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Secondary outcomes included pain evolution, quality of life, pain interference, symptom progression, medication changes, and pain alerts. In this prospective clinical validation study, adult patients with cancer-related pain used a mobile device to log pain intensity, symptoms, and daily rescue medication. The system alerted clinicians to patients with elevated pain or a high number of rescue medications. Eighty-seven patients with different tumors were recruited (60.92% women; median age 63 years; range 27\u201394). Data recording adherence was 73.56%. Compared to baseline (5.49\u2009\u00b1\u20091.86), patients reported decreased pain 30 days (3.79\u2009\u00b1\u20092.48,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.0001), 45 days (4.18\u2009\u00b1\u20092.42,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.0001), and 60 days (3.82\u2009\u00b1\u20092.37,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.0001) after starting treatment. Patients with localized tumors reported poorer health and quality of life than those with metastasis (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.0001). Asthenia was the most frequent symptom. Daily rescue medication reporting increased at 46\u201360 days after inclusion (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.01). Physicians received a mean of 2.53\u2009\u00b1\u20093.89 alerts per week during the study. Ambulatory pain monitoring is feasible and allows remote assessment of patients\u2019 clinical status, which could improve pain management and overall care quality. In our study, gender and metastatic stage are the factors that most influence treatment adherence.\n                  <\/jats:p>","DOI":"10.1038\/s41598-025-34057-5","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T19:33:31Z","timestamp":1770060811000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Validation of a patient-based strategy for ambulatory monitoring of oncological pain by a mobile application"],"prefix":"10.1038","volume":"16","author":[{"given":"Marina","family":"Castillo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Casado-G\u00f3mez-Pallete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"L\u00e1zaro-Bail\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M.","family":"Iniesta-Chamorro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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The Funding section now reads \u201cThe study was funded by ISCIII, Ministry of Health (Project PI24\/00860), and co-funded by the European Union.\u201d The original article has been corrected.","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"5404"}}