{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T20:27:46Z","timestamp":1784233666805,"version":"3.55.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"vor","delay-in-days":22,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Royan Institute for Reproductive Biomedicine, ACECR, Iran","award":["401000042"],"award-info":[{"award-number":["401000042"]}]},{"name":"Royan Lotus Charity Foundation, Iran","award":["2447\/1400\/D"],"award-info":[{"award-number":["2447\/1400\/D"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-34202-0","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T09:04:20Z","timestamp":1770627860000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Administration of N-acetylcysteine influence the expression of apoptotic genes in the granulosa cells of infertile women diagnosed with endometriosis"],"prefix":"10.1038","volume":"16","author":[{"given":"Zahra Sadat","family":"Heshmati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Amiri-Yekta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Khosravifar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Akbarian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashraf","family":"Moini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poopak","family":"Eftekhari-Yazdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Hafezi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parvaneh","family":"Afsharian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,9]]},"reference":[{"issue":"13","key":"34202_CR1","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1056\/NEJMra1810764","volume":"382","author":"KT Zondervan","year":"2020","unstructured":"Zondervan, K. T., Becker, C. M. & Missmer, S. A. Endometriosis. N. Engl. J. Med. 382(13), 1244\u20131256 (2020).","journal-title":"N. Engl. J. Med."},{"key":"34202_CR2","doi-asserted-by":"publisher","first-page":"1382067","DOI":"10.3389\/fpsyg.2024.1382067","volume":"15","author":"S El Hadad","year":"2024","unstructured":"El Hadad, S. et al. Partnership and relationship happiness in endometriosis related chronic pelvic pain: A multicenter case-control study. Front. Psychol. 15, 1382067 (2024).","journal-title":"Front. Psychol."},{"issue":"8","key":"34202_CR3","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.3390\/biom12081055","volume":"12","author":"L Clower","year":"2022","unstructured":"Clower, L., Fleshman, T., Geldenhuys, W. J. & Santanam, N. targeting oxidative stress involved in endometriosis and its pain. Biomolecules 12(8), 1055 (2022).","journal-title":"Biomolecules"},{"issue":"5","key":"34202_CR4","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1016\/j.fertnstert.2009.09.035","volume":"94","author":"GD Adamson","year":"2010","unstructured":"Adamson, G. D. & Pasta, D. J. Endometriosis fertility index: The new, validated endometriosis staging system. Fertil. Steril. 94(5), 1609\u20131615 (2010).","journal-title":"Fertil. Steril."},{"key":"34202_CR5","unstructured":"Tsamantioti, E. S. & Mahdy, H. Endometriosis: Treasure Island (FL) (2022)."},{"issue":"2","key":"34202_CR6","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1093\/humrep\/dew293","volume":"32","author":"NP Johnson","year":"2017","unstructured":"Johnson, N. P. et al. World endometriosis society consensus on the classification of endometriosis. Hum. Reprod. 32(2), 315\u2013324 (2017).","journal-title":"Hum. Reprod."},{"issue":"13","key":"34202_CR7","doi-asserted-by":"publisher","first-page":"7138","DOI":"10.3390\/ijms22137138","volume":"22","author":"L Cacciottola","year":"2021","unstructured":"Cacciottola, L., Donnez, J. & Dolmans, M.-M. Can endometriosis-related oxidative stress pave the way for new treatment targets?. Int. J. Mol. Sci. 22(13), 7138 (2021).","journal-title":"Int. J. Mol. Sci."},{"key":"34202_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2021.106801","volume":"231","author":"LG Barrozo","year":"2021","unstructured":"Barrozo, L. G. et al. N-acetyl-cysteine and the control of oxidative stress during in vitro ovarian follicle growth, oocyte maturation, embryo development and cryopreservation. Anim. Reprod. Sci. 231, 106801 (2021).","journal-title":"Anim. Reprod. Sci."},{"issue":"6","key":"34202_CR9","doi-asserted-by":"publisher","first-page":"4686","DOI":"10.3390\/ijerph20064686","volume":"20","author":"E Anastasi","year":"2023","unstructured":"Anastasi, E. et al. Efficacy of N-acetylcysteine on endometriosis-related pain, size reduction of ovarian endometriomas, and fertility outcomes. Int. J. Environ. Res. Public Health 20(6), 4686 (2023).","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"34202_CR10","doi-asserted-by":"publisher","first-page":"711","DOI":"10.2147\/IJWH.S141021","volume":"9","author":"S Ekarattanawong","year":"2017","unstructured":"Ekarattanawong, S. et al. Possibility of using superoxide dismutase and glutathione peroxidase as endometriosis biomarkers. Int. J. Women\u2019s Health 9, 711\u2013716 (2017).","journal-title":"Int. J. Women\u2019s Health"},{"issue":"4","key":"34202_CR11","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14016","volume":"7","author":"G Jelodar","year":"2019","unstructured":"Jelodar, G. & Azimifar, A. Evaluation of serum cancer antigen 125, resistin, leptin, homocysteine, and total antioxidant capacity in rat model of endometriosis treated with Curcumin. Physiol. Rep. 7(4), e14016 (2019).","journal-title":"Physiol. Rep."},{"issue":"15","key":"34202_CR12","doi-asserted-by":"publisher","first-page":"25310","DOI":"10.18632\/oncotarget.15813","volume":"8","author":"H Yang","year":"2017","unstructured":"Yang, H., Xie, Y., Yang, D. & Ren, D. Oxidative stress-induced apoptosis in granulosa cells involves. Oncotarget 8(15), 25310\u201325322 (2017).","journal-title":"Oncotarget"},{"issue":"1","key":"34202_CR13","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2015.275","volume":"7","author":"S Baig","year":"2016","unstructured":"Baig, S. et al. Potential of apoptotic pathway-targeted cancer therapeutic research: Where do we stand?. Cell Death Dis. 7(1), e2058 (2016).","journal-title":"Cell Death Dis."},{"issue":"2","key":"34202_CR14","doi-asserted-by":"publisher","first-page":"205","DOI":"10.15171\/apb.2019.024","volume":"9","author":"R Jan","year":"2019","unstructured":"Jan, R. & Chaudhry, G. E. S. Understanding apoptosis and apoptotic pathways targeted cancer therapeutics. Adv. Pharm. Bull. 9(2), 205\u2013218 (2019).","journal-title":"Adv. Pharm. Bull."},{"issue":"1","key":"34202_CR15","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1002\/tox.22221","volume":"32","author":"JK Bhardwaj","year":"2017","unstructured":"Bhardwaj, J. K. & Saraf, P. N-acetyl cysteine-mediated effective attenuation of methoxychlor-induced granulosa cell apoptosis by counteracting reactive oxygen species generation in caprine ovary. Environ. Toxicol. 32(1), 156\u2013166 (2017).","journal-title":"Environ. Toxicol."},{"issue":"5","key":"34202_CR16","first-page":"3267","volume":"17","author":"L Vassilopoulou","year":"2019","unstructured":"Vassilopoulou, L. et al. Defining the genetic profile of endometriosis. Exp. Ther. Med. 17(5), 3267\u20133281 (2019).","journal-title":"Exp. Ther. Med."},{"key":"34202_CR17","doi-asserted-by":"publisher","first-page":"7265238","DOI":"10.1155\/2017\/7265238","volume":"2017","author":"G Scutiero","year":"2017","unstructured":"Scutiero, G. et al. Oxidative stress and endometriosis: A systematic review of the literature. Oxid. Med. Cell. Longev. 2017, 7265238 (2017).","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"10","key":"34202_CR18","doi-asserted-by":"publisher","first-page":"407","DOI":"10.3390\/toxins10100407","volume":"10","author":"J Wang","year":"2018","unstructured":"Wang, J. et al. Protective effect of N-acetylcysteine against oxidative stress induced by zearalenone via mitochondrial apoptosis pathway in SIEC02 cells. Toxins. 10(10), 407 (2018).","journal-title":"Toxins."},{"key":"34202_CR19","doi-asserted-by":"publisher","first-page":"4176170","DOI":"10.1155\/2017\/4176170","volume":"2017","author":"W Gao","year":"2017","unstructured":"Gao, W., Liang, J.-X., Ma, C., Dong, J. & Yan, Q. The protective effect of N-acetylcysteine on ionizing radiation induced ovarian failure and loss of ovarian reserve in female mouse. BioMed Res. Int.. 2017, 4176170 (2017).","journal-title":"BioMed Res. Int.."},{"issue":"4","key":"34202_CR20","doi-asserted-by":"publisher","first-page":"740","DOI":"10.7150\/ijms.69807","volume":"19","author":"P Yu","year":"2022","unstructured":"Yu, P. et al. N-acetylcysteine ameliorates vancomycin-induced nephrotoxicity by inhibiting oxidative stress and apoptosis in the in vivo and in vitro models. Int. J. Med. Sci. 19(4), 740\u2013752 (2022).","journal-title":"Int. J. Med. Sci."},{"issue":"10","key":"34202_CR21","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1071\/RD22020","volume":"34","author":"L Fan","year":"2022","unstructured":"Fan, L. et al. N-acetylcysteine improves oocyte quality through modulating the Nrf2 signaling pathway to ameliorate oxidative stress caused by repeated controlled ovarian hyperstimulation. Reprod. Fertil. Dev. 34(10), 736\u2013750 (2022).","journal-title":"Reprod. Fertil. Dev."},{"key":"34202_CR22","doi-asserted-by":"publisher","first-page":"6298","DOI":"10.3390\/ijms25126298","volume":"25","author":"I Dymanowska-Dyjak","year":"2024","unstructured":"Dymanowska-Dyjak, I., Frankowska, K., Abramiuk, M. & Polak, G. Oxidative imbalance in endometriosis-related infertility\u2014The therapeutic role of antioxidants. Int. J. Mol. Sci. 25, 6298 (2024).","journal-title":"Int. J. Mol. Sci."},{"key":"34202_CR23","doi-asserted-by":"publisher","first-page":"100","DOI":"10.4103\/abr.abr_157_17","volume":"7","author":"F Mostajeran","year":"2018","unstructured":"Mostajeran, F., Ghasemi Tehrani, H. & Rahbary, B. N-acetylcysteine as an adjuvant to letrozole for induction of ovulation in infertile patients with polycystic ovary syndrome. Adv. Biomed. Res. 7, 100 (2018).","journal-title":"Adv. Biomed. Res."},{"key":"34202_CR24","doi-asserted-by":"publisher","first-page":"34","DOI":"10.55561\/ajhr.v2i1.83","volume":"2","author":"A Wicaksana","year":"2023","unstructured":"Wicaksana, A., Dwijayasa, P., Rahajeng, R. & Riskianto, C. Comparative study of BAX\/BcL2 expression ratio in menstrual blood between endometriosis women and women without endometriosis. Asian J. Health Res. 2, 34\u201337 (2023).","journal-title":"Asian J. Health Res."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-34202-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-34202-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-34202-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T22:01:37Z","timestamp":1772575297000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-34202-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,9]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["34202"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-34202-0","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,9]]},"assertion":[{"value":"16 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The study was conducted in accordance with the Declaration of Helsinki, and approved by the Research Ethics Committee of the Royan Institute (Code No.: IR.ACECR.ROYAN.REC.1398.111).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Institutional review board statement"}},{"value":"Informed consent was obtained from all subjects involved in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}],"article-number":"7961"}}