{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T20:17:29Z","timestamp":1769804249469,"version":"3.49.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":18,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2024YFC2421200"],"award-info":[{"award-number":["2024YFC2421200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82400403"],"award-info":[{"award-number":["82400403"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Three-year action plan project to promote clinical skills and clinical innovation ability of Shanghai municipal hospitals","award":["SHDC2020CR1039B"],"award-info":[{"award-number":["SHDC2020CR1039B"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-34554-7","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T15:44:37Z","timestamp":1768232677000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Left atrial appendage closure with a novel nonpacifier device for stroke prevention in atrial fibrillation"],"prefix":"10.1038","volume":"16","author":[{"given":"Ziyong","family":"Hao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weifeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongping","family":"Ning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenyang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianjun","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisheng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"key":"34554_CR1","doi-asserted-by":"publisher","first-page":"e125","DOI":"10.1161\/CIR.0000000000000665","volume":"140","author":"CT January","year":"2019","unstructured":"January, C. T. et al. 2019 AHA\/ACC\/HRS focused update of the 2014 AHA\/ACC\/HRS guideline for the management of patients with atrial fibrillation: A report of the American college of cardiology\/American heart association task force on clinical practice guidelines and the heart rhythm society in collaboration with the society of thoracic surgeons. Circulation 140, e125\u2013e151 (2019).","journal-title":"Circulation"},{"key":"34554_CR2","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1093\/eurheartj\/ehaa612","volume":"42","author":"G Hindricks","year":"2021","unstructured":"Hindricks, G. et al. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): The Task Force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC. Eur. Heart J. 42, 373\u2013498 (2021).","journal-title":"Eur. Heart J."},{"key":"34554_CR3","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1016\/S0140-6736(06)68845-4","volume":"367","author":"S Connolly","year":"2006","unstructured":"Connolly, S. et al. Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): A randomised controlled trial. The Lancet 367, 1903\u20131912 (2006).","journal-title":"The Lancet"},{"key":"34554_CR4","doi-asserted-by":"publisher","first-page":"1988","DOI":"10.1001\/jama.2014.15192","volume":"312","author":"VY Reddy","year":"2014","unstructured":"Reddy, V. Y. et al. Percutaneous left atrial appendage closure vs warfarin for atrial fibrillation: A randomized clinical trial. JAMA 312, 1988\u20131998 (2014).","journal-title":"JAMA"},{"key":"34554_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jacc.2014.04.029","volume":"64","author":"DR Holmes","year":"2014","unstructured":"Holmes, D. R. et al. Prospective randomized evaluation of the Watchman Left Atrial Appendage Closure device in patients with atrial fibrillation versus long-term warfarin therapy: The PREVAIL trial. J. Am. Coll. Cardiol. 64, 1\u201312 (2014).","journal-title":"J. Am. Coll. Cardiol."},{"key":"34554_CR6","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1161\/CIR.0000000000001193","volume":"149","author":"JA Joglar","year":"2024","unstructured":"Joglar, J. A. et al. 2023 ACC\/AHA\/ACCP\/HRS guideline for the diagnosis and management of atrial fibrillation: A report of the American college of cardiology\/American heart association joint committee on clinical practice guidelines. Circulation 149, e1\u2013e156 (2024).","journal-title":"Circulation"},{"key":"34554_CR7","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1056\/NEJMoa2101897","volume":"384","author":"RP Whitlock","year":"2021","unstructured":"Whitlock, R. P. et al. Left atrial appendage occlusion during cardiac surgery to prevent stroke. N. Engl. J. Med. 384, 2081\u20132091 (2021).","journal-title":"N. Engl. J. Med."},{"key":"34554_CR8","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1161\/CIRCULATIONAHA.119.040860","volume":"140","author":"L Asmarats","year":"2019","unstructured":"Asmarats, L. et al. Recurrence of device-related thrombus after percutaneous left atrial appendage closure. Circulation 140, 1441\u20131443 (2019).","journal-title":"Circulation"},{"key":"34554_CR9","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1016\/j.jcin.2019.02.003","volume":"12","author":"A Aminian","year":"2019","unstructured":"Aminian, A. et al. Incidence, characterization, and clinical impact of device-related thrombus following left atrial appendage occlusion in the prospective global AMPLATZER amulet observational study. JACC Cardiovasc. Intervent. 12, 1003\u20131014 (2019).","journal-title":"JACC Cardiovasc. Intervent."},{"key":"34554_CR10","doi-asserted-by":"publisher","first-page":"e944","DOI":"10.4244\/EIJ-D-21-00320","volume":"17","author":"VH Agudelo","year":"2021","unstructured":"Agudelo, V. H. et al. Prevalence, mechanisms and impact of residual patency and device-related thrombosis following left atrial appendage occlusion: A computed tomography analysis. EuroIntervention 17, e944\u2013e952 (2021).","journal-title":"EuroIntervention"},{"key":"34554_CR11","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.jacc.2022.04.062","volume":"80","author":"SR Dukkipati","year":"2022","unstructured":"Dukkipati, S. R. et al. Impact of peridevice leak on 5-year outcomes after left atrial appendage closure. J. Am. Coll. Cardiol. 80, 469\u2013483 (2022).","journal-title":"J. Am. Coll. Cardiol."},{"key":"34554_CR12","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1161\/CIRCULATIONAHA.120.050117","volume":"143","author":"S Kar","year":"2021","unstructured":"Kar, S. et al. Primary outcome evaluation of a next-generation left atrial appendage closure device: Results from the PINNACLE FLX trial. Circulation 143, 1754\u20131762 (2021).","journal-title":"Circulation"},{"key":"34554_CR13","first-page":"1543","volume":"144","author":"D Lakkireddy","year":"2021","unstructured":"Lakkireddy, D. et al. Amplatzer amulet left atrial appendage occluder versus watchman device for stroke prophylaxis (amulet IDE): A randomized. Controlled Trial. Circulation 144, 1543\u20131552 (2021).","journal-title":"Controlled Trial. Circulation"},{"key":"34554_CR14","doi-asserted-by":"publisher","first-page":"2188","DOI":"10.1016\/j.jcin.2017.06.072","volume":"10","author":"H Huang","year":"2017","unstructured":"Huang, H. et al. Percutaneous left atrial appendage closure with the lambre device for stroke prevention in atrial fibrillation. JACC Cardiovasc. Intervent. 10, 2188\u20132194 (2017).","journal-title":"JACC Cardiovasc. Intervent."},{"key":"34554_CR15","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.974994","volume":"9","author":"Y Bai","year":"2020","unstructured":"Bai, Y. et al. A newly designed disk-lobe occluder with isogenous barbs for left atrial appendage closure: Initial multicenter experience. Front. Cardiovasc. Med. 9, 974994 (2020).","journal-title":"Front. Cardiovasc. Med."},{"key":"34554_CR16","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.jacasi.2022.04.009","volume":"2","author":"X Zhang","year":"2022","unstructured":"Zhang, X. et al. Percutaneous left atrial appendage closure with a novel LAA occluder for stroke prevention in atrial fibrillation. JACC Asia 2, 547\u2013556 (2022).","journal-title":"JACC Asia"},{"key":"34554_CR17","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.4244\/EIJY19M08_01","volume":"15","author":"M Glikson","year":"2020","unstructured":"Glikson, M. et al. EHRA\/EAPCI expert consensus statement on catheter-based left atrial appendage occlusion: An update. EuroIntervention 15, 1133\u20131180 (2020).","journal-title":"EuroIntervention"},{"key":"34554_CR18","doi-asserted-by":"publisher","first-page":"2736","DOI":"10.1161\/CIRCULATIONAHA.110.009449","volume":"123","author":"R Mehran","year":"2011","unstructured":"Mehran, R. et al. Standardized bleeding definitions for cardiovascular clinical trials: A consensus report from the Bleeding Academic Research Consortium. Circulation 123, 2736\u20132747 (2011).","journal-title":"Circulation"},{"key":"34554_CR19","doi-asserted-by":"publisher","first-page":"e590","DOI":"10.4244\/EIJ-D-18-00344","volume":"14","author":"U Landmesser","year":"2018","unstructured":"Landmesser, U. et al. Left atrial appendage occlusion with the AMPLATZER Amulet device: One-year follow-up from the prospective global Amulet observational registry. EuroIntervention 14, e590\u2013e597 (2018).","journal-title":"EuroIntervention"},{"key":"34554_CR20","doi-asserted-by":"publisher","first-page":"2127","DOI":"10.1016\/j.jcin.2022.09.001","volume":"15","author":"MJ Price","year":"2022","unstructured":"Price, M. J. et al. Peridevice leak after transcatheter left atrial appendage occlusion. JACC Cardiovasc. Intervent. 15, 2127\u20132138 (2022).","journal-title":"JACC Cardiovasc. Intervent."},{"key":"34554_CR21","first-page":"2071","volume":"99","author":"K Korsholm","year":"2022","unstructured":"Korsholm, K., Jensen, J. M., N\u00f8rgaard, B. L. & Nielsen-Kudsk, J. E. Temporal changes and clinical significance of peridevice leak following left atrial appendage occlusion with Amplatzer devices. Cathet. Cardio. Intervent. 99, 2071\u20132079 (2022).","journal-title":"Cathet. Cardio. Intervent."},{"key":"34554_CR22","doi-asserted-by":"publisher","first-page":"90","DOI":"10.4244\/EIJ-D-19-00821","volume":"17","author":"C So","year":"2021","unstructured":"So, C. et al. Procedural and short-term outcomes of occluding large left atrial appendages with the LAmbre device. EuroIntervention 17, 90\u201392 (2021).","journal-title":"EuroIntervention"},{"key":"34554_CR23","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1016\/j.jcin.2024.01.310","volume":"17","author":"R Galea","year":"2024","unstructured":"Galea, R. et al. Pericardial effusion after left atrial appendage closure. JACC Cardiovasc. Intervent. 17, 1295\u20131307 (2024).","journal-title":"JACC Cardiovasc. Intervent."},{"key":"34554_CR24","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1093\/eurheartj\/ehad828","volume":"45","author":"A Samaras","year":"2024","unstructured":"Samaras, A. et al. Residual leaks following percutaneous left atrial appendage occlusion and outcomes: A meta-analysis. Eur. Heart J. 45, 214\u2013229 (2024).","journal-title":"Eur. Heart J."},{"key":"34554_CR25","doi-asserted-by":"publisher","first-page":"224","DOI":"10.4244\/EIJ-D-21-01010","volume":"18","author":"TS Simard","year":"2022","unstructured":"Simard, T. S., Hibbert, B., Alkhouli, M. A., Abraham, N. A. & Holmes, D. H. Device-related thrombus following left atrial appendage occlusion. EuroIntervention 18, 224\u2013232 (2022).","journal-title":"EuroIntervention"},{"key":"34554_CR26","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/j.jcin.2022.02.009","volume":"15","author":"MJ Price","year":"2022","unstructured":"Price, M. J. et al. Clinical outcomes at 1 year following transcatheter left atrial appendage occlusion in the United States. JACC Cardiovasc. Intervent. 15, 741\u2013750 (2022).","journal-title":"JACC Cardiovasc. Intervent."},{"key":"34554_CR27","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1056\/NEJMoa2408308","volume":"392","author":"OM Wazni","year":"2025","unstructured":"Wazni, O. M. et al. Left atrial appendage closure after ablation for atrial fibrillation. N. Engl. J. Med. 392, 1277\u20131287 (2025).","journal-title":"N. Engl. J. Med."},{"key":"34554_CR28","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1001\/jamacardio.2024.2335","volume":"9","author":"X Freixa","year":"2024","unstructured":"Freixa, X. et al. Low-dose direct oral anticoagulation vs dual antiplatelet therapy after left atrial appendage occlusion. JAMA Cardiol. 9, 922 (2024).","journal-title":"JAMA Cardiol."},{"key":"34554_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jacc.2021.10.023","volume":"79","author":"P Osmancik","year":"2022","unstructured":"Osmancik, P. et al. 4-Year outcomes after left atrial appendage closure versus Nonwarfarin oral anticoagulation for atrial fibrillation. J. Am. Coll. Cardiol. 79, 1\u201314 (2022).","journal-title":"J. Am. Coll. Cardiol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-34554-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-34554-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-34554-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T10:24:00Z","timestamp":1769768640000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-34554-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,12]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["34554"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-34554-7","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,12]]},"assertion":[{"value":"26 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The author(s) declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"4287"}}