsins and their extracellular roles: shaping the microenvironment. Cells 8 https:\/\/doi.org\/10.3390\/cells8030264 (2019).","DOI":"10.3390\/cells8030264"},{"key":"33936_CR53","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-021-02582-5","author":"JS Shavadia","year":"2021","unstructured":"Shavadia, J. S. et al. Novel multi-marker proteomics in phenotypically matched patients with ST-segment myocardial infarction: association with clinical outcomes. J. Thromb. Thrombolysis. https:\/\/doi.org\/10.1007\/s11239-021-02582-5 (2021).","journal-title":"J. Thromb. Thrombolysis"},{"key":"33936_CR54","doi-asserted-by":"publisher","unstructured":"Chorell, E., Olsson, T., Jansson, J. H. & Wennberg, P. Lysophospholipids as predictive markers of ST-Elevation myocardial infarction (STEMI) and Non-ST-Elevation myocardial infarction (NSTEMI). Metabolites 11 https:\/\/doi.org\/10.3390\/metabo11010025 (2020).","DOI":"10.3390\/metabo11010025"},{"key":"33936_CR55","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.cophys.2020.10.004","volume":"19","author":"R 55 Li","year":"2021","unstructured":"55 Li, R. & Frangogiannis, N. G. Chemokines in cardiac fibrosis. Curr. Opin. Physiol. 19, 80\u201391. https:\/\/doi.org\/10.1016\/j.cophys.2020.10.004 (2021).","journal-title":"Curr. Opin. Physiol."},{"key":"33936_CR56","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1096\/fj.00-0745fje","volume":"15","author":"NG Frangogiannis","year":"2001","unstructured":"Frangogiannis, N. G. et al. Induction and suppression of interferon-inducible protein 10 in reperfused myocardial infarcts May regulate angiogenesis. FASEB J. 15, 1428\u20131430. https:\/\/doi.org\/10.1096\/fj.00-0745fje (2001).","journal-title":"FASEB J."},{"key":"33936_CR57","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1007\/s12265-016-9703-3","volume":"9","author":"R Altara","year":"2016","unstructured":"Altara, R. et al. CXCL10 is a Circulating inflammatory marker in patients with advanced heart failure: a pilot study. J. Cardiovasc. Transl Res. 9, 302\u2013314. https:\/\/doi.org\/10.1007\/s12265-016-9703-3 (2016).","journal-title":"J. Cardiovasc. Transl Res."},{"key":"33936_CR58","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1161\/CIRCRESAHA.109.199471","volume":"105","author":"M Bujak","year":"2009","unstructured":"Bujak, M. et al. Induction of the CXC chemokine interferon-gamma-inducible protein 10 regulates the reparative response following myocardial infarction. Circ. Res. 105, 973\u2013983. https:\/\/doi.org\/10.1161\/CIRCRESAHA.109.199471 (2009).","journal-title":"Circ. Res."},{"key":"33936_CR59","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1189\/jlb.0212107","volume":"92","author":"A Asai","year":"2012","unstructured":"Asai, A., Nakamura, K., Kobayashi, M., Herndon, D. N. & Suzuki, F. CCL1 released from M2b macrophages is essentially required for the maintenance of their properties. J. Leukoc. Biol. 92, 859\u2013867. https:\/\/doi.org\/10.1189\/jlb.0212107 (2012).","journal-title":"J. Leukoc. Biol."},{"key":"33936_CR60","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1038\/s44161-022-00049-1","volume":"1","author":"Z Mallat","year":"2022","unstructured":"Mallat, Z. & Binder, C. J. The why and how of adaptive immune responses in ischemic cardiovascular disease. Nat. Cardiovasc. Res. 1, 431\u2013444. https:\/\/doi.org\/10.1038\/s44161-022-00049-1 (2022).","journal-title":"Nat. Cardiovasc. Res."},{"key":"33936_CR61","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.yjmcc.2019.05.009","volume":"132","author":"M Vila-Caballer","year":"2019","unstructured":"Vila-Caballer, M. et al. Disruption of the CCL1-CCR8 axis inhibits vascular Treg recruitment and function and promotes atherosclerosis in mice. J. Mol. Cell. Cardiol. 132, 154\u2013163. https:\/\/doi.org\/10.1016\/j.yjmcc.2019.05.009 (2019).","journal-title":"J. Mol. Cell. Cardiol."},{"key":"33936_CR62","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1038\/ni735","volume":"2","author":"RS Bystry","year":"2001","unstructured":"Bystry, R. S., Aluvihare, V., Welch, K. A., Kallikourdis, M. & Betz, A. G. B cells and professional apcs recruit regulatory T cells via CCL4. Nat. Immunol. 2, 1126\u20131132. https:\/\/doi.org\/10.1038\/ni735 (2001).","journal-title":"Nat. Immunol."},{"key":"33936_CR63","doi-asserted-by":"publisher","first-page":"6480","DOI":"10.1038\/s41467-024-50806-y","volume":"15","author":"YK Alshoubaki","year":"2024","unstructured":"Alshoubaki, Y. K. et al. Tregs delivered post-myocardial infarction adopt an injury-specific phenotype promoting cardiac repair via macrophages in mice. Nat. Commun. 15, 6480. https:\/\/doi.org\/10.1038\/s41467-024-50806-y (2024).","journal-title":"Nat. Commun."},{"key":"33936_CR64","doi-asserted-by":"publisher","unstructured":"DeLeon-Pennell, K. Y. et al. Periodontal-induced chronic inflammation triggers macrophage secretion of Ccl12 to inhibit fibroblast-mediated cardiac wound healing. JCI Insight. 2 https:\/\/doi.org\/10.1172\/jci.insight.94207 (2017).","DOI":"10.1172\/jci.insight.94207"},{"key":"33936_CR65","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.ajpath.2013.04.011","volume":"183","author":"A Falkenham","year":"2013","unstructured":"Falkenham, A. et al. Early fibroblast progenitor cell migration to the AngII-exposed myocardium is not CXCL12 or CCL2 dependent as previously thought. Am. J. Pathol. 183, 459\u2013469. https:\/\/doi.org\/10.1016\/j.ajpath.2013.04.011 (2013).","journal-title":"Am. J. Pathol."},{"key":"33936_CR66","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/1755-1536-4-23","volume":"4","author":"JE Ekert","year":"2011","unstructured":"Ekert, J. E. et al. Chemokine (C-C motif) ligand 2 mediates direct and indirect fibrotic responses in human and murine cultured fibrocytes. Fibrogenesis Tissue Repair. 4, 23. https:\/\/doi.org\/10.1186\/1755-1536-4-23 (2011).","journal-title":"Fibrogenesis Tissue Repair."},{"key":"33936_CR67","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1165\/rcmb.2005-0239OC","volume":"35","author":"BB Moore","year":"2006","unstructured":"Moore, B. B. et al. The role of CCL12 in the recruitment of fibrocytes and lung fibrosis. Am. J. Respir Cell. Mol. Biol. 35, 175\u2013181. https:\/\/doi.org\/10.1165\/rcmb.2005-0239OC (2006).","journal-title":"Am. J. Respir Cell. Mol. Biol."},{"key":"33936_CR68","doi-asserted-by":"publisher","first-page":"2711","DOI":"10.1084\/jem.20080759","volume":"205","author":"M Martinez-Moczygemba","year":"2008","unstructured":"Martinez-Moczygemba, M. et al. Pulmonary alveolar proteinosis caused by deletion of the GM-CSFRalpha gene in the X chromosome pseudoautosomal region 1. J. Exp. Med. 205, 2711\u20132716. https:\/\/doi.org\/10.1084\/jem.20080759 (2008).","journal-title":"J. Exp. Med."},{"key":"33936_CR69","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/bs.ai.2019.04.001","volume":"142","author":"S Laffont","year":"2019","unstructured":"Laffont, S. & Gu\u00e9ry, J. C. Deconstructing the sex bias in allergy and autoimmunity: from sex hormones and beyond. Adv. Immunol. 142, 35\u201364. https:\/\/doi.org\/10.1016\/bs.ai.2019.04.001 (2019).","journal-title":"Adv. Immunol."},{"key":"33936_CR70","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/ng0892-333","volume":"1","author":"CM Disteche","year":"1992","unstructured":"Disteche, C. M. et al. The human pseudoautosomal GM-CSF receptor alpha subunit gene is autosomal in mouse. Nat. Genet. 1, 333\u2013336. https:\/\/doi.org\/10.1038\/ng0892-333 (1992).","journal-title":"Nat. Genet."},{"key":"33936_CR71","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.jaut.2012.12.006","volume":"41","author":"A Hewagama","year":"2013","unstructured":"Hewagama, A. et al. Overexpression of X-linked genes in T cells from women with lupus. J. Autoimmun. 41, 60\u201371. https:\/\/doi.org\/10.1016\/j.jaut.2012.12.006 (2013).","journal-title":"J. Autoimmun."},{"key":"33936_CR72","doi-asserted-by":"publisher","unstructured":"Reynders, N. et al. The distinct roles of CXCR3 variants and their ligands in the tumor microenvironment. Cells 8 https:\/\/doi.org\/10.3390\/cells8060613 (2019).","DOI":"10.3390\/cells8060613"},{"key":"33936_CR73","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1161\/CIRCGENETICS.113.000630","volume":"8","author":"T Wilsgaard","year":"2015","unstructured":"Wilsgaard, T. et al. Clinically significant novel biomarkers for prediction of first ever myocardial infarction: the Troms\u00f8 study. Circ. Cardiovasc. Genet. 8, 363\u2013371. https:\/\/doi.org\/10.1161\/CIRCGENETICS.113.000630 (2015).","journal-title":"Circ. Cardiovasc. Genet."},{"key":"33936_CR74","doi-asserted-by":"publisher","first-page":"H948","DOI":"10.1152\/ajpheart.00318.2020","volume":"319","author":"A Hanna","year":"2020","unstructured":"Hanna, A., Shinde, A. V. & Frangogiannis, N. G. Validation of diagnostic criteria and histopathological characterization of cardiac rupture in the mouse model of nonreperfused myocardial infarction. Am. J. Physiol. Heart Circ. Physiol. 319, H948\u2013H964. https:\/\/doi.org\/10.1152\/ajpheart.00318.2020 (2020).","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"33936_CR75","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1007\/s00395-011-0183-y","volume":"106","author":"SK Sanganalmath","year":"2011","unstructured":"Sanganalmath, S. K., Abdel-Latif, A., Bolli, R., Xuan, Y. T. & Dawn, B. Hematopoietic cytokines for cardiac repair: mobilization of bone marrow cells and beyond. Basic. Res. Cardiol. 106, 709\u2013733. https:\/\/doi.org\/10.1007\/s00395-011-0183-y (2011).","journal-title":"Basic. Res. Cardiol."},{"key":"33936_CR76","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/s00395-004-0473-8","volume":"99","author":"J Terrovitis","year":"2004","unstructured":"Terrovitis, J. et al. No effect of stem cell mobilization with GM-CSF on infarct size and left ventricular function in experimental acute myocardial infarction. Basic. Res. Cardiol. 99, 241\u2013246. https:\/\/doi.org\/10.1007\/s00395-004-0473-8 (2004).","journal-title":"Basic. Res. Cardiol."},{"key":"33936_CR77","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1016\/j.jacc.2004.05.083","volume":"44","author":"Y Maekawa","year":"2004","unstructured":"Maekawa, Y. et al. Effect of granulocyte-macrophage colony-stimulating factor inducer on left ventricular remodeling after acute myocardial infarction. J. Am. Coll. Cardiol. 44, 1510\u20131520. https:\/\/doi.org\/10.1016\/j.jacc.2004.05.083 (2004). https:\/\/doi.org\/http:\/\/dx.doi.","journal-title":"J. Am. Coll. Cardiol."},{"key":"33936_CR78","doi-asserted-by":"publisher","first-page":"5691","DOI":"10.4049\/jimmunol.181.8.5691","volume":"181","author":"K Naito","year":"2008","unstructured":"Naito, K. et al. Differential effects of GM-CSF and G-CSF on infiltration of dendritic cells during early left ventricular remodeling after myocardial infarction. J. Immunol. 181, 5691\u20135701. https:\/\/doi.org\/10.4049\/jimmunol.181.8.5691 (2008).","journal-title":"J. Immunol."},{"key":"33936_CR79","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/S0021-9150(01)00637-2","volume":"159","author":"IR Buschmann","year":"2001","unstructured":"Buschmann, I. R. et al. GM-CSF: a strong arteriogenic factor acting by amplification of monocyte function. Atherosclerosis 159, 343\u2013356. https:\/\/doi.org\/10.1016\/S0021-9150(01)00637-2 (2001). https:\/\/doi.org\/https:\/\/","journal-title":"Atherosclerosis"},{"key":"33936_CR80","doi-asserted-by":"publisher","first-page":"2012","DOI":"10.1161\/hc4201.097835","volume":"104","author":"C Seiler","year":"2001","unstructured":"Seiler, C. et al. Promotion of collateral growth by granulocyte-macrophage colony-stimulating factor in patients with coronary artery disease - A randomized, double-blind, placebo-controlled study. Circulation 104, 2012\u20132017 (2001).","journal-title":"Circulation"},{"key":"33936_CR81","doi-asserted-by":"publisher","first-page":"1636","DOI":"10.1016\/j.jacc.2005.01.068","volume":"46","author":"S Zbinden","year":"2005","unstructured":"Zbinden, S., Zbinden, R., Meier, P., Windecker, S. & Seiler, C. Safety and efficacy of Subcutaneous-Only Granulocyte-Macrophage Colony-Stimulating factor for collateral growth promotion in patients with coronary artery disease. J. Am. Coll. Cardiol. 46, 1636\u20131642. https:\/\/doi.org\/10.1016\/j.jacc.2005.01.068 (2005).","journal-title":"J. Am. Coll. Cardiol."},{"key":"33936_CR82","doi-asserted-by":"publisher","unstructured":"De Villiers, C. & Riley, P. R. Mouse models of myocardial infarction: comparing permanent ligation and ischaemia-reperfusion. Dis. Model. Mech. 13 https:\/\/doi.org\/10.1242\/dmm.046565 (2020).","DOI":"10.1242\/dmm.046565"},{"key":"33936_CR83","doi-asserted-by":"publisher","first-page":"H1201","DOI":"10.1152\/ajpheart.00862.2003","volume":"286","author":"D Ahn","year":"2004","unstructured":"Ahn, D. et al. Induction of myocardial infarcts of a predictable size and location by branch pattern probability-assisted coronary ligation in C57BL\/6 mice. Am. J. Physiol. Heart Circ. Physiol. 286, H1201\u20131207. https:\/\/doi.org\/10.1152\/ajpheart.00862.2003 (2004).","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"33936_CR84","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1111\/bph.15595","volume":"179","author":"TP Martin","year":"2022","unstructured":"Martin, T. P. et al. Preclinical models of myocardial infarction: from mechanism to translation. Br. J. Pharmacol. 179, 770\u2013791. https:\/\/doi.org\/10.1111\/bph.15595 (2022).","journal-title":"Br. J. Pharmacol."},{"key":"33936_CR85","doi-asserted-by":"publisher","first-page":"192","DOI":"10.3109\/13813455.2012.705301","volume":"118","author":"B Houser","year":"2012","unstructured":"Houser, B. Bio-Rad\u2019s Bio-Plex\u00ae suspension array system, xMAP technology overview. Arch. Physiol. Biochem. 118, 192\u2013196. https:\/\/doi.org\/10.3109\/13813455.2012.705301 (2012).","journal-title":"Arch. Physiol. Biochem."},{"key":"33936_CR86","doi-asserted-by":"publisher","first-page":"2464","DOI":"10.1161\/ATVBAHA.111.231563","volume":"31","author":"T Quillard","year":"2011","unstructured":"Quillard, T. et al. Selective Inhibition of matrix metalloproteinase-13 increases collagen content of established mouse atherosclerosis. Arterioscler. Thromb. Vasc Biol. 31, 2464\u20132472. https:\/\/doi.org\/10.1161\/ATVBAHA.111.231563 (2011).","journal-title":"Arterioscler. Thromb. Vasc Biol."},{"key":"33936_CR87","doi-asserted-by":"publisher","first-page":"101113","DOI":"10.1016\/j.xpro.2021.101113","volume":"3","author":"MM Morales","year":"2022","unstructured":"Morales, M. M., Pedowitz, N. J. & Pratt, M. R. A 2D and 3D cell culture protocol to study O-GlcNAc in sphingosine-1-phosphate mediated fibroblast contraction. STAR. Protoc. 3, 101113. https:\/\/doi.org\/10.1016\/j.xpro.2021.101113 (2022).","journal-title":"STAR. Protoc."},{"key":"33936_CR88","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/978-1-0716-1924-7_9","volume":"2419","author":"KS Wadey","year":"2022","unstructured":"Wadey, K. S. et al. Monitoring cellular Proliferation, Migration, and apoptosis associated with atherosclerosis plaques in Vitro. Methods in molecular biology. (Clifton N J). 2419, 133\u2013167. https:\/\/doi.org\/10.1007\/978-1-0716-1924-7_9 (2022).","journal-title":"(Clifton N J)"},{"key":"33936_CR89","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1161\/ATVBAHA.116.307626","volume":"36","author":"H Williams","year":"2016","unstructured":"Williams, H. et al. Wnt2 and WISP-1\/CCN4 induce intimal thickening via promotion of smooth muscle cell migration. Arterioscler. Thromb. Vasc Biol. 36, 1417\u20131424. https:\/\/doi.org\/10.1161\/ATVBAHA.116.307626 (2016).","journal-title":"Arterioscler. Thromb. Vasc Biol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-33936-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-33936-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-33936-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T16:22:46Z","timestamp":1781626966000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-33936-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,9]]},"references-count":89,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["33936"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-33936-1","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,9]]},"assertion":[{"value":"4 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"3870"}}