{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T14:38:00Z","timestamp":1769783880636,"version":"3.49.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T00:00:00Z","timestamp":1767398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":26,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-34038-8","type":"journal-article","created":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T02:14:10Z","timestamp":1767492850000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fluid resuscitation practice in patients with acute pancreatitis in Danish intermediate and intensive care units - a retrospective cohort study"],"prefix":"10.1038","volume":"16","author":[{"given":"Johanne","family":"Lacoppidan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malou Woldbye","family":"Tholin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus Tjelle","family":"Kristiansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srdan","family":"Novovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morten H.","family":"Bestle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolai","family":"Haase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina","family":"Waldau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ditte Gry","family":"Strange","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theis Skovsgaard","family":"Itenov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,1,3]]},"reference":[{"key":"34038_CR1","doi-asserted-by":"publisher","first-page":"411","DOI":"10.3109\/00365529609006419","volume":"31","author":"FA Halvorsen","year":"1996","unstructured":"Halvorsen, F. A. & Ritland, S. Acute pancreatitis in Buskerud County, Norway. Incidence and etiology. Scand. J. Gastroenterol. 31, 411\u2013414 (1996).","journal-title":"Scand. J. Gastroenterol."},{"key":"34038_CR2","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1056\/NEJMe2209132","volume":"387","author":"TB Gardner","year":"2022","unstructured":"Gardner, T. B. Fluid resuscitation in acute pancreatitis - going over the WATERFALL. N Engl. J. Med. 387, 1038\u20131039 (2022).","journal-title":"N Engl. J. Med."},{"key":"34038_CR3","doi-asserted-by":"publisher","first-page":"2142","DOI":"10.1056\/NEJMcp054958","volume":"354","author":"DC Whitcomb","year":"2006","unstructured":"Whitcomb, D. C. Clinical practice. Acute pancreatitis. N Engl. J. Med. 354, 2142\u20132150 (2006).","journal-title":"N Engl. J. Med."},{"key":"34038_CR4","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1016\/j.pan.2021.07.003","volume":"21","author":"S Zhou","year":"2021","unstructured":"Zhou, S. et al. Comprehensive meta-analysis of randomized controlled trials of lactated ringer\u2019s versus normal saline for acute pancreatitis. Pancreatology 21, 1405\u20131410 (2021).","journal-title":"Pancreatology"},{"key":"34038_CR5","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1016\/j.cgh.2008.05.005","volume":"6","author":"TB Gardner","year":"2008","unstructured":"Gardner, T. B., Vege, S. S., Pearson, R. K. & Chari, S. T. Fluid resuscitation in acute pancreatitis. Clin. Gastroenterol. Hepatol. 6, 1070\u20131076 (2008).","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"34038_CR6","doi-asserted-by":"publisher","first-page":"2008","DOI":"10.1053\/j.gastro.2018.12.041","volume":"156","author":"PK Garg","year":"2019","unstructured":"Garg, P. K. & Singh, V. P. Organ failure due to systemic injury in acute pancreatitis. Gastroenterology 156, 2008\u20132023 (2019).","journal-title":"Gastroenterology"},{"key":"34038_CR7","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1016\/j.hpb.2021.06.426","volume":"23","author":"M Di Martino","year":"2021","unstructured":"Di Martino, M. et al. Systematic review and meta-analysis of fluid therapy protocols in acute pancreatitis: type, rate and route. HPB (Oxford). 23, 1629\u20131638 (2021).","journal-title":"HPB (Oxford)"},{"key":"34038_CR8","doi-asserted-by":"publisher","first-page":"2459","DOI":"10.1056\/NEJMoa2202707","volume":"386","author":"TS Meyhoff","year":"2022","unstructured":"Meyhoff, T. S. et al. Restriction of intravenous fluid in ICU patients with septic shock. N Engl. J. Med. 386, 2459\u20132470 (2022).","journal-title":"N Engl. J. Med."},{"key":"34038_CR9","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1007\/s00134-015-3822-1","volume":"41","author":"DC Angus","year":"2015","unstructured":"Angus, D. C. et al. A systematic review and meta-analysis of early goal-directed therapy for septic shock: the ARISE, process and promise investigators. Intensive Care Med. 41, 1549\u20131560 (2015).","journal-title":"Intensive Care Med."},{"key":"34038_CR10","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1056\/NEJMoa2202884","volume":"387","author":"E de-Madaria","year":"2022","unstructured":"de-Madaria, E. et al. Aggressive or moderate fluid resuscitation in acute pancreatitis. N Engl. J. Med. 387, 989\u20131000 (2022).","journal-title":"N Engl. J. Med."},{"key":"34038_CR11","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1016\/S0140-6736(07)61602-X","volume":"370","author":"E von Elm","year":"2007","unstructured":"von Elm, E. et al. The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet 370, 1453\u20131457 (2007).","journal-title":"Lancet"},{"key":"34038_CR12","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1136\/gutjnl-2012-302779","volume":"62","author":"PA Banks","year":"2013","unstructured":"Banks, P. A. et al. Classification of acute pancreatitis\u20132012: revision of the Atlanta classification and definitions by international consensus. Gut 62, 102\u2013111 (2013).","journal-title":"Gut"},{"issue":"Suppl 3","key":"34038_CR13","doi-asserted-by":"crossref","first-page":"iii1","DOI":"10.1136\/gut.2004.057026","volume":"54","author":"Working Party of the British Society of Gastroenterology","year":"2005","unstructured":"Working Party of the British Society of Gastroenterology. Association of surgeons of great Britain and Ireland, pancreatic society of great Britain and Ireland & association of upper GI surgeons of great Britain and Ireland. UK guidelines for the management of acute pancreatitis. Gut 54 (Suppl 3), iii1\u20139 (2005).","journal-title":"Gut"},{"key":"34038_CR14","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1007\/s00423-017-1581-x","volume":"402","author":"MJ Jones","year":"2017","unstructured":"Jones, M. J., Neal, C. P., Ngu, W. S., Dennison, A. R. & Garcea, G. Early warning score independently predicts adverse outcome and mortality in patients with acute pancreatitis. Langenbecks Arch. Surg. 402, 811\u2013819 (2017).","journal-title":"Langenbecks Arch. Surg."},{"key":"34038_CR15","first-page":"1","volume":"2","author":"J Kellum","year":"2012","unstructured":"Kellum, J. et al. KDIGO clinical practice guideline for acute kidney injury. Kidney Int. Supplements. 2, 1\u2013138 (2012).","journal-title":"Kidney Int. Supplements"},{"key":"34038_CR16","doi-asserted-by":"publisher","first-page":"2428","DOI":"10.1007\/s00268-013-2105-7","volume":"37","author":"MD Haydock","year":"2013","unstructured":"Haydock, M. D. et al. National survey of fluid therapy in acute pancreatitis: current practice lacks a sound evidence base. World J. Surg. 37, 2428\u20132435 (2013).","journal-title":"World J. Surg."},{"key":"34038_CR17","doi-asserted-by":"publisher","first-page":"1843","DOI":"10.1038\/ajg.2011.236","volume":"106","author":"E de-Madaria","year":"2011","unstructured":"de-Madaria, E. et al. Influence of fluid therapy on the prognosis of acute pancreatitis: a prospective cohort study. Am. J. Gastroenterol. 106, 1843\u20131850 (2011).","journal-title":"Am. J. Gastroenterol."},{"key":"34038_CR18","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1186\/s13054-015-1085-4","volume":"19","author":"N Wang","year":"2015","unstructured":"Wang, N. et al. Fluid balance and mortality in critically ill patients with acute kidney injury: a multicenter prospective epidemiological study. Crit. Care. 19, 371 (2015).","journal-title":"Crit. Care"},{"key":"34038_CR19","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1056\/NEJMoa2212663","volume":"388","author":"National Heart, Lung, and Blood Institute Prevention and Early Treatment of Acute Lung Injury Clinical Trials Network","year":"2023","unstructured":"National Heart, Lung, and Blood Institute Prevention and Early Treatment of Acute Lung Injury Clinical Trials Network. Early restrictive or Liberal fluid management for sepsis-induced hypotension. N Engl. J. Med. 388, 499\u2013510 (2023).","journal-title":"N Engl. J. Med."},{"key":"34038_CR20","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1186\/s13054-024-04952-w","volume":"28","author":"A Lind\u00e9n","year":"2024","unstructured":"Lind\u00e9n, A. et al. Protocolized reduction of non-resuscitation fluids versus usual care in septic shock patients (REDUSE): a randomized multicentre feasibility trial. Crit. Care. 28, 166 (2024).","journal-title":"Crit. Care"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-34038-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-34038-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-34038-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T22:02:55Z","timestamp":1769724175000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-34038-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,3]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["34038"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-34038-8","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,3]]},"assertion":[{"value":"1 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The study was retrospective and proved by the health board the capital region of Denmark. Nr. R-22074321 The need for individual patient consent was waived.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}],"article-number":"4006"}}