{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T10:43:16Z","timestamp":1782988996633,"version":"3.54.5"},"reference-count":103,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":21,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5R01EY036002"],"award-info":[{"award-number":["5R01EY036002"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-34243-5","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T17:05:27Z","timestamp":1767978327000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Soluble guanylate cyclase deficiency drives retinal ganglion cell neurodegeneration with age in female mice through disrupted oxidative metabolism"],"prefix":"10.1038","volume":"16","author":[{"given":"Olivia L.","family":"Bossardet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin L.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sequoia","family":"Wade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia A.","family":"Snyder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shane","family":"Mecca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph M.","family":"Holden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elio","family":"Almaoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rucha","family":"Konety","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghazi O. Bou","family":"Ghanem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina D.","family":"Korobkina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonia S.","family":"Rex","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren K.","family":"Wareham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,9]]},"reference":[{"key":"34243_CR1","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1007\/978-3-540-68964-5_23","volume":"191)","author":"U Walter","year":"2009","unstructured":"Walter, U. & Gambaryan, S. cGMP and cGMP-dependent protein kinase in platelets and blood cells. Handb. Exp. Pharmacol. 191), 533\u2013548 (2009).","journal-title":"Handb. Exp. Pharmacol."},{"issue":"3","key":"34243_CR2","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1002\/1097-4652(200009)184:3<409::AID-JCP16>3.0.CO;2-K","volume":"184","author":"JA Carvajal","year":"2000","unstructured":"Carvajal, J. A., Germain, A. M., Huidobro-Toro, J. P. & Weiner, C. P. Molecular mechanism of cGMP-mediated smooth muscle relaxation. J. Cell. Physiol. 184 (3), 409\u2013420 (2000).","journal-title":"J. Cell. Physiol."},{"issue":"6000","key":"34243_CR3","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1038\/313310a0","volume":"313","author":"EE Fesenko","year":"1985","unstructured":"Fesenko, E. E., Kolesnikov, S. S. & Lyubarsky, A. L. Induction by Cyclic GMP of cationic conductance in plasma membrane of retinal rod outer segment. Nature 313 (6000), 310\u2013313 (1985).","journal-title":"Nature"},{"key":"34243_CR4","doi-asserted-by":"crossref","unstructured":"Wareham, L. K. et al. Increased bioavailability of Cyclic guanylate monophosphate prevents retinal ganglion cell degeneration. Neurobiol Dis, 121, 65-75 (2018).","DOI":"10.1016\/j.nbd.2018.09.002"},{"key":"34243_CR5","doi-asserted-by":"publisher","first-page":"174987","DOI":"10.1016\/j.ejphar.2022.174987","volume":"925","author":"JY You","year":"2022","unstructured":"You, J. Y. et al. A novel phosphodiesterase 9A inhibitor LW33 protects against ischemic stroke through the cGMP\/PKG\/CREB pathway. Eur. J. Pharmacol. 925, 174987 (2022).","journal-title":"Eur. J. Pharmacol."},{"key":"34243_CR6","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.nbd.2018.01.002","volume":"113","author":"A Mancini","year":"2018","unstructured":"Mancini, A. et al. Microglial activation and the nitric oxide\/cGMP\/PKG pathway underlie enhanced neuronal vulnerability to mitochondrial dysfunction in experimental multiple sclerosis. Neurobiol. Dis. 113, 97\u2013108 (2018).","journal-title":"Neurobiol. Dis."},{"key":"34243_CR7","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.neulet.2018.04.026","volume":"676","author":"DE Kouzoukas","year":"2018","unstructured":"Kouzoukas, D. E., Bhalla, R. C. & Pantazis, N. J. Activation of Cyclic GMP-dependent protein kinase blocks alcohol-mediated cell death and calcium disruption in cerebellar granule neurons. Neurosci. Lett. 676, 108\u2013112 (2018).","journal-title":"Neurosci. Lett."},{"issue":"4","key":"34243_CR8","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1111\/cns.12834","volume":"24","author":"A Cardinale","year":"2018","unstructured":"Cardinale, A. & Fusco, F. R. Inhibition of phosphodiesterases as a strategy to achieve neuroprotection in huntington\u2019s disease. CNS Neurosci. Ther. 24 (4), 319\u2013328 (2018).","journal-title":"CNS Neurosci. Ther."},{"issue":"1","key":"34243_CR9","doi-asserted-by":"publisher","first-page":"61","DOI":"10.3390\/ph14010061","volume":"14","author":"E Fedele","year":"2021","unstructured":"Fedele, E. & Ricciarelli, R. Memory enhancers for alzheimer\u2019s dementia: focus on cGMP. Pharmaceuticals 14 (1), 61 (2021).","journal-title":"Pharmaceuticals"},{"issue":"7","key":"34243_CR10","doi-asserted-by":"publisher","first-page":"2325","DOI":"10.1523\/JNEUROSCI.16-07-02325.1996","volume":"16","author":"SE Farinelli","year":"1996","unstructured":"Farinelli, S. E., Park, D. S. & Greene, L. A. Nitric oxide delays the death of trophic factor-deprived PC12 cells and sympathetic neurons by a cGMP-mediated mechanism. J. Neurosci. 16 (7), 2325\u20132334 (1996).","journal-title":"J. Neurosci."},{"issue":"36","key":"34243_CR11","doi-asserted-by":"publisher","first-page":"21898","DOI":"10.1074\/jbc.271.36.21898","volume":"271","author":"DS Park","year":"1996","unstructured":"Park, D. S., Stefanis, L., Yan, C. Y. I., Farinelli, S. E. & Greene, L. A. Ordering the cell death pathway: differential effects of bcl2, an interleukin-1-converting enzyme family protease inhibitor, and other survival agents on Jnk activation in serum\/nerve growth factor-deprived pc12 cells *. J. Biol. Chem. 271 (36), 21898\u201321905 (1996).","journal-title":"J. Biol. Chem."},{"key":"34243_CR12","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1146\/annurev.cb.11.110195.002221","volume":"11","author":"SR Jaffrey","year":"1995","unstructured":"Jaffrey, S. R. & Snyder, S. H. Nitric oxide: a neural messenger. Annu. Rev. Cell. Dev. Biol. 11, 417\u2013440 (1995).","journal-title":"Annu. Rev. Cell. Dev. Biol."},{"issue":"4162","key":"34243_CR13","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1126\/science.186.4162.449","volume":"186","author":"DB Farber","year":"1974","unstructured":"Farber, D. B. & Lolley, R. N. Cyclic Guanosine monophosphate: elevation in degenerating photoreceptor cells of the C3H mouse retina. Science 186 (4162), 449\u2013451 (1974).","journal-title":"Science"},{"issue":"6","key":"34243_CR14","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1111\/jnc.15251","volume":"157","author":"M Rasmussen","year":"2021","unstructured":"Rasmussen, M., Welinder, C., Schwede, F. & andEkstr\u00f6m The cGMP system in normal and degenerating mouse neuroretina: new proteins with cGMP interaction potential identified by a proteomics approach. J. Neurochem. 157 (6), 2173\u20132186 (2021).","journal-title":"J. Neurochem."},{"key":"34243_CR15","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1146\/annurev-biochem-050410-100030","volume":"81","author":"ER Derbyshire","year":"2012","unstructured":"Derbyshire, E. R. & Marletta, M. A. Structure and regulation of soluble guanylate cyclase. Annu. Rev. Biochem. 81, 533\u2013559 (2012).","journal-title":"Annu. Rev. Biochem."},{"key":"34243_CR16","doi-asserted-by":"publisher","first-page":"1007768","DOI":"10.3389\/fmolb.2022.1007768","volume":"9","author":"G Wu","year":"2022","unstructured":"Wu, G., Sharina, I. & Martin, E. Soluble Guanylyl cyclase: molecular basis for ligand selectivity and action in vitro and in vivo. Front. Mol. Biosci. 9, 1007768 (2022).","journal-title":"Front. Mol. Biosci."},{"key":"34243_CR17","doi-asserted-by":"crossref","unstructured":"Jehle, A. & Garaschuk, O. The Interplay between cGMP and Calcium Signaling in Alzheimer\u2019s Disease. Int J. Mol. Sci, 23(13), 7048 (2022).","DOI":"10.3390\/ijms23137048"},{"issue":"4","key":"34243_CR18","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1111\/nan.12203","volume":"41","author":"A Ugarte","year":"2015","unstructured":"Ugarte, A. et al. Decreased levels of Guanosine 3\u2019, 5\u2019-monophosphate (cGMP) in cerebrospinal fluid (CSF) are associated with cognitive decline and amyloid pathology in alzheimer\u2019s disease. Neuropathol. Appl. Neurobiol. 41 (4), 471\u2013482 (2015).","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"34243_CR19","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/1750-1326-6-60","volume":"6","author":"S Pugazhenthi","year":"2011","unstructured":"Pugazhenthi, S., Wang, M., Pham, S., Sze, C. I. & Eckman, C. B. Downregulation of CREB expression in alzheimer\u2019s brain and in Abeta-treated rat hippocampal neurons. Mol. Neurodegener. 6, 60 (2011).","journal-title":"Mol. Neurodegener"},{"key":"34243_CR20","doi-asserted-by":"crossref","unstructured":"Saavedra, A., Giralt, A., Arumi, H., Alberch, J. & Perez-Navarro, E. Regulation of hippocampal cGMP levels as a candidate to treat cognitive deficits in Huntington\u2019s disease. PLoS One, 8(9),e73664. (2013).","DOI":"10.1371\/journal.pone.0073664"},{"issue":"6","key":"34243_CR21","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1016\/j.neuron.2016.10.064","volume":"92","author":"V Beaumont","year":"2016","unstructured":"Beaumont, V. et al. Phosphodiesterase 10A Inhibition improves Cortico-Basal ganglia function in huntington\u2019s disease models. Neuron 92 (6), 1220\u20131237 (2016).","journal-title":"Neuron"},{"key":"34243_CR22","doi-asserted-by":"crossref","unstructured":"Wareham, L. K., Buys, E. S. & Sappington, R. M. The nitric oxide-guanylate cyclase pathway and glaucoma. Nitric Oxide, 77, 75-87 (2018).","DOI":"10.1016\/j.niox.2018.04.010"},{"issue":"6","key":"34243_CR23","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.4103\/1673-5374.360169","volume":"18","author":"JM Holden","year":"2023","unstructured":"Holden, J. M. & Wareham, L. K. cGMP signaling: a potential therapeutic target for neurodegeneration in glaucoma? Neural Regen Res. 18 (6), 1267\u20131268 (2023).","journal-title":"Neural Regen Res."},{"key":"34243_CR24","doi-asserted-by":"crossref","unstructured":"Holden, J. M. et al. Dysfunctional cGMP signaling leads to Age-Related retinal vascular alterations and astrocyte remodeling in mice. Int J. Mol. Sci, 23(6), 3066 (2022).","DOI":"10.3390\/ijms23063066"},{"key":"34243_CR25","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s12035-010-8104-x","volume":"41","author":"KU Domek-\u0141opaci\u0144ska","year":"2010","unstructured":"Domek-\u0141opaci\u0144ska, K. U. & Strosznajder, J. B. Cyclic GMP and nitric oxide synthase in aging and alzheimer\u2019s disease. Mol. Neurobiol. 41, 129\u2013137 (2010).","journal-title":"Mol. Neurobiol."},{"issue":"1\u20132","key":"34243_CR26","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/S0006-8993(01)02588-4","volume":"907","author":"C Ibarra","year":"2001","unstructured":"Ibarra, C., Nedvetsky, P. I., Gerlach,Riederer, M. & Schmidt, H. H. Regional and age-dependent expression of the nitric oxide receptor, soluble Guanylyl cyclase, in the human brain. Brain Res. 907 (1\u20132), 54\u201360 (2001).","journal-title":"Brain Res."},{"key":"34243_CR27","doi-asserted-by":"crossref","unstructured":"Hesse, R. et al. Reduced cGMP levels in CSF of AD patients correlate with severity of dementia and current depression. Alzheimer\u2019s Research & Therapy, 9(1),17. (2017).","DOI":"10.1186\/s13195-017-0245-y"},{"key":"34243_CR28","unstructured":"WHO. Blindness and vision impairment prevention: Priority eye diseases: Glaucoma. April 8, 2020]; Available from: https:\/\/www.who.int\/blindness\/causes\/priority\/en\/index6.html.\u00a0(2020)."},{"key":"34243_CR29","doi-asserted-by":"crossref","unstructured":"Tham, Y. C. et al. Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis. Ophthalmology, 121(11), 2081\u201390 (2014).","DOI":"10.1016\/j.ophtha.2014.05.013"},{"key":"34243_CR30","doi-asserted-by":"crossref","unstructured":"Calkins, D. J. Adaptive responses to neurodegenerative stress in glaucoma. Prog Retin Eye Res, 84, 100953. (2021).","DOI":"10.1016\/j.preteyeres.2021.100953"},{"issue":"2","key":"34243_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1167\/tvst.4.2.1","volume":"4","author":"R Susanna Jr","year":"2015","unstructured":"Susanna, R. Jr., De Moraes, C. G., Cioffi, G. A. & Ritch, R. Why do people (Still) go blind from glaucoma? Transl Vis. Sci. Technol. 4 (2), 1 (2015).","journal-title":"Transl Vis. Sci. Technol."},{"issue":"6","key":"34243_CR32","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1136\/bjo.2003.028357","volume":"88","author":"F Galassi","year":"2004","unstructured":"Galassi, F. et al. Nitric oxide proxies and ocular perfusion pressure in primary open angle glaucoma. Br. J. Ophthalmol. 88 (6), 757\u2013760 (2004).","journal-title":"Br. J. Ophthalmol."},{"key":"34243_CR33","doi-asserted-by":"crossref","unstructured":"Buys, E. S. et al. Soluble guanylate cyclase alpha1-deficient mice: a novel murine model for primary open angle glaucoma. PloS one, 8(3),2013.e60156.","DOI":"10.1371\/journal.pone.0060156"},{"issue":"9","key":"34243_CR34","doi-asserted-by":"publisher","first-page":"3221","DOI":"10.1167\/iovs.05-0368","volume":"46","author":"JF Logan","year":"2005","unstructured":"Logan, J. F. et al. Evidence for association of endothelial nitric oxide synthase gene in subjects with glaucoma and a history of migraine. Invest. Ophthalmol. Vis. Sci. 46 (9), 3221\u20133226 (2005).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"2","key":"34243_CR35","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1167\/iovs.09-4266","volume":"51","author":"JH Kang","year":"2010","unstructured":"Kang, J. H. et al. Endothelial nitric oxide synthase gene variants and primary open-angle glaucoma: interactions with sex and postmenopausal hormone use. Invest. Ophthalmol. Vis. Sci. 51 (2), 971\u2013979 (2010).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"1","key":"34243_CR36","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1093\/cvr\/cvn068","volume":"79","author":"ES Buys","year":"2008","unstructured":"Buys, E. S. et al. Gender-specific hypertension and responsiveness to nitric oxide in sGC[alpha]1 knockout mice. Cardiovasc. Res. 79 (1), 179\u2013186 (2008).","journal-title":"Cardiovasc. Res."},{"issue":"8","key":"34243_CR37","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1161\/CIRCULATIONAHA.106.677245","volume":"116","author":"P Vermeersch","year":"2007","unstructured":"Vermeersch, P. et al. Soluble guanylate cyclase-alpha1 deficiency selectively inhibits the pulmonary vasodilator response to nitric oxide and increases the pulmonary vascular remodeling response to chronic hypoxia. Circulation 116 (8), 936\u2013943 (2007).","journal-title":"Circulation"},{"issue":"Pt 3","key":"34243_CR38","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1113\/jphysiol.2007.140608","volume":"584","author":"G Vanneste","year":"2007","unstructured":"Vanneste, G., Dhaese,Sips, I., Buys,Brouckaert, E. & Lefebvre, R. A. Gastric motility in soluble guanylate cyclase alpha 1 knock-out mice. J. Physiol. 584 (Pt 3), 907\u2013920 (2007).","journal-title":"J. Physiol."},{"key":"34243_CR39","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/978-1-4939-7407-8_3","volume":"1695","author":"DJ Calkins","year":"2018","unstructured":"Calkins, D. J., Lambert, W. S., Formichella, C. R., McLaughlin, W. M. & Sappington, R. M. The microbead occlusion model of ocular hypertension in mice. Methods Mol. Biol. 1695, 23\u201339 (2018).","journal-title":"Methods Mol. Biol."},{"issue":"9","key":"34243_CR40","doi-asserted-by":"publisher","first-page":"3161","DOI":"10.1523\/JNEUROSCI.4089-13.2014","volume":"34","author":"NJ Ward","year":"2014","unstructured":"Ward, N. J., Ho, K. W., Lambert, W. S., Weitlauf, C. & Calkins, D. J. Absence of transient receptor potential vanilloid-1 accelerates stress-induced axonopathy in the optic projection. J. Neurosci. 34 (9), 3161\u20133170 (2014).","journal-title":"J. Neurosci."},{"key":"34243_CR41","doi-asserted-by":"crossref","unstructured":"Ribeiro, M. et al. Intraocular delivery of a collagen mimetic peptide repairs retinal ganglion cell axons in chronic and acute injury models. Int J. Mol. Sci, 23(6), 2911 (2022).","DOI":"10.3390\/ijms23062911"},{"key":"34243_CR42","doi-asserted-by":"publisher","first-page":"764709","DOI":"10.3389\/fphar.2021.764709","volume":"12","author":"NR McGrady","year":"2021","unstructured":"McGrady, N. R. et al. Restoring the extracellular matrix: a neuroprotective role for collagen mimetic peptides in experimental glaucoma. Front. Pharmacol. 12, 764709 (2021).","journal-title":"Front. Pharmacol."},{"issue":"7","key":"34243_CR43","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nmeth.2019","volume":"9","author":"J Schindelin","year":"2012","unstructured":"Schindelin, J. et al. Fiji: an open-source platform for biological-image analysis. Nat. Methods. 9 (7), 676\u2013682 (2012).","journal-title":"Nat. Methods"},{"key":"34243_CR44","doi-asserted-by":"crossref","unstructured":"Masin, L. et al. A novel retinal ganglion cell quantification tool based on deep learning. Scientific reports, 11(1),702. (2021).","DOI":"10.1038\/s41598-020-80308-y"},{"key":"34243_CR45","doi-asserted-by":"crossref","unstructured":"Bossardet, O. L., Holden, J. M. & Wareham, L. K. Measuring uptake of the glucose Analog, 6-(N-(7-Nitrobenz-2-Oxa-1,3-Diazol-4-yl)Amino)-6-Deoxyglucose, in intact murine neural retina. J Vis. Exp, 217 (2025).","DOI":"10.3791\/67921"},{"key":"34243_CR46","doi-asserted-by":"crossref","unstructured":"Holden, J. M., Bossardet, O. L., Bou Ghanem, G., Calkins, D. J. & Wareham, L. K. Chronic hyperglycemia alters retinal astrocyte microstructure and uptake of cholera toxin B in a murine model of diabetes. Journal of Neurochemistry, 169(1),2025.e16237.","DOI":"10.1111\/jnc.16237"},{"issue":"13","key":"34243_CR47","doi-asserted-by":"publisher","first-page":"8428","DOI":"10.1167\/iovs.15-17901","volume":"56","author":"K Kooragayala","year":"2015","unstructured":"Kooragayala, K. et al. Quantification of oxygen consumption in retina ex vivo demonstrates limited reserve capacity of photoreceptor mitochondria. Investig. Ophthalmol. Vis. Sci. 56 (13), 8428\u20138436 (2015).","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"46","key":"34243_CR48","doi-asserted-by":"publisher","first-page":"15369","DOI":"10.1523\/JNEUROSCI.3424-14.2014","volume":"34","author":"C Weitlauf","year":"2014","unstructured":"Weitlauf, C. et al. Short-term increases in transient receptor potential vanilloid-1 mediate stress-induced enhancement of neuronal excitation. J. Neurosci. 34 (46), 15369\u201315381 (2014).","journal-title":"J. Neurosci."},{"key":"34243_CR49","doi-asserted-by":"crossref","unstructured":"Buys, E. S. et al. sGC\u03b11-deficient mice: a novel murine model of spontaneous primary open angle glaucoma. BMC Pharmacology, 11 (Suppl 1)(2011.P13.","DOI":"10.1186\/1471-2210-11-S1-P13"},{"issue":"6","key":"34243_CR50","doi-asserted-by":"publisher","first-page":"109916","DOI":"10.1016\/j.isci.2024.109916","volume":"27","author":"J Li","year":"2024","unstructured":"Li, J. et al. Comprehensive single-cell atlas of the mouse retina. iScience 27 (6), 109916 (2024).","journal-title":"iScience"},{"issue":"10","key":"34243_CR51","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1080\/00207454.2020.1713776","volume":"130","author":"M Bandookwala","year":"2020","unstructured":"Bandookwala, M. & andSengupta 3-Nitrotyrosine: a versatile oxidative stress biomarker for major neurodegenerative diseases. Int. J. Neurosci. 130 (10), 1047\u20131062 (2020).","journal-title":"Int. J. Neurosci."},{"issue":"17","key":"34243_CR52","doi-asserted-by":"publisher","first-page":"7797","DOI":"10.1073\/pnas.88.17.7797","volume":"88","author":"TM Dawson","year":"1991","unstructured":"Dawson, T. M., Bredt, D. S., Fotuhi, M., Hwang, P. M. & Snyder, S. H. Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues. Proc. Natl. Acad. Sci. U S A. 88 (17), 7797\u20137801 (1991).","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"issue":"3\u20134","key":"34243_CR53","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/S0891-5849(00)00308-7","volume":"29","author":"S Chen","year":"2000","unstructured":"Chen, S., Wu, K. & Knox, R. Structure-function studies of DT-diaphorase (NQO1) and NRH: Quinone oxidoreductase (NQO2). Free Radic Biol. Med. 29 (3\u20134), 276\u2013284 (2000).","journal-title":"Free Radic Biol. Med."},{"key":"34243_CR54","doi-asserted-by":"crossref","unstructured":"Wang, F. et al. Fundamental mechanisms of the cell death caused by nitrosative stress. Frontiers Cell. Dev. Biology, 9, 742483(2021).","DOI":"10.3389\/fcell.2021.742483"},{"issue":"2","key":"34243_CR55","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s12035-010-8113-9","volume":"41","author":"Z Gu","year":"2010","unstructured":"Gu, Z., Nakamura, T. & Lipton, S. A. Redox reactions induced by nitrosative stress mediate protein misfolding and mitochondrial dysfunction in neurodegenerative diseases. Mol. Neurobiol. 41 (2), 55\u201372 (2010).","journal-title":"Mol. Neurobiol."},{"issue":"5608","key":"34243_CR56","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1126\/science.1079368","volume":"299","author":"E Nisoli","year":"2003","unstructured":"Nisoli, E. et al. Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide. Science 299 (5608), 896\u2013899 (2003).","journal-title":"Science"},{"issue":"6","key":"34243_CR57","doi-asserted-by":"publisher","first-page":"2316","DOI":"10.1172\/JCI60119","volume":"122","author":"ES Buys","year":"2012","unstructured":"Buys, E. S. et al. Genetic modifiers of hypertension in soluble guanylate cyclase alpha1-deficient mice. J. Clin. Invest. 122 (6), 2316\u20132325 (2012).","journal-title":"J. Clin. Invest."},{"key":"34243_CR58","doi-asserted-by":"crossref","unstructured":"Ratko, M., Crljen, V. & Tkal\u010di\u0107, M. A. Ma\u017eurani\u0107,Bubalo,\u0160kavi\u0107, et al., Expression of guanylate cyclase C in human prefrontal cortex depends on sex and feeding status. Front Mol Neurosci, 171361089. (2024).","DOI":"10.3389\/fnmol.2024.1361089"},{"key":"34243_CR59","doi-asserted-by":"publisher","first-page":"854321","DOI":"10.3389\/fmolb.2022.854321","volume":"9","author":"B Ebanks","year":"2022","unstructured":"Ebanks, B. & Chakrabarti, L. Mitochondrial ATP synthase is a target of oxidative stress in neurodegenerative diseases. Front. Mol. Biosci. 9, 854321 (2022).","journal-title":"Front. Mol. Biosci."},{"key":"34243_CR60","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.mito.2023.05.007","volume":"71","author":"T Alqahtani","year":"2023","unstructured":"Alqahtani, T. et al. Mitochondrial dysfunction and oxidative stress in alzheimer\u2019s disease, and parkinson\u2019s disease, huntington\u2019s disease and amyotrophic lateral sclerosis-an updated review. Mitochondrion 71, 83\u201392 (2023).","journal-title":"Mitochondrion"},{"issue":"11","key":"34243_CR61","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1038\/s41580-024-00757-5","volume":"25","author":"RA Nixon","year":"2024","unstructured":"Nixon, R. A. & Rubinsztein, D. C. Mechanisms of autophagy\u2013lysosome dysfunction in neurodegenerative diseases. Nat. Rev. Mol. Cell Biol. 25 (11), 926\u2013946 (2024).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"4","key":"34243_CR62","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1038\/s41573-024-01105-0","volume":"24","author":"O Antico","year":"2025","unstructured":"Antico, O., Thompson, P. W., Hertz, N. T., Muqit, M. M. & Parton, L. E. Targeting mitophagy in neurodegenerative diseases. Nat. Rev. Drug Discovery. 24 (4), 276\u2013299 (2025).","journal-title":"Nat. Rev. Drug Discovery"},{"issue":"4","key":"34243_CR63","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1002\/jnr.490420404","volume":"42","author":"F Maher","year":"1995","unstructured":"Maher, F. Immunolocalization of GLUT1 and GLUT3 glucose transporters in primary cultured neurons and glia. J. Neurosci. Res. 42 (4), 459\u2013469 (1995).","journal-title":"J. Neurosci. Res."},{"issue":"1","key":"34243_CR64","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1007\/s00018-021-04074-4","volume":"79","author":"YT Nguyen","year":"2022","unstructured":"Nguyen, Y. T., Ha, H. T., Nguyen, T. H. & Nguyen, L. N. The role of SLC transporters for brain health and disease. Cell. Mol. Life Sci. 79 (1), 20 (2022).","journal-title":"Cell. Mol. Life Sci."},{"key":"34243_CR65","doi-asserted-by":"publisher","first-page":"656000","DOI":"10.3389\/fnmol.2021.656000","volume":"14","author":"FO Viegas","year":"2021","unstructured":"Viegas, F. O. & Neuhauss, S. C. A metabolic landscape for maintaining retina integrity and function. Front. Mol. Neurosci. 14, 656000 (2021).","journal-title":"Front. Mol. Neurosci."},{"issue":"4","key":"34243_CR66","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1002\/(SICI)1520-7560(199907\/08)15:4<261::AID-DMRR43>3.0.CO;2-Z","volume":"15","author":"AK Kumagai","year":"1999","unstructured":"Kumagai, A. K. Glucose transport in brain and retina: implications in the management and complications of diabetes. Diab.\/Metab. Res. Rev. 15 (4), 261\u2013273 (1999).","journal-title":"Diab.\/Metab. Res. Rev."},{"issue":"4","key":"34243_CR67","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1111\/j.1471-4159.2006.04088.x","volume":"99","author":"A Tabernero","year":"2006","unstructured":"Tabernero, A., Medina, J. M. & Giaume, C. Glucose metabolism and proliferation in glia: role of astrocytic gap junctions. J. Neurochem. 99 (4), 1049\u20131061 (2006).","journal-title":"J. Neurochem."},{"issue":"41","key":"34243_CR68","doi-asserted-by":"publisher","first-page":"14937","DOI":"10.1073\/pnas.0405315101","volume":"101","author":"Y Bernardinelli","year":"2004","unstructured":"Bernardinelli, Y., Magistretti, P. J. & Chatton, J. Y. Astrocytes generate Na+-mediated metabolic waves. Proc. Natl. Acad. Sci. U S A. 101 (41), 14937\u201314942 (2004).","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"issue":"4","key":"34243_CR69","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1038\/nn.3966","volume":"18","author":"EA Winkler","year":"2015","unstructured":"Winkler, E. A. et al. GLUT1 reductions exacerbate alzheimer\u2019s disease vasculo-neuronal dysfunction and degeneration. Nat. Neurosci. 18 (4), 521\u2013530 (2015).","journal-title":"Nat. Neurosci."},{"key":"34243_CR70","doi-asserted-by":"publisher","first-page":"263310552110115","DOI":"10.1177\/26331055211011507","volume":"16","author":"M Tang","year":"2021","unstructured":"Tang, M. & Monani, U. R. Glut1 deficiency syndrome: new and emerging insights into a prototypical brain energy failure disorder. Neurosci. Insights. 16, 26331055211011507 (2021).","journal-title":"Neurosci. Insights"},{"key":"34243_CR71","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.bbrc.2020.12.067","volume":"540","author":"K G\u0142uchowska","year":"2021","unstructured":"G\u0142uchowska, K., Pliszka, M. & Szablewski, L. Expression of glucose transporters in human neurodegenerative diseases. Biochem. Biophys. Res. Commun. 540, 8\u201315 (2021).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"34243_CR72","doi-asserted-by":"crossref","unstructured":"Correia, S. S. et al. The CNS-penetrant soluble guanylate cyclase stimulator CYR119 attenuates markers of inflammation in the central nervous system. J Neuroinflammation, 18(1),213. (2021).","DOI":"10.1186\/s12974-021-02275-z"},{"issue":"4","key":"34243_CR73","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1002\/cne.21206","volume":"500","author":"JD Ding","year":"2007","unstructured":"Ding, J. D. & Weinberg, R. J. Distribution of soluble Guanylyl cyclase in rat retina. J. Comp. Neurol. 500 (4), 734\u2013745 (2007).","journal-title":"J. Comp. Neurol."},{"issue":"3","key":"34243_CR74","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1096\/fj.02-0359fje","volume":"17","author":"M Kajimura","year":"2003","unstructured":"Kajimura, M. et al. Visualization of gaseous monoxide reception by soluble guanylate cyclase in the rat retina. Faseb J. 17 (3), 506\u2013508 (2003).","journal-title":"Faseb J."},{"issue":"2","key":"34243_CR75","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1210\/en.2017-00863","volume":"159","author":"Y Tian","year":"2017","unstructured":"Tian, Y. et al. cGMP\/PKG-I Pathway\u2013Mediated GLUT1\/4 regulation by NO in female rat granulosa cells. Endocrinology 159 (2), 1147\u20131158 (2017).","journal-title":"Endocrinology"},{"issue":"8","key":"34243_CR76","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1007\/s00204-015-1520-y","volume":"89","author":"DC Liemburg-Apers","year":"2015","unstructured":"Liemburg-Apers, D. C., Willems, P. H. G. M., Koopman, W. J. H. & Grefte, S. Interactions between mitochondrial reactive oxygen species and cellular glucose metabolism. Arch. Toxicol. 89 (8), 1209\u20131226 (2015).","journal-title":"Arch. Toxicol."},{"issue":"30","key":"34243_CR77","doi-asserted-by":"publisher","first-page":"18982","DOI":"10.1074\/jbc.272.30.18982","volume":"272","author":"SC Rumsey","year":"1997","unstructured":"Rumsey, S. C. et al. Glucose transporter isoforms GLUT1 and GLUT3 transport dehydroascorbic acid. J. Biol. Chem. 272 (30), 18982\u201318989 (1997).","journal-title":"J. Biol. Chem."},{"issue":"7","key":"34243_CR78","doi-asserted-by":"publisher","first-page":"4244","DOI":"10.1016\/S0021-9258(20)64313-7","volume":"266","author":"R Radi","year":"1991","unstructured":"Radi, R., Beckman, J. S., Bush, K. M. & Freeman, B. A. Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide. J. Biol. Chem. 266 (7), 4244\u20134250 (1991).","journal-title":"J. Biol. Chem."},{"issue":"4","key":"34243_CR79","doi-asserted-by":"publisher","first-page":"1881","DOI":"10.1152\/physrev.00005.2022","volume":"102","author":"L Piacenza","year":"2022","unstructured":"Piacenza, L., Zeida, A., Trujillo, M. & Radi, R. The superoxide radical switch in the biology of nitric oxide and peroxynitrite. Physiol. Rev. 102 (4), 1881\u20131906 (2022).","journal-title":"Physiol. Rev."},{"issue":"16","key":"34243_CR80","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1016\/j.clinbiochem.2008.08.064","volume":"41","author":"O Khymenets","year":"2008","unstructured":"Khymenets, O. et al. Role of sex and time of blood sampling in SOD1 and SOD2 expression variability. Clin. Biochem. 41 (16), 1348\u20131354 (2008).","journal-title":"Clin. Biochem."},{"key":"34243_CR81","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1016\/j.freeradbiomed.2020.09.014","volume":"160","author":"M Qu","year":"2020","unstructured":"Qu, M. et al. Sex-specific association between peripheral superoxide dismutase, BDNF and cognitive impairment in drug-naive first episode patients with schizophrenia. Free Radic. Biol. Med. 160, 887\u2013893 (2020).","journal-title":"Free Radic. Biol. Med."},{"issue":"2","key":"34243_CR82","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.jss.2010.11.312","volume":"165","author":"ES Moreira","year":"2011","unstructured":"Moreira, E. S. et al. Nitric oxide regulation of SOD-1 expression is gender specific and differs in diabetic environments: possible implications for the differential efficacy of no in the vasculature. J. Surg. Res. 165 (2), 327\u2013328 (2011).","journal-title":"J. Surg. Res."},{"issue":"5","key":"34243_CR83","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1111\/jcmm.13038","volume":"21","author":"MC Kander","year":"2017","unstructured":"Kander, M. C., Cui, Y. & Liu, Z. Gender difference in oxidative stress: a new look at the mechanisms for cardiovascular diseases. J. Cell. Mol. Med. 21 (5), 1024\u20131032 (2017).","journal-title":"J. Cell. Mol. Med."},{"key":"34243_CR84","doi-asserted-by":"crossref","unstructured":"Houldsworth, A. Role of oxidative stress in neurodegenerative disorders: a review of reactive oxygen species and prevention by antioxidants. Brain Communications, 6(1), fcad356 (2024).","DOI":"10.1093\/braincomms\/fcad356"},{"issue":"5","key":"34243_CR85","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1089\/ars.2019.7952","volume":"34","author":"AWK Yeung","year":"2020","unstructured":"Yeung, A. W. K. et al. Reactive oxygen species and their impact in neurodegenerative diseases: literature landscape analysis. Antioxid. Redox. Signal. 34 (5), 402\u2013420 (2020).","journal-title":"Antioxid. Redox. Signal."},{"issue":"5\u20136","key":"34243_CR86","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1054\/ceca.2000.0167","volume":"28","author":"EC Toescu","year":"2000","unstructured":"Toescu, E. C., Myronova, N. & Verkhratsky, A. Age-related structural and functional changes of brain mitochondria. Cell. Calcium. 28 (5\u20136), 329\u2013338 (2000).","journal-title":"Cell. Calcium"},{"issue":"3","key":"34243_CR87","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/BF03401915","volume":"4","author":"YM Kim","year":"1998","unstructured":"Kim, Y. M. et al. Inhibition of protein synthesis by nitric oxide correlates with cytostatic activity: nitric oxide induces phosphorylation of initiation factor eIF-2\u03b1. Mol. Med. 4 (3), 179\u2013190 (1998).","journal-title":"Mol. Med."},{"key":"34243_CR88","doi-asserted-by":"crossref","unstructured":"Ryder, L. et al. Nitric oxide-induced ribosome collision activates ribosomal surveillance mechanisms. Cell Death & Disease, 14(7),467. (2023).","DOI":"10.1038\/s41419-023-05997-5"},{"issue":"4","key":"34243_CR89","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1161\/ATVBAHA.108.181628","volume":"30","author":"CT Taylor","year":"2010","unstructured":"Taylor, C. T., Moncada, S., Oxide, N., Cytochrome, C. &, Oxidase, and the cellular response to hypoxia. Arterioscler. Thromb. Vasc. Biol. 30 (4), 643\u2013647 (2010).","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"15","key":"34243_CR90","doi-asserted-by":"publisher","first-page":"4283","DOI":"10.1113\/JP271942","volume":"594","author":"S Chalmers","year":"2016","unstructured":"Chalmers, S., Saunter, C. D., Girkin, J. M. & McCarron, J. G. Age decreases mitochondrial motility and increases mitochondrial size in vascular smooth muscle. J. Physiol. 594 (15), 4283\u20134295 (2016).","journal-title":"J. Physiol."},{"key":"34243_CR91","doi-asserted-by":"crossref","unstructured":"Neikirk, K. et al. Call to action to properly utilize electron microscopy to measure organelles to monitor disease. European Journal of Cell Biology, 102(4),151365. (2023).","DOI":"10.1016\/j.ejcb.2023.151365"},{"key":"34243_CR92","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.neuroimage.2014.04.078","volume":"98","author":"SL Peng","year":"2014","unstructured":"Peng, S. L. et al. Age-related increase of resting metabolic rate in the human brain. NeuroImage 98, 176\u2013183 (2014).","journal-title":"NeuroImage"},{"key":"34243_CR93","doi-asserted-by":"crossref","unstructured":"Gaignard, P., Liere,Th\u00e9rond, M., Schumacher, A. & Slama and R. Guennoun, role of sex hormones on brain mitochondrial function, with special reference to aging and neurodegenerative diseases. Frontiers Aging Neuroscience, 9, 406 (2017).","DOI":"10.3389\/fnagi.2017.00406"},{"issue":"3","key":"34243_CR94","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.3233\/JAD-170585","volume":"62","author":"RH Swerdlow","year":"2018","unstructured":"Swerdlow, R. H. Mitochondria and mitochondrial cascades in alzheimer\u2019s disease. J. Alzheimer\u2019s Disease. 62 (3), 1403\u20131416 (2018).","journal-title":"J. Alzheimer\u2019s Disease"},{"issue":"8","key":"34243_CR95","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/s41582-018-0032-9","volume":"14","author":"MT Ferretti","year":"2018","unstructured":"Ferretti, M. T. et al. Sex differences in alzheimer disease\u2014the gateway to precision medicine. Nat. Reviews Neurol. 14 (8), 457\u2013469 (2018).","journal-title":"Nat. Reviews Neurol."},{"issue":"5","key":"34243_CR96","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1176\/appi.ajp.159.5.738","volume":"159","author":"GE Alexander","year":"2002","unstructured":"Alexander, G. E., Chen,Pietrini, K., Rapoport, S. I. & Reiman, E. M. Longitudinal PET evaluation of cerebral metabolic decline in dementia: a potential outcome measure in alzheimer\u2019s disease treatment studies. Am. J. Psychiatry. 159 (5), 738\u2013745 (2002).","journal-title":"Am. J. Psychiatry"},{"issue":"7","key":"34243_CR97","first-page":"1238","volume":"36","author":"S Minoshima","year":"1995","unstructured":"Minoshima, S., Frey, K. A., Koeppe, R. A., Foster, N. L. & Kuhl, D. E. A diagnostic approach in alzheimer\u2019s disease using three-dimensional stereotactic surface projections of fluorine-18-FDG PET. J. Nucl. Med. 36 (7), 1238\u20131248 (1995).","journal-title":"J. Nucl. Med."},{"issue":"17","key":"34243_CR98","doi-asserted-by":"publisher","first-page":"2120","DOI":"10.1001\/jama.286.17.2120","volume":"286","author":"DH Silverman","year":"2001","unstructured":"Silverman, D. H. et al. Positron emission tomography in evaluation of dementia: regional brain metabolism and long-term outcome. Jama 286 (17), 2120\u20132127 (2001).","journal-title":"Jama"},{"key":"34243_CR99","doi-asserted-by":"publisher","first-page":"e935135","DOI":"10.12659\/MSM.935135","volume":"28","author":"J Dziedziak","year":"2022","unstructured":"Dziedziak, J., Zaleska-\u017bmijewska, A., Szaflik, J. P. & Cudnoch-J\u0119drzejewska, A. Impact of arterial hypertension on the eye: A review of the Pathogenesis, diagnostic Methods, and treatment of hypertensive retinopathy. Med. Sci. Monit. 28, e935135 (2022).","journal-title":"Med. Sci. Monit."},{"key":"34243_CR100","doi-asserted-by":"publisher","first-page":"107706","DOI":"10.1016\/j.exer.2019.107706","volume":"186","author":"AJ Feola","year":"2019","unstructured":"Feola, A. J. et al. Menopause exacerbates visual dysfunction in experimental glaucoma. Exp. Eye Res. 186, 107706 (2019).","journal-title":"Exp. Eye Res."},{"key":"34243_CR101","doi-asserted-by":"crossref","unstructured":"Hogan, K., Cui, X., Giangiacomo, A. & Feola, A. J. Postmenopausal Hormone Therapy Was Associated With Later Age of Onset Among Glaucoma Cases. Invest Ophthalmol Vis Sci, 65(10),31. (2024).","DOI":"10.1167\/iovs.65.10.31"},{"issue":"1","key":"34243_CR102","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s10571-021-01179-z","volume":"43","author":"A Douglass","year":"2023","unstructured":"Douglass, A., Dattilo, M. & Feola, A. J. Evidence for menopause as a Sex-Specific risk factor for glaucoma. Cell. Mol. Neurobiol. 43 (1), 79\u201397 (2023).","journal-title":"Cell. Mol. Neurobiol."},{"key":"34243_CR103","doi-asserted-by":"publisher","first-page":"101336","DOI":"10.1016\/j.preteyeres.2025.101336","volume":"105","author":"SH Zhao","year":"2025","unstructured":"Zhao, S. H. et al. Comparative insights into the role of sex hormones in glaucoma among women and men. Prog Retin Eye Res. 105, 101336 (2025).","journal-title":"Prog Retin Eye Res."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-34243-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-34243-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-34243-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T11:03:35Z","timestamp":1769771015000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-34243-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,9]]},"references-count":103,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["34243"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-34243-5","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,9]]},"assertion":[{"value":"8 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"4167"}}